Pemetrexed is Mildly Active with Good Tolerability for Treatment of Patients with Colorectal Cancer

Zhang, Hui-Qing,Lian, Chang-Hong,Ping, Yao-Dong,Song, Wen-Bin,Lu, Qing-Pu,Xie, Shu-Zhe,Lin, Tao,Cheng, Lin-Zhong Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.19

Purpose: This systematic analysis was conducted to evaluate the efficacy and safety of pemetrexed based salvage chemotherapy for treatment of patients with metastatic colorectal cancer. Methods: Clinical studies evaluating the efficacy and safety of pemetrexed based regimens on response and safety for patients with colorectal cancer were identified using a predefined search strategy. Pooled response rates (RRs) were calculated. Results: For pemetrexed based regimens, 4 clinical studies including 201 patients with advanced colorectal cancer were considered eligible for inclusion. The analysis suggested that, in all patients, pooled RR was 20.4% (41/201). Major adverse effects were neutropenia, anorexia, fatigue, and anemia. No treatment related death occurred with pemetrexed based treatment. Conclusion: This systematic analysis suggests that pemetrexed based regimens are associated with mild activity with good tolerability in treating patients with metastatic colorectal cancer.

油畵中邊緣線的空間性表現硏究

양련술청 ( Yang Lin Shu Qing ) 한국동양예술학회 2020 동양예술 Vol.48 No.-

線,是人類在認知和反映自然形態最簡明了的表現形式。在繪畵中,線就象骨架一樣,支撐著整個 畵 面。而一件完整的作品构建是否得当,邊緣線起着至關重要的作用。油畵作品中,畵面的空間构是其作品所要表現的重要內容,邊緣線不但可以作為形體的一種畵面构成要素存在,而且還是一种空間意識的呈現,是分割畵面的重要手段、空間塑造的重要語言。邊緣線同光影、色彩、結构等其他构成畵面的元素一樣,以多樣的表現形式和方法,服務於畵面,突出主題,塑造空間,促使藝術風格的改變和情感的表達。 本文試着從空間這一角度入手,解讀邊緣線自身的特点及表現形式,結合具有代表性的作品分析其自身空間特点及与周圍元素在油畵處理中交織而産生的視覺空間效果,把停留在對邊緣線的處理方式、擅變歷程和風格硏究,擴展到對其空間塑造的探討上來。從而使藝術家們更能深層次的掌握和運用線這一繪畵語言,使其達到新的高度,全面地發揮其在繪畵中的價值。 Lines are the most concise expression for human beings to recognize and reflect nature. In painting, the line is like a skeleton, supporting the entire picture. And whether a complete work is properly constructed, the marginal line plays a vital role. In oil paintings, the spatial construction of the picture is an important content to be expressed in the work. The marginal line is not only a part of the picture, but also is a representation of spatial awareness, an important means of dividing the picture, and a critical language of shaping the space. The marginal line plays a similar role to light and shadow, color, structure, and other elements that make up the picture. It serves the picture in various forms and ways, highlighting the theme, shaping the space, and promoting the change of artistic style and the expression of emotion. From the perspective of space, this research interprets the characteristics and manifestations of the marginal line and analyzes its spatial characteristics and the visual speace ffect produced by the interweaving of the surrounding elements in the oil painting process in combination with representative works. The research on the processing methods, tampering history, and style of the marginal line extends to the discussion of its spatial shaping. This enables artists to master and use the painting language of line more deeply, to reach a new level, and to give full play to its value in painting.

