말단 비대증의 임상적 특성

박은미,안용환,김현정,김병수,임종주,김하영,박병현,조정구 圓光大學校 醫科學硏究所 2004 圓光醫科學 Vol.19 No.2

화일시스템에서 뷰 인덱스 기법을 이용한 접근 비용의 최소화

고미경,주수종 圓光大學校 1996 論文集 Vol.31 No.2

분산화일시스템에서 접근 기법은 시스템 성능에 큰 영향을 미치며, 대량의 정보에 대한 인덱스 구축이나 인덱스의 유지문제는 빠른 자료 접근을 위해 꼭 필요한 연구이다. 따라서 본 논문에서는 정보 유지면에 촛점을 둔다. 즉, 임의 관련 정보들이 자주 참조되는 경우에 이를 인덱스로 만들어 놓고, 시간의 흐름에 따라서 변경되는 내용을 인덱스에 반영시키므로써 정보의 접근 속도를 향상시키도록 하는데 목적을 두었다. 이를 위해 본 논문에서는 뷰 인덱스 방법을 제시하여 인덱스의 유지문제를 해결하였다. 연구의 결과로서 재수행 방법, 인덱스 방법 그리고 뷰 인덱스 방법들의 유지비용과 화일 총 접근 비용의 산출식을 각각 얻어내어 그들간의 성능(유지 비용, 접근 비용)을 비교.분석 하였다. 마지막으로 뷰 인덱스 방식이 기존 방식보다 효율적임을 보였다. Access schemes in file systems are very important to improve system performance. for reducing an access cost about given information, we are necessary to construct its index, and reflect up-to-date information upon an index(called index maintenance) immediately. In this paper, we focus on cases of occurring retrieves or updates about given information frequently, we are to improve access performance using up-to-date index reflected updating contents. For this reason, we suggest the view index method to solve problems of index maintenance. As results, we formulated the expressions of index maintenance cost and access cost for the existing re-execution method, an B index method and the view index method respectively. Via comparisons of their total costs, we showed the view method is more efficient than others.

전신성 홍반성 루푸스에서 F-18 FDG PET상 기저핵 포도당대사 증가 소견을 보이는 무도병 1예 : Evidence for Bilateral Putaminal Hypermetabolism on F-18 FDG PET

서욱장,정선미,고수진,이창근,김재승,임주혁,유빈,문희범 대한핵의학회 2003 핵의학 분자영상 Vol.37 No.5

Purpose: We describe a 54-year-old woman with systemic lupus erythematosus (SLE) who suddenly presented with chorea and had positive antiphospholipid antibodies. F-18 FDG PET showed abnormally increased glucose metabolism in bilateral putamen and primary motor cotex. Tc-99m ECD SPECt also showed abnormally increased regional cerebral blood flow in bilateral putamen. She was treated with corticosteroid and aspirin after which the symptoms improved. Four months later, follow up F-18 FDG PET showed improvement with resolution of hypermetabolism in bilateral putamen. This case suggests that striatal hypermetabolism is associated with chorea in SLE.

Propylthiouracil에 의한 중증 급성간염 1예

임종주,심미령,이명수,김태현,오석규,안선호,박무림,김남호,박병현,조성구 圓光大學校 醫科學硏究所 2002 圓光醫科學 Vol.17 No.2

PTU에 의한 간염의 발생은 매우 드물게 발생하는 것으로 알려져 있으나 저자들은 Graves씨 병으로 진단 받고 propylthiouracil 투여를 받고있던 환자에서 중증의 급성 간염이 발생한 1예를 경험하였기에 보고하는 바이다. Propylthiouracil is widely used to treat patients with hyperthyroidism. This drug has been associated with severe hepatotoxicity rarely. We presented the case of jaundice and profound liver dysfunction from a 23-year old woman treated with propylthiouracil for hyperthyroidism. Viral, metabolic, and autoimmune liver disease could be excluded and liver biopsy revealed a pattern of acute hepatitis. After discontinuing the drug, there was a progressive resolution of hepatic symptoms and decrease in biochemical data of the liver. Despite propylthiouracil induced hepatitis in rare case, patients receiving propylthiouracil are exposed to develope severe hepatotoxicity. Therefore it might be advisable to monitor level of the transaminase on regular base from patients receiving propylthiouracil.

