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        현대 체위요가의 기원과 다국적 변화

        Mark Singleton 한국요가학회 2016 요가학연구 Vol.- No.16

        이 논문은 현대의 글로벌화된 세계 속에서 요가의 일차적 측면인 체위 (asana) 수련의 출현을 탐구하고 있다. 현대 이전에 체위가 요가수행(sadhana) 의 중요측면으로 취급된 적은 거의 없었다. 오늘날의 대중적 형태의 기원으로 주장되는 중세 하타요가 체계에서의 체위는 호흡 (pranayama), 정화법 (kriya), 집중법 (dharana) 과 소리명상(nada)에 종속된 것이었다. 1920년대와 30년대 동안에 체위요가는 비베카난다 (Vivekananda) 에서 시작된 현대요가 프로젝트에 동화되기 시작했다. 아마 가장 중요한 것은 스리 요겐드라 (Sri Yogendra)와 스와미 쿠발라야난다 (Swami Kuvalayananda) 로 그들은 서구과학과 의학, 그리고 국제적 체육 문화운동에 영향 받아 체위의 체계를 발전시켰다. 시간이 지난 후 체위는 현대적, 과학적 그리고 합리 적인 것으로 세계인들의 눈에 비치게 되었는데, 이것은 이 두 사람과 더 불어 티루말라이 크리쉬나마차리야 (Tirumalai Krishnamacharya) 와 같은 이들의 노력에 기인한 것이다. 체위는 서구의 치유적 체조, “ 영적 ” 인 운동과 무용의 전통들과 상호교류하고 부분적으로 흡수되기도 하였지만, 하타요가 원래의 비의들과 특이한 수행법들은 많이 탈각되었다.

      • Electric polarization observed in single crystals of multiferroicLu2MnCoO6

        Chikara, S.,Singleton, J.,Bowlan, J.,Yarotski, D. A.,Lee, N.,Choi, H. Y.,Choi, Y. J.,Zapf, V. S. American Physical Society 2016 Physical Review B Vol.93 No.18

        <P>We report electric polarization and magnetization measurements in single crystals of double perovskite Lu2MnCoO6 using pulsed magnetic fields and optical second harmonic generation in dc magnetic fields. We observe well-resolved magnetic field-induced changes in the electric polarization in single crystals and thereby resolve the question about whether multiferroic behavior is intrinsic to these materials or is an extrinsic feature of polycrystals. We find electric polarization along the crystalline b axis, that is suppressed by applying a magnetic fields along the c axis, and advance a model for the origin of magnetoelectric coupling. We furthermore map the phase diagram using both capacitance and electric polarization to identify regions of ordering and regions of magnetoelectric hysteresis. This compound is a rare example of coupled hysteretic behavior in the magnetic and electric properties. The ferromagneticlike magnetic hysteresis loop that couples to hysteretic electric polarization can be attributed not to ordinary ferromagnetic domains, but to the rich physics of magnetic frustration of Ising-like spins in the axial next-nearest-neighbor interaction model.</P>

      • Further evaluation and validation of a commercially available competitive ELISA (cELISA) for the detection of antibodies specific to equine arteritis virus (EAV)

        Pfahl, K.,Chung, C.,Singleton, M. D.,Shuck, K. M.,Go, Y. Y.,Zhang, J.,Campos, J.,Adams, E.,Adams, D. S.,Timoney, P. J.,Balasuriya, U. B. R. BMJ Group Group Ltd 2016 The Veterinary record Vol.178 No.4

        <P>The purpose of this study was to further evaluate and validate two commercially available equine arteritis virus (EAV) competitive ELISAs (original and enhanced cELISAs) using archived equine sera from experimentally inoculated animals and field sera submitted for laboratory diagnosis. First, the original and subsequently enhanced cELISAs were compared with the virus neutralisation test (VNT) using a panel of archived serum samples from experimentally inoculated animals. Then, the enhanced cELISA was compared with the VNT using a large panel of archived serum samples. The total number of equine sera tested was 3255, which included sera against 25 different EAV strains. The study confirmed that the enhanced cELISA was more sensitive than the original cELISA. Based on testing sera from experimentally inoculated animals and field sera, the enhanced cELISA had an estimated sensitivity (98.9 percent and 99.6 percent, respectively) and specificity (98.3 percent and 98.7 percent, respectively). The currently marketed enhanced VMRD EAV antibody cELISA test kit (VMRD Inc., Pullman, Washington, USA) has high sensitivity and specificity relative to the VNT. Based on the findings of this study, the authors would propose that the enhanced cELISA should be considered as an alternative approved method to the VNT for the detection of antibodies to EAV.</P>