Mechanisms of Electroacupuncture Pretreatment in Alleviating Myocardial Ischemia Reperfusion Injury: Interactions between the Cerebellar Fastigial Nucleus and Lateral Hypothalamic Area

Yu Qing,Wu Li-bin,Zhang Fan,Wei Xiao-tong,Chen Pian-pian,Wang Shuai-ya,Cai Mei-yi,Shu Qi,Li Liao-yuan,Wu Zi-jian,Cai Rong-lin,Hu Ling 사단법인약침학회 2021 Journal of Acupuncture & Meridian Studies Vol.14 No.6

Background: Myocardial ischemia reperfusion injury (MIRI) is an important mechanism of post-myocardial infarction injury and a main cause of death in patients with ischemic heart disease. Electroacupuncture (EA) pretreatment is effective for the prevention and treatment of MIRI, but mechanisms mediating the effects of cardiovascular disease EA treatments remain unclear. Objectives: To determine whether the lateral hypothalamus (LHA) and the cerebellar fastigial nucleus (FN) are involved in the protective effects of EA stimulation on MIRI. Methods: EA pretreatment was performed for 7 days before the establishment of the MIRI model. ST-segment changes on electrocardiograms were recorded and the Curtis–Walker arrhythmia score was used to evaluate changes in reperfusion injury. Hematoxylin–eosin staining was applied to evaluate the pathological and morphological changes in myocardial tissue. c-fos expression in the LHA and FN was determined by immunofluorescence staining. Glutamic (Glu) and γ-Aminobutyric acid (GABA) levels were measured using a high-performance liquid chromatography-electrochemical method. Results: EA pretreatment reduced ST-segment elevation, arrhythmia scores, and morphological changes in MIRI myocardial cells in rats, and decreased the c-fos protein expression in LHA/FN nuclei. MIRI was associated with an imbalance between GABA and Glu levels, whereas EA pretreatment increased GABA levels and decreased Glu levels in the LHA/FN. Conclusion: FN and LHA are involved in the EA-mediated attenuation of MIRI. Pretreatment with EA plays a protective role in the myocardium by regulating Glu and GABA release in the LHA and FN.

ON THE EXISTENCE OF SOLUTIONS OF FERMAT-TYPE DIFFERENTIAL-DIFFERENCE EQUATIONS

Chen, Jun-Fan,Lin, Shu-Qing Korean Mathematical Society 2021 대한수학회보 Vol.58 No.4

We investigate the non-existence of finite order transcendental entire solutions of Fermat-type differential-difference equations [f(z)f'(z)]ⁿ + P²(z)f^m(z + 𝜂) = Q(z) and [f(z)f'(z)]ⁿ + P(z)[∆_𝜂f(z)]^m = Q(z), where P(z) and Q(z) are non-zero polynomials, m and n are positive integers, and 𝜂 ∈ ℂ \ {0}. In addition, we discuss transcendental entire solutions of finite order of the following Fermat-type differential-difference equation P²(z) [f^(k)(z)]² + [αf(z + 𝜂) - 𝛽f(z)]² = e^r(z), where $P(z){\not\equiv}0$ is a polynomial, r(z) is a non-constant polynomial, α ≠ 0 and 𝛽 are constants, k is a positive integer, and 𝜂 ∈ ℂ \ {0}. Our results generalize some previous results.

Influence of Preparation Conditions on the Formation of Copper (II) Architectures with Pyrazine-2,3,5-tricarboxylic Acid

Feng-Qin Wang,Shu Lin,Ming-Lin Guo,Jun-Jian Xu,Xiao-Qing Wang,Yong-Nan Zhao 대한화학회 2011 Bulletin of the Korean Chemical Society Vol.32 No.7

Three new metal-organic copper(II) complexes, [Cu(H_2PZTC)_2]_n·2nH_2O (1), [Cu(HPZTC)·2H_2O]_n·2nH_2O (2),and Cu_2[(PZHD)(OH)(H_2O)_2]_n (3) (H_3PZTC = pyrazine-2,3,5-tricarboxylic acid, PZHD^3− = 2-hydroxypyrazine-3,5-dicarboxylate), have been synthesized from Cu(II)/H3PZTC system under different synthetic conditions, and characterized by single-crystal X-ray diffraction, elemental analysis, IR spectroscopy and thermogravimetric analysis. In complexes 1 and 2, H_3PZTC ligands loose one and two protons, which were transformed into H_2PZTC− anion and HPZTC^2− dianion under different preparation condition, respectively. Furthermore, two ligands coordinate with Cu(II) cations in different modes, leading to the formation of the different chain structures. In complex 3, H_3PZTC ligand was converted into a new ligand-PZHD by in situ decarboxylation and hydroxylation under a higher pH value than that for complexes 1 and 2. PZHD ligands link the Cu(II) cations to form a 2D layer structure. These results demonstrate that the preparation conditions,including pH value and reaction temperature etc, play an important role in the construction of complexes based on H_3PZTC ligand.

