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RISS 인기검색어
- 검색키워드
- 저자 : Sul'ain, Mohd Dasuki (검색결과 3 건)
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Association of The IDH1 C.395G>A (R132H) Mutation with Histological Type in Malay Brain Tumors
Yusoff, Abdul Aziz Mohamed,Zulfakhar, Fatin Najwa,Sul'ain, Mohd Dasuki,Idris, Zamzuri,Abdullah, Jafri Malin Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.12
Background: Brain tumors, constituting one of the most deadly forms of cancer worldwide, result from the accumulation of multiple genetic and epigenetic alterations in genes and signaling pathways. Isocitrate dehydrogenase enzyme isoform 1 (IDH1) mutations are frequently identified in primary brain tumors and acute myeloid leukemia. Studies on IDH1 gene mutations have been extensively performed in various populations worldwide but not in Malaysia. This work was conducted to study the prevalence of IDH1 c.395G>A (R132H) hotspot mutations in a group of Malaysian patients with brain tumors in order to gain local data for the IDH1 mutation profile in our population. Methods: Mutation analysis of c.395G>A (R132H) of IDH1 was performed in 40 brain tumor specimens by the polymerase chain reaction-restriction fragment length polymorphism method (PCR-RFLP) and then verified by direct sequencing. Associations between the IDH1 c.395G>A (R132H) mutation and clinicopathologic characteristics were also analyzed. Results: The IDH1 c.395G>A (R132H) mutation was detected in 14/40 patients (35%). A significant association was found with histological tumor types, but not with age, gender and race. Conclusions: IDH1 is frequently mutated and associated with histological subtypes in Malay brain tumors.
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Zamani, Afiqah,Jusoh, Siti Asmaa Mat,Al-Jamal, Hamid Ali Nagi,Sul'ain, Mohd Dasuki,Johan, Muhammad Farid Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.11
Background: Imatinib mesylate, a tyrosine kinase inhibitor specifically targeting the BCR/ABL fusion protein, induces hematological remission in patients with chronic myeloid leukemia (CML). However, the majority of CML patients treated with imatinib develop resistance with prolonged therapy. Dendrophthoe pentandra (L.) Miq. is a Malaysian mistletoe species that has been used as a traditional treatment for several ailments such as smallpox, ulcers, and cancers. Methods: We developed a resistant cell line (designated as K562R) by long-term co-culture of a BCR/ABL positive CML cell line, K562, with imatinib mesylate. We then investigated the anti-proliferative effects of D. pentandra methanol extract on parental K562 and resistant K562R cells. Trypan blue exclusion assays were performed to determine the IC50 concentration; apoptosis and cell cycle analysis were conducted by flow cytometry. Results: D. pentandra extract had greater anti-proliferative effects towards K562R ($IC50=192{\mu}g/mL$) compared to K562 ($500{\mu}g/mL$) cells. Upon treatment with D. pentandra extract at the IC50. concentration: K562 but not K562R demonstrated increase in apoptosis and cell cycle arrest in the G2/M phase. Conclusion: D. pentandra methanol extract exerts potent anti-proliferative effect on BCR/ABL positive K562 cells.
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Evaluation on composition, antioxidant and toxicity of Melaleuca cajuputi leaves
Noor Arif Azimi Md,Yusuf Siti Mahirah,Wahab Wan Nor Amilah Wan Abdul,Adam Md Faizul Ismal Che,Sul’ain Mohd Dasuki 경희대학교 융합한의과학연구소 2021 Oriental Pharmacy and Experimental Medicine Vol.21 No.4
Melaleuca cajuputi (MC) is an aromatic herb that belongs to Myrtaceae family. MC leaves are widely used as traditional medicine, cooking flavour and freshening agent in cosmetics. In this study, the proximate analysis of MC leaves comprised of moisture (2.74%), ash (7.76 ± 0.04%), crude fat (4.83 ± 0.20%), calorie (4974 Cal/g), dietary fibre (9.49 ± 0.01%), protein (6.42 ± 0.06%) and carbohydrates (78.25 ± 1.02%). Besides that, in BSLA only MCME produced toxicity effect with LC50 value of 427 µg/mL while MCEO, MCAE and MCDE not showed any toxicity effect based on Meyer’s and Clarkson’s classification. Moreover, MCME produced the highest TPC and TFC value followed with MCAE, MCEO and MCDE which indicated highest free radical scavenging activity. Next, GCMS analysis revealed that 19 compounds are found in MCEO that possess antidepressant and anxiolytic effects. Furthermore, the concentrations of heavy metals in MCEO (lead, cadmium, arsenic and mercury) are within normal range concentrations based on British pharmacopoeia 2008.
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