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- 저자 : Shaker El-Sappagh (검색결과 2 건)
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Priority-Based Cloud Computing Architecture for Multimedia-Enabled Heterogeneous Vehicular Users
Ali, Amjad,Liu, Hongwu,Bashir, Ali Kashif,El-Sappagh, Shaker,Ali, Farman,Baig, Adeel,Park, Daeyoung,Kwak, Kyung Sup Hindawi Limited 2018 Journal of advanced transportation Vol.2018 No.-
<P>In recent days, vehicles have been equipped with smart devices that offer various multimedia-related applications and services, such as smart driving assistance, traffic congestions, weather forecasting, road safety alarms, and many entertainment and comfort applications. Thus, these smart vehicles produce a large amount of multimedia-related data that require fast and real-time processing. However, due to constrained computing and storage capacities, such huge amounts of multimedia-related data cannot be processed in on-board standalone devices. Thus, multimedia cloud computing (MCC) has emerged as an economical and scalable computing technology that can process multimedia-related data efficiently while providing improved Quality of Service (QoS) to vehicular users from anywhere, at any time and on any device, at reduced costs. However, there are certain challenges, such as fast service response time and resource cost optimization, that can severely affect the performance of the MCC. Therefore, to tackle these issues, in this paper, we propose a dynamic priority-based architecture for the MCC. In the proposed scheme, we divide multimedia processing into four different subphases, while computing resources to each computing server are assigned dynamically, according to the workload, in order to process multimedia tasks according to the multimedia user Quality of Experience (QoE) requirements. The performance of the proposed scheme is evaluated in terms of service response time and resource cost optimization using the CloudSim simulator.</P>
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Prognostic role of EGR1 in breast cancer: a systematic review
( Subbroto Kumar Saha ),( S. M. Riazul Islam ),( Tripti Saha ),( Afsana Nishat ),( Polash Kumar Biswas ),( Minchan Gil ),( Lewis Nkenyereye ),( Shaker El-sappagh ),( Saiful Islam ),( Ssang-goo Cho ) 생화학분자생물학회 2021 BMB Reports Vol.54 No.10
EGR1 (early growth response 1) is dysregulated in many cancers and exhibits both tumor suppressor and promoter activities, making it an appealing target for cancer therapy. Here, we used a systematic multi-omics analysis to review the expression of EGR1 and its role in regulating clinical outcomes in breast cancer (BC). EGR1 expression, its promoter methylation, and protein expression pattern were assessed using various publicly available tools. COSMIC-based somatic mutations and cBioPortal-based copy number alterations were analyzed, and the prognostic roles of EGR1 in BC were determined using Prognoscan and Kaplan-Meier Plotter. We also used bc-GenEx-Miner to investigate the EGR1 co-expression profile. EGR1 was more often downregulated in BC tissues than in normal breast tissue, and its knockdown was positively correlated with poor survival. Low EGR1 expression levels were also associated with increased risk of ER+, PR+, and HER2- BCs. High positive correlations were observed among EGR1, DUSP1, FOS, FOSB, CYR61, and JUN mRNA expression in BC tissue. This systematic review suggested that EGR1 expression may serve as a prognostic marker for BC patients and that clinicopathological parameters influence its prognostic utility. In addition to EGR1, DUSP1, FOS, FOSB, CYR61, and JUN can jointly be considered prognostic indicators for BC. [BMB Reports 2021; 54(10): 497-504]
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