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Sewon Oh,Youngjae Oh,Keumsun Kim,Hyeondae Han,Yu Mi Kim,Kyungho Won,Daeil Kim 한국원예학회 2020 Horticulture, Environment, and Biotechnology Vol.61 No.4
Genetic linkage map of pear (( Pyrus pyrifolia × P. communis ) × P. pyrifolia ) was constructed to validate the eff ectiveness ofthe two-enzyme approach in GBS library preparation. In addition, allele inheritance was analyzed to investigate the usefulnessof the pear pseudo-BC 1 in genetic analysis. A total of 905 GBS-SNPs and 69 SSRs were anchored in 17 linkage groupswith total genetic distance of 1760.1 cM and average marker distance of 1.88 cM. The genetic linkage map represents 80.5%of pear genome. GBS two-enzyme approach improved marker density and genome coverage compared to the single-enzymeapproach. In addition, the inheritance analysis of SSR alleles demonstrated that pseudo-BC could allow genetic dissectionof donor parent specifi c trait segregating in the F 2 . The high-resolution genetic linkage map of pear pseudo-BC 1 will be usedfor candidate gene identifi cation. Moreover, genetic analysis of donor parent specifi c traits segregating in the pseudo-BC 1hybrids will promote marker development for molecular breeding in pear.
Acrodermatitis continua of Hallopeau: A case series
( Sewon Hwang ),( Ji Won Yun ),( Jihong Lim ),( Yuri Woo ),( Miri Kim ),( Hyun Jeong Park ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Acrodermatitis continua of Hallopeau (ACH) is a rare form of pustular psoriasis clinically characterized by the presence of periungual and subungual sterile pustules with paronychia, onychodystrophy and osteolysis of the distal phalanx of the fingers, toes and atrophic skin. In this case series, 16 cases of ACH are included. 13 out of 16 patients were female and the range of age was from 9 to 61. All patients had subungual pustulosis with nail changes such as onycholysis(69%), trachyonychia(69%) or yellowish chromonychia(44%). Two patients had additional psoriatic lesions on the other body parts. Histopathological results of the subungual biopsy of 9 patients showed acanthosis, inflammatory cell infiltrates and pustular formation. Treatment included dapsone(69%), NSAIDs (63%), methotrexate(31%) and acitretin(13%). 62.5% of the patients required long-term treatment duration over 5 months. Among these patients, 60% showed poor treatment response of <25%. ACH is often difficult to treat and tends to show recalcitrant prognosis because of its failure or only partial response to various therapies. Therefore, further studies regarding effective treatment regimen for ACH are needed due to lack of established therapy.