중년 여성의 평상 식이 지방산이 체지방 함량 및 혈중 지질 함량에 미치는 영향

주은정,손희숙,차연수 동아시아식생활학회 1996 동아시아식생활학회지 Vol.6 No.1

The present study undertaken to investigate the interrelationship among their regular dietary fatty acid intake, body fat content(BFC), and plasma lipid fractions(PLF) of middle-aged Korean women. Forty-nine women(age 30 to 49) participated in this study in which the aim was to determine their total nutrient intake per day, BFC and PLF, and to analyse the intercorrelations of these. Strong correlation was seen among their body mass index, mid-upper-arm-circumference, and BFC which were positively correlated with plasma total lipids(TL) and triglycerides(TG). Dietary myristic acid and lauric acid were positively correlated with both total cholesterol(TC) and LDL-cholesterol(LDL-C) in plasma. Palmitic acid, stearic acid, oleic acid, and total monounsaturated fatty acid(MUFA) were negatively correlated with HDL-cholesterol(HDL-C). Although dietary total saturated fatty acid(SFA) was not correlated with TC and LDL-C, it was positively correlated with TL and TG in plasma. However, dieary n-3 polyunsaturated fatty acid(PUFA) in regular Korean diet was not correlated with any of lipid fractions in plasma which might he due to the high ratio of n-6/n-3 in their diet. From the above results, it was concluded that plasma lipid fractions were modulated by their dietary nutrients, especially the types of the fatty acids. Dietary SFA and MUFA intake not PUFA are strongly correlated with LDL-C and HDL-C in the Korean diet. This may relate to the frequency of coronary heart disease in the age group.

Changes in Dermatomal Somatosensory Evoked Potentials according to Stimulation Intensity and Severity of Carpal Tunnel Syndrome

Sohn, Soo-Youn,Seo, Jeong-Hwan,Min, Yong,Seo, Min-Ho,Eun, Jong-Pil,Song, Kyung-Jin The Korean Neurosurgical Society 2012 Journal of Korean neurosurgical society Vol.51 No.5

Objective : To investigate the change of latency of cervical dermatomal somatosensory evoked potential (DSEP) according to stimulation intensity (SI) and severity of carpal tunnel syndrome (CTS). Methods : Stimulation sites were the C6, C7, and C8 dermatomal areas. Two stimulation intensities $1.5{\times}$sensory threshold (ST) and $2.5{\times}ST$ were used on both normal and CTS patients. Results : In moderate CTS, the latencies of C6 and C7 DSEP during $1.5{\times}ST$ SI and those of C7 DSEP during $2.5{\times}ST$ SI were significantly delayed compared with the values of normal subjects. Significant correlation between the latency of C7 DSEP of $2.5{\times}ST$ stimulation and the median sensory nerve conduction velocity was observed. Conclusion : We suggest that these data can aid in the diagnosis of cervical sensory radiculopathy using low stimulation intensity and of those who have cervical sensory radiculopathy combined with CTS patients.

Design and Antitumor Activity of A Novel Polymeric Prodrug of Platinum (2) Complexes

Youn Soo Sohn,Hyong Gee Baek,Yang Ha Cho,Young A Lee,Ok Sang Jung,Chong Ok Lee,Yun Soo Kim 생화학분자생물학회 1996 제4회 산학연 심포지움 Vol.- No.-

Bt 벼의 토양미생물상 영향 비교평가

손수인(Soo-In Sohn),안병옥(Byung-Ohg Ahn),지희연(Hee-Youn Chi),조병관(Hee-Youn Chi),조민석(Min-Seok Cho),신공식(Kong Sik Shin) 한국토양비료학회 2012 한국토양비료학회지 Vol.45 No.5

