The role of miRNA‑155 in monocrotaline‑induced pulmonary arterial hypertension through c‑Fos/NLRP3/caspase‑1

Shou‑Dong Chai,Zhen‑Kun Li,Rui Liu,Tao Liu,Ming‑Feng Dong,Pei‑Zhe Tang,Jian‑Tang Wang,Sheng‑Jun Ma 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.3

Background Nisoldipine can effectively suppress pulmonary arterial smooth muscle cell proliferation and c-Fos expression. Objective To identify the mechanism of the anti-inflammatory effects in monocrotaline-induced pulmonary arterial hypertension (PAH), focusing on the c-Fos/NLRP3/caspase-1 pathway. Results In a mice model of monocrotaline-induced PAH, miRNA-155 expression was increased. In an in vitro model, overexpression of miRNA-155 promoted inflammation and induced c-Fos, NLRP3, and caspase-1 protein expression. The inhibition of c-Fos reduced the effects of miRNA-155 on inflammation in an in vitro model of monocrotaline-induced PAH. The inhibition of NLRP3 reduced the effects of miRNA-155 on inflammation in an in vitro model of monocrotaline-induced PAH. Conclusions miRNA-155 increased inflammation in monocrotaline-induced PAH through c-Fos/NLRP3/caspase-1.

PacCAF: a Grid Portal in Pacific Asia for the CDF Experiment

S. Hou,T. L. Hsieh,P. K. Teng 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.55 No.5

We present the PacCAF (Pacific CDF Analysis Farm) computing model for the CDF (Collider Detector at Fermilab) experiment. The PacCAF is a portal for job submission to a pool of computing nodes collected from the LCG (LHC Computing Grid) and the OSG (Open Science Grid) sites in the Pacific Asia region. It has a suit of services for user authentication, software distribution, and network connection to worker nodes. It also provides a web-based online monitoring system for the status of batch jobs and the processes running on worker nodes. The PacCAF architecture is modular and is easy to modify. We discuss the upgrade from being a dedicated local cluster to joining shared resources in a Grid computing environment. We present the PacCAF (Pacific CDF Analysis Farm) computing model for the CDF (Collider Detector at Fermilab) experiment. The PacCAF is a portal for job submission to a pool of computing nodes collected from the LCG (LHC Computing Grid) and the OSG (Open Science Grid) sites in the Pacific Asia region. It has a suit of services for user authentication, software distribution, and network connection to worker nodes. It also provides a web-based online monitoring system for the status of batch jobs and the processes running on worker nodes. The PacCAF architecture is modular and is easy to modify. We discuss the upgrade from being a dedicated local cluster to joining shared resources in a Grid computing environment.

論中國傳統企業效率問題

康 埈 荣,张守鑫 韓國外國語大學校 外國學綜合硏究센터 中國硏究所 2005 中國硏究 Vol.35 No.-

1997~2000년에 발생된 황사에 관한 연구

정용승,김학성,낫짜가도르지 엘,적데어 디,첸 수잰 한국교원대학교 환경과학연구소 2002 환경연구논문집 Vol.- No.7

Joint monitoring of yellow sand (YS) phenomena occurred from 1997 to 2000 was carried out. It was found that the YS in source regions occurred in any time during the year, while the severe dust storms occurred frequently from March to May after the spring thaw. Wind erosion occurred usually with wind greater than about 8 ms^-1 in the source region in any seasons. However, severe YS phenomenon found to occur with wind greater than 15 ms^-1 at least for 3 hours or more. In source regions, YS occurred over 60∼120 days per year. In Korea, YS was found to occur 8∼12 cases per year with 12-22 YS days. It was recorded that maximum concentrations of TSP were 989∼1396 ㎍ m^-3 with PM10 values of 861∼996 ㎍ m^-3 and with the lowest visibility of 1.4∼1.6km. In Mongolia, however, it was observed that the number of dusty days decreased due to the increase in rainy days.