      • SCISCIESCOPUS

        Bioinformatics-driven discovery of rational combination for overcoming EGFR-mutant lung cancer resistance to EGFR therapy

        Kim, Jihye,Vasu, Vihas T.,Mishra, Rangnath,Singleton, Katherine R.,Yoo, Minjae,Leach, Sonia M.,Farias-Hesson, Eveline,Mason, Robert J.,Kang, Jaewoo,Ramamoorthy, Preveen,Kern, Jeffrey A.,Heasley, Lynn Oxford University Press 2014 Bioinformatics Vol.30 No.17

        <P><B>Motivation:</B> Non–small-cell lung cancer (NSCLC) is the leading cause of cancer death in the United States. Targeted tyrosine kinase inhibitors (TKIs) directed against the epidermal growth factor receptor (EGFR) have been widely and successfully used in treating NSCLC patients with activating EGFR mutations. Unfortunately, the duration of response is short-lived, and all patients eventually relapse by acquiring resistance mechanisms.</P><P><B>Result:</B> We performed an integrative systems biology approach to determine essential kinases that drive EGFR-TKI resistance in cancer cell lines. We used a series of bioinformatics methods to analyze and integrate the functional genetics screen and RNA-seq data to identify a set of kinases that are critical in survival and proliferation in these TKI-resistant lines. By connecting the essential kinases to compounds using a novel kinase connectivity map (K-Map), we identified and validated bosutinib as an effective compound that could inhibit proliferation and induce apoptosis in TKI-resistant lines. A rational combination of bosutinib and gefitinib showed additive and synergistic effects in cancer cell lines resistant to EGFR TKI alone.</P><P><B>Conclusions:</B> We have demonstrated a bioinformatics-driven discovery roadmap for drug repurposing and development in overcoming resistance in EGFR-mutant NSCLC, which could be generalized to other cancer types in the era of personalized medicine.</P><P><B>Availability and implementation:</B> K-Map can be accessible at: http://tanlab.ucdenver.edu/kMap.</P><P><B>Contact:</B> aikchoon.tan@ucdenver.edu or finiganj@njhealth.org</P><P><B>Supplementary information:</B> Supplementary data are available at <I>Bioinformatics</I> online.</P>

      • Fermi surface reconstruction and multiple quantum phase transitions in the antiferromagnet CeRhIn<sub>5</sub>

        Jiao, Lin,Chen, Ye,Kohama, Yoshimitsu,Graf, David,Bauer, E. D.,Singleton, John,Zhu, Jian-Xin,Weng, Zongfa,Pang, Guiming,Shang, Tian,Zhang, Jinglei,Lee, Han-Oh,Park, Tuson,Jaime, Marcelo,Thompson, J. D National Academy of Sciences 2015 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.112 No.3

