후기 분만 후 자간증 2예

소병학,김영민,박규남,김세경 대한응급의학회 2001 대한응급의학회지 Vol.12 No.2

Eclampsia is characterized by generalized tonic-clonic convulsions that develop in women with hypertension induced or aggravated by pregnancy. Because identification of patients at risk and preventive therapies are imperfect, eclamptic seizures continue to occur occasionally during puerperium. Nearly all cases of postpartum eclampsia develop within 24 hours of delivery, but typical cases are seen up to 26 days postpartum. Convulsion with initial presentation more than 48 hours but less than 4 weeks after delivery are commonly referred to as late postpartum eclampsia. We describe two cases of late postpartum eclampsia and give a review of literature.

양식산 넙치와 자연산 넙치의 관능적 특성 및 저장중 신선도 변화 연구

박병학,박소희,조재선 한국조리과학회 2003 한국식품조리과학회지 Vol.19 No.1

This study was conducted to investigate the physicochemical and organoleptic characteristics and freshness of wild and cultivated Paralichthys olivaceus during storage. By the results of morphological observation, wild Paralichthys olivaceus had white abdomen, light black skin and transparent muscle, but cultivated Paralichthys olivaceus had black spotted abdomen, dark black skin and dark pink muscle. Moisture contents of wild and cultivated Paralichthys olivaceus were similar, but the lipid content was higher in cultivated Paralichthys olivaceus than that of wild Paralichthys olivaceus. Sensory scores of appearance, Taste, texture and overall acceptability were higher in wild paralichthys olivaceus than that of cultivated Paralichthys olivaceus. The reason was that lipid content was higher in cultivated Paralichthys olivaceus. The freshness of cultivated paralichthys olivaceus seemed to last shorter than that of wild one due to rapid increase of the volatile basic nitrogen content, pH and total microbial count during storage.

크론병에 대한 CoPPLX의 방어효과에 대한 연구

이호학,김유림,문창기,이재일,양병윤,김종수,이정민,정재혁,안석진,박상준,김윤권,김소연,김영중,조민구,최영자,장성조 圓光大學校 醫科學硏究所 2005 圓光醫科學 Vol.20 No.1

SEK1 카이네이즈 과발현(overexpression)생쥐 대식세포주(RAW264,7)의 Nitric Oixde(NO)유도성 세포고사 (apoptosis) 기전에 관한 연구

정병학,소홍섭,박래길,정헌택 圓光大學校 醫科學硏究所 1998 圓光醫科學 Vol.14 No.2

Nitric oxide (NO) induces apoptotic cell death in murine RAW 264.7 macrophages. To A elucidate the NO-induced apoptotic mechanisms in SEK1/MKK4 overexpressed RAW 264.7 cells, we generated clones of RAW 264.7 cells which stably overexpressd kinase inactive SEK1 (RAW/SEK1-KI) or wild type SEK1 (RAW/SEK1-WT). Treatment of kinase inactive SEK1 transfected RAW 264.7 cells (RAW/SEK1-KI) with sodium nitroprusside (SNP), a NO donor, significantly decreased the cell viability than that of RAW control cells which were treated with the same amount of SNP. However, RAW/SEK1-WT cells were less susceptible to NO induced apoptosis. Furthermore, the treatment of NO with farnesyltransferase inhibitor (FTI) of Ras or MEK inhibitor (PD098059) significantly increased the apoptotic death of RAW/SEK1-KI. However, SB203580, a specific p38 inhibitor, did not affect NO-induced apoptosis of kinase inactive SEK1 transfected RAW 264.7 cells. For a while, caspase 3-like protease activity in NO plus FTI treated RAW/SEK1-KI cells were more increased than that of NO only. In addition, nuclear transcription factor kB (NFkB) was significantly activated in NO-treated RAW/SEK1-KI cells, whereas these transcriptional factor was not markedly activated in NO-treated RAW/SEK1-WT cells. Supershift analysis demonstrates that NFkB was composed of mainly p50 homodimer. Also pyrrolidine dithiocarbamate (PDTC), a strong inhibitor of NFkB, significantly inhibits the NO-induced apoptosis in RAW/SEK1-KI cells. Taken together, we suggest that SEK1 may play anti-apoptotic role in RAW cells from NO-induced apoptosis via the modulation of NFkB. In addition, in the absence of SEK1 kinase cascade activation, the viability of RAW cells may be mainly dependent on Ras/Raf/MEK/ERK pathway.

