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나노압입시험기를 이용한 MEMS 공정조건에 따른 SU-8 감광제의 기계적 물성 측정
최현주(Hyun-ju Choi),김재현(Jae-Hyun Kim),이학주(Hak-joo Lee),현승민(Seungmin Hyun),한승우(Seung-Woo Han) 대한기계학회 2006 대한기계학회 춘추학술대회 Vol.2006 No.11
The interest of utilizing SU-8 for the fabrication of thick micro-electro-mechanical systems(MEMS) has been growing recently. Especially SU-8 is a widespread material for soft structures in MEMS applications. However, the fabrication of thick SU-8 MEMS process has been experienced severe problems such as cracks, distortions and delaminations due to post expose bake(PEB) photolithography process. In order to design a reliable device using SU-8 , it is necessary to measure the mechanical properties of SU-8. The mechanical behavior of micro-scale structures usually is very different from that of the bulk materials. The behavior of small scale structures is dependent on their dimension and fabrication process. In this study, we used an advanced Pillar Compression Test using nanoindentation apparatus to measure the stress-strain relationship of SU-8 micro pillars fabricated by MEMS process. Stress-strain curves and mechanical properties of baked SU-8 pillar at 65℃ ~ 120 ℃ were extracted from measured load-displacement data.
공명법을 사용한 나노 스케일 Al 박막의 열-기계적 거동 측정
현승민(Seungmin Hyun),박정민(Jungmin Park),이학주(Hak-Joo Lee),Walter Brown 대한기계학회 2008 대한기계학회 춘추학술대회 Vol.2008 No.5
Thin films in the sub micrometer thickness range have been studied due to their importance in applications such as semiconductor devices, storage media and micromechanical systems. There has been enormous progress in micromechanical system design and fabrication to take advantage of structures with small dimensions. For micromechanical systems such as micromirrors, the long-term stress stability of the thin metal films is a major concern because residual stresses present in metal layers and changes in those stresses with time cause undesired curvature and curvature changes in films on substrates. Among several metal films that serve as structural elements or reflective surfaces in this type of application, Al is attractive because it is light and provides good reflectivity at low cost compared to more noble metals. In order to gain a better understanding of mechanical behavior in very thin films we have studied the stress changes of nanoscale Al thin films using a unique resonance system
용량형 Bulge 시험기를 이용한 금속 박막의 기계적 물성 측정
현승민(Seungmin Hyun),이학주(Hak-Joo Lee),이상주(Sang-Joo Lee),박현성(Hyun-Sung Park) 대한기계학회 2007 대한기계학회 춘추학술대회 Vol.2007 No.10
The mechanical behavior of thin films is very important to semiconductor and MEMS devices due to reliability issues. Thin metal films are often used as structural elements under various conditions. To understand mechanical behavior of thin film, we have utilized a bulge system and measured mechanical behavior of Al thin films. Al thin films were prepared on 2㎜ ×12 ㎜ rectangular silicon nitride membrane window in 2 x 2 ㎝ silicon frame. Load was applied to the membrane by Nitrogen gas and the bulge displacement was measured by the capacitance changes between the membrane and an electrode. The system provides a precise measurement of stress relaxation behavior of Al thin films at low strain.
Biliary Obstruction Caused by Non-Hodgkin Lymphoma Involvement: A Case Report
Jae Hyun Lim,Huapyong Kang,Jung Hyun Jo,Hee Seung Lee,Jeong Youp Park,Seungmin Bang,Seung Woo Park,Si Young Song,Moon Jae Chung Korean Society of Gastrointestinal Cancer 2018 Journal of digestive cancer reports Vol.6 No.1
Non-Hodgkin's lymphoma is known to be a rare and unusual cause of biliary obstruction. We report a case of biliary obstruction that a 25-year-old male showed icteric sclera and yellow discoloration of his skin caused by metastasis of non-Hodgkin lymphoma. Initial imaging & endoscopic work-up led us to an impression of either cholangiocarcinoma or IgG4-related disease, yet the pathological results weren't diagnostic. Through our thorough re-examination, we found a 5cm sized round, fixed, non-tender sternal mass, and additional imaging studies were suggestive of lymphoma, which was also consistent with the results of incisional chest wall biopsy. Biliary obstruction by lymphoma was successfully treated by endoscopic plastic stent insertion procedure and chemotherapy. Although it is widely accepted that lymphoma accounts for very few portion of malignant biliary obstruction, due to the fact that lymphoma and cholangiocarcinoma are often indistinguishable, careful diagnostic approach should be done.
