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입원 중인 베트남 참전 군인의 삶의 만족도와 관련된 요인
김애리,박종,김율,노희송,박광희,김은숙,김형철,홍강식,류소연,강명근,김기순 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.2
Background and Objectives: The aim of the study was to identify the factors associated with life satisfaction of hospitalized Vietnam veterans. Material and Methods: The data were collected from 200 hospitalized Vietnam veterans of 5 veterans hospitals in Korea from September 13 to 23, 2004. Information of general characteristics, health behavior, disease history, family function, depression and life satisfaction were collected by structured questionnaire. Results: The mean of life satisfaction was 21.48(±6.03), and the mean of depression was 53.10(±9.64). The prevalence of depression was mild depression 24.0%, moderate depression 43.5% and severe depression 25.0%. Depression was associated with life satisfaction and depression was higher, life satisfaction was lower. Family function and age were positively associated with life satisfaction, Conclusion: Life satisfaction was affected by depression and family function in hospitalized Vietnam veterans. Therefore, it was thought that psychosocial approaches such as improve depression and family function in care of hospitalized Vietnam veterans is required.
랫드에서 인체 재조합 적혈구 조혈인자, rHuEPO의 13주 정맥투여 아만성독성에 관한 연구
김형식,곽승준,천선아,박현선,한하수,임소영,안미영,김원배,김병문,안병옥,홍성렬,이병무 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1
A recombinant human erythropoietin (rHuEPO) was administered intravenously at dosage levels of 0, 100, 500, and 2500 IU/㎏/day for a period of 13 weeks. There were no observed clinical signs and deaths related to treatment in all groups tested. Decreases in body weight gain and food consumption were observed only in males of 2,500 IU/㎏ group after 2 weeks. In hematological parameters, erythrocyte content, hematocrit values and hemoglobin concentration were dose-dependently increased in rHuEPO treated groups. The ratio between kidney weight and whole body weight was significantly increased in females of 500 and 2,500 IU/㎏ groups. The spleen weight was also increased in both sexes of 500 and 2,500 IU/㎏ groups. However, the absolute weight change of other organs was not observed. In histopathological examinations, the renal tubular basophilia was observed only in males and females of 2,500 IU/㎏ groups. From these results, it is concluded that the no-observed adverse effect level(NOAEL) of rHuEPO is 100 IU/㎏ in rats in the present study.
공황장애에서 Paroxetine 단기약물치료가 심리적 상태에 미치는 영향
이소영,김지혜,김율리,강은호,이동수,유범희 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.3
Objectives : This study was designed to evaluate clinical effect of paroxetine treatment and to explore psychological Pre-dictors of treatment response. Methods : Patients (n=26) who met DSM-IV criteria for panic disorder with or without agoraphobia were treated by Pa-roxetine for 12 weeks. We assessed symptom improvement using Clinical Global Impression (CGI), and clinical characteristics using Anxiety Sen&itivity Index (ASI), Anxious Thoughts and Tendencies (AT & T), Agoraphobic Cognition Questionnaire (ACQ), Body Sensation Questionnaire (BSQ), Beck Anxiety Inventory (BAI), and Beck Depression Inventory (BDI). T-test, correlation analysis, and stepwise multiple regression analysis were performed. Results : Panic patients showed significant improvement in seventy of illness and each clinical characteristic after 12 weeks of paroxetine treatment. There were significant correlations among severity of illness, anxiety, and depression, and subjective seventy was related with catastrophic thoughts. The more catastrophic thoughts and the higher sensitivity of body sensation, Patients had the worse symptom improvement they shorved. Multiple regression analysis showed that catastrophic thought related to agoraphobia was the best predictor of symptom improvement (22%). Conclusion : This study suggests that short-term treatment of paroxetine is effective in panic disorder with or without ago-raphobia, and that catastrophic thought could be a predictor of poor treatment response. Thus cognitive intervention on Catastro-phic thoughts may play an important role in symptom improvement in panic disorder.