한국인 직무 스트레스 측정도구의 개발 및 표준화

장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.

인체 지방 및 간장조직 중 유기염소제류의 확인 및 정량기법 체계화

이상기,양자열,인상환,김기욱,이수연,오승민,김미영,정규혁 內務部 國立科學搜査硏究所 2001 國立 科學 搜査 硏究所 年報 Vol.33 No.-

In vitro induction of tetraploids in an interspecific hybrid of Calanthe (Calanthe discolor 3 Calanthe sieboldii) through colchicine and oryzalin treatments

Mi-Young Chung,Chang Kil Kim,Chang Young Kim,Jeon Su Min,Do-JinLee,Aung Htay Naing,Jae Dong Chung 한국식물생명공학회 2014 Plant biotechnology reports Vol.8 No.3

Tetraploids were successfully produced fromdiploid seeds obtained through interspecific crossingbetween Calanthe discolor and Calanthe sieboldii bytreating with colchicine or oryzalin. Colchicine was testedat concentrations of 0.05 and 0.1 % for 0, 3, or 7 days andoryzalin was tested at a concentration of 0.003 % for 1, 2,4, and 7 days, and the ploidy of the seedlings was determinedby flow cytometry. Tetraploids (49) were obtainedfrom the interspecific hybrid seeds treated with all colchicineand oryzalin concentrations. The most efficient conditionfor inducing tetraploids seemed to be treated with0.003 % oryzalin for 1 or 2 days. Cytological and morphologicalevidence confirmed the results of flow cytometricanalysis. The stomatal density and sizes of thetetraploid plants were significantly higher and larger thanthose of the diploid plants. Differences in leaf shape werefound between the tetraploid and diploid plants under thesame growing conditions: the leaves of the diploids wereelongated and those of the tetraploids were round.

Poster Session 5 : Tumor Biology Developmental Biology Plant Biology Molecular Medicine and Gene Therapy Procaryotic Genetics Biotechnology ; Insulin and hypoxia share common target genes but not the hypoxia-inducible factor-1α

( Su Mi Choi ),( Su Jin Yim ),( Yong Yeon Choi ),( Na Ery Lee ),( Ji Eun Chung ),( Hyun Sung Park ) 한국생화학분자생물학회 (구 한국생화학회) 2003 생화학분자생물학회 춘계학술발표논문집 Vol.2003 No.-

Gene Expression of the Cytokines in Mouse Spleen Cell by Ionizing Radiation

Chung, Su-Mi,Choi, Ihl Bohng,Kim, Choon-Yul,Shinn, Kyung Sub CATHOLIC MEDICAL CENTER 1995 Bulletin of the Clinical Research Institute Vol.23 No.1

Exposure of mammals to ionizing radiation causes the development of the complex, dose-dependent series of potentially fatal physiologic and morphologic changes. Radiation-induced destruction of the lymphoid and hematopoietic systems is the primary cause of septicemia and death. It has been suggested that cytokines produced by various stimuli can be attributed to their capacity to enhance hematopoietic and immune functions. We performed this study to assess that gene expression of cytokine can be induced in the mouse spleen cell by various dosage of ionizing radiation according to the time incubation after irradiation. Spleen cells from specific pathogen-free BALB/C mice were incubated for 3-4hr and then irradiated with dosage of 10Gy, 20Gy and 30Gy, using 6MV X-ray with 1Gy/min dose rate. Irradiated cells were brought back for further incubation for various lengths of time. The c-DNA were synthesized from the cells immediately obtained and incubated during 30 min, 1hr, 2hr, 3hr and 4hr after irradiation. Using the reverse transcriptation-polymerase chain reaction, we examined the gene expression of interleukin-1β (IL-1β), interleukin-6 (IL-6) and transforming growth factor-β(TGF-β). The results were as follows: 1. In 10Gy irradiated cells, expression of the IL-1β gene was induced at 30 min after irradiation and maintained for 30 min thereafter. TGf-β gene was detected immediately after irradiation and observed for 2hr. 2. In 20Gy irradiated cells, IL-1β gene was expressed immediately after irradiation and prolonged for 1hr. TGF-β gene was detectable immediately after irradiation and prolonged for 3hr. 3. In 30Gy irradiated cells, expression of IL-1β gene was induced immediately after irradiation and wns detectable for 3hr. TGF-β gene was expressed imuediately after irradiation and was prolonged for 3hr. 4. IL-6 gene was not expressed in all irradiated groups. We conclude that ionizing radiation can induce the gene of IL-1β and TGF-β and the time and duration of the gene expression is dependent on the dosage of radiation in IL-1β but less likely in TGF-β. The results of this study suggest that splenic irradiation induced various cytokines may enhance the engraftment of donor marrow hematopoietic stem cells in bone marrow transplantation conditioned with supralethal total body irradiation.