Comparative Analysis of Logistic Regression, Support Vector Machine and Artificial Neural Network for the Differential Diagnosis of Benign and Malignant Solid Breast Tumors by the Use of Three-Dimensional Power Doppler Imaging

Shou-Tung Chen,Yi-Hsuan Hsiao,Yu-Len Huang,Shou-Jen Kuo,Hsin-Shun Tseng,Hwa-Koon Wu,Dar-Ren Chen 대한영상의학회 2009 Korean Journal of Radiology Vol.10 No.5

Objective: Logistic regression analysis (LRA), Support Vector Machine (SVM) and a neural network (NN) are commonly used statistical models in computeraided diagnostic (CAD) systems for breast ultrasonography (US). The aim of this study was to clarify the diagnostic ability of the use of these statistical models for future applications of CAD systems, such as three-dimensional (3D) power Doppler imaging, vascularity evaluation and the differentiation of a solid mass. Materials and Methods: A database that contained 3D power Doppler imaging pairs of non-harmonic and tissue harmonic images for 97 benign and 86 malignant solid tumors was utilized. The virtual organ computer-aided analysis-imaging program was used to analyze the stored volumes of the 183 solid breast tumors. LRA, an SVM and NN were employed in comparative analyses for the characterization of benign and malignant solid breast masses from the database. Results: The values of area under receiver operating characteristic (ROC) curve, referred to as Az values for the use of non-harmonic 3D power Doppler US with LRA, SVM and NN were 0.9341, 0.9185 and 0.9086, respectively. The Az values for the use of harmonic 3D power Doppler US with LRA, SVM and NN were 0.9286, 0.8979 and 0.9009, respectively. The Az values of six ROC curves for the use of LRA, SVM and NN for non-harmonic or harmonic 3D power Doppler imaging were similar. Conclusion: The diagnostic performances of these three models (LRA, SVM and NN) are not different as demonstrated by ROC curve analysis. Depending on user emphasis for the use of ROC curve findings, the use of LRA appears to provide better sensitivity as compared to the other statistical models. Objective: Logistic regression analysis (LRA), Support Vector Machine (SVM) and a neural network (NN) are commonly used statistical models in computeraided diagnostic (CAD) systems for breast ultrasonography (US). The aim of this study was to clarify the diagnostic ability of the use of these statistical models for future applications of CAD systems, such as three-dimensional (3D) power Doppler imaging, vascularity evaluation and the differentiation of a solid mass. Materials and Methods: A database that contained 3D power Doppler imaging pairs of non-harmonic and tissue harmonic images for 97 benign and 86 malignant solid tumors was utilized. The virtual organ computer-aided analysis-imaging program was used to analyze the stored volumes of the 183 solid breast tumors. LRA, an SVM and NN were employed in comparative analyses for the characterization of benign and malignant solid breast masses from the database. Results: The values of area under receiver operating characteristic (ROC) curve, referred to as Az values for the use of non-harmonic 3D power Doppler US with LRA, SVM and NN were 0.9341, 0.9185 and 0.9086, respectively. The Az values for the use of harmonic 3D power Doppler US with LRA, SVM and NN were 0.9286, 0.8979 and 0.9009, respectively. The Az values of six ROC curves for the use of LRA, SVM and NN for non-harmonic or harmonic 3D power Doppler imaging were similar. Conclusion: The diagnostic performances of these three models (LRA, SVM and NN) are not different as demonstrated by ROC curve analysis. Depending on user emphasis for the use of ROC curve findings, the use of LRA appears to provide better sensitivity as compared to the other statistical models.

Effects of (1R,9S)-ß-Hydrastine Hydrochloride on Cytotoxicity in PC12 Cells

Shou Yo Yin, Jae Joon Lee, Yu Mi Kim, Chun Mei Jin, Yoo Jung Yang, Myung Koo Lee 충북대학교 약품자원개발연구소 2005 약학논문집 Vol.20 No.-

-본문참고-

Study on Analysis of Environmental Change of City Land Coverage and Influence of Traffic Infrastructure

Shou Shuai Du,Heung Man Kim 한국생활환경학회 2015 한국생활환경학회지 Vol.22 No.5

With the rapid development of economy, urbanization expands extensively and land use in urban and suburban areas changes dramatically. To achieve sustainable development, it is important to take a full consideration of environmental factors during urbanization process. Focused on Zhengzhou, Kaifeng and Zhongmu, this study investigates the change in land coverage and the characteristics of urbanization of city agglomerations in the middle and lower reaches of Yellow River, based on Landsat data and the survey of local land use. The map of land coverage classification will be constructed and the current situation of land coverage in targeted areas analyzed. On this basis, the change of built-up area will be studied using the Kernel Density Presumption method, and the influence of traffic infrastructure analyzed, leading to the elucidation of the characteristic of urbanization.

