Effects of Phenytoin and Diazepam on the Seizure Activity in the Cortical Dysplasia Animal Models

Kim, Si-Hyung,Choi, In-Sun,Cho, Jin-Hwa,Park, Eun-Ju,Jang, Il-Sung,Choi, Byung-Ju,Kim, Hyun-Jung,Kim, Young-Jin,Nam, Soon-Hyeun The Korean Academy of Oral Biology 2006 International Journal of Oral Biology Vol.31 No.2

Dysplasia-associated seizure disorders are markedly resistant to pharmacological intervention. Relatively little research has been conducted studying the effects of antiepileptic drugs(AEDs) on seizure activity in a rat model of dysplasia. We have used rats exposed to methylazoxymethanol acetate(MAM) in utero, an animal model featuring nodular heterotopia, to investigate the effects of AEDs in the dysplastic brain. Pilocarpine was used to induce acute seizure in MAM-exposed and age-matched vehicle-injucted control animals. Field potential recordings were used to monitor amplitude and numbers population spikes, and paired pulse inhibition in response to stimulation of commissural pathway. Two commonly used AEDs were tested: diazepam 5, 2.5mg/kg;phenytoin 40, 60mg/kg. Diazepam(DZP) and phenytoin(PHT) reduced the amplitude of population spike in control and MAM-exposed rats. However, the amplitude of population spike was nearly eliminated in control rats as compared to the MAM-exposed rats. Pharmaco-resistance was tested by measuring seizure latencies in awake rats after pilocarpine administration(320mg/kg, i.p.) with and without pretreatment with AEDs. Pre-treatment with PHT 60 mg prolonged seizure latency in control rats, but not in MAM-exposed animals. The main findings of this study are that acute seizures initiated in MAM-exposed rats are relatively resistant to standard AEDs assessed in vivo. These data suggest that animal model with cortical dysplasia can be used to screen the effects of potential AEDs.

학생선수용 체육진로흥미검사지의 다집단 동일성 검증

권형일(Kwon, Hyung-Il),한시완(Han, Si-Wan) 한국체육과학회 2017 한국체육과학회지 Vol.26 No.3

Career should be understood as a process of continuous changes and development, rather than a fixed choice at a certain time (Super, 1990). Career guidance for student-athletes should reflect cultural specificity that both study and exercise are required at the same time, and should be conducted systematically by utilizing proper tools suitable for each development stage. The purpose of this study is to test if sport career interest inventory (SCII) for student-athletes, which was developed in the previous studies (Kwon Hyung-il, Bang Shin-woong, Han Si-wan, Yoo Jeong-ae, 2016), can be used in common by a group, that is, by school and class. For the study, 342 subjects (172 high school students and 170 university students) received multi-group construct invariance test of SCII. As a result, configural invariance and measurement equivalence were tested. These results provide supportive materials for construct invariance of SCII and can be utilized for comparative study by school and class to explore career according to the change in grade of the students.

A Study on Improvement and Degradation of Si/SiO₂ Interface Property for Gate Oxide with TiN Metal Gate

Lee, Byung-Hyun,Kim, Yong-Il,Kim, Bong-Soo,Woo, Dong-Soo,Park, Yong-Jik,Park, Dong-Gun,Lee, Si-Hyung,Rho, Yong-Han The Korean Institute of Electrical and Electronic 2008 Transactions on Electrical and Electronic Material Vol.9 No.1

In this study, we investigated effects of hydrogen annealing (HA) and plasma nitridation (PN) applied in order to improve $Si/SiO_2$ interface characteristics of TiN metal gate. In result, HA and PN showed a positive effect decreasing number of interface state $(N_{it})$ respectively. After FN stress for verifying reliability, however, we identified rapid increase of $N_{it}$ for TiN gate with HA, which is attributed to hydrogen related to a change of $Si/SiO_2$ interface characteristic. In contrast to HA, PN showed an improved Nit and gate oxide leakage characteristic due to several possible effects, such as blocking of Chlorine (Cl) diffusion and prevention of thermal reaction between TiN and $SiO_2$.

