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A Case of Acute Pancreatitis Associated with Risperidone Treatment
Kentaro Kawabe,Shu-ichi Ueno 대한정신약물학회 2014 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.12 No.1
Acute pancreatitis with antipsychotic treatment is rare but sometimes causes a fatal adverse effect. Most cases of acute pancreatitisdue to atypical antipsychotic agents are reported to occur within six months of starting antipsychotic administration. Caused by risperidone is rare. The patient had a high fever, stomachache and vomiting. The results of the abdominal computedtomograhpy scan were negative. The results of the abdominal ultrasonography were positive for gallstones in gallbladder anddistention of the common bile duct. She had been fasting and received antibiotic intravenous injections. Amylase and lipasetiters were high. After risperidone discontinuation, both the levels of the amylase and the lipase were gradually decreased. Threemonths later, the patient still maintains a good clinical balance. Although atypical antipsychotic-induced pancreatitis has beenreported in conjunction with hyperglycemia, the pathophysiologic mechanism of these adverse events remains unclear. Thiscase got pancreatitis 6 month after risperidone treatment. Using the antipsychotic agents, it is necessary to monitor pancreasfunction.
Wagdi Saber Soliman,Shu-ichi Sugiyama,Ahmed M. Abbas 한국원예학회 2018 Horticulture, Environment, and Biotechnology Vol.59 No.1
Salinity is a potential environmental stress factor for plants. Improving plant growth under salinity stress requires an understandingof resistance mechanisms. Salinity stress resistance is related to both salinity avoidance and tolerance. In this study,interspecific differences in salinity stress resistance, avoidance, and tolerance were examined in eight C3turfgrass species,namely Agrostis alba, Agrostis tenius, Dactylis glomerata, Festuca ovina, Festuca rubra, Lolium perenne, Phleum pratense,and Poa pratensis. In a greenhouse experiment, plants were exposed to 50, 100, or 200 mM NaCl for 2 weeks supplied via ahydroponics system. We found that interspecific differences in salinity stress resistance were associated mainly with salinitytolerance. Salinity avoidance mechanisms also contributed significantly to stress resistance. The contribution of genotypetowards interspecific variation in salinity resistance and tolerance was higher than that of Na+concentration. Salinity stresshad negative effects on shoot dry mass, water status, and membrane stability. Relative water content was significantly correlatedwith salinity resistance, avoidance, and tolerance, whereas no significant correlation was observed for ion leakage. Mineral contents showed no clear contribution to salinity tolerance. Species varied in their proline content even in controlconditions, and there was a positive association between proline content and salinity resistance and tolerance, but a negativeassociation between proline content and salinity avoidance. F. ovina and P. pratense displayed the highest and lowest salinitystress resistance, respectively. The results of this study suggest that both salinity tolerance and avoidance mechanismscontribute towards salinity resistance, and that variation in salinity stress resistance among species is attributed to differencesin proline content.
Association between Sleep Habits and Problems and Internet Addiction in Adolescents
Kentaro Kawabe,Fumie Horiuchi,Yasunori Oka,Shu-ichi Ueno 대한신경정신의학회 2019 PSYCHIATRY INVESTIGATION Vol.16 No.8
Objective This study examined the association between sleep habits and problems and Internet addiction in adolescents. Methods Junior high school students from a local town in Japan (n=853; male/female, 425/428) were the subjects of this study, and were assessed for severity of Internet addiction and sleep habits and problems using the self-reported version of the Young’s Internet Addiction Test (IAT) and Child and Adolescent Sleep Checklist (CASC). Results The wake time on weekdays was not significantly different among the three groups; addicted, possibly-addicted, and non-addicted. In the addicted group, the total night sleep time was significantly shorter, and the bedtime was significantly delayed on both weekdays and weekends compared with those in the possibly-addicted and non-addicted groups. The wake time of the addicted group was significantly later than that of the other groups. The total scores of sleep problems measured by the CASC were significantly higher in the addicted and possibly-addicted groups than in the non-addicted group. Conclusion Internet addiction is strongly associated with sleep habits and problems in adolescents. These findings suggest that internet addiction should be considered while examining adolescent lifestyle.
Shinichiro Ochi,Takaaki Mori,Jun-ichi Iga,Shu-ichi Ueno 대한정신약물학회 2021 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.19 No.3
Objective: To investigate the efficacy of tandospirone, an azapirone anxiolytic similar to buspirone that is used in Japan, for behavioral and psychological symptoms of dementia (BPSD), especially in oldest-old patients. Methods: This was an open-label observational study involving residents with BPSD in a special elderly nursing home between August 2013 and August 2018. The severity of dementia was assessed using the Clinical Dementia Rating (CDR) scale; as the main outcomes, the severity of BPSD was assessed using the Clinical Global Impressions-Severity scale (CGI-S) and Neuropsychiatric Inventory-12 (NPI-12) at baseline and 4 weeks after the maintenance dose of tandospirone was reached. The administration of tandospirone started at 30 mg, divided into three doses per day. Two weeks later, if the efficacy was sufficient based on the clinical nursing record, that dose was continued; if the efficacy was insufficient, the daily dose was increased from 40 mg/day to a maximum dose of 60 mg/day. Results: Thirty-three participants (25 females [76%], mean age 87.1 ± 5.4 years) completed the study. Twenty-three participants (70%) were oldest-old (18 females [78%], mean age 89.9 ± 3.4 years). The mean CDR score was 2.9 ± 0.3 in all participants. Tandospirone treatment showed few or no obvious adverse effects and significantly improved CGI-S scores, as well as total scores and many subscale scores on the NPI-12, in both the sample at large and the oldest-old participants. Conclusion: This study demonstrated the efficacy and safety of tandospirone for BPSD in oldest-old participants.