Uniqueness of meromorphic solutions of a certain type of difference equations

Jun-Fan Chen,Shu-Qing Lin 대한수학회 2022 대한수학회보 Vol.59 No.4

In this paper, we study the uniqueness of two finite order transcendental meromorphic solutions $f(z)$ and $g(z)$ of the following complex difference equation $$A_{1}(z)f(z+1)+A_{0}(z)f(z)=F(z)e^{\alpha(z)}$$ when they share 0, $\infty$ CM, where $A_{1}(z),$ $A_{0}(z),$ $F(z)$ are non-zero polynomials, $\alpha(z)$ is a polynomial. Our result generalizes and complements some known results given recently by Cui and Chen, Li and Chen. Examples for the precision of our result are also supplied.

Influence of Preparation Conditions on the Formation of Copper (II) Architectures with Pyrazine-2,3,5-tricarboxylic Acid

Wang, Feng-Qin,Lin, Shu,Guo, Ming-Lin,Xu, Jun-Jian,Wang, Xiao-Qing,Zhao, Yong-Nan Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.7

Three new metal-organic copper(II) complexes, $[Cu(H_2PZTC)_2]_n{\cdot}2nH_2O$ (1), $[Cu(HPZTC){\cdot}2H_2O]_n{\cdot}2nH_2O$ (2), and $Cu_2[(PZHD)(OH)(H_2O)_2]_n$ (3) ($H_3PZTC$ = pyrazine-2,3,5-tricarboxylic acid, $PZHD^{3-}$ = 2-hydroxypyrazine-3,5-dicarboxylate), have been synthesized from $Cu(II)/H_3PZTC$ system under different synthetic conditions, and characterized by single-crystal X-ray diffraction, elemental analysis, IR spectroscopy and thermogravimetric analysis. In complexes 1 and 2, $H_3PZTC$ ligands loose one and two protons, which were transformed into $H_2PZTC^-$ anion and $HPZTC^{2-}$ dianion under different preparation condition, respectively. Furthermore, two ligands coordinate with Cu(II) cations in different modes, leading to the formation of the different chain structures. In complex 3, $H_3PZTC$ ligand was converted into a new ligand-PZHD by in situ decarboxylation and hydroxylation under a higher pH value than that for complexes 1 and 2. PZHD ligands link the Cu(II) cations to form a 2D layer structure. These results demonstrate that the preparation conditions, including pH value and reaction temperature etc, play an important role in the construction of complexes based on $H_3PZTC$ ligand.

Guided waves of porous FG nanoplates with four edges clamped

Zhao, Jing-Lei,She, Gui-Lin,Wu, Fei,Yuan, Shu-Jin,Bai, Ru-Qing,Pu, Hua-Yan,Wang, Shilong,Luo, Jun Techno-Press 2022 Advances in nano research Vol.13 No.5

Based on the nonlocal strain gradient (NSG) theory and considering the influence of moment of inertia, the governing equations of motion of porous functionally graded (FG) nanoplates with four edges clamped are established; The Galerkin method is applied to eliminate the spatial variables of the partial differential equation, and the partial differential governing equation is transformed into an ordinary differential equation with time variables. By satisfying the boundary conditions and solving the characteristic equation, the dispersion relations of the porous FG strain gradient nanoplates with four edges fixed are obtained. It is found that when the wave number is very small, the influences of nonlocal parameters and strain gradient parameters on the dispersion relation is very small. However, when the wave number is large, it has a great influence on the group velocity and phase velocity. The nonlocal parameter represents the effect of stiffness softening, and the strain gradient parameter represents the effect of stiffness strengthening. In addition, we also study the influence of power law index parameter and porosity on guided wave propagation.

