Plasma Secretin Concentrations in Fasting and Postprandial States of Normal Korean Subjects

심여림,조양혁,심상수,남상채,김명석,Sim, Yeo-Rim,Jo, Yang-Hyeok,Sim, Sang-Soo,Nam, Sang-Chae,Kim, Myung-Suk The Korean Physiological Society 1985 대한생리학회지 Vol.19 No.2

한국의 정상 성인 20 명에서 공복시 및 음식물 섭취후의 철장 secretin농도를 방사면역 측정법(radioimmunoassay)으로 다음과 같이 측정하였다. 20명중 12명은 단백질 음식물인 햄버거와 쌀밥을 일주일 간격으로 섭취하였다. 햄버거 섭취 추 평균 혈장 secretin농도$(12{\sim}16\;pg/ml)$는 공복시의 평균 혈장 secretin농도(10 pg/m1 이하) 보다 유의하게 증가하였으며 그 증가가 오랫동안 지속하였다. 쌀밥의 섭취 후에는 혈장 secretin농도$(9{\sim}13\;pg/ml)$가 공복시의 값보다 증가하는 경향이었으며, 단지 식후 30분의 값에서만 유의하게 증가하였다. 식후 혈장 secretin농도의 증가폭은 햄버거에서의 증가 값이 쌀밥에서의 값보다 더 컸다. 나머지 8명은 자당 용액과 생리 식염수를 마셨다. 자당 용액의 섭취후 평균 혈장 secretin농도$(10{\sim}14\;pg/ml)$는 공복시의 값보다 유의하게 증가하였으나 쌀밥의 값과 마찬가지로 일시적이었다. 그러나 생리 식염수를 섭취한 후에는 혈장 secretin농도에 이렇다할 변화가 없었다. 이상의 결과로 미루어 정상 한국 성인에서는 단백질 음식물은 물론 탄수화물 음식물의 섭취로도 혈장 secretin농도가 증가한다고 사료된다. This study was conducted to investigate fasting plasma secretin and postprandial secretin concentrations after ingestion of a protein meal or a sucrose solution in 20 healthy Korean subjects. In 12 subjects, ingestion of a protein meal, hamburger resulted in a significant and sustained increase in the mean plasma secretin concentrations, from mean fasting levels of less than 10 pg/ml to $12{\sim}16\;pg/ml$, and the mean plasma secretin concentrations, $9{\sim}13\;pg/ml$, after a rice meal increased significantly but transiently compared with mean fasting levels. The magnitude of postprandial increase in the Plasma secretin concentration after the hamburger was greater than that of the rice meal. In the remaining 8 subjects, drinking of a sucrose solution resulted also in a significant but transient increase in the mean Plasma secretin concentrations, from mean fasting levels of less than 10 pg/ml to $10{\sim}14\;pg/ml$ which were significantly greater than that after a physiological saline. Significant increase in the plasma secretin concentration was not observed during the postprandial period after the physiological saline. It is inferred from the above results that the Plasma secretin levels increase significantly after ingestions of a carbohydrate meal as well as a protein meal in the Korean race.

Does Age Influence the Poor Prognosis after Aneurysmal SAH Surgery in Elderly Patients?

Sim, Jong-Eun,Kim, Hyung-Dong,Song, Young-Jin,Noh, Seung-Jin The Korean Neurosurgical Society 2006 Journal of Korean neurosurgical society Vol.40 No.5

Objective : The incidence of aneurysmal subarachnoid hemorrhage has been increasing. At the same time, surgical results for elderly patients are unsatisfactory and no guidelines of treatment are available. We carried out a study comparing variable factors and surgical results between young and old age groups to find ways to improve prognosis. Methods : A retrospective study was carried out on 754 patients who were operated on between 1990 and 2004 by the same surgeon in our hospital. The patients were divided into seven groups according to age : 93 patients below 40 years of age [Group I], 419 patients aged $40{\sim}59$ [Group II], 115 patients aged $60{\sim}64$ [Group III], 82 patients aged $65{\sim}69$ [Group IV], 28 patients aged $70{\sim}74$ [Group V], 12 patients aged $75{\sim}79$ [Group VI] and 5 patients over the age of 80 [Group VII]. We then checked their medical history, Fisher's grade, Hunt-Hess grade, postoperative complications, and Glasgow Outcome Scale. Results : Age was not a statistically significant factor among patients below 70 years of age [P $value{\ge}0.05$]. But for those aged 70 and older, the age factor had a statistical value [P $value{\le}0.001$]. In addition, there was a close correlation between Hunt-Hess grade IV and V patients, and those with vasospasm, and hydrocephalus after surgery, with poor prognosis in elderly patients as well as young patients [P $value{\le}0.001$]. Conclusion : Advanced age [under the age of 70] dose not precluded adequate surgical treatment in patient with AN SAH, and we should be also alert to preventable causes of delayed neurological deterioration for improving the outcome in all elderly groups.

