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6G-LEGO: A framework for 6G network slices
Slawomir Kukliński,Lechosław Tomaszews,Robert Kołakowski,Prosper Chemouil 한국통신학회 2021 Journal of communications and networks Vol.23 No.6
Network slicing is a relatively recent paradigmthat has become a subject of intensive research. Most of theexisting approaches follow the ETSI NFV MANO model withsome extensions related to multi-domain slicing, slice selection,etc. The framework is a part of the standalone variant ofthe 5G network standardized by 3GPP. However, the currentimplementation of network slicing in 5G has several limitations,especially regarding management and orchestration: The isolationof slice management is not appropriately addressed, the slicetenant management capabilities are limited, and the managementand orchestration centralization raises serious scalability andreliability issues. Moreover, the slice-level operations are notwell-separated from other processes due to a lack of properseparation of concerns. As a result, the overall network slicingarchitecture has complex interactions with many components ofthe 5G network. In this paper, we describe a new framework thatuses an approach to sustain self-managed and self-orchestratedslices. To that end, we propose a modular architecture in whichslices have embedded (in-slice) management and orchestrationsupport, and multi-domain slices rely on multiple slice-agnosticorchestrators. The framework enables the composition of newslices as a combination of single domain-slices in a relativelyeasy, technology-independent manner.
Kaczmarek, Slawomir,Marquardt, Tomasz Korean Society of Applied Entomology 2006 Journal of Asia-Pacific Entomology Vol.9 No.3
The mesostigmatid mites speciation of the family Zerconidae in the Korean Peninsula was analysed in relation to the range of this group in the world. The Korean Peninsula is located on the edge of the Holarctic and is characterised by a uniquely diversified climate shaping the longitudinally changing flora. At present, there are altogether 40 genera included in the family Zerconidae. So far, in the Korean Peninsula there have been recognised 18 species of the Zerconidae belonging to 11 genera. The endemic genera within the area include: Metazercon, Eurozercon, Xenozercon, Koreozercon, Kaikiozercon, Aquilonozercon, and cf. Mesozercon gen. nov. A very high level of endemism (over 60%) proves the intensity of the speciation processes within the Zerconidae family on the Korean Peninsula.
Treatment of orthotopic malignant peripheral nerve sheath tumors with oncolytic herpes simplex virus
Antoszczyk, Slawomir,Spyra, Melanie,Mautner, Victor Felix,Kurtz, Andreas,Stemmer-Rachamimov, Anat O.,Martuza, Robert L.,Rabkin, Samuel D. Oxford University Press 2014 Neuro-oncology Vol.16 No.8
<P><B>Backgrounds</B></P><P>Malignant peripheral nerve sheath tumors (MPNSTs) are an aggressive and often lethal sarcoma that frequently develops in patients with neurofibromatosis type 1 (NF1). We developed new preclinical MPNST models and tested the efficacy of oncolytic herpes simplex viruses (oHSVs), a promising cancer therapeutic that selectively replicates in and kills cancer cells.</P><P><B>Methods</B></P><P>Mouse NF1<SUP>−</SUP> MPNST cell lines and human NF1<SUP>−</SUP> MPNST stemlike cells (MSLCs) were implanted into the sciatic nerves of immunocompetent and athymic mice, respectively. Tumor growth was followed by external measurement and sciatic nerve deficit using a hind-limb scoring system. Oncolytic HSV G47Δ as well as “armed” G47Δ expressing platelet factor 4 (PF4) or interleukin (IL)-12 were injected intratumorally into established sciatic nerve tumors.</P><P><B>Results</B></P><P>Mouse MPNST cell lines formed tumors with varying growth kinetics. A single intratumoral injection of G47Δ in sciatic nerve tumors derived from human S462 MSLCs in athymic mice or mouse M2 (37-3-18-4) cells in immunocompetent mice significantly inhibited tumor growth and prolonged survival. Local IL-12 expression significantly improved the efficacy of G47Δ in syngeneic mice, while PF4 expression prolonged survival. Injection of G47Δ directly into the sciatic nerve of athymic mice resulted in only mild symptoms that did not differ from phosphate buffered saline control.</P><P><B>Conclusions</B></P><P>Two new orthotopic MPNST models are described, including in syngeneic mice, expanding the options for preclinical testing. Oncolytic HSV G47Δ exhibited robust efficacy in both immunodeficient and immunocompetent MPNST models while maintaining safety. Interleukin-12 expression improved efficacy. These studies support the clinical translation of G47Δ for patients with MPNST.</P>
