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- 검색키워드
- 저자 : Sukumaran Anil (검색결과 6 건)
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Anil, Sukumaran,Gopikrishnan, PB,Basheer, Ashik Bin,Vidyullatha, BG,Alogaibi, Yahya A,Chalisserry, Elna P,Javed, Fawad,Dalati, MHN,Vellappally, Sajith,Hashem, Mohamed Ibrahim,Divakar, Darshan Devang Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.8
Background: Oral cancers account for approximately 2% of all cancers diagnosed each year; however, the vast majority (80%) of the affected individuals are smokers whose risk of developing a lesion is five to nine times greater than that of non-smokers. Tobacco smoke contains numerous carcinogens that cause DNA damage, including oxidative lesions that are removed effectively by the base-excision repair (BER) pathway, in which poly (ADP-ribose) polymerase 1 (PARP-1), plays key roles. Genetic variations in the genes encoding DNA repair enzymes may alter their functions. Several studies reported mixed effects on the association between PARP-1 variants and the risk of cancer development. Till now no reported studies have investigated the association between PARP-1 variants and oral squamous cell carcinoma (OSCC) risk in an Indian population. Materials and Methods: In the present case control study 100 OSCC patients and 100 matched controls were genotyped using PARP1 single nucleotide peptides (SNP's) rs1136410 and rs3219090 using TaqMan assays. Results: The results indicated significantly higher risk with PARP1 rs1136410 minor allele "C" (OR=1.909; p=0.02942; CI, 1.060-3.439). SNP rs1136410 also showed significantly increased risk in patients with smoking habit at C/C genotype and at minor allele C. Conclusions: The PAPR-1 Ala762Val polymorphism may play a role in progression of OSCC. Larger studies with a greater number of samples are needed to verify these findings.
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Hydroxyapatite Derived from Marine Resources and their Potential Biomedical Applications
Jayachandran Venkatesan,Sukumaran Anil 한국생물공학회 2021 Biotechnology and Bioprocess Engineering Vol.26 No.3
Utilization of bone graft substitutes have increased due to the rising number of accidents, trauma, and aging population. Autograft is still considered as a gold standard for treating bone defects. However, limitations such as insufficient donor sites and secondary surgery, leads to the development of alternative grafts. Hydroxyapatite (HA) from natural resources gained much attention in recent years as a bone graft substitute due to its biocompatibility, excellent osteointegration, osteoconductive, and osteoinductive properties. In the current review, we have presented the isolation procedures of HA from marine fishbone and cuttlefish bone. Further, composite preparation using marine derived HA with other polymeric and ceramic materials were discussed, and cell-materials interaction were reviewed in detail towards bone tissue construction. Composite biomaterials with HA showed better cell proliferation, cell adhesion, increased gene expression (collagen, osteocalcin, osteopontin, bone sialoprotein, BMP- 2 etc.), and in vivo studies demonstrated significant bone formation with HA composite materials. Hence, composite biomaterials with hydroxyapatite will be potential candidates for artificial synthetic bone graft substitute.
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Combination of Nano-Hydroxyapatite with Stem Cells for Bone Tissue Engineering
Venkatesan, Jayachandran,Lowe, Baboucarr,Anil, Sukumaran,Kim, Se-Kwon,Shim, Min Suk American Scientific Publishers 2016 Journal of Nanoscience and Nanotechnology Vol.16 No.9
<P>Tissue engineering seeks to exploit functional biomaterials and engineer them to serve as artificial templates that promote the regeneration of tissues and damaged organs. Engineered scaffold materials recapitulate the extracellular matrix and provide cells with information essential for tissue development. Nanotechnologies make use of the material at the nanoscale for targeted interactions at molecular levels and deliver biochemical cues for cell growth required for tissue formation. In bone tissue engineering, nano-hydroxyapatite (nHA), which is a calcium phosphate-based material, is extensively used as a bone defect substitute to mimic the natural bioceramic portion of bone. nHA can be functionalized in the form of composite scaffolds along with other polymers, ceramic, and growth factors to enable bone tissue regeneration. In addition, the material directs stem cell differentiation into specific lineages. This stem cell-based therapy is a prominent approach in organ development and tissue regeneration. Here, we examine nHA interactions with stem cells in the form of designed scaffolds and offer important considerations about the fundamental challenges and prospects for its application in bone tissue engineering.</P>
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Hydroxyapatite from Cuttlefish Bone: Isolation, Characterizations, and Applications
Jayachandran Venkatesan,Rekha P. D.,Sukumaran Anil,Ira Bhatnagar,Sudha P. N.,Chutiwan Dechsakulwatana,김세권,심민석 한국생물공학회 2018 Biotechnology and Bioprocess Engineering Vol.23 No.4
Hydroxyapatite (HA), a bioceramic, is a widely utilized material for bone tissue repair and regeneration because of its excellent properties such as biocompatibility, exceptional mechanical strength, and osteoconductivity. HA can be obtained by both synthetic and natural means. Animal bones are often considered a promising natural resource for the preparation of pure HA for biological and biomedical applications. Cuttlefish bone, also called as cuttlebone, mainly consists of calcium carbonate, and pure HA can be produced by adding phosphoric acid or ammonium hydrogen phosphate to it. Recently, cuttlefish bone-derived HA has shown promising results in terms of bone tissue repair and regeneration. The synthesized cuttlefish bone-derived has shown excellent biocompatibility, cell proliferation, increased alkaline phosphate activity, and efficient biomineralization ability with mesenchymal stem cells and osteoblastic cells. To further improve the biological properties of cuttlefish bone-derived HA, bioglass, polycaprolactone, and polyvinyl alcohol were added to it, which gave better results in terms of cell proliferation and osteogenic differentiation. Cuttlefish bone-derived HA with polymeric substances provides excellent bone formation under in vivo conditions. The studies indicate that cuttlefish bone-derived HA, along with polymeric and, protein materials, will be promising biomaterials in the field of bone tissue regeneration.
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AIDS Awareness: Indispensible Prerequisite Among Fishermen Population
Swapna B. Shetty,Darshan D. Divakar,M.H.N. Dalati,Sajith Vellappally,Sukumaran Anil,Marey A. Alshehry,Baher Felemban,Al S. Mamdouh,Obaid A. Alshahrani 질병관리본부 2016 Osong Public Health and Research Persptectives Vol.7 No.5
Objectives: Fishermen are among the most vulnerable groups for human immunodeficiency virus (HIV)/AIDS with reported high prevalence. Poor knowledge base has been evidenced by a few studies. The present study was conducted to assess the knowledge regarding HIV/AIDS among fishermen of the Kutch coast, Gujarat, India. Methods: A descriptive cross-sectional study was conducted among 950 fishermen of the Kutch coast, in the months of January-February 2015. Knowledge of HIV/AIDS of fishermen was assessed using structured interview schedules with 12 questions. The information on socio-demographic characteristics was also obtained. Chi-square test and multivariate logistic regression analysis were used for statistical analysis. The confidence level and level of significance were fixed at 95% and 5%, respectively. Results: A major proportion of participants (57.2%) had no access to any potential source of information and had never heard about HIV/AIDS (65.1%). Some of them were aware of modes of transmission of AIDS but only a few of them knew about the methods of prevention. Only 23.1% of participants were observed with appropriate knowledge regarding HIV/AIDS. Bivariate and multivariate analysis revealed significant variation in the proportion of participants with appropriate knowledge with age and educational status.
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