( Tomoyuki Inui ),( Kotaro Ichino ),( Isao Matsuoka ),( Tatsuya Takeguchi ),( Shinji Iwamoto ),( Shu Bin Pu ),( Sei Ichi Nishimoto ) 한국화학공학회 1997 Korean Journal of Chemical Engineering Vol.14 No.6
Development in highly active catalysts for the reforming of methane with CO₂and partial oxidation of methane was conducted to produce hydrogen and carbon monoxide with high reaction rates. An Ni-based four-components catalyst, Ni-Ce₂O₃-Pt-Rh, supported on an alumina wash-coated ceramic fiber in a plate shape was suitable for the objective reaction. By combining the catalytic combustion of ethane or propane, methane conversion was markedly enhanced, and a high space-time yield of syngas, 25,000 ㏖/ℓ·h was obtained at a catalyst temperature of 700℃ or furnace temperature of 500℃. The extraordinary high space-time yield of syngas was also confirmed even under the very rapid flow rate conditions as a contact time of 3 m-sec by using a monolithic shape of catalyst bed without back pressure.
Inui, Tomoyuki,Ichino, Kotaro,Matsuoka, Isao,Takeguchi, Tatsuya,Iwamoto, Shinji,Pu, Shu Bin,Nishimoto, Sei-ichi 한국화학공학회 1997 Korean Journal of Chemical Engineering Vol.14 No.6
Development in highly active catalysts for the reforming of methane with CO₂and partial oxidation of methane was conducted to produce hydrogen and carbon monoxide with high reaction rates. An Ni-based four-components catalyst, Ni-Ce₂O₃-Pt-Rh, supported on an alumina wash-coated ceramic fiber in a plate shape was suitable for the objective reaction. By combining the catalytic combustion of ethane or propane, methane conversion was markedly enhanced, and a high space-time yield of syngas, 25,000 ㏖/ℓ·h was obtained at a catalyst temperature of 700℃ or furnace temperature of 500℃. The extraordinary high space-time yield of syngas was also confirmed even under the very rapid flow rate conditions as a contact time of 3 m-sec by using a monolithic shape of catalyst bed without back pressure.
Yuta Yoshino,Takaaki Mori,Taku Yoshida,Yasutaka Toyota,Hideaki Shimizu,Jun-ichi Iga,Shusaku Nishitani,Shu-ichi Ueno 대한정신약물학회 2017 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.15 No.3
Objective: Donepezil is used to improve cognitive impairment of dementia with Lewy bodies (DLB). Visuo-spatial dysfunction is a well-known symptom of DLB. Non-verbal Raven’s Colored Progressive Matrices (RCPM) were used to assess both visual perception and reasoning ability in DLB subjects treated with donepezil. Methods: Twenty-one DLB patients (mean age, 78.7±4.5 years) were enrolled. RCPM assessment was performed at the time of starting donepezil and within one year after starting donepezil. Results: There were significant improvements of RCPM in the total scores between one year donepezil treatment (p=0.013), in both Set A score (p=0.002) and Set AB score (p=0.015), but trend in the Set B score (p=0.083). Conclusion: Donepezil is useful for improving visuo-spatial impairment in DLB, but not for problem-solving impairment
Kiyohiro Yamazaki,Yuta Yoshino,Yoko Mori,Shinichiro Ochi,Taku Yoshida,Takashi Ishimaru,Shu-ichi Ueno 대한정신약물학회 2015 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.13 No.3
Nasu-Hakola disease (NHD) is a rare autosomal recessive neuropsychiatric disorder characterized by bone cysts, fractures, and cognitive impairment. Two genes are responsible for the development of NHD; TYROBP and TREM2. Although it presents with typical signs and symptoms, diagnosing this disease remains difficult. This case report describes a male with NHD with no family or past history of bone fractures who was diagnosed using exome sequencing. His frontal lobe psychiatric symptoms recovered partially following treatment with sodium valproate, but not with an antipsychotic.
Shinichiro Ochi,Saori Inoue,Yuta Yoshino,Hideaki Shimizu,Jun-ichi Iga,Shu-ichi Ueno 대한정신약물학회 2019 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.17 No.4
Schizophrenic patients resistant to antipsychotics are diagnosed as having treatment-refractory schizophrenia, and they are treated with clozapine. However, clozapine is sometimes combined with electroconvulsive therapy (ECT) if clozapine monotherapy fails. In this report, a severe treatment-refractory schizophrenic patient who did not respond to clozapine even with ECT, but who recovered with asenapine monotherapy, is presented. Asenapine, considered a serotonin spectrum dopamine modulator, is a new atypical antipsychotic with unique pharmacological features that is used not only for schizophrenia, but also for bipolar disorder. The unique features of asenapine may be effective for some treatment- refractory schizophrenic patients.
Combined Clozapine and Electroconvulsive Therapy in a Japanese Schizophrenia Patient: A Case Report
Yuta Yoshino,Yuki Ozaki,Koichiro Kawasoe,Shinichiro Ochi,Takanori Niiya,Naomi Sonobe,Teruhisa Matsumoto,Shu-ichi Ueno 대한정신약물학회 2014 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.12 No.2
Clozapine is well-known for successful use in schizophrenic patients treatment resistant to other antipsychotics. However, evenwith clozapine, 25% of schizophrenic patients are not in remission. Recently, as adjunctive treatment with clozapine, electroconvulsivetherapy has been reported to be an effective and safe adjunctive treatment. We report a Japanese schizophrenicwoman who was not in remission with clozapine alone but with both clozapine and electroconvulsive therapy.