우리 나라 自然洞窟의 現況과 利用에 關한 硏究

洪始煥,朴寬燮,任文淳,全順任 건국대학교 1978 學術誌 Vol.22 No.1

Our country has many limestone caves. There are about two hundred and thirty caves all over the country. Among them ninth percentages are limestone caves. We divide them into four classes as the limestone cove, lava cave erosion cave. We dlassify them with the component of formation for example, the limestone cave in the Karst region, the erosion cave in the seaside and the lava cave around the volcanic zone in Jeaioo Island. With geographical distribution, we could discover the limestone eave generally around the Gangwon Province, the Gyungsang Province the Chungcheung Province and the lava cave in Jea boo Province. The erosion caves are developed along the coast. With the geological period, we could discover the limestone cave mainly in the Cambro-Oldovisian Stage. We can see the anvient creature in the cave, not discovered at the surface, because the living things in the cave were late for the development. And the direction of the cave has connection with geological features. Mainly it agree with a fault plane. Generally Caves maintain the temperature from 14 degrees to 17 degrees. Thus, the fried temperature is a character of the cave. From old time, cave is made use for the place of the residence. Academic study for the cave began in earnest at the late 19th century. Comparaticely spealcing, we started studying only ten years ago. We used only cave for the place of refuse. And the cave is used for storehouse or the place in order to train the mind. Now we had to study to utilize the cave in our new period. For the temperature of the cave is fixed, we can use the cave for store. Now we had to study to utilize the cave in our new period. For the temperature of the cave is fixed, we can use the cave for storehouse of the crops or of the military goods. It is important for the cave to use for the military strategy. And it is possible to captivate the mushroom in the cave. Besides, we can use the pond of the cave for fish-breeding, as Japan is utilizing the cave for a fry-breeding. It is vary important to investigate the size or form of our many caves so as to serve the national safety.

우리나라 鍾乳窟의 特性과 環境汚染에 關한 硏究

洪始煥,朴冕用 건국대학교 1979 學術誌 Vol.23 No.2

This paper reviews the general status of stalactite caves which were found and are utilized for sight-seeing in Korea, and also summarizes the results of investigations on properties of natural stalactite caves. The cavernous phenomena such as the water quality, atmospheric phenomena, secondary grown products, ecological adaptation, environmental pollution and the breakage of stalactite are compared between those of cave a which are opened already sight-seeing and unresults are discussed and also compared with the caves in other countries. Environmental pollutions in Korean stalactite caves are as the following : The animate matters in caves are disappeared gradually from the time of exposure for sight-seeing. The kinds and abundance of the animate matters favoring the cavernous life or coming from the outside of caves have relativity to temperature, moisture and atmospheric conditions in caves. The water quality is consistent throughout the entire flow passage in a cave, but calcium content were less with the increase of flowing water volume in a cave. Atmospheric phenomena at entrance of a cave show a slight difference from the inner atmosphere, and the moisture content in cavernous atmosphere are increased with the cave depth. The secondary growth of stalactite are not taken place at the entry, because of low moesture content in air. However, stalactite secondary growth were prominent at inner cave where the moisture content is more than 90%. The temperature variation in the caves are negligible through all seasones in a year. The following conditions are critical to conserve the cavernous environmental pollution and the original form of caves. Some caves should not be exposed to the sight-seeing for academic studies. If the caves are open for sight-seeing, the entrance should be restricted with an adequate to limit the changes of atmospheric phenomena. In rainy season, the surface water flowing outside of cave should be protected from entering into the caves and water pool should be drained out to outside of cave. Proper number of waste cans should be provided along the pathway in the caves.