경제적 및 농업적 장점은 유전자 변형 작물 재배면적의 증가를 가져왔다. 그러나 유전자 변형 작물의 상업적 재배전에 유전자 변형 작물의 인간건강 및 환경에 미칠 잠재적 위해성에 대한 면밀한 검토가 필수적이다. 본 연구에서는 Bt벼의 토양미생물 군집에 미치는 영향을 조사하였다. 토양화학성분을 분석한 결과, Bt벼와 낙동벼 근권토양 간 화학 성분의 유의성 있는 차이는 없는 것으로 조사되었다. 재배전, 재배초기, 최고 분얼기의 토양미생물 군집밀도를 조사했을 때 Bt벼 근권토양의 세균, 방선균, 진균 군집밀도는 낙동 벼와 유사한 수준으로 나타났다. 시기별 DGGE 분석결과 Bt 벼 근권토양 전체미생물상은 낙동벼와 차이가 없는 것으로 조사되었다. Pyrosequencing을 통한 Bt벼와 낙동벼의 미생 물 군집조성을 조사한 결과 주요 미생물상 분포에 있어서도 매우 유사한 양상을 나타내었다. 위의 결과들을 종합해볼 때 Bt 재배에 따른 토양미생물상에 미치는 영향은 미미한 것으로 사료된다. 수확 후 벼 잔존물이 토양환경에 미치는 영향에 대해서는 좀 더 연구가 진행되어야 할 것이다. The cultivation of genetically modified (GM) crops has increased due to their economic and agronomic advantages. Before commercialization of GM crops, however, we must assess the potential risks of GM crops on human health and environment. The aim of this study was to investigate the possible impact of Bt rice on the soil microbial community. Microbial communities were isolated from the rhizosphere soil cultivated with Bt rice and Nakdong, parental cultivar and were subjected to be analyzed using both culture-dependent and molecular methods. The total counts of bacteria, fungi, and actinomycetes in the rhizosphere of transgenic and conventional rice were not significantly different. Denaturing gradient gel electrophoresis (DGGE) analysis of PCR-amplified 16S rRNA genes revealed that the bacterial community structures during cultural periods were very similar each other. Analysis of dominant isolates in the rhizosphere cultivated with Bt and Nakdong rice showed that the dominant isolates from the soil of Bt rice and Nakdong belonged to the Proteobacteria, Cloroflexi, Actinobacteria, Firmicutes, and Acidobacteria. These results indicate that the Bt rice has no significant impact on the soil microbial communities during cultivation period. Further study remains to be investigated whether the residue of Bt rice effect on the soil environment.

Development and evaluation of targeting ligands surface modified paclitaxel nanocrystals

Sohn, Jeong Sun,Yoon, Doo-Soo,Sohn, Jun Youn,Park, Jeong-Sook,Choi, Jin-Seok Elsevier S.A. 2017 Materials Science and Engineering C Vol. No.

<P>Three different types of PTX-NCs with a mean size of 236.0 +/- 100.6 nm (PTX-NC), 302.0 +/- 152.0 nm (Tf-PTX-NC) and 339 +/- 180.6 nm (HA-FIX-NC) were successfully prepared. The drug release profiles showed 29.1%/6.9% (PTX (pure)), 40.7%/23.9% (PTX-NC), 50.5%/25.1% (Tf-PTX-NC) and 46.8/24.8% (HA-PTX-NC) in PBS with/without 0.5% (w/v) Tween 80 for 24 h, respectively. As per the results, the drug release of PTX-NCs showed the faster release as compared to that of PTX (pure). Surface modified PTX-NCs exhibited higher values for cell permeability than unmodified PTX-NC in the cellular uptake study. Surface modified PTX-NCs inhibited the cell growth approximately to 60% in MCF-7 cells, however effect of surface modified PTX-NCs on normal cell line was lower than the PTX-NC and PTX (pure). In conclusion, biological macromolecules (Tf or HA) surface modified PTX-NC enhanced the cellular uptake and the cell growth inhibition. (C) 2016 Elsevier B.V. All rights reserved.</P>

Risk Factor of Post-Polypectomy Bleeding in Early Liver Cirrhosis

( Youn Ju Jeon ),( Kyung Hoon Lee ),( Hyuk Soo Choi ),( Jung Hee Kwon ),( Kyoung Min Sohn ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1

Aims: Bleeding is the most common colonoscopic polypectomy complication. However, the risk of post-polypectomy bleeding in liver cirrhosis is unknown. We aimed to investigate the incidence and risk factors of post-polypectomy bleeding after a colonoscopic polypectomy in patients with early liver cirrhosis(LC). Methods: We performed a retrospective study of patients with early LC who underwent colonoscopic polypectomy at a single center between January 2006 and December 2015. In total, 41 patients with early LC were enrolled. We investigated the incidence of immediate PPB (IPPB) and delayed PPB (DPPB) in these patients. Results: Among 41 patients, 36 (87.8%) were Child-Turcotte-Pugh class A, 5 (12.2%) were class B. The mean prothrombin time was 1.26 ± 0.33, and the mean platelet count was 124.87 ± 71.32 × 103/L. A total of 78 polyps in 41 patients were removed. IPPB was observed 5 (6.41 %) of the 78 removed polyps presented with mild oozing and were controlled by hemostatic procedures using endoscopic hemoclips. Both IPPB and non IPPB group, during the observation period there were no DPPB. Conclusions: The risk of hemorrhage after polypectomy in the case of early cirrhosis of the liver did not increase significantly. However, when the size of the polyps are large, it is necessary to caution about bleeding after polypectomy.

