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급성뇌경색증에 동반된 악성 뇌부종 환자에 있어서 뇌경막확장성형술을 통한 두개골 감압술의 효용성
손성호,김수영,정영균,조봉수,박혁,이동열,Son, Sung Ho,Kim, Soo Young,Jeong, Young Gyun,Cho, Bong Soo,Park, Hyuck,Rhee, Dong Youl 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.9
Objectives : There is continuing controversy about the benefits of decompressive craniectomy in massive cerebral edema following space occupying hemispheric cerebral infarction. The aims of this study are to determine the effectiveness and to confirm the life-saving nature of decompressive craniectomy with dural augmentation for massive cerebral infarction. Patients and Methods : We present twelve patients with medically uncontrollable hemispheric cerebral infarction. All were treated with extensive craniectomy and duroplasty without resection of necrotic tissue. We evaluated various characteristics(size of hemispheric infarction, Glasgow Coma Scale, volume of low density and midline shift in CT) at three different periods(preoperative, immediate postoperative and 3-4weeks after operation) and evaluated effectiveness of hemicraniectomy for massive cerebral edema after large hemispheric infarction. Results : All patients have survived from surgery. Nine patients with nondominant hemispheric infarction showed significant functional recovery with minimal assistance, and remaining two patients with dominant hemispheric infarction and one patient with nondominant hemispheric infarction have functionally dependent. The volume of low density and midline shift in CT were significantly reduced after decompressive craniectomy. Conclusions : Our results indicate that decompressive craniectomy with dural augmentation without resection of necrotic tissue for massive cerebral hemispheric infarction not only reduce the mortality and infarction size but also significantly improve the outcome, especially for nondominant hemispheric infarction.
4배체 현사시나무 (Populus alba L. X P. gludulosa Uyeki)의 약배양에 의한 식물체 재분화
손성호,김정희,문흥규,노은운,이윤희,김미희,박진선,이용욱,윤양,이석구,Son, Sung-Ho,Kim, Jung-Hee,Moon, Heung-Kyu,No, Eun-Woon,Lee, Yoon-Hee,Kim, Mi-Hee,Park, Jin-Sun,Lee, Yong-Wook,Yoon, Yang,Lee, Seok-Gu 한국식물생명공학회 1995 식물생명공학회지 Vol.22 No.3
현사시나무 4배체의 약배양에 의하여 2배체 식물을 얻을 수 있었다. 약배양에 의한 캘러스 유도에는 2,4-D가 효과적 인 것으로 나타났다. 증식된 캘러스로부터 식물체 재분화를 위해서는 16시간의 광조건하에 6-8 $\mu$M의 zeatin 처리가 가장 좋은 반응을 보였는데 이때 얻어진 줄기수는 평균 7.7개 였다. 재분화된 식물체는 MS 기본배지에서 쉽게 뿌리를 유기시킬 수 있었으며, 이들 식물체는 폿트묘로 육성하여 온실 및 포지로 이식하였다. 약배양유래의 300클론에 대한 생육상태를 조사한 결과 삽목묘에 비하여 33%는 생장이 저해됨을, 47%는 생장이 더 좋은 것으로 나타났으며, 그중 20%는 삽목묘에 비해 직경이 5배 이상되는 거대 엽을 가지고 있었다. 염색체 수는 대체로 2배체성 혹은 4배성을 띠고 있었으며, RAPD marker를 이용하여 DNA polymorphism을 본 결과 약배양 유래의 몇몇 식물체에 있어 서 밴드 형태적인 차이를 나타내는 개체를 발견할 수 있었다. Diploid plants were obtained by anther culture of tetraploid poplar(Populus alba L. X P.glandutosa Uyeki). The effect 2,4D on callus formation from anther culture was greater than any other auxins tested. The highest average number of multiple shoots per callus was obtained when zeatin was used at levels of 6-8 ${\mu}$M. Regenerated shoots were excised and transferred to MS basal medium. Rooted plantlets were subsequently transferred to pots containing artificial soil mix. Finally 100 plane were transplanted in nursery located in forest Genetics Research Institute. for the 300 anther clones growing in greenhouse for 6 months after transplanting, 33% were slow-growing, 47% were rapid-growing and 20% had huge leaf size with rapid-growing characteristics. Chromosome study showed a narrow range of variation from diploid to tetraploid. DNA polymorphism studies using various RAPD markers revealed some extend of differences among the anther-clones in their band pattern.
다발성 "De Novo" 동맥류 1예 - 증 례 보 고 -
손성호,정영균,김수영,박화성,박혁,이동열,Son, Sung Ho,Jeong, Young Gyun,Kim, Soo Young,Park, Hwa Sung,Park, Hyuck,Rhee, Dong Youl 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.2
The development of completely new intracranial aneurysms after previous successfully treated aneurysm is uncommon. A 50-year-old female presented with a case of multiple de novo aneurysm which were an aneurysm of right ophthalmic segment of internal carotid artery and an aneurysm of right A1 artery, 6 years after the clipping of an aneurysm of right posterior communicating artery. She had no history of hypertension, cigarette smoking and use of oral contraceptives, and had no evidence of genetic disorder. The laboratory findings were normal. All de novo aneurysms were clipped by basal anterior interhemispheric approach in one stage due to the direction of the aneurysm of the ophthalmic segment of the internal carotid artery.