The Clinical Characteristics and Surgical Outcomes of Carcinoma of the External Auditory Canal: A Multicenter Study

Park, Jung Mee,Kong, Ji Sun,Chang, Ki Hong,Jun, Beom Cho,Jeon, Eun Ju,Park, So Young,Park, Shi Nae,Park, Kyoung Ho AVES Publishing Co. 2018 The journal of international advanced otology Vol.14 No.2

Clinical Characteristics and Pregnancy-Related Outcomes of Pregnant Women Hospitalized with COVID-19 During the Delta Wave: A Single-Center Observational Study

Hong Shin Hee,Shi Hye Jin,Kim Suk Young,Park Yoonseon,Eom Joong Sik 대한감염학회 2022 Infection and Chemotherapy Vol.54 No.3

Background Coronavirus disease 2019 (COVID-19) during pregnancy is associated with increased disease severity and an increased risk of perinatal complications. However, few studies of pregnant women with COVID-19 have been conducted in Korea. The purpose of this study was to describe the clinical course and pregnancy outcomes of pregnant women admitted to our hospital with COVID-19 according to the severity. Materials and Methods This retrospective cohort study included women aged 18 years of age or older who were hospitalized in the Gachon University Gil Medical Center with COVID-19 during pregnancy between July 1, 2021 and January 31, 2022. COVID-19 severity was classified according to the “Criteria for severity classification by symptoms of COVID-19” presented by the Korea Disease Control and Prevention Agency. Severe cases were defined as those who required oxygen treatment administered via a high-flow nasal cannula or invasive mechanical ventilation or should be applied extracorporeal membrane oxygenation (ECMO) or continuous renal replacement therapy. Results A total of 103 pregnant women were hospitalized with COVID-19 during the study period. Their mean age was 33 (± 4.14) years, and 4 (3.9%) had been vaccinated against COVID-19. At the time of diagnosis of COVID-19, 3 (2.9%), 33 (32.0%), and 67 (65.1%) patients were in the first, second, and third trimester, respectively. The most common symptoms were cough (99 patients, 96.1%) and fever (85 patients, 82.5%). There was 1 (1.0%) asymptomatic patient. Forty patients (38.8%) required supplemental oxygen and 19 patients (18.4%) had severe disease. Of the 19 severe cases, 7 were in the 2nd trimester and 12 were in the 3rd trimester. Forty-one (39.8%) patients delivered, including two twin deliveries. Of the 41 cases of delivery, 14 were premature, 4 out of 21 (19.0%) in mild, 4 out of 12 (25.0%) in moderate, and 6 out of 8 (75.0%) in severe. Severe disease was associated with an increased rate of preterm birth (P = 0.012). Four of the 43 neonates (9.1%) received oxygen treatment. Conclusion Pregnant women with COVID-19 had a high rate of severe disease and a high preterm delivery rate, especially among those with severe disease. Background Coronavirus disease 2019 (COVID-19) during pregnancy is associated with increased disease severity and an increased risk of perinatal complications. However, few studies of pregnant women with COVID-19 have been conducted in Korea. The purpose of this study was to describe the clinical course and pregnancy outcomes of pregnant women admitted to our hospital with COVID-19 according to the severity. Materials and Methods This retrospective cohort study included women aged 18 years of age or older who were hospitalized in the Gachon University Gil Medical Center with COVID-19 during pregnancy between July 1, 2021 and January 31, 2022. COVID-19 severity was classified according to the “Criteria for severity classification by symptoms of COVID-19” presented by the Korea Disease Control and Prevention Agency. Severe cases were defined as those who required oxygen treatment administered via a high-flow nasal cannula or invasive mechanical ventilation or should be applied extracorporeal membrane oxygenation (ECMO) or continuous renal replacement therapy. Results A total of 103 pregnant women were hospitalized with COVID-19 during the study period. Their mean age was 33 (± 4.14) years, and 4 (3.9%) had been vaccinated against COVID-19. At the time of diagnosis of COVID-19, 3 (2.9%), 33 (32.0%), and 67 (65.1%) patients were in the first, second, and third trimester, respectively. The most common symptoms were cough (99 patients, 96.1%) and fever (85 patients, 82.5%). There was 1 (1.0%) asymptomatic patient. Forty patients (38.8%) required supplemental oxygen and 19 patients (18.4%) had severe disease. Of the 19 severe cases, 7 were in the 2nd trimester and 12 were in the 3rd trimester. Forty-one (39.8%) patients delivered, including two twin deliveries. Of the 41 cases of delivery, 14 were premature, 4 out of 21 (19.0%) in mild, 4 out of 12 (25.0%) in moderate, and 6 out of 8 (75.0%) in severe. Severe disease was associated with an increased rate of preterm birth (P = 0.012). Four of the 43 neonates (9.1%) received oxygen treatment. Conclusion Pregnant women with COVID-19 had a high rate of severe disease and a high preterm delivery rate, especially among those with severe disease.

