The genetic variation in Monocarboxylic acid transporter 2 ( <i>MCT2</i> ) has functional and clinical relevance with male infertility

Lee, Jinu,Lee, Dong Ryul,Lee, Suman Medknow PublicationsMedia Pvt Ltd 2014 ASIAN JOURNAL OF ANDROLOGY Vol.16 No.5

<P>Monocarboxylic acid transporter 2 (MCT2) transports pyruvate and lactate outside and inside of sperms, mainly as energy sources and plays roles in the regulation of spermatogenesis. We investigated the association among genetic variations in the <I>MCT2</I> gene, male infertility and <I>MCT2</I> expression levels in sperm. The functional and genetic significance of the intron 2 (+28201A > G, rs10506398) and 3’ untranslated region (UTR) single nucleotide polymorphism (SNP) (+2626G > A, rs10506399) of MCT2 variants were investigated. Two MCT2 polymorphisms were associated with male infertility (<I>n</I> = 471, <I>P</I> < 0.05). In particular, the MCT2-3’ UTR SNP (+2626 G > A) had a strong association with the oligoasthenoteratozoospermia (OAT) group. The +2626GG type had an almost 2.4-fold higher sperm count than that of the +2626AA type (+2626GG; 66 × 10<SUP>6</SUP><I>vs</I> +2626AA; 27 × 10<SUP>6</SUP>, <I>P</I> < 0.0001). The MCT2-3’ UTR SNP may be important for expression, as it is located at the MCT2 3’ UTR. The average MCT2 protein amount in sperm of the +2626GG type was about two times higher than that of the +2626AA type. The results suggest that genetic variation in MCT2 has functional and clinical relevance with male infertility.</P>

AC impedance spectroscopic studies of transport properties in metal oxide doped α-NPD

Suman, C.K.,Yun, Jinyoung,Kim, Seohee,Lee, Sin-Doo,Lee, Changhee Elsevier 2009 CURRENT APPLIED PHYSICS Vol.9 No.5

<P><B>Abstract</B></P><P>The potential application of molecular organic semiconductor needs the control adjustment of conductivity. The hole transport materials (HTL) α<B>-</B>NPD (<I>N</I>,<I>N′</I>-di(1-naphthyl)-<I>N</I>,<I>N</I>′-diphenylbenzidin) has been doped with metal oxide (molybdenum oxide) for the study of transport phenomena. Impedance spectroscopic measurements were performed with the applied external electric filed. The activation energy calculated (0.55, 0.48 and 0.50eV) decreases with doping of metal oxide. There is a clear indication of space charge limited (SCL) conduction in the doped and undoped thin films. The cole–cole plot indicates the device can be represented by a parallel resistance and capacitance network in series with a series resistance (of 70Ω). At high frequency; the conduction follows the universal power law for both doped–undoped α-NPD with MoO<SUB>3</SUB> and the onset frequency increases with increasing bias voltages. The conduction mechanism can be explained by classical hopping barriers (CHB) mechanism for the system.</P>

Wound Healing Effects of <i> Prunus yedoensis</i> Matsumura Bark in Scalded Rats

Lee, Jin-Ho,Lee, Kyungjin,Lee, Mi-Hwa,Kim, Bumjung,Chinannai, Khanita Suman,Hur, Heseung,Ham, Inhye,Choi, Ho-Young Hindawi 2017 Evidence-based Complementary and Alternative Medic Vol.2017 No.-

<P>Pruni Cortex has been used to treat asthma, measles, cough, urticaria, pruritus, and dermatitis in traditional Korean medicine. The objective of this study was to investigate the effects of<I> Prunus yedoensis</I> Matsumura bark methanol extract (PYE) on scald-induced dorsal skin wounds in rats. Scalds were produced in Sprague-Dawley rats with 100°C water and treated with 5% and 20% PYE (using Vaseline as a base), silver sulfadiazine (SSD), and Vaseline once a day for 21 days, beginning 24 hours after scald by treatment group allocation. The PYE-treated groups showed accelerated healing from 12 days after scald, demonstrated by rapid eschar exfoliation compared to the control and SSD groups. PYE-treated groups showed higher wound contraction rates and better tissue regeneration in comparison with the control group. Serum analysis showed that transforming growth factor beta 1 and vascular endothelial growth factor levels remained high or gradually increased up to day 14 in both PYE groups and then showed a sharp decline by day 21, implying successful completion of the inflammatory phase and initiation of tissue regeneration. These findings suggested that PYE is effective in promoting scald wound healing in the inflammation and tissue proliferation stages.</P>

Gene Expression Analysis of Cultured Amniotic Fluid Cell with Down Syndrome by DNA Microarray