Plasma Carnitine Profiles in Different Aged Normal Korean Women

Youn-Soo Cha,Eun-Jung Joo,Hee-Sook Sohn 한국영양학회 1998 Nutritional Sciences Vol.1 No.1

The Effect of High-Sucrose and High-Fat Diets on the Expression of Uncoupling Proteins (UCPs) mRNA Levels in Mice

Sohn, Hee-Sook,Nam, Ji-hyun,Cha, Youn-Soo The Korean Nutrition Society 2004 Nutritional Sciences Vol.7 No.2

The objective of this study was to examine diet-induced changes in the expression of UCP2 mRNA in the liver and UCP3 mRNA in the skeletal muscle of mice fed a high-sucrose or high-fat diet. Male ICR mice, aged 4 weeks, were divided into three dietary groups and fed control (N) or modified AIN-76 high-sucrose (US) or high-fat (HF) diets for 12 weeks. The serum total cholesterol (TC) and LDL-cholesterol concentrations of the HF group were significantly higher than those of the N and HS groups. The hepatic TC and triglyceride contents of the HS and HF groups were also significantly higher than those of the N group. The HS diet group had higher serum leptin and insulin levels compared to those of the HF group. Hepatic UCP2 mRNA expression was significantly higher in the HS group than in the N group, but the level in the HF group did not differ from that of the N group. Muscular UCP3 mRNA level was significantly higher in the HF group and especially in the HS group than in N the group. We observed that two gene (UCP2, 3) levels exhibited a similar tendency. These results suggest that UCPs mRNA levels and energy expenditure may be altered or controlled by various dietary patterns. Further research is needed to elucidate the effects of diet on the regulation of many obesity-related genes.

Spontaneous cephalohematoma associated with the temporal meningocele and hemicranial dysplasia

Sohn, Hyo Chung,Kim, Youn,Choi, Kil Soo,Chu, Jeong Wha,Sim, Bo Sung 대한신경외과학회 1972 Journal of Korean neurosurgical society Vol.1 No.1

측두부 수막류는 극히 드문 선천성 기형이며 1967년 Nagulich의 8예보고 이후 추가 보고예가 없었다. 환자는 21세의 남자로 좌측 두부와 안면의 심한 팽대성 종창과 안구돌출을 주소로 1971년 7월 본원 신경외과에 입원하였다. 단순두개방사선상은 좌측측두부 호접골대익후상정(pterion)에 4×3㎝의 두개골결손을 보였고, 그 연변은 분화구와같이 돌출해 있었다. 뇌하수체와는 확장 및 함몰을 보였고 좌측 중두개와 및 안와는 비대칭적으로 확대되었고 안면골의 우측 편이를 본 수 있었다. 과거력에서 뇌압항진이나 안와 및 두개내종양을 의심할 수 없었다. 좌측 측두부와 안면의 팽대종괴는 두부외상의 병력없이 입원 5일전부터 심한 동통과 함께 급격히 커지면서 급진하는 안구돌출을 유발하였다. 수술소견에서 이 종괴는 동맥성 피하출혈임이 확인되었고 방사선상의 두개골 결손부위에는 수막류가 있었고 두개강내 종양은 발견할 수 없었다. 두개(저)골 발육이상과 측두부 수막류의 합병은 희귀한 예이다. 측두부 수막류의 발생기전, 선천성 편측 두개(저)골 발육이상 및 이에 따르는 안구돌출에 대한 문헌고찰과 특발성 두피혈종의 형성 및 발생에 대하여 고찰하였다. We have reported a rare case of spontaneous cephalohematoma associated with the temporal meningocele and hemicranial dysplasia. We reviewed the literatures for pathogenesis of temporal meningocele and hemicranial dysplasia, respectively. And possible mechanism for spontaneous cephalohematoma was described.

발레공연 전 · 후 영양소 섭취의 차이

손보람(Sohn, Bo-Ram),조정호(Cho, Jung-Ho),정재현(Jung, Jae-Hyun),신말연(Shin, Mal-Ryun),이지현(Lee, Ji-Hyun),김선민(Kim, Sun-Min),김수연(Kim, Soo-Youn) 한국체육과학회 2013 한국체육과학회지 Vol.22 No.4

The purpose of this study was to investigate the nutrient intake and actual environmental factors with dietary habits in ballet dancers before and after performance. Forty three ballet dancers were recruited cluster sampling method and they were divided into an amateur ballet company (n=9), a semi-pro ballet company (n=15), or a professional ballet company (n=19). Body composition was measured by (In- body 3.0, Biospace Co., Korea) and nutrient intake was measured by 24-hours recall method (Computer Aided Nutritional Analysis program ; CAN-Pro version 2.0) Analysis of covariance was used to compare group differences and multiple range test was used for post hoc method. The findings of this study showed there was a significant difference in the vitamin B2 but, carbohydrate, fat, protein, mineral, and some vitamin showed no significant differences among the groups(p>.05). In conclusion, the ballet performance maybe particalarly important on nutrient supplementation in ballet dancer.