2상 유동 내 관군에서의 압력 손실

심우건(Woo Gun Sim),닥단(Dagdan Banzragch) 대한기계학회 2016 大韓機械學會論文集B Vol.40 No.3

수평 관군에 대하여 수직이고 상향으로 흐르는 2상 유동에 의한 감쇠비를 예측하기 위한 해석모델이 Sim에 의하여 개발되었다. 이 모델에서 평가된 2상 유동의 기공률, 압력손실 등의 유동변수는 기존의 실험식을 사용하여 계산하였다. 그러나 관군의 경우에 사용하기에는 약간의 개선이 요구된다. 따라서 관군 내에 흐르는 2상 유동의 유동 변수에 대한 더 많은 정보를 획득하기 위하여 실험적으로 연구할 필요가 있다. 실험은 공기 - 물의 2상 유동이 흐르는 정사각형 배열 관군에서의 압력계수와 2상 유동 마찰승수를 계산하기 위하여 수행되었다. 피치 직경 비는 1.35이었고, 실린더의 직경은 18 mm이다. 압력센서와 신호처리 장치를 이용하여 관군에서의 압력차를 측정하였다. 2상 유동 마찰승수와 오일러수를 계산하기 위하여 관군에 적용되는 비균질 유동의 기공률은 Feenstra 등의 실험식을 사용하여 계산하였다. 균질과 비균질 2상 유동의 마찰승수와 오일러의 수를 실험적으로 구하고 Sim의 어림적 모델에 근거한 이론적 해석 결과와 비교・분석하였다. An analytical model was developed by Sim to estimate the two-phase damping ratio for upward two-phase flow perpendicular to horizontal tube bundles. The parameters of two-phase flow, such as void fraction and pressure loss evaluated in the model, were calculated based on existing experimental formulations. However, it is necessary to implement a few improvements in the formulations for the case of tube bundles. For the purpose of the improved formulation, we need more information about the two-phase parameters, which can be found through experimental test. An experiment is performed with a typical normal square array of cylinders subjected to the two-phase flow of air-water in the tube bundles, to calculate the two-phase Euler number and the two-phase friction multiplier. The pitch-to-diameter ratio is 1.35 and the diameter of cylinder is 18mm. Pressure loss along the flow direction in the tube bundles is measured with a pressure transducer and data acquisition system to calculate the two-phase Euler number and the two-phase friction multiplier. The void fraction model by Feenstra et al. is used to estimate the void fraction of the two-phase flow in tube bundles. The experimental results of the two phase friction multiplier and two-phase Euler number for homogeneous and non-homogeneous two-phase flows are compared and evaluated against the analytical results given by Sim"s model.

새로운 상호연결망 하프 버블정렬 그래프 설계 및 성질 분석

서정현,심현,이형옥,Seo, Jung-Hyun,Sim, Hyun,Lee, Hyeong Ok 한국정보통신학회 2017 한국정보통신학회논문지 Vol.21 No.7

The Bubble sort graph is node symmetric, and can be used in the data sorting algorithm. In this research we propose and analyze that Half Bubble sort graph that improved the network cost of Bubble sort graph. The Half Bubble sort graph's number of node is n!, and its degree is ${\lfloor}n/2{\rfloor}+1$. The Half Bubble sort graph's degree is $${\sim_=}0.5$$ times of the Bubble sort, and diameter is $${\sim_=}0.9$$ times of the Bubble sort. The network cost of the Bubble sort graph is $${\sim_=}0.5n^3$$, and the network cost of the half Bubble sort graph is $${\sim_=}0.2n^3$$. We have proved that half bubble sort graph is a sub graph of the bubble sort graph. In addition, we proposed a routing algorithm and analyzed the diameter. Finally, network cost is compared with the bubble sort graph.