Cognitive decline and increased hippocampal p-tau expression in mice with hearing loss

Park, So Young,Kim, Min Jung,Kim, Hong Lim,Kim, Dong Kee,Yeo, Sang Won,Park, Shi Nae Elsevier 2018 Behavioural brain research Vol.342 No.-

<P><B>Abstract</B></P> <P>Hearing and cognition are commonly involved in both normal and pathological aging. Current clinical interest lies in whether peripheral hearing loss promotes cognitive decline. In our previous publication, the authors have shown a causal relationship between hearing and cognitive impairments in C57BL/6 mice. Here we extended the follow-up to 12 months to determine the long-term effects of hearing loss on cognition and to observe hippocampal p-tau and lipofuscin. One month old male mice were randomly allocated into two groups, the control (<I>n</I> = 12) and noise-induced hearing loss (NIHL) (<I>n </I>= 12). After baseline hearing and cognitive measurements, the mice in the NIHL group were exposed to 110 dB SPL white noise for 1 h every day for 20 consecutive days. Cognitive function was assessed by radial arm maze and novel object recognition tests. p-Tau was observed by the western blot, immunofluorescence, and immunogold staining. The mice in the NIHL group showed elevated auditory brainstem response thresholds and poorer performances in spatial working and recognition memories than the controls. They exhibited more p-tau and lipofuscin in the hippocampus. The cognitive impact of hearing loss varied with the types of memory. Working memory impairment was reversible, whereas recognition memory impairment was permanent. Our results provide behavioral and histopathological evidence for hearing-related cognitive decline. Early hearing loss is suggested to be one of the important determinants between normal and pathological cognitive aging.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Mice with hearing loss showed working and recognition memory impairments. </LI> <LI> The impact of hearing loss on cognition varied with the types of memory. </LI> <LI> Working memory was recovered, but recognition memory impairment was permanent. </LI> <LI> Mice with cognitive decline had more p-tau and lipofuscin in the hippocampus. </LI> <LI> Hearing loss is one of the causal factors for pathological cognitive aging. </LI> </UL> </P>

Reports : Effects of different target sites on antisense RNA-mediated regulation of gene expression

( Hong Marn Park ),( Yeong Seong Yoon ),( Shi Nae Suk ),( Ji Young Lee ),( Young Hoon Lee ) 생화학분자생물학회(구 한국생화학분자생물학회) 2014 BMB Reports Vol.47 No.11

Antisense RNA is a type of noncoding RNA (ncRNA) that binds to complementary mRNA sequences and induces gene repression by inhibiting translation or degrading mRNA. Recently, several small ncRNAs (sRNAs) have been identified in Escherichia coli that act as antisense RNA mainly via base pairing with mRNA. The base pairing predominantly leads to gene repression, and in some cases, gene activation. In the current study, we examined how the location of target sites affects sRNA-mediated gene regulation. An efficient antisense RNA expression system was developed, and the effects of antisense RNAs on various target sites in a model mRNA were examined. The target sites of antisense RNAs suppressing gene expression were identified, not only in the translation initiation region (TIR) of mRNA, but also at the junction between the coding region and 3`` untranslated region. Surprisingly, an antisense RNA recognizing the upstream region of TIR enhanced gene expression through increasing mRNA stability. [BMB Reports 2014; 47(11): 619-624]

Identification of Porcine Follicular Fluid Proteins of Mature and Immature Follicles in Using Proteomics

Shi, Quan Van,Lee, Hye-Ran,Kim, Hong-Rye,Park, Chang-Sik,Jin, Dong-Il 한국수정란이식학회 2006 한국수정란이식학회 학술대회 Vol.2006 No.1

음핵에 발생한 림프관종의 1예

박상일,홍길표,이귀왕,정시영,곽태로,오훈규 대한부인종양 콜포스코피학회 2003 Journal of Gynecologic Oncology Vol.14 No.3