So-Hyun Kim,Dae-Gwan Kim,Jung-Bun Kim,Haying-Youl Lee,Yoon-Ah Jang,Seok-Woo Jang,Tae-Sung Kim 한국원예학회 2021 한국원예학회 학술발표요지 Vol.2021 No.10
This study was carried out to provide preliminary data to find useful molecular markers that can improve lettuce productivity under hot weather conditions. Lettuce is circulated as a fresh product, so the fresh weight(FW, g) is the most critical measure to judge lettuce productivity. However, FW may not be a dependable breeding target since the breeding value might be low, potentially due to the high G(genetic)xE(environmental) effect. To search more reliable estimates, we investigated other productivity-related phenotypes, including leaf weight(LW, g), leaf number(LN, ea), effective leaf number(ELN, ea), leaf a rea(LA, ㎡), specific leaf weight(SLW, g/㎡) and specific leaf area(SLA, ㎡/g). First, we found a strong correlation between FW and LN (r = 0.7510), which is also supported by the PCA analysis, based on two years of field data. Second, we also performed the multiple linear regression analysis to confirm which phenotypes can explain FW variability. We found that LN, LW, LA, SLA, ELN, and SLW were significant terms. Finally, LN is the most critical term, explaining about 92% of the variability of the dependent variable, predicting 7.5g of FW is gained when a leaf of lettuce is augmented according to the model. We also noticed that LN could be a reliable breeding target to improve FW since the broad sense of heritability(H) of LN is 61.5% which is the highest among the phenotypes. Thus, we searched the possibilities of associated molecular markers with LN and proceeded to perform a genome-wide association study(GWAS) using 218,834 SNPs obtained from genotyping by sequencing(GBS) method. As a result, we found a prominent association peak for LN at chromosome 5, selecting 10 candidate SNPs based on P-value, allele frequency, and genotype quality. Among these, we found that allelic variation in the SNP that resides at chromosome 5 can increase 3.6 sheets of leaves in lettuce on average, concomitant with 27g of enhancement in FW. Therefore, we anticipate this study would provide valuable solutions to the lettuce breeding research community, improving lettuce productivity under hot weather conditions.
Kim, So Yeon,Lee, Myong Jin,Kim, Jeong Won,Na, Yu-Ran,Lee, Ho-Youl,Cho, Hyunju,Lee, Keun Byeol,Lee, You Mie,Lee, Cheolju,Park, Hyunsung,Yang, Eun Gyeong Pharmaceutical Society of Japan 2012 Biological & pharmaceutical bulletin Vol.35 No.12
<P>We previously found that clioquinol (CQ) increases functional hypoxia-inducible factor-1α (HIF-1α) with enhanced transcription of its target genes. Here we report that compounds derived from 8-hydroxyquinoline including CQ, broxyquinoline (BQ), iodoquinol (IQ) and chloroacetoxyquinoline (CAQ) promote neovascularization effectively based on chick chorioallantoic membrane assays. The CQ analogues induce stabilization of HIF-1α as well as enhance HIF-1-mediated vascular endothelial growth factor transcription. These analogues also exert inhibitory effects on the activity of prolyl and asparaginyl hydroxylations of HIF-1α in vitro. Despite metal ion-dependent restoration of the inhibited HIF-1α hydroxylase activity, the cellular HIF-1α-inducing effects of the CQ analogues are reversed to varying degrees by Zn(2+) and Fe(2+). While CQ and BQ are completely reversed by Zn(2+), co-administration of Zn(2+) and IQ has only a partial reversing effect. On the other hand, CAQ-mediated stabilization of HIF-1α is reversed by Fe(2+) but not by Zn(2+). These phenomena are found to coincide with elevation of the intracellular Zn(2+) and Fe(2+) levels by the CQ analogues, suggesting that metal ion effects on HIF-1α in cells likely reflect the differential transporting capability of the analogues.</P>