Impact of Obesity on a Chinese Population with Erosive Esophagitis and Barrett`s Esophagus

( Shou-wu Lee ),( Han-chung Lien ),( Teng-yu Lee ),( Chun-fang Tung ),( Hong-zen Yeh ),( Chi-sen Chang ) 대한간학회 2017 Gut and Liver Vol.11 No.3

Background/Aims: The aim of this study was to investigate the associations between obesity and erosive esophagitis (EE) or Barrett`s esophagus (BE) in a Chinese population. Methods: Data from subjects were retrospectively collected from 2006 to 2009. Individuals with BE were identified and age- and sex-matched at a 1:2 ratio with normal esophagocardial junction and EE patients. The subjects were stratified into two groups: the normal weight group and overweight/ obesity group (body mass index ≥25 mg/m2) or the normal waist group and abdominal obesity group (waist circumference ≥90 cm for men and ≥80 cm for women). Results: Overall, 45%, 72%, and 52% were overweight/obese and 23%, 65%, and 18% had abdominal obesity in the normal, EE, and BE groups, respectively. Positive associations were identified between EE and overweight/obesity (odds ratio [OR], 3.14; 95% confidence interval [CI], 1.75 to 5.66) and abdominal obesity (OR, 6.22; 95% CI, 3.34 to 11.57); however, the associations were nonsignificant between BE and overweight/obesity (OR, 1.32; 95% CI, 0.67 to 2.61) or abdominal obesity (OR, 0.73; 95% CI, 0.31 to 1.73). Female BE patients had a significantly increased rate of being overweight/obese. Conclusions: Obesity is a contributing factor in EE. The association of BE and obesity was not significant, with the exception of female BE cases. (Gut Liver 2017;11:377-382)

Water spray heat transfer through a piezoelectric atomizer with a single-hole micronozzle

Shou-Shing Hsieh,Ching-Feng Huang,Yung-Ming Lu 대한기계학회 2020 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.34 No.8

We report an experimental study on the flow and heat transfer for a single microhole of water spray impingement on an indium tin oxide (ITO) heating plate using a piezoelectric atomizer. A microhole of d j = 35 µm was used and tested with a volumetric flow rate of 0.22 cm 3 /min for three different spray heights of 10, 20 and 30 mm and five heater initial temperatures of 25 o C, 50 o C, 100 o C, 150 o C, and 200 o C. Through the optical measuring techniques of the microparticle image velocimetry (µPIV) as well as interferometric particle imaging (IPI) and micro laser-induced fluorescence (µLIF), the velocity field, such as spray centerline velocity, droplet impact velocity and impact crater diameter, including impinged liquid film thickness and heat transfer performance (CHF) can be measured and calculated. The effects of the spray height and initial heater temperature on the flow and thermal characteristics are presented and discussed herein. The experimental results show that both the spray centerline velocity and spray droplet impact velocity were significantly influenced by the initial surface temperature as well as by the spray height. As a result, the cooling performance would be, in turn, affected by the aforesaid two parameters.

An Improved Interval AHP Method for Assessment of Cloud Platform-based Electrical Safety Monitoring System

Shou-Xiang Wang,Lei-Jiao Ge,Sheng-Xia Cai,Dong Zhang 대한전기학회 2017 Journal of Electrical Engineering & Technology Vol.12 No.2

Electrical safety monitoring System (ESMS) is a critical component in modern power systems, which is characterized by large-scale access points, massive users and versatile requirements. For convenience of the information integration and analysis, the software development, maintenance, and application in the system, the cloud platform based ESMS is established and assessed in this paper. Firstly the framework of the system is proposed, and then the assessment scheme with a set of evaluation indices are presented, by which the appropriate cloud product can be chosen to meet the requirements of a specific application. Moreover, to calculate the weights of the evaluation indices under uncertainty, an improved interval AHP method is adopted to take into consideration of the fuzziness of expert scoring, the qualitative consistency test, and the two normalizations in the process of eigenvectors. Case studies have been made to verify the feasibility of the assessment approach for ESMS.