HBx형질전환 생쥐에서 발생한 간세포암종에서 H-ras 및 c-myc의 발현에 관한 연구

문형배,소병준,김학철,윤기중,한원철,조향정,유대열,정영진 圓光大學校 醫科學硏究所 2002 圓光醫科學 Vol.17 No.2

<연구목적> HBx형질전환 생쥐에서 발생한 간세포암종의 발암과정에 종양유전자(H-rgs, c-myc)의 발현 정도를 조사하고자 하였다. <연구방법> 정상생쥐 12마리(4-18개월) 및 HBx 형질전환 생쥐 44마리(4-18개월)를 대상으로 포르말린에 고정하고 파라핀에 포매한 간 조직을 이용하여 면역조직화학적염색을 실시하였다. 실험군은 정상 부위, 이형성 부위 및 종양 부위로 구분하였으며, 종양 부위는 소결절성병변 부위와 간세 포암종 부위로 구분하였고, 이형성병변 부위는 이형성병변만 발견되는 부위, 소결절성병변과 동반된 이형성병변 부위 및 간세포암종과 동반된 이형성병변 부위로 구분하였다. <연구결과> H-rgs의 발현은 정상 간조직에 비하여 이형성병변 부위(P<0.05) 및 종양 부위(P<0.01)에서 증가하였으며, 소결절성병변 부위과 간세포암종 부위 사이에서는 간세포암종 부위에서 증가된 경향이었으나 통계학적으로 유의한 차이가 없었으며, 각 이형성병변 부위 사이에서도 유의한 차이는 없었다. c-myc의 발현은 정상 간조직 및 이형성병변 부위에 비해 종양 부위에서 증가하였으며(P<0.001), 소결절성병변 부위와 간세포암종 부위에서는 비슷하였고, 각 이형성병변부위 사이에서도 비슷하였다. <결론> HBx형질전환 생쥐에서 발생하는 간세포암종의 발생에 H-rgs는 이형성 변화를 일으키는 시기에 관여하며, c-myc은 이형성병변에서 암으로 이행하는 시기에 관여할 것으로 생각한다. Background: This experiment was designed for the expression of H-ras and c-myc in hepatocarcinogenesis of the HBx transgenic mice. Methods: Immunohistochemical stains in the paraffin embedded tissue of the liver were used for the detection of H-ras and c-myc in the 12 normal mice and 44 HBx transgenic mice of the 4-18 month old. Results: Expression of the H-ras was significantly increased in the dysplastic area (P<0.05) and tumor area (P<0.01) than in the normal liver. But there were no differences of H-ras expression between areas of microscopically identified hepatocellular carcinoma (MI-HCC) and grossly identified hepatocellular carcinoma (GI-HCC) and dysplastic areas among the only dysplastic areas, dysplastic areas with MI-HCC and GI-HCC. Expression of the c-myc was significantly increased in the tumor area (P<0.001) than in the normal liver and dysplastic area. But there were no differences of c-myc expression between areas of MI-HCC and GI-HCC, and dysplastic areas among only dysplastic areas, dysplastic areas with MI-HCC and GI-HCC. Conclusions: Our study suggests that H-ras is related to the dysplastic change and c-myc is related to the neoplastic change in the hepatocarcinogenesis of the HBx transgenic mice.

2008년 국내 중독환자 실태조사; 예비연구

소병학 ( Byung Hak So ),이미진 ( Mi Jin Lee ),김현 ( Hyun Kim ),문정미 ( Jeong Mi Moon ),박경혜 ( Kyung Hye Park ),성애진 ( Ae Jin Sung ),염석란 ( Seok Ran Yeom ),오성범 ( Seong Beom Oh ),유지영 ( Ji Young You ),이경우 ( Kyung Wo 대한임상독성학회 2010 대한임상독성학회지 Vol.8 No.2

Purpose: The aim of this study was to investigate toxic exposures in emergency centers with using a toxic exposure surveillance system-based report form as a preliminary study. Methods: We retrospectively reviewed the medical records of toxic exposure patients who visited emergency centers from January to December 2008. Results: 3,157 patients from 11 emergency centers were enrolled. Males were involved in 47.9% of the total cases of exposure and in 60.1% of the cases of fatal exposure. Suicidal intent was the most common (61.0%) reason and most (87.4%) fatal exposures were suicidal. Pesticides were involved in 30.7% of the cases and sedative/hypnotics/ antipsychotics were involved in 20.5%. The substances most frequently involved in fatalities were pesticides, and a 48.4% fatality rate was recorded for paraquat exposure. Conclusion: The toxic exposure data showed the preliminary poisoning events in emergency centers. It is recommended that toxicology professionals should develop a toxic surveillance system and serial reporting should be performed.