Results in the Treatment of Nasopharyngeal Carcinoma Using combined Radiotherapy

Su Mi Chung(정수미) , Sei Chul Yoon(윤세철) , Kyung Sub Shinn(신경섭) , Yong Whee Bahk(박용휘) , Hoon Kyo Kim(김훈교) , Kyung Shik Lee(이경식) , Seung Ho Cho(조승호) 대한방사선종양학회 1991 Radiation Oncology Journal Vol.9 No.1

1983년에서 1989년까지 가톨릭의대 부속 성모병원 방사선치료실에서 비인강종양으로 확진되어 치요를 시행한 환자 31명중 치료가 불완전했던 환자 8명을 제외한 23명의 치료성적으로 후향조사 하였다. 이들 중 11명의 환자에 있어서는 방사선 단독요법을 시행하였으며, 12명의 환자에소는 cisplatin+5-fluorouracil 혹은 cisplatin-bleomycin-vincristine을 이용하여 1회 내지 3회에 걸친 유도 화학요법후 방사선치료를 시행하였다. 방사선 단독요법으로 치료된 11명의 환자에서 완전 관해율은 55%(6/11). 부분관해율은 45%(5/11)였다. 유도화학요법을 시행한 12명의 환자중 약물 치료후 완전관해율은 25%(3/12)였으며, 부분 관해율은 75%(9/12)였고, 연속적으로 시행된 방사선 치료후에는 완전 관해율이 83%(10/12)로 증가되었으며, 부분 관해율은 17%(2/12)였다. 유도 항암요법에 부분관해를 보였던 환자중 stage Ⅲ 환자 1명과 stage Ⅳ 환자 6명이 추가 방사선 치료후 완전 관해를 보였다. 방사선 단독요법군에서는 4명에 국소재발이 발생했으며, 약물요법과 방사선치료를 병행했던 군에서는 국소재발 3명과 폐로의 원격전이가 1명에서 발생되었다. 방사선단독으로 치료한 환자군과 유도화학요법과 방사선 치료를 병행한 환자군에서의 생존율의 차이가 통계적으로 유의하지 않았다. (M±SD=28.55±17.15 and M±SD=28.588±25.39, p>0.05) 치료 환자군의 수가 적은 이유로 통계분석 결과 큰 의의를 발견할 수 없었다. Thirty-one patients with previously untreated and locally advanced nasopharyngeal cancer were retrospectively reviewed for comparing the effects of radical radiotherapy alone with that of combining chemotherapy and radiotherapy from 1983 to 1989 at Kangnam St. Mary's hospital. 23/31 were evaluable for recurrence and survival. There were 8 patients for stage Ⅲ, and 15 patients for stage Ⅳ. Eleven patients were treated with radical radiation therapy alone (arm I). Twelve patients were given 1~3 courses of cisplatin-5FU or cisplatin-bleomycin-vincristine prior to radiation therapy (arm Ⅱ). The two arms were comparable in patient characteristics Of 11 radiotherapy patients, complete response was 55% (6/11) and partial response 45% (5/11). Among 12 patients after induction chemotherapy, complete response was 25% (3/12) and partial response 75% (9/12). After subsequent radiotherapy, complete response was increased to 83% (10/12) and partial response was 17% (2/12). Treatment failure was 36% (local recurrence; 3/11, and regional recurrence; 1/11) in arm I and 33% (local recurrence; 1/12, regional recurrence; 2/12 and distant metastasis; 1/12) in arm Ⅱ. There was no significant difference in survival between arm I and arm Ⅱ (p>0.05). The toxicities of treatment were acceptable. More controlled clinical trials must be completed before acceptance of chemotherapy as part of a standard radical treatment for locally advanced nasopharyngeal cancer.