Lee Suman,이숙환,이교원,Park Sang hee,Cha Kwang Yul,김남순,김용성,Chung In Hyuk,Yoo Hyang Sook 대한의학회 2005 Journal of Korean medical science Vol.20 No.1

The American Public’s Perception of China’s Hard Power, Soft Power, and World Influence

Suman Lee,Hyehyun Hong Korean Academic Society For Public Relations 2021 Asian Journal of Public Relations Vol.4 No.1

In the age of globalization, understanding what and how foreign publics think of a nation is essential because it provides valuable insights into the directions of public diplomacy. In this regard, this study examined the American public’s perceptions of China - particularly, its significant hard and soft power factors and overall world influence. A dataset of 2,046 responses was analyzed from the 2018 national survey in the U.S. While two hard power factors (i.e., economic power and military strength) were the strongest predictors of an evaluation of China’s world influence, soft power factors, such as presidential image and technology/innovation, also contributed to a positive evaluation of China. This study showed current challenges being faced by China as well as opportunities for Chinese public diplomacy efforts.

Identification of New Proteins in Follicular Fluid from Mature Human Follicles by Direct Sample Rehydration Method of Two-Dimensional Polyacrylamide Gel Electrophoresis

Lee Han Chul,이상화,이교원,이숙환,Cha Kwang Yul,김계현,Lee Suman 대한의학회 2005 Journal of Korean medical science Vol.20 No.3

The American Public’s Perception of China’s Hard Power, Soft Power, and World Influence

( Suman Lee ),( Hyehyun Hong ) 한국PR학회 2021 AJPR Vol.4 No.1

In the age of globalization, understanding what and how foreign publics think of a nation is essential because it provides valuable insights into the directions of public diplomacy. In this regard, this study examined the American public’s perceptions of China - particularly, its significant hard and soft power factors and overall world influence. A dataset of 2,046 responses was analyzed from the 2018 national survey in the U.S. While two hard power factors (i.e., economic power and military strength) were the strongest predictors of an evaluation of China’s world influence, soft power factors, such as presidential image and technology/innovation, also contributed to a positive evaluation of China. This study showed current challenges being faced by China as well as opportunities for Chinese public diplomacy efforts.

Measurement of MDA of Soil Samples Using Unsuppression System and Compton Suppression of Environmental Radioactivity in Processing Technology

강수만(Suman Kang),임인철(Inchul Im),이재승(Jaeseung Lee),장은성(Eunsung Jang),이미현(Mihyeon Lee),권경태(Kyungtae Kwon),김창태(Changtae Kim) 한국방사선학회 2014 한국방사선학회 논문지 Vol.8 No.6

Compton suppression 장치는 Compton 산란 반응을 이용하여, 스펙트럼의 Compton continuum 부분을 억제함으로써 Compton continuum 영역 내에서의 감마선 피크들의 분석을 보다 명확하게 할 수 있게 해주는 장치이다. 표층토양시료에서 검출된 인공 방사능인 ¹³⁷Cs과 자연 방사능인 40K핵종의 방사능 농도 값들에 대한 방사능 계수치가 백그라운드를 상회하는 측정값이 발생되거나, 불필요한 방해피크나 비해석 대상 피크에 대하여 검출된 표준선원의 방사능 농도값들의 실측치에 대한 background를 비억제 스펙트럼(Compton Unsuppression)과 억제 스펙트럼(Compton suppression)을 적용시켜 측정 에너지에 대한 교정을 알고자 점선원인 ¹³⁷Cs을 거리별에 따라 측정하여, 몬테칼로 시뮬레이션과 비교 분석함으로서 효율적인 검출 능력을 얻고자 함이며, Compton 억제 인자를 보면 거리가 멀어짐에 따라 CSF 값이 클수록 더 많은 Compton suppression가 이루어졌음을 알 수 있고, ¹³⁷Cs을 이용한 컴프턴 비억제 모드와 억제모드로 측정된 스펙트럼에서 컴프턴 연속에 의한 백그라운드가 감소함을 알 수 있었다. Compton suppression device is a device by using the Compton scattering reaction and suppress the Compton continuum portion of the spectrum, so can be made more clear analysis of gamma ray peak in the Compton continuum region. Measurements above background occurs or, radioactivity counts of radioactivity concentration value of 40K nuclides ¹³⁷Cs and natural radioactivity artificial radioactivity detected from the surface soil sample, unwanted non-target analysis and interference peak who dotted line you know the calibration of the measurement energy is allowed to apply the (Compton suppression) non-suppressed spectrum inhibition spectrum and (Compton Unsuppression) the background to the measured value of the activity concentration value of the standard-ray source is detected relative to the peak of By measuring according to the different distances cause ¹³⁷Cs, and comparative analysis of the Monte Carlo simulation, in order to obtain a detection capability for efficient, looking at the Compton inhibitor, as the CSF value increases with increase in the distance, more It was found that the background due to Compton continuum of the measured spectrum suppression mode Compton unrestrained mode can know that the Compton suppression many were made, using a ¹³⁷Cs is reduced.