        <P><B>Significance</B></P><P>Conventional, thermally driven continuous phase transitions are described by universal critical behavior that is independent of microscopic details of a specific material. An analogous description is lacking for phase transitions that are driven at absolute zero temperature by a nonthermal control parameter. Classification of quantum-driven phase transitions is a fundamental but open problem that arises in diverse contexts and multiple classes of materials. Here we report the first observation, to our knowledge, of a sharp Fermi surface reconstruction while applying a strong magnetic field to suppress an antiferromagnetic transition to zero temperature. These experiments demonstrate that direct measurements of the Fermi surface can distinguish theoretically proposed models of quantum criticality and point to a universal description of quantum phase transitions.</P><P>Conventional, thermally driven continuous phase transitions are described by universal critical behavior that is independent of the specific microscopic details of a material. However, many current studies focus on materials that exhibit quantum-driven continuous phase transitions (quantum critical points, or QCPs) at absolute zero temperature. The classification of such QCPs and the question of whether they show universal behavior remain open issues. Here we report measurements of heat capacity and de Haas–van Alphen (dHvA) oscillations at low temperatures across a field-induced antiferromagnetic QCP (<I>B</I><SUB>c0</SUB> ≈ 50 T) in the heavy-fermion metal CeRhIn<SUB>5</SUB>. A sharp, magnetic-field-induced change in Fermi surface is detected both in the dHvA effect and Hall resistivity at [Formula] ≈ 30 T, well inside the antiferromagnetic phase. Comparisons with band-structure calculations and properties of isostructural CeCoIn<SUB>5</SUB> suggest that the Fermi-surface change at [Formula] is associated with a localized-to-itinerant transition of the Ce-4<I>f</I> electrons in CeRhIn<SUB>5</SUB>. Taken in conjunction with pressure experiments, our results demonstrate that at least two distinct classes of QCP are observable in CeRhIn<SUB>5</SUB>, a significant step toward the derivation of a universal phase diagram for QCPs.</P>

      • SCISCIE

        Frustration and Glasslike Character in RIn<sub>1-<i>x</i></sub>Mn<sub><i>x</i></sub>O<sub>3</sub> (R = Tb, Dy, Gd)

        Chen, Peng,Holinsworth, Brian S.,O’Neal, Kenneth R.,Luo, Xuan,Topping, Craig V.,Cheong, Sang W.,Singleton, John,Choi, Eun S.,Musfeldt, Janice L. American Chemical Society 2018 Inorganic Chemistry Vol.57 No.20

        <P>We bring together <I>ac</I> susceptibility and <I>dc</I> magnetization to uncover the rich magnetic field-temperature behavior of a series of rare earth indium oxides, RInO<SUB>3</SUB> (R = Tb, Dy, and Gd). The degree of frustration is much larger than expected, particularly in TbInO<SUB>3</SUB>, and the ground states are glasslike with antiferromagnetic tendencies. The activation energy for spin reorientation is low. Chemical substitution with Mn<SUP>3+</SUP> ions to form TbIn<SUB>1-<I>x</I></SUB>Mn<SUB><I>x</I></SUB>O<SUB>3</SUB> (<I>x</I> ≤ 0.01) relieves much of the frustration that characterizes the parent compound and slightly enhances the short-range antiferromagnetic order. The phase diagrams developed from this work reveal the rich competition between spin orders and provide an opportunity to compare the dynamics in the RInO<SUB>3</SUB> and Mn-substituted systems. These structure-property relations may be useful for understanding magnetism in other geometrically frustrated multiferroics.</P><P>We combined <I>dc</I> magnetization and <I>ac</I> susceptibility to reveal the rich magnetic field-temperature phase diagrams of a series of rare earth indium oxides. These systems sport high degrees of frustration as described by the frustration index, <I>F</I>, as well as glasslike slow magnetic relaxation in combination with antiferromagnetic tendencies. Structure−composition−property investigations reveal that both the choice of rare earth center as well as introduction of a paramagnetic impurity like Mn<SUP>3+</SUP> can control frustration in this new class of geometrically frustrated multiferroics.</P> [FIG OMISSION]</BR>

      • Magnetic field-temperature phase diagram of multiferroic [(CH3)2NH2]Mn(HCOO)3

        Clune, A. J.,Hughey, K. D.,Lee, C.,Abhyankar, N.,Ding, X.,Dalal, N. S.,Whangbo, M.-H.,Singleton, J.,Musfeldt, J. L. American Physical Society 2017 Physical Review B Vol.96 No.10

        <P>We combined pulsed field magnetization and first-principles spin-density calculations to reveal the magnetic field-temperature phase diagram and spin state character in multiferroic [(CH3)(2)NH2]Mn(HCOO)(3). Despite similarities with the rare earth manganites, the phase diagram is analogous to other Mn-based quantum magnets with a 0.31 T spin flop, a 15.3 T transition to the fully polarized state, and short-range correlations that persist above the ordering temperature. The experimentally accessible saturation field opens the door to exploration of the high-field phase.</P>

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