Concept Verification of Three-Layer DOI Detectors for Small Animal PET

Hong, Seong Jong,Kwon, Sun Il,Ito, Mikiko,Lee, Geon Song,Sim, Kwang-Souk,Park, Kwang Suk,Rhee, June Tak,Lee, Jae Sung IEEE 2008 IEEE transactions on nuclear science Vol.55 No.3

<P> Improved spatial resolution without sacrificing sensitivity is one of the most challenging developmental goals for small animal PET scanners. The 3-layer configuration that we propose here utilizes relative offsets of half a crystal pitch in x- and y-directions, and pulse shape discrimination to obtain depth of interaction (DOI). Three layers of crystals with a dimension 1.5<TEX>$\,\times\,$</TEX>1.5<TEX>$\,\times\,$</TEX>7.0mm <TEX>$^{3}$</TEX> were composed of a L <TEX>$_{0.2}$</TEX> GSO (Lu<TEX>$_{0.4}$</TEX> Gd<TEX>$_{1.6}$</TEX> SiO<TEX>$_{4}$</TEX>: Ce) crystal layer and a L<TEX>$_{0.9}$</TEX> GSO (Lu<TEX>$_{1.8}$</TEX> Gd <TEX>$_{0.2}$</TEX> SiO<TEX>$_{4}$</TEX> : Ce) crystal layer aligned with each other, and a L <TEX>$_{0.9}$</TEX> GSO crystal layer offset at half a crystal pitch in x- and y-directions. The L<TEX>$_{0.9}$</TEX> GSO crystal layer was attached to a Hamamatsu H9500 flat-panel PMT. The devised small animal PET scanner has a diameter of 84 mm with one detector ring, and can be upgraded to two detector rings. GEANT4 Monte-Carlo simulation was used to estimate sensitivities of <TEX>$\sim 12\hbox{\%}$</TEX> and <TEX>$\sim 20\hbox{\%}$</TEX>, respectively, at the center of one and two PMT ring system with an energy window of 350 <TEX>$\sim$</TEX> 750 keV. We present flood images with peak-to-valley ratios of about 5–6 obtained using <TEX>$^{22}$</TEX> Na and layer identification capability of <TEX>$\sim 99\hbox{\%}$</TEX> with pulse shape analysis, and verified the basic concepts of multi-layer small animal PET. </P>

Two New Speies of the Genus Psammocinia(Dictyoceratida, Irchiniidae) from korea

Sim, Chung-Ja,Lee, Kyung-Jin 한국동물분류학회 2001 Animal Systematics, Evolution and Diversity Vol.17 No.2

Two new species of the genus Psammocinia (Dictyoceratida, Irciniidae), P. bergquisti n. sp. and P. gageoensis n. sp., are described from Gageodo Island (Sohuksando Island), Korea. P. bergquisti n. sp. is characterized by the thumb like appearance and secondary fibre which makes a broad plate or secondary web while other known species in Psammocinia has many narrow and simple secondary fibres. P. gageoensis n. sp. is very similar to P. mosulpia Sim 1998 in shape, but primary fibre of the new species has more complex fascicles and it is difficult to see the detritus in the fibre. The primary fibre of this new species is cored with the smaller sand than that of P. mosulpia. 한국 가거도에서 채집된 모래해면속(망각해면목: 가는실해면과)의 2 신종, 버키스트모래해면(Psammocinis bergquisti n. sp.) 과 가거모래해면(P. gageoensis n. sp.)을 기색한다. 버키스트모래해면은 외형이 엄지손가락 모양이며 지금까지 알려진 모래해면 속의 종들은 좁고 단순한 형태의 2차섬유를 갖는 반면 본 신종은 2차섬유가 얇은 판 모양이거나 넓은 망구조이다. 가거모래해면은 모슬모래해면(P. mosulpia Sim. 1998) 과 외형에서 매우 유사하지만, 1차섬유가 복잡한 총생모양으로 섬유 내부에 있는 모래와 골편들의 겉으로 잘 보이지 않은 점이 특징이다. 가거모래해면의 1차섬유 속에는 모슬모래해면의 1차섬유 속의 모래보다 작은 모래들이 있다.