방사선치료 선량 측정에 사용되는 열형광체에 따른 최대 형광 강도 특성

강수만(Suman Kang),임인철(Inchul Im),박철우(Cheolwoo Park),이미현(Mihyeon Lee),이재승(Jaeseung Lee) 한국방사선학회 2014 한국방사선학회 논문지 Vol.8 No.4

본 연구는 방사선 치료 영역의 선량 측정을 위하여 상용화된 열형광선량계의 가열 온도에 따른 형광 곡선의 특성을 분석하였다. 본 연구에 사용된 열형광선량계는 LiF:MgㆍTi, LiF:MgㆍCuㆍP, CaF₂:Dy, CaF₂:Mn(Thermo Fisher Scientific Inc., USA)이었다. 선원과 고체 팬텀 표면(RW3 slab, IBA Dosimetry, Germany)간 거리를 100cm로 하여 기준점 깊이에서 6MV, 15MV X선과 6MeV, 12MeV 전자선을 각각 100MU 조사하였다. 방사선 조사 후 열형광 판독기(Hashaw 3500, Thermo Fisher Scientific Inc., USA)를 사용하여 50°C에서 260°C까지 15°C/sec의 가온율로 가열하여 형광 곡선을 분석하였다. 트랩 준위에 포획된 전자가 정공과 결합하면서 빛을 방출하는 형광 피크(glow peak)는 2개 또는 3개의 피크가 나타났으며 방사선 조사 후 TLD의 온도를 일정하게 증가시켰을 때 최대 형광 피크를 나타내는 형광 온도의 경우 각각의 에너지에 따라 LiF:Mg·Ti 선량계는 185.5±1.3°C, LiF:Mg·Cu·P 선량계는 135.0±5.1°C, CaF₂:Dy 선량계는 144.0±1.6°C, CaF₂:Mn 선량계는 294.3±3.8°C 근처에서 최대 형광 피크를 각각 나타났다. 방사선 조사 후 포획 전자의 형광 방출 확률은 가열 온도에 의존하게 되므로 방사선 치료 영역의 선량 측정에서 방사선 조사 후 열형광선량계에 일정한 가온율을 적용함으로써 고유한 물리적 특성에 따른 측정 정확도를 향상시킬 수 있을 것으로 판단되었다. The purpose of this study were to analyze the characteristic of the glow curves in order to the glow temperature of the thermoluminescent dosimeters (TLDs) for the absorbed dose measurement of the radiation therapy. In this study, we was used the TLDs of the LiF:MgㆍTi, LiF:MgㆍCuㆍP, CaF₂:Dy, CaF₂:Mn (Thermo Fisher Scientific Inc., USA). The source-to-solid dry phantom (RW3 slab, IBA Dosmetry, Germany) surface distance was set at 100 cm, and the exposure dose of 100 MU (monitor unit) was used 6- and 15-MV X-rays, and 6- and 12-MeV electron beams in the reference depth, respectively. After the radiations exposure, we were to analyze the glow curves by using the TL reader (Hashaw 3500, Thermo Fisher Scientific Inc., USA) at the fixed heating rate of 15°C/sec from 50°C to 260°C. The glow peaks, the trapping level in the captured electrons and holes combined with the emitted light, were discovered the two or three peak. When the definite increasing the temperature of the TLDs, the maximum glow peak representing the glow temperature was follow as; LiF:Mg·Ti: 185.5±1.3°C, LiF:Mg·Cu·P: 135.0±5.1°C, CaF₂:Dy: 144.0±1.6°C, CaF₂:Mn: 294.3±3.8°C, respectively. Because the glow emission probability of the captured electrons depend on the heating temperature after the exposure radiation, TLDs by applying the fixed heating rate, the accuracy of measurement will be able to improve within the absorbed dose measurement of the radiation therapy.

IoT 기술을 이용한 차량 실내 자동 온습도 조절장치에 관한 연구

이수만(Suman Lee),이소윤(Soyun Lee),최고은(Goeun Choi),강규창(Kyuchang Kang) 한국통신학회 2019 한국통신학회 학술대회논문집 Vol.2019 No.6