A Study on Improvement and Degradation of Si/SiO2 Interface Property for Gate Oxide with TiN Metal Gate

이병현,Yong-Il Kim,Bong-Soo Kim,Dong-Soo Woo,Yong-Jik Park,Dong-Gun Park,Si-Hyung Lee,Yonghan Rho 한국전기전자재료학회 2008 Transactions on Electrical and Electronic Material Vol.9 No.1

In this study, we investigated effects of hydrogen annealing (HA) and plasma nitridation (PN) applied in order to improve Si/SiO₂ interface characteristics of TiN metal gate. In result, HA and PN showed a positive effect decreasing number of interface state (Nit) respectively. After FN stress for verifying reliability, however, we identified rapid increase of Nit for TiN gate with HA, which is attributed to hydrogen related to a change of Si/SiO₂ interface characteristic. In contrast to HA, PN showed an improved Nit and gate oxide leakage characteristic due to several possible effects, such as blocking of Chlorine (Cl) diffusion and prevention of thermal reaction between TiN and SiO₂.

사회공포증과 관련된 양육태도검사의 개발 연구

이시형,오강섭,허묘연 대한소아ㆍ청소년정신의학회 1998 소아청소년정신의학 Vol.9 No.2

데모主動學生의 社會精神醫學的 分析 : 데모性向 性格의 分析

李時炯 大韓神經精神醫學會 1972 신경정신의학 Vol.11 No.4

Twelve of male college students from Taegu area, who are considered as the most active participant and as the leader in the student protest movement in the Korean Campus during the 60's are analysed. Seven students out of 12, are defined as so called "Protest Prone Personality", ① and longitudinal psychohistorical analysis of their personality development is done, with much emphasis on Father-Son relationship in particular. 1) Student's father have a relatively higher education and been employed as Government official since Japanese occupation. Their ambivalent compromise between "New and Old" cultural climate is unavoidable, due to their deep seated agricultural influence, however, which is constantly challenged by their Western influence, on the other. 2) Students have felt a "Sense of Specialness" in themselves, and being expected to be "great" from their early childhood on. Indentification with a strong father image was challenged, as they dout of father's omnipotence, however, this conflict from ambivalent father image became resolved. as they understood the ambivalent compromise on father's part, and thus the conflict, of father then his, was projected on to the society. 3) Protest is, then, seen as a result of father's unconscious provoke on their son. 4) Ambivalent acceptance of "Modernization" ② due to fear for the loss of subjectivity, is acute among these students. It is therefore that Government, who puts the pressure for modernization, is seen as a threat, which then is indirectly expressed by the student as protest. In this sense, protest is for the protection of "Subjectivity". 5) Core value of traditional Korean agricutural culure is well inherited to those students. However, formal value. is, social, political, religeous, and philosophical ets, is completely different from grandfather's. yet they are same as father's "latent" value system, which is different from his father's, yet not expressed, and now inherited to his son.

응급센터에서 기관내 삽관을 시행하지 않은 호흡곤란 환자의 동맥혈 이산화탄소분압과 호기말 이산화탄소분압의 연관성분석

김형국,박승현,오동렬,박규남,이원재,황두영,최승필,이운정,정시경,김세경 大韓應急醫學會 1998 대한응급의학회지 Vol.9 No.4

Background: The end-tidal carbon dioxide tension(ETCO₂) is defined as a partial pressure of carbon dioxide at the end of an exhaled breath. The purpose of this study is to determine the correlation between ETCO₂and arterial carbon dioxide tension(PaO₂) in nonintubated patients with respiratory distress in emergency department(ED). Methods: A prospective non-blind study was performed in ED of our university hospitals. Participants included all nonintubated adult patients with respiratory distress requiring arterial blood gas analysis. ETCO₂was measured with a capnography monitor during tidal volume breathing. ETCO₂were recoreded at the time of arterial blood gas sampling. The correlation between ETCO₂and PaCO₂was analyzed in all patients and in subgroups by simple linear regression. Results: Sixty patients were enrolled. In all patients, ETCO₂was 5.72mmHg lower than PaCO₂and correlated well with PaCO₂(r²=0.716). ETCO₂correlated best with PaCO₂in patients who were either acidotic or non-smoking. Conclusion: ETCO₂correlate well with PaCO₂in nonintubated patients with respiratory distress in ED. ETCO₂may be sufficient to reflect PaCO₂in selected patients and obviate the need for repeat arterial blood gas determination.

임베디드 장치용 사용자 인터페이스 라이브러리 설계 및 개발

김시관,홍상렬,박형순 금오공과대학교 2006 論文集 Vol.27 No.-

임베디드 시스템 장치에서 사용자에게 정보를 제공하고 사용자의 입력을 받기 위한 언터페이스의 중요성은 인터넷의 발전 및 휴대 전화 PDA 등과 같은 개인 정보 접속 장치의 대중화로 점차 커져가고 있다. 개인 정보 접속 장치뿐만 아니라 산업 현장에서 사용되고 있는 임베디드 시스템에서도 장치 제어 및 감시에 사용될 GUI의 요구 증가는 계속 되고 있다. 하지만 임베디드 장치의 제어 및 감시를 위한 GUI 라이브러리의 개발은 아직 미비한 실정이다. 따라서 임베디드 시스템 장치를 제어하고 감시하기 위한 기존의 GUI 라이브러리 보다 더 발전된 Gill 라이브러리를 설계하고 개발하였다. 그리고 새로운 GUI 리아브러리를 이용한 데모 프로그램을 작성하였다.