The Changes of Bridge Loads During the Long-term Period
Karas Slawomir,Hypki Mateusz 대한토목학회 2016 KSCE JOURNAL OF CIVIL ENGINEERING Vol.20 No.5
The aim of the paper is an analysis of bridge loads changes in the 20th century. The Polish bridge load standards issued in the 20th century are considered here. The two static approaches are adopted on the basis of the model of the real composite of a steel and concrete bridge carrying-deck. The first of them, the traditional simplified Courbon method which was in use up to the 1970s, gives bending moment results. The other one is the analysis by the ABAQUS FEM. The dynamic response of the structure is performed for the set of velocities starting from 10 km/h to 90 km/h. Basing on the obtained results, it is concluded that the load increase is essential for bridge sustainability in all phases i.e. for design, maintenance and optional rebuilding. Having in mind that, in general, the indicative service life of a bridge is intended for 100 years approximately, i.e. for three generations, the prognosis of load changes is crucial. The bridge load effects increase over the past century is estimated at 60% to 85%, it being at least 30%.
Gamasid mite assemblage on mountain fire sites
Chuleui Jung,Tomasz Marquardt,Slawomir Kaczmarek,Hoonbok Yi 한국응용곤충학회 2008 한국응용곤충학회 학술대회논문집 Vol.2008 No.10
Gamasid mites are free living predators of soil mites, collembolans, nematodes and other small insects in soil surface. We studied the faunal assemblages of gamasid mites in the severely disturbed mountain sites by fire. Total 12 families 55 species were found from this study. From all sites, species in the family of Parholaspidae were dominant; Holaspina alstoni and H. dentatus. Also, Rhodacarus dentitulatus was also abundant regardless of fire disturbance. In control site, Asca aphidioides was also abundant but not in any of the fire disturbed sites. The abundance was highest in control site followed by IC2, IT3 and lower in IT2 and IT1. Species richness was in the same order of abundance ranging from 2.6 to 12.8 per site. In all sites, species diversities were relatively low ranging from 0.6 to 1.7, but it was higher in control site and lower in IT1. Further discussion will be made on the recovery process of soil inhabiting mites.
SADEA-II:Ageneralizedmethodforefficient global optimization ofantennadesign
Bo Liu,Slawomir Koziel,Nazar Ali 한국CDE학회 2017 Journal of computational design and engineering Vol.4 No.2
Efficiency improvementisofgreatsignificance forsimulation-drivenantennadesignoptimizationmethodsbasedonevolutionaryalgorithms(EAs). Thetwomainefficiency enhancementmethodsexploitdata-drivensurrogatemodelsand/ormulti-fidelity simulationmodelstoassistEAs. However, optimizationmethodsbasedonthelattereitherneedadhoclow-fidelity modelsetuporhavedifficulties inhandlingproblemswithmore thanafewdesignvariables,whichisamainbarrierforindustrialapplications.Toaddressthisissue,ageneralizedthreestagemulti-fidelitysimulation-model assistedantennadesignoptimizationframeworkisproposedinthispaper.Themainideasincludeintroductionofanoveldatamining stagehandlingthediscrepancybetweensimulationmodelsofdifferent fidelities, andasurrogate-model-assistedcombinedglobalandlocal searchstageforefficient high-fidelity simulationmodel-basedoptimization.ThisframeworkisthenappliedtoSADEA,whichisastate-of-the-art surrogate-model-assistedantennadesignoptimizationmethod,constructingSADEA-II.ExperimentalresultsindicatethatSADEA-IIsuccessfully handlesvariousdiscrepancybetweensimulationmodelsandconsiderablyoutperformsSADEAintermsofcomputationalefficiencywhile ensuringimproveddesignquality.