긴장성 기뇌 1례

소병학,박승현,김기명,김세경 대한응급의학회 2002 대한응급의학회지 Vol.13 No.2

This paper presents one case of subdural tension pneumocephalus which deteriorated in the early phase of head trauma. Pneumocephalus occurs in 0.5 to 1.0% of head trauma cases. Most patients have nonspecific signs and symptoms, such as headache. Therefore, a high index of suspicion in a patient with recent head trauma is necessary. Therapy is often noninvasive, allowing the craniodural defect to heal spontaneously. However, if enough air collects within the cranium or the brain itself, a mass effect with marked midline shift may develop. This is referred to as tension pneumocephlus and may result in herniation symdrome. Prompt decompression is essential.

담도절개후 단순원천 봉합에 대한 임상적 고찰

이학승(Hak Seung Lee),채권묵(Kwon Mook Chae),이광만(Kwang Man Lee),이광만(Kwang Man Lee),이정균(Jeong Kyun Rhee),소병준(Byung Jun So) 대한외과학회 1993 Annals of Surgical Treatment and Research Vol.45 No.6

계열별 대학생의 연구윤리의식 차이

윤소정 ( So Jung Yune ),최용성 ( Yong Seong Choi ),양삼석 ( Sam Seok Ryang ),최병학 ( Byung Hak Choi ),김회용 ( Hoy Yong Kim ) 한국윤리학회 2011 倫理硏究 Vol.81 No.1

For solving the study on the consciousness of research ethics of university student, this study is to examine the actuality of 5 kinds of elements and students are surveyed by the department. And this study attempts to analyze and seek an alternative direction for research ethics education. One element of 5 elements is research integrity. Second element is ethical issues in scientific publication. Third element is ethical issues in the laboratory. Forth element is ethical issues in the special scientific realm. Fifth element is the scientist`s responsibility in society. These elements should be connected and managed collectively. And with this assumption, we examined concrete each of these elements about actuality and attempted to seek alternatives. The results of each elements in this study are still insufficient and inadequate levels for effective education of research ethics education. In addition, the difference of department was presented in each curriculum. And the differences in each curriculum had a blind spot of research ethics education. After all, we presented research ethics education of the whole school level than individual level.

대학생의 연구윤리교육에서의 표절 실태 및 대안 연구

윤소정 ( So Jung Yune ),최용성 ( Yong Seong Choi ),최병학 ( Byung Hak Choi ),양삼석 ( Sam Seok Ryang ) 한국윤리교육학회 2011 윤리교육연구 Vol.0 No.24

본 연구의 목적은 대학생의 표절 문제를 입체적으로 해결하기 위하여 설정한 5요소 즉, 표절 기준·검색·제지·홍보·예방·교육에 따라 P 대학의 표절 현실태를 진단해 보고 이에 대한 대안을 모색하고자 하였다. 표절문제를 입체적으로 해결하기 위한 5요소는 보다 구체적으로, 1요소는 대학 차원에서 표절 기준 및 규정 확립, 2요소표절 규정 가이드 및 홍보, 3요소 표절검색 프로그램 완비, 4요소 표절제재조치의 제도화, 5요소 학문적 글쓰기의 내실화라는 5가지 요소로 구성되었다. 표절의 현실태 진단을 위하여 설문을 개발하였으며, 내용타당도 검정과 예비 검사를 통해 수정후 사용하였다. 최종 설문은 P대학 대학생 398명을 대상으로 실시되었다. 조사 결과 분석에는 다변량분석과 교차분석을 이용하였다. 그 결과 표절 기준과 표절 실태에 대한 인식과 대학내 학술적 글쓰기 및 인용법 교육에 대한 실태 인식에 있어 계열별 차이가 나타났다. 또한 학교 전체적 차원에서 보다 관심을 기울여야 할 요소로 모든 계열에서 표절 예방을 위한 홍보 및 클린 캠퍼스 운영이 필요하다고 답하였다. 본 연구를 통해 표절방지 및 학술적 글쓰기의 개선을 위해서는 개별적 차원보다 학교 전체 차원에서의 입체적인 표절예방교육이 보다 강조되어야 함을 알 수 있다. For solving the plagiarism problem collectively, this study is to examine the actuality of P University through 5 kinds of elements and students are surveyed by the department. And this study attempts to analyze and seek an alternative direction for plagiarism prevention education. One element of 5 elements is regulations established by the University in terms of plagiarism, Second element is plagiarism rules guide and promoting. Third element is equipping with search program. Forth element is the institutionalization of plagiarism sanctions. Fifth element is academic writing. These elements should be connected and managed collectively. And with this assumption, we examined concrete each of these elements about actuality and attempted to seek alternatives. The results of each elements in this study are still insufficient and inadequate levels for effective education of prevention plagiarism. In addition, the difference of department was presented in each curriculum. And the differences in each curriculum had a blind spot of plagiarism prevention education. For the improvement in search program, plagiarism sanctions and academic writing, school official`s effort was more important. After all, we presented plagiarism prevention education of the whole school level than individual level.