VERTICAL PROPERTIES OF THE GLOBAL HAZE ON TITAN DEDUCED FROM METHANE BAND SPECTROSCOPY BETWEEN 7100 AND 9200Å

Sim, Chae-Kyung,Kim, Sang-Joon,Kim, Joo-Hyeon,Seo, Haing-Ja,Jung, Ae-Ran,Kim, Ji-Hyun The Korean Astronomical Society 2008 Journal of The Korean Astronomical Society Vol.41 No.3

We have investigated the optical properties of the global haze on Titan from spectra recorded between 7100 and $9200{\AA}$, where $CH_4$ absorption bands of various intensities occur. The Titan spectra were obtained on Feb. 23, 2005 (UT), near the times of the Cassini T3 flyby and Huygens probe, using an optical echelle spectrograph (BOES) on the 1.8-m telescope at Bohyunsan Observatory in Korea. In order to derive the optical properties of the haze as a function of altitude, we developed an inversion radiative-transfer program using an atmospheric model of Titan and laboratory $CH_4$ absorption coefficients available from the literature. The derived extinction coefficients of the haze increase toward the surface, and the coefficients at shorter wavelengths are greater than those at longer wavelengths for the 30 - 120 km altitude range, indicating that the Titanian haze becomes optically thin toward the longer wavelength range. Total optical depths of the haze are estimated to be 1.4 and 1.2 for the 7270 - $7360{\AA}$ and 8940 - $9150{\AA}$ ranges, respectively. Based on the Huygens/DISR data set, Tomasko et al. (2005) reported total optical depths of 2.5 - 3.5 at $8290{\AA}$, depending on the assumed fractal aggregate particle model. The total optical depths based on our results are smaller than those of Tomasko et al., but they partially overlap with their results if we consider a large uncertainty from possible variations of the $CH_4$ mixing ratio over Titan's disk. We also derived the single scattering albedo of the haze particles as a function of altitude: it is less than 0.5 at altitudes higher than ${\sim}150\;km$, and approaches 1.0 toward the surface. This behavior suggests that, at altitudes above ${\sim}150\;km$, the average particle radius is smaller than the wavelengths, whereas near the surface, it becomes comparable or greater.

The Antimutagenic and Antioxidant Effects of Red Pepper Seed and Red Pepper Pericarp (Capsicum annuum L.)

Sim, Ki-Hyeon,Han, Young-Sil The Korean Society of Food Science and Nutrition 2007 Preventive Nutrition and Food Science Vol.12 No.4

In this study, we examined the antimutagenicity of red pepper seed and red pepper pericarp ethanol extracts using the standard Ames test in the presence and absence of S9 mix. The extracts showed inhibitory effects on both the TA98 and TA100 Salmenella Typhimurium strains against the mutagenic activity of promutagen 2-aminoanthracene, and were also protective against the directly acting mutagens sodium azide and 2-nitrofluorene. The red pepper seed elicited stronger antimutagenicity than the red pepper pericarp. Both the red pepper seed and red pepper pericarp directly quenched nitric oxide to different degrees and the scavenging activities increased with increasing concentrations. Nitric oxide scavenging activity ranged from $22{\sim}77%$ in the red pepper seed, and from $36{\sim}49%$ in the red pepper pericarp. The TEAC values for red pepper seed extract were $47.89{\pm}1.64mg\;g^{-1}$ in the ABTS radical scavenging assays, while those of red pepper pericarp extract were $94.18{\pm}1.61mg\;g^{-1}$. Therefore, we conclude that red pepper seed and red pepper pericarp have antimutagenic activities as well as antioxidant activity.

Cloning and Spatiotemporal Expression Analysis of Bombyx mori elav, an Embryonic Lethal Abnormal Visual Gene

Wang, Geng-Xian,Liu, Ying,Sim, Yang-Hu,Zhang, Sheng-Xiang,Xu, Shi-Qing Korean Society of Sericultural Science 2009 International Journal of Industrial Entomology Vol.18 No.2