아시클로버 - 아시알로페투인 접합체의 간 포획 및 안정성
손성호,허근,이영대,오두만,용철순 ( Sung Ho Son,Keun Huh,Young Dae Lee,Doo Man Oh,Chul Soon Yong ) 한국약제학회 1997 Journal of Pharmaceutical Investigation Vol.27 No.1
N/A For the purpose of improving the chemotherapeutic index of acyclovir(ACV), it was conjugated with asialofetuin(AF), which has been reported to enter into hepatocytes. When [H³] acyclovir in itself or its conjugate were administered to rats, the latter was taken up more selectively by the liver than any other tissues. The stability of ACVMP-AF conjugate in phosphate buffer (pH 5.0) and rat liver homogenate showed a pseudo-first order profile. ACVMP-AF, however, was relatively stable in pH7.4 phosphate buffer and rat plasma. The conjugate was added to the isolated rat hepatocyte and cellular uptake was monitored by scintillation counting for up to 6 hours at 37℃. Hepatocytes incubated with the conjugate exhibited radioactivities significantly enhanced over control levels dose-dependently, i.e., a 3-40 fold increase in radioactivities was observed over controls at the conjugate concentrations of 0.1-10 ㎍/㎖. The AUQ in the liver, kidney, spleen. intestine and lung was higher in treatment with ACVMP-AF than that in treatment with ACV. In treatment with ACVMP-AF, the weighted-average overall drug targeting efficiency(Te) for the liver was higher than in treatment with ACV(57.00 vs 13.31%), and the weighted-average tissue exposure(Re) was 5.03 for the liver. These results indicated that ACVMP-AF conjugate was rapidly taken up by hepatocytes and could be an efficient and selective hepatic targeting system.
Q_방법론을 적용한 일 지역주민의 고통과 죽음에 관한 태도:그리스도교적 관점에서의 고찰
손성호(Son, Sung Ho),조계화(Jo, Kae Hwa) 대구가톨릭대학교 가톨릭사상연구소 2003 가톨릭사상 Vol.- No.28
복 연구의 목적은 일 지역 주민의 고통과 죽음의 태도를 유형화하고, 그 유형별 특성과 구조를 파악하여 그리스도교적 관점에서 비평, 해석함으로써 현 시대의 깊이 있는 인간이해의 기초 자료를 제공하고자 한다. 연구방법은 Q 방법론을 적용하여 시도되었다. 관련된 문헌고찰과 개별적인 면담을 통해 최종 주출된 진술문은 40개였으며 연구대상자는 일 지역주민 성인 46명이었다. 자료 분석은 Quanl PC 프로그램을 사용하였다. 연구결과 고통과 죽음인식 유형은 모두 5 가지로 나타났다. 제1유형은 고통의미 부여형이다. 제2유형은 가족중심적 현세치중형이다. 제3유형은 생사존엄 갈등형이다. 제4유형은 종교적 보상 지향형이다. 제5유형은 현실적 운명대처형이다. 결론적으로 위의 유형에서 밝혀진 고통과 죽음의 인식유형은 이 시대의 인간 특성을 이해하고, 고통과 죽음에 대한 본질적 의미를 밝히는데 기초 자료로 유용하게 활용될 것이다. Purpose: The purpose of this study is to typify the attitude on the suffering and death of the residents of a region and to present the basic materials for the profound understaning of the human beings of the present age by grasping the typical characteristics and structures and by criticizing and interpreting them from the Christian viewpoints. Method: The authors have tried to apply the Q- methodology. The final 40 statements were chosen through the examination of the literature and the individual interviews with the subjects consisting of 46 adult residents of the region. The analyses of the materials were conducted by using the PC Quanl Program. Result: Results of the study: 5 types of the attitudes on suffering and death have been identified. Type Ⅰ is the attitude to give meaning of suffering. Type Ⅱ is the attitude to concentrate on this world with a focus on the family. Type Ⅲ is the attitude to have conflicting feelings of the dignity of suffering and death. Type Ⅳ is the attitude to pursue the religious compensation. Type Ⅴ is the attitude to cope with the fates of the present. Conclusion: The types of the awareness of suffering and death identified in the types above will be used valuably as basic materials for the understanding of the charateristics of the human beings of this age and for the revelation of the fundamental meanings of suffering and death.
해외 신재생에너지 의무할당제 시행사례 분석 : 미국을 중심으로
손성호(Sung-ho Son),조기선(Ki-Seon Cho) 대한전기학회 2008 대한전기학회 학술대회 논문집 Vol.2008 No.11
본 논문은 신재생에너지 보급 확대를 위한 정책수단으로 활용되고 있는 신재생에너지 의무할당제(RPS; Renewable Portfolio Standards)의 시행현황과 제도 동향을 미국 사례 중심으로 분석하였다. 신재생에너지 의무할당제의 전반적인 시행 사례 분석을 통하여 국내에 RPS 도입 시 고려할 다양한 제반사항을 식별하고 활용할 수 있는 기회를 제공하였다.
손성호(Sung-ho Son),조기선(Ki-Seon Cho),조인승(In-Seung Jo) 대한전기학회 2007 대한전기학회 학술대회 논문집 Vol.2007 No.11
본 논문은 신재생에너지 보급 확대의 정책 수단으로 활용되고 있는 녹색가격제도(Green Pricing)의 전반적 시행 현황과 제도의 동향을 미국사례 중심으로 분석하였다. 녹색가격제도의 전반적인 시행 사례 분석을 통하여 국내에 녹색가격제도 도입 시에 고려할 다양한 제반사항을 식별하고 활용할 수 있는 기회를 제공하였다.