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LINKING EVALUATION OF SUBJECTIVE TIRE TESTS ON THE ROAD WITH OBJECTIVELY MEASURED DATA
Stumpf, H.W. The Korean Society of Automotive Engineers 2001 International journal of automotive technology Vol.2 No.1
Measurements of the initial values lead to an inverse and mathematically unprecisely formulated problem. A precise definition of an inverse problem is possible. It is to state a mathematical model of a physical process with clearly defined initial and exit values for the system behind the process. One can grasp the idea of an inverse problem by considering the tire as a copy of the objects of nature in a room with observations. Interpretation of nature is generally a result of an inverse problem. On one hand, the tire may be represented through the sensory organs and the nervous system as well as the experiences of the developer's existing apparatus of the projection of reality. On the other hand, it may be represented by a physical law or a model that can be confirmed or is to be refuted with the help of suitable measurements. During reconstruction of a measuring signal and the identification of a black box that can be assumed to be linear and causal, the tire becomes a first type Volterra integral equation of the convolution type. But measurements of the initial values are always fuzzy, the errors grow and the system behavior can no longer be forecasted. Thus, we have to deal with a chaotic system. This chaos produces fractals in a natural way. These are self-similar geometric structures. This self-similarity is clearly visible in the design.
LINKING EVALUATION OF SUBJECTIVE TIRE TESTS ON THE ROAD WITH OBJECTIVELY MEASURED DATA
H. W. STUMPF 한국자동차공학회 2001 International journal of automotive technology Vol.2 No.1
Measurements of the initial values lead to an inverse and mathematically unprecisely formulated problem. A precise definition of an inverse problem is possible. It is to state a mathematical model of a physical process with clearly defined initial and exit values for the system behind the process. One can grasp the idea of an inverse problem by considering the tire as a copy of the objects of nature in a room with observations. Interpretation of nature is generally a result of an inverse problem. On one hand. the tire may be represented through the sensory organs and the nervous system as well as the experiences of the developer's existing apparatus of the projection of reality. On the other hand. it may be represented by a physical law or a model that can he confirmed or is to be refuted with the help of suitable measurements. During reconstruction of a measuring signal and the identification of a black box that can he assumed to he linear and causal. the tire becomes a first type Volterra integral equation of the convolution type. But measurements of the initial values are always fuzzy. the errors grow and the system behavior can no longer he forecasted. Thus. we have to deal with a chaotic system. This chaos produces fractals in a natural way. These are self-similar geometric st겨ctures. This selfsimilarity is clearly visible in the design.<br/>
Anger, Thomas,Klintworth, Nils,Stumpf, Christian,Daniel, Werner G.,Mende, Ulrike,Garlichs, Christoph D. Korean Society for Biochemistry and Molecular Biol 2007 Journal of biochemistry and molecular biology Vol.40 No.6
Extracellular Regulated Kinases (ERK) and Protein Kinase B (Akt) are intermediaries in relaying extracellular growth signals to intracellular targets. Each pathway can become activated upon stimulation of G protein-coupled receptors mediated by $G_q$ and $G_{i/o}$ proteins subjected to regulation by RGS proteins. The goal of the study was to delineate the specificity in which cardiac RGS proteins modulate $G_{q^-}$ and $G_{i/o}$-induced ERK and Akt phosphorylation. To isolate $G_{q^-}$ and $G_{i/o}$-mediated effects, we exclusively expressed muscarinic $M_2$ or $M_3$ receptors in COS-7 cells. Western blot analyses demonstrated increase of phosphorylation of ERK 1.7-/3.3-fold and Akt 2.4-/6-fold in $M_{2^-}/M_{3^-}$ expressing cells through carbachol stimulation. In co-expressions, $M_3/G_q$-induced activation of Akt was exclusively blunted through RGS3s/RGS3, whereas activation of ERK was inhibited additionally through RGS2/RGS5. $M_2/G_{i/o}$ induced Akt activation was inhibited by all RGS proteins tested. RGS2 had no effect on $M_2/G_{i/o}$-induced ERK activation. The high degree of specificity in RGS proteins-depending modulation of $G_{q^-}$ and $G_{i/o}$-mediated ERK and Akt activation in the muscarinic network cannot merely be attributed exclusively to RGS protein selectivity towards $G_q$ or $G_{i/o}$ proteins. Counter-regulatory mechanisms and inter-signaling cross-talk may alter the sensitivity of GPCR-induced ERK and Akt activation to RGS protein regulation.