사회공포증 환자의 성격요인과 방어기제에 대한 연구

이시형,백상빈,노경선,오강섭,신영철 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.6

연구목적: 사회공포 환자의 성격요인과 방어기제의 특징을 알아보고, 비가해형 및 가해형에 따라 유의미한 차이가 있는지 알아보고자 본 연구를 시행하였다. 방 법: 강북삼성병원 외래치료 환자중 DSM-Ⅳ에 근거하여 사회공포로 진단된 환자 28명을 대상으로 성격요인검사(Sixteen Personality Factor Questionnaire 한국판) 및 이화방어기제검사를 시행하였고 통계처리는 각 검사에 대한 빈도분석과 비가해형과 가해형에 대한 Independent-Sample t-test를 시행하였다. 결 과: 사회공포 환자에서 성격요인(평균점수) 중 shyness/boldness 요인이 정상보다 낮은 소견을 보였으며 방어기제에서는 유우머 항목이 정상보다 낮은 소견을 보였다. 성격요인과 방어기제 모두에서 비가해형과 가해형간에 유의미한 차이는 보이지 않았다. 결 론: 성격요인의 결과상 사회공포 환자들은 감정 표현을 억제하며 비사교적이다. 또한 자기주장을 못하여 타인에게 순종적, 동조적이며 정서적 불안정감이 심하다. 이러한 성격요인들은 모두 자율신경계의 약화, 불안의 증가, 공포증의 유발가능성의 증가등으로 사회공포와 관련되어 있다. 또한 방어기제의 결과상 사회공포 환자들은 유우머가 부족하고 지나치게 긴장, 경직되어 있어 사회공포 증세를 유발하기 쉬운 것으로 판단되었다. 사회공포의 두 유형인 비가해형과 가해형간에는 성격요인, 방어기제 모두에서 유의미한 차이가 없는 것으로 나타났다. Objectives: The purpose of this study was to evaluate the characteristics of personality factor and defense mechanism and to compare the difference between non-offensive and offensive types of social phobia patients. Methods: Study subjects consisted of 28 social phobia patients diagnosed with the criteria of DSM-Ⅳ. Data were collected through Sixteen Personality Factor Questionnaire and Ehwa Diagnostic Test of Defense Mechanism. We employed was the independent sample t-test for the analysis. Result: Among the personality factor, the shyness/boldness factor scored lower than normal in social phobia patients. Humor defense scored lower than normal among defense mechanisms. There was no significant correlation between non-offensive and offensive types of social phobia in personality factors and defense mechanisms. Conclusions: Social phobia patients were shier and less frequently use humor defense than the ordinary people. There was no significant correlation between non-offensive and offensive types of social phobia patients in personality factors and defense mechanisms.

불면증의 임상적 연구 (1) : -종합병원 입원환자의 수면장애에 대하여-

李時炯,申泓湜,朴泉漢 大韓神經精神醫學會 1973 신경정신의학 Vol.12 No.3

Forty five of admitted patients, who have complained of poor sleep since their admission at Kyung Puk Univ. Hospital, were studied as follows: 1) Comparison between before and after admission of their sleep pattern 2) Comparison between Medical and Surgical part 3) Comparison between "Good sleeper" (also admitted patients) abd "Poor sleeper" of their depression and anxiety by using of Taylor's Manifest Anxiety Scale and Zung's Self Rating Depression Scale Results; 1) Comparing to prior to their admission, the amount of sleep has significantly reduced since their admission, and the quality of sleep also has become significantly irregular and poor. 2) Comparing to prior to their admission, "Bed time" tends to be later, "Sleep onset" tends to be delayed, and "Feeling on awake" become worse since their admission. 3) No significant differences are noted between two groups; Surgical and Medical. 4) Comparing to Good sleeper, Poor sleeper tends to show higher score in depression scale, however. anxiety score is so significantly higher that it might be used as a sensitive indicator for measuring poor sleep. 5) Contrary to our expectation, the hospital environment is not highly regarded as the interrupting factor for sleep, according to patient's own evaluation of the cause of their poor sleep.