Embryonic lethal abnormal visual (elav) is a lethal gene in Drosophila inducing the abnormal development and function of nervous system. We cloned a Bm-elav gene by bioinformatics and biological experiment, based on sequence of ELAV protein and dbEST of Bombyx mori. The full-length of Bm-elav cDNA is 1498 bp, contains a 906 bp open read frame (ORF) encoding a precursor of 301 amino acid residues with a calculated molecular weight of 34 kDa and pI of 8.99. Bm-ELAV protein precursor contains three RNA recognition motifs (RRM) in $24{\sim}91$, $110{\sim}177$ and $222{\sim}295$ bit amino acid residues respectively, and belongs to RNA-binding protein family. Bm-ELAV shared varying positives, ranging from 56% to 60% (Identities from 41% to 45%), with RRM from other species of Xenopus tropicalis, Apis mellifera, Tribolium castaneum, Branchiostoma belcheri and Drosophila. Gene localization indicated that Bm-elav is a single-copy gene, gene mapping within 12-chromosome from 7916.68 knt to 7918.16 knt region of nscaf2993. Spatiotemporal expressions pattern analysis revealed that Bm-elav expressed higher in most tested tissues and developmental stages in whole generation, such as silk gland, fat body, midgut, hemopoietic organ and ovary, but almost no expression in terminated diapause eggs. This suggested that the expression of Bm-elav in early developmental embryonic stages might induce abnormal development like in Drosophila. Cloning of the Bm-elav gene enables us to test its potential role in controlling pests by transferring the gene into field lepidopteran insects in the future.

The Function of Dimeric Structure of Soluble Intercellular Adhesion Molecule-1 (sICAM-1): Inhibition of Leukocyte Function Associated Antigen-1 (LFA-1) Binding to ICAM-3

Choi, Suck-Chei,Han, Weon-Cheol,Park, Do-Sim,Kim, Eun-Cheol,Oh, Hyun-Mee,Oh, Jung-Mi,Jun, Chang-Duk The Korean Society for Microbiology 2002 Journal of Bacteriology and Virology Vol.32 No.1

Intercellular adhesion molecule-1 (ICAM-1) is a membrane protein, exists as a dimer on the cell surface, and interacts with leukocyte function associated antigen-1 (LFA-1), a member of ${\beta}_2$-integrin family. A soluble circulating form of ICAM-1 (sICAM-1) is also detected in human serum, and has been implicated as a regulator for LFA-1-dependent cell-cell interaction in vivo. However, previous reports demonstrated that sICAM-1 shows little inhibitory effect on LFA-1 binding to ICAM-1, indicating that sICAM-1 is unlikely to antagonize LFA-1/ICAM-1-mediated cellular events in vivo. Here, we investigated the property of the dimeric sICAM-1 as an inhibitor of LFA-1 interaction with ICAM-3, since the lower avidity of LFA-1 for ICAM-3 compared with ICAM-1 or ICAM-2 had been speculated. Using recently constructed heterodimeric sICAM-1 joined at the C terminus via an ${\alpha}$-helical coiled coil (ACID-BASE) (Jun, CD. et al., 2001, Proc Natl Acad Sci 98, 6830-6835), we also tested whether the structural integrity in dimer could affect the inhibitory action of sICAM-1. Engineered sICAM-1 dimer that contained intact ectodomain (E34/E34) significantly blocked SKW3 cell (LFA-$1^+$) binding to ICAM-3, but not to ICAM-1 and ICAM-2, indicating the lower avidity of LFA-1 to ICAM-3 than that of both ICAM-1 and ICAM-2. A one binding site knock out mutant (E34/K34) showed ${\sim}2$-fold reduction in efficiency compared with E34/E34 to inhibit cell binding. Interestingly, a one binding domain deletion mutant (E34/${\Delta}D1$-D2) showed significant reduction (${\sim}5$-fold) compare with E34/K34, suggesting that structural integrity, which is precluded in E34/${\Delta}D1$-D2, is necessary for optimal binding of dimeric sICAM-1 to LFA-1, thereby inhibiting LFA-1/ICAM-3-dependent adhesion. Furthermore, BIAcore affinity measurements revealed that E34/${\Delta}D1$-D2 bound to immobilized soluble open LFA-1 I domain with an ${\sim}3$-fold reduced affinity compared with E34/K34. Overall, our results demonstrate that maintaining the structural integrity in dimer is necessary for optimal binding of sICAM-1 to LFA-1, and further suggest the therapeutic potential of dimeric sICAM-1 to antagonize LFA-1/ICAM-3-mediated cellular events in vivo.