Smad4 mediates malignant behaviors of human ovarian carcinoma cell through the effect on expressions of E-cadherin, plasminogen activator inhibitor-1 and VEGF

( Chen Chen ),( Ming Zhong Sun ),( Shu Qing Liu ),( Dong Mei Yeh ),( Li Jun Yu ),( Yang Song ),( Lin Lin Gong ),( Li Hong Hao ),( Jun Hu ),( Shu Juan Shao ) 생화학분자생물학회 (구 한국생화학분자생물학회) 2010 BMB Reports Vol.43 No.8

Smad4 is involved in cancer progression and metastasis. Using a pair of human syngeneic epithelial ovarian cancer cells with low (HO-8910) and high (HO-8910PM) metastatic abilities, we aimed to reveal the role of Smad4 in ovarian cancer metastasis in vitro. Smad4 was down-regulated in HO-8910PM cell line relative to HO-8910 by implicating Smad4 was probably a potential tumor suppressor gene for ovarian cancer. Re-expression of Smad4 decreased the migration ability and inhibited the invasion capacity of HO-8910PM, while promoted the cell adhesion capacity for HO-8910PM. The stable expression of Smad4 increased the expression of E-cadherin, reduced the expression of plasminogen activator inhibitor-1 (PAI-1) and slightly down-regulated the expression of VEGF. Smad4 suppresses human ovarian cancer cell metastasis potential through its effect on the expressions of PAI-1, E-cadherin and VEGF. Results from current work implicate Smad4 might suppress the invasion and metastasis of human ovarian tumor cells through a TGF-β/Smad-mediated pathway. [BMB reports 2010; 43(8): 554-560]

Association of Single Nucleotide Polymorphisms in the Prostaglandin-endoperoxide Synthase 2 (PTGS2) and Phospholipase A₂ Group IIA (PLA2G2A) Genes with Susceptibility to Esophageal Squamous Cell Carcinoma

Liu, Fen,Wei, Wen-Qiang,Cormier, Robert T.,Zhang, Shu-Tian,Qiao, You-Lin,Li, Xin-Qing,Zhu, Sheng-Tao,Zhai, Yan-Chun,Peng, Xiao-Xia,Yan, Yu-Xiang,Wu, Li-Juan,He, Dian,He, Yan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.4

Background: The prostaglandin-endoperoxide synthase 2 (PTGS2) and phospholipase A2 group IIA (PLA2G2A) genes encode enzymes that are involved in arachidonic acid and prostaglandin biosynthesis. Dysregulation of both genes is associated with inflammation and carcinogenesis, including esophageal squamous cell carcinoma (ESCC). We therefore hypothesized that there is an association between single nucleotide polymorphisms (SNPs) in these genes and susceptibility to ESCC. Methods: We performed a gene-wide tag SNP-based association study to examine the association of SNPs in PTGS2 and PLA2G2A with ESCC in 269 patients and 269 healthy controls from Taihangshan Mountain, Henan and Hebei Provinces, the rural area of China which has the highest incidence of esophageal cancer in the world. Thirteen tag SNPs in PLA2G2A and 4 functional SNPs in PTGS2 were selected and genotyped using a high-throughput Mass Array genotyping platform. Results: We found a modest increased risk of ESCC in subjects with the PTGS2 rs12042763 AA genotype (OR=1.23; 95% CI, 1.00-3.04) compared with genotype GG. For PLA2G2A, a decreased risk of ESCC was observed in subjects with the rs11677 CT (OR=0.51, 95%CI, 0.29-0.85) or TT genotype (OR=0.51, 95%CI, 0.17-0.96) or the T carriers (CT+TT) (OR=0.52, 95%CI, 0.31-0.85) when compared with the CC genotype. Also for PLA2G2A, rs2236771 C allele carriers were more frequent in the control group (P=0.02). Subjects with the GC (OR=0.55, 95%CI, 0.33-0.93) or CC genotype (OR=0.38, 95% CI, 0.16-0.94) or the C carriers (GC+CC) (OR=0.52, 95%CI, 0.32-0.85) showed a negative association with ESCC susceptibility. Conclusions: Our results suggest that PTGS2 and PLA2G2A gene polymorphisms may modify the risk of ESCC development.