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Popliteal Lymphography in a Dog with Chylothorax
Sohyun Bang,Hanbin Lee,Daehwan Park,Taegeon An,Hyunryung Kim,Jin Yu,Hyunglok Yoon,Gayeon An,Hyejong Oh,Jinhwa Chang,Gonhyung Kim,Dongwoo Chang 한국임상수의학회 2018 한국임상수의학회지 Vol.35 No.6
Signalment: A dog which had been hit by car a month prior and had been experiencing recurrent pleuralchyle effusion was referred to Chung-buk National University Animal Medical Center. The clinical signs includedtachypnea and salivation. Results: Ultrasound-guided popliteal lymphography was performed. The computed tomographyimaging revealed that the thoracic duct was ruptured and the lymph was leaking into the cranial mediastinal region. After this discovery, thoracic duct ligation was performed. The ultrasound-guided popliteal lymphography was repeatedafter the surgery. The second computed tomography imaging revealed that the thoracic duct rupture was resolved. Clinical relevance: We identified the etiology of chylothorax through the computed tomographic lymphography andimaged specific leakage areas. After surgery, the computed tomography imgaing confirmed the lymphatic flowmodification and the treatment was successful.
GWAB: a web server for the network-based boosting of human genome-wide association data
Shim, Jung Eun,Bang, Changbae,Yang, Sunmo,Lee, Tak,Hwang, Sohyun,Kim, Chan Yeong,Singh-Blom, U. Martin,Marcotte, Edward M.,Lee, Insuk Oxford University Press 2017 Nucleic acids research Vol.45 No.w1
<P><B>Abstract</B></P><P>During the last decade, genome-wide association studies (GWAS) have represented a major approach to dissect complex human genetic diseases. Due in part to limited statistical power, most studies identify only small numbers of candidate genes that pass the conventional significance thresholds (e.g. <I>P</I> ≤ 5 × 10<SUP>−8</SUP>). This limitation can be partly overcome by increasing the sample size, but this comes at a higher cost. Alternatively, weak association signals can be boosted by incorporating independent data. Previously, we demonstrated the feasibility of boosting GWAS disease associations using gene networks. Here, we present a web server, GWAB (www.inetbio.org/gwab), for the network-based boosting of human GWAS data. Using GWAS summary statistics (<I>P</I>-values) for SNPs along with reference genes for a disease of interest, GWAB reprioritizes candidate disease genes by integrating the GWAS and network data. We found that GWAB could more effectively retrieve disease-associated reference genes than GWAS could alone. As an example, we describe GWAB-boosted candidate genes for coronary artery disease and supporting data in the literature. These results highlight the inherent value in sub-threshold GWAS associations, which are often not publicly released. GWAB offers a feasible general approach to boost such associations for human disease genetics.</P>
Hwang, Young Sun,Seo, Minseok,Bang, Sohyun,Kim, Heebal,Han, Jae Yong Federation of American Society for Experimental Bi 2018 The FASEB Journal Vol.32 No.4
<P>Maternal-to-zygotic transition (MZT) is the critical process for the establishment of embryonic identity across vertebrates. During this period, the massive transcriptional activation, called zygotic genome activation (ZGA), is mediated by maternally stored factors, and maternal mRNA clearance by conserved zygotic microRNAs (miRNAs) occurs; however, the important transition in avian species was identified by morphologic perspectives only. In this study, we performed transcriptome analysis to examine the molecular transitions of intrauterine development in chickens. On the basis of coexpression analyses on RNA sequencing data, 2 waves of ZGA-mediated MZT were observed across the early embryonic stages and were associated with transcriptional and translational dynamics. Furthermore, definite transitions were observed according to the distinct developmental characteristics between cleavage and the area pellucida formation period in the functional analysis. Finally, epigenetic modification and the evolutionarily conserved miRNA expression suggest that certain MZT proceeds from Eyal-Giladi and Kochav stage VIII in early chicken development. We expect our study to provide an evolutionary link among vertebrates from the perspective of MZT regulation.</P>