Ahmed Abdel Samie,Michael Stumpf,Rui Sun,Lorenz Theilmann 대한소화기내시경학회 2013 Clinical Endoscopy Vol.46 No.4
Background/Aims: Dual antiplatelet therapy has to be used for at least 1 month after placement of bare metal coronary stents and for a minimum of 1 year after placement of drug eluting stents. Because of the higher risk of bleeding, guidelines strongly recommend to delay elective surgery until dual antiplatelet therapy is ended. However, no data are available regarding the bleeding risk in patients on combined aspirin/clopidogrel therapy undergoing surgical or high-risk endoscopic procedures. Methods: We retrospectively analyzed the medical reports of patients on dual antiplatelet therapy, the patients who had to undergo emergency biliary-pancreatic surgery or endoscopic retrograde cholangiography with endoscopic sphincterotomy while in our unit between January 2009 and July 2012. Results: In our series, biliary-pancreatic surgical and endoscopic procedures were safely performed in 11 consecutive patients on dual antiplatelet therapy with no evidence of bleeding. Conclusions: In emergency, surgical and high risk endoscopic procedures may be performed in patients on dual antiplatelet therapy.
Kim, H.,Shen, Z.,Kim, I.,Kim, K.,Stumpf, A.,Yu, J. Elsevier ; Elsevier Science Pub. Co 2016 AUTOMATION IN CONSTRUCTION - Vol.68 No.-
To reduce fossil fuel based energy consumption in buildings, different methods have been proposed. Interestingly, one of the most significant factors in building energy consumption has been reported in the area of improving building designs. However, building energy analysis (BEA) is typically conducted late in design, by energy analyst specialists. The ability to try out new ideas early in the design process in order to choose the best alternative is not ordinarily taken advantage of, due to the difficulty and expense of modeling the building and energy systems. Building information modeling (BIM) provides the user with an opportunity to explore different energy saving alternatives in the design process while avoiding the time-consuming process of re-entering all the building geometry, enclosure, and HVAC information necessary for a complete energy analysis. While significant time savings are being made by not having to create the building geometry within the simulation interface in BIM energy modeling simulation, there is a good possibility of missing, misplaced, or deformed building elements during a BIM data exchange process. This research focuses on one of the major limitations - inaccuracies through simplifications in construction/material data - and aims to improve the accuracy of energy modeling process by developing an object based approach in materials in which the energy modeler may change and expand various properties in building materials. In testing the performance of the proposed approach, the results from the proposed energy modeling process in the case study are compared to those of existing energy modeling software which showed significant gains in accuracy.
Do Nascimento, Gustavo M.,Do Pim, Walace D.,Endo, Morinobu,Choi, go Bong,Kim, Yoong Ahm,Pradie, Noriberto A.,Stumpf, Humberto O. Elsevier 2019 Journal of molecular structure Vol.1176 No.-
<P><B>Abstract</B></P> <P>Nanocomposites formed from the precursor of molecule-based magnets [Cu(opba)]<SUP>2−</SUP> [opba = <I>o</I>-phenylenebis(oxamate)] and single-wall carbon nanotubes (SWCNTs) were characterized by X-ray absorption near edge structure (XANES) and X-ray photoelectron spectroscopy (XPS) at Carbon and Nitrogen <I>K</I> edges and Cu <SUB> L 2,3 </SUB> edges. The N <I>K</I> XANES, XPS and micro-ATR-FTIR data strongly suggested that [Cu(opba)]<SUP>2−</SUP> molecules be flatly bonded onto the surface of the SWCNTs. Therefore, higher charge delocalization and electronic modifications were observed. The presence of a new band at 286.1 eV in the Carbon peak of XPS spectra of nanocomposites was assigned to the Carbon surface of the SWCNTs modified by interaction with the metal complex. The micro-ATR-FTIR data supported by DFT calculations show many changes in the bands related to νC = C and νC = O groups of the metal complex in the nanocomposites. Such changes confirmed that the vibrational properties of the complex also changed due to interaction with the carbon nanotubes.</P> <P><B>Highlights</B></P> <P> <UL> <LI> XANES and XPS data of (NBu<SUB>4</SUB>)<SUB>2</SUB>[Cu(opba)]-SWCNT nanocomposites at several atomic edges. </LI> <LI> Micro-ATR-FTIR used for studying the metallic complex over SWCNT surface. </LI> <LI> Oxamate-based complex have strong interaction with SWCNT by −CuN− sites. </LI> </UL> </P>