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A Moveable Feast: A Phenomenological Approach
( Jung¸ Shinhee ) 현대영미어문학회 2019 현대영미어문학회 추계학술대회 발표논문집 Vol.2019 No.-
This paper aims to study Ernest Hemingway’s A Moveable Feast phenomenologically. The work is a kind of diary. It is the episodes he experienced from twenty-one to twenty-six years old. It depended on his memory. Therefore, the record can be analyzed as a phenomenological approach. Especially, as Hemingway was an expatriate in Paris, he criticized the things and people that he had. This supports the theory.
Blood cadmium and volume of uterine fibroids in premenopausal women
Shinhee Ye,Hye Won Chung,Kyungah Jeong,Yeon-Ah Sung,Hyejin Lee,So Yun Park,Hyunjoo Kim,Eun-Hee Ha 대한직업환경의학회 2017 대한직업환경의학회지 Vol.29 No.-
Background: A number of studies have found associations between heavy metals and uterine fibroids, but the results are inconsistent. Here, we conducted this research to demonstrate the relationships between blood heavy metal concentrations and uterine fibroid volume as well as the rate of uterine fibroid presence. Methods: In a cross-sectional study, we collected data from 308 premenopausal women aged 30–49 years in Seoul; uterine fibroids are ascertained by past history of myomectomy and pelvic ultrasonography. In the analytic phase, we first analyzed the presence of the fibroids and the concentrations of heavy metals via logistic regression. In subgroup analysis, we used simple and multiple linear regression analyses to examine the associations between heavy metals and uterine fibroid volume. Results: There was no connection between the heavy metal concentrations and the presence of uterine fibroids, but the odds of women having fibroids were higher with three particular metals. In subgroup analysis, the association between blood cadmium concentrations and uterine fibroid volume was statistically significant (adjusted beta coefficient = 2.22, 95% confidential interval: 0.06–4.37). In contrast, blood mercury and lead concentrations were not significantly associated with uterine fibroid volume. Conclusions: Our findings are the first that we know to report the association of blood cadmium concentrations with the volume of uterine fibroids. We expect that our findings will be used as evidence for supporting policies to improve premenopausal Korean women’s health.
( Shinhee Park ),( An-soo Jang ),( Pureun-haneul Lee ),( Ae-rin Baek ),( Jong-sook Park ),( June-hyuk Lee ),( Sung-Woo Park ),( Do-jin Kim ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Objectives Chronic obstructive pulmonary disease (COPD) imposes a major healthcare burden. A tight junction protein, claudin-4 (CLDN4), may play a protective role in acute lung injury, but its role in COPD is unclear. To investigate the relationship between CLDN4 and COPD, we evaluated the association of CLDN4 with the clinical parameters of COPD, including exacerbations. Methods We analyzed a cohort of 30 patients with COPD and 25 healthy controls, and evaluated their clinical parameters, including lung function. The plasma CLDN4 level in stable and exacerbated COPD was measured. Results The COPD patients were all males, and predominantly smokers; their initial lung function was poorer than the healthy controls. The mean CLDN4 plasma level was 0.0219 ± 0.0205 ng/mg in the control group, 0.0086 ± 0.0158 ng/mg in the stable COPD group (COPD-ST) and 0.0917 ± 0.0871 ng/mg in the exacerbated COPD (COPD-EXA) group. The plasma CLDN4 level was significantly lower in the COPD-ST than control group, but was significantly elevated in the COPD-EXA group. The plasma CLDN4 level was inversely correlated with FVC and FEV1 in the COPD-EXA group (r = 0.506, P = 0.001 and r = 0.527, P < 0.001, respectively). Conclusions The plasma CLDN4 level is closely correlated with COPD exacerbations and decreased lung function. This suggests that CLDN4 has potential as a severity marker for COPD.
( Shinhee Park ),( An-soo Jang ),( Pureun-haneul Lee ),( Ae-rin Baek ),( Jong-sook Park ),( June-hyuk Lee ),( Sung-Woo Park ),( Do-jin Kim ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Objectives The SRY-related high-mobility group box 18 (SOX18) is an angiogenic transcription factor involved in tissue injury, wound healing and development of vessels. The expression of SOX18 is increased in acute lung injury and asthma exacerbation, but the role of SOX18 in chronic obstructive pulmonary disease (COPD) has not been studied. To investigate the relationship between SOX18 and COPD, we evaluated the relationship between SOX18 with the clinical parameters of COPD, including lung functions and exacerbations. Methods We recruited a cohort of 30 patients with COPD and 25 healthy controls, and compared their clinical parameters, including lung function. We measured the plasma SOX18 level of healthy controls and COPD patients who were in stable and exacerbated state. Results The COPD patients were all males, and predominantly smokers; their baseline lung function was lower than the healthy controls. The mean SOX18 plasma level was 0.0272 ± 0.0145 ng/mg in the control group, 0.1574 ± 0.0692 ng/mg in the stable COPD group (COPD-ST) and 0.2336 ± 0.1921 ng/mg in the exacerbated COPD (COPD-EXA) group. The plasma SOX18 level was significantly higher in both COPD-ST and COPD-EXA groups compared to healthy control group. The plasma SOX18 level was inversely correlated with BMI, FVC, and FEV1 of COPD patients (r = -0448, P < 0.001, r = -0.511, P < 0.001, and r = 0.607, P < 0.001, respectively). Conclusions The plasma SOX18 level was increased in COPD patients regardless of exacerbation and negatively correlated with lung function. These findings suggest that SOX18 may play a role in pathogenesis of COPD.
ADAM29 Elevation in Patients with COPD and Its Association with Lung Function
( Shinhee Park ),( Min Hyeok An ),( Pureun-haneul Lee ),( Yun Ha Nam ),( Ae Rin Baek ),( Jong Sook Park ),( Junehyuk Lee ),( Sung-woo Park ),( Do Jin Kim ),( An Soo Jang ) 대한결핵 및 호흡기학회 2023 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.136 No.0