림프관종은 림프계가 정상적으로 소통되지 못함으로 격리가 일어나서 생기는 선천성 기형으로 생각된다. 대부분이 유아기 때 발생하나 드물게 성인에서 나타나기도 한다. 저자들은 음핵에 종괴를 보이는 17세 여자에서 발생한 본 증례를 보고한다. 확진은 병리조직학적으로 기질에서 림프구 집합체 침윤을 확인하여 혈관종 등과 감별하여야 한다. 치료는 수술적 완전 절제이다. 본 증례에서 완전 절제로 좋은 결과를 얻었다. Most authors regard lymphangiomas as malformations that arise from sequestrations of lymphatic tissue that should communicate normally with the lymphatic system. The majority of lymphangiomas seem developmental lesions occurring relatively early in life, but it rarely present in adult life. We report the case of a 17-year-old female with clitorial mass. Histological features that favor the diagnosis of lymphangioma over hemangioma are the presence of lymphoid aggregates in the stroma and more irregular lumina with widely spaced nuclei. The therapy of choice is a complete surgical excision. Our patient was excised her lesion completely and resulted in good prognosis.

자궁경부에 발생한 악성 림프종 1예

홍길표,박상우,신규식,박상일,이귀왕,정시영,곽태로 대한부인종양 콜포스코피학회 2003 Journal of Gynecologic Oncology Vol.14 No.3

악성 임파종의 2가지의 주된 변이는 Hodgkin 림프종과 non-Hodgkin 림프종이다. 그 중에 90% 이상이 B세포의 non-Hodgkin 림프종이다. 자궁에서의 국한된 악성 림프종은 매우 드물며, 특징상 임상소견을 잘 나타내지 않는다. 그리고 자궁에 국한된 악성 림프종이 진단되는 경우 자궁경부가 체부에 비해 3배 높다. 저자들은 자궁경부의 원발성 악성 임파종 1예를 경험하였기에 간단한 문헌 고찰과 함께 보고하는 바이다. The two major variants of malignant lymphoma are non-Hodgkin’s lymphomas and Hodgkin’s disease. More than 90% of all cases of non-Hodgkin’s lymphomas are of B-cell derivation. The malignant lymphoma localized in uterus is rare and characteristically symptom-free expressed, but when it does, the cervix is the presenting site three times more often than is the endometrium. We have experienced a case of malignant lymphoma originated from uterine cervix, so we report with a brief of literature.

Effect of LiBiO2 on low-temperature sintering of PZT-PZNN ceramics

Hong Sung Cheul,Kim Shi Yeon,Yeo Dong-Hun,Shin Hyo-Soon,Park Zee Hoon,남산 한국세라믹학회 2022 한국세라믹학회지 Vol.59 No.5

In this study, the sintering characteristics of 0.69Pb(Zr 0.47 Ti 0.53 )O 3 -0.31Pb[(Zn 0.4 Ni 0.6 ) 1/3 Nb 2/3 ] (PZT-PZNN) ceramics after the addition of LiBiO 2 were studied. This addition lowered the sintering temperature from 1150 to 900 °C. The crystal structure changed from tetragonal to rhombohedral as the additive content increased by 0.7%. The polarization of the sintered specimen was conducted at an electric fi eld of 3 kV/mm. When 0.7 wt% of LiBiO 2 was added and sintered at 900 °C, the piezoelectric constant ( d 33 ) was 602 pC/N; moreover, the electromechanical coupling coefficient ( k P ), sintered density, and Curie temperature ( T c ) at 1 kHz were 66.3%, 7.99 g/cm 3 , and 252.8 °C, respectively. When 0.7 wt% of LiBiO 2 was added, the PZT-PZNN ceramic showed an increased strain curve of 0.118% at 2 kV/mm. The interdiffusion between the copper (Cu) electrode and ceramic material was not observed in the scanning electron microscopy (SEM) results; thus, the possibility of manufacturing an actuator using a Cu electrode using a novel composition was confirmed. The actuator displacement with the voltage 400 V was 1.2 μm. The thickness of the multi-layered actuator was 1 mm. Through this, the possibility of manufacturing a multi-layered actuator with a Cu electrode was confirmed through the composition of 0.69PZT-0.31PZNN (LiBiO 2 0.7 wt%).