Lee, Seungmin,Moon, Byung Joon,Lee, Hyun Jung,Bae, Sukang,Kim, Tae-Wook,Jung, Yong Chae,Park, Jong Hyeok,Lee, Sang Hyun American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.20
<P>In this study, we developed reduced graphene oxide (rGO)-incorporated porous agarose (Ar-rGO) composites that were prepared via a “one-pot” sol-gel method involving a mixing and vacuum freeze-drying process. These composites represent an easy-to-use adsorbent for organic contaminant removal. Ar-rGOs can efficiently adsorb organic molecules, especially aromatic organic compounds from wastewater, because of the synergistic effect between the agarose bundles, which function as a water absorption site, and the rGO sheets, which function as active sites for pollutant binding. The pore structures and morphology of the Ar-rGO composites varied according to the added rGO, resulting in effective water infiltration into the composites. The main adsorption mechanism of the aromatic organic compounds onto Ar-rGOs involved π-π interactions with the rGO sheets. The surface interaction was more effective for adsorbing/desorbing the aromatic pollutants than the electrostatic interaction via the O-containing functional groups. In addition, we confirmed that Ar-rGO is highly stable over the entire pH range (1-13) because of the presence of the rGO sheets.</P> [FIG OMISSION]</BR>
Yeo, Seungmin,Nandi, Dip K.,Rahul, R.,Kim, Tae Hyun,Shong, Bonggeun,Jang, Yujin,Bae, Jong-Seong,Han, Jeong Woo,Kim, Soo-Hyun,Kim, Hyungjun Elsevier 2018 APPLIED SURFACE SCIENCE - Vol.459 No.-
<P><B>Abstract</B></P> <P>Tungsten disulfide (WS<SUB>2</SUB>) thin films are grown on several types of substrates by plasma-enhanced atomic layer deposition (PEALD) technique using tungsten hexacarbonyl [W(CO)<SUB>6</SUB>] and H<SUB>2</SUB>S plasma at a relatively low temperature of 350 °C. The method delivers polycrystalline WS<SUB>2</SUB> film with (0 0 2) preferential growth and the high quality films could be successfully grown with as low as 30 ALD cycles (corresponding to ∼3 nm of thickness). Density functional theory (DFT) calculation results reveal that both adsorption of W(CO)<SUB>6</SUB> and removal of CO ligand would be facilitated by usage of H<SUB>2</SUB>S plasma by generating the different defect sites on the basal plane. The typical self-limiting film growth (growth rate of ∼0.1 nm/cycle), characteristic of ideal ALD, is clearly observed with both the precursor and reactant pulsing time. X-ray diffractometry (XRD), Raman spectroscopy, transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), and Rutherford backscattering spectrometry (RBS) are performed in details to study the as-grown WS<SUB>2</SUB> film on Si/SiO<SUB>2</SUB> substrate. The analysis results confirm the formation of polycrystalline film, with high purity and well-defined stoichiometry. The as-deposited WS<SUB>2</SUB> films are then explored as an electrode in the field of energy generation as well as energy storage. The films are uniformly and conformally grown on high surface-area 3 dimensional Ni-foam that show excellent activity towards hydrogen evolution reaction (HER). Significantly low overpotential of ∼280 mV is observed at a high operational current density of 100 mA cm<SUP>−2</SUP> during HER in acid electrolyte. In addition, the as-grown films on stainless steel substrate also reveal the stable electrochemical performances in Na-ion battery as an anode with reasonably high areal capacity of ∼44.5 μAh cm<SUP>−2</SUP> at the end of 50 charge-discharge cycles.</P> <P><B>Highlights</B></P> <P> <UL> <LI> PEALD grown polycrystalline WS<SUB>2</SUB> using W(CO)<SUB>6</SUB> precursor and H<SUB>2</SUB>S plasma as a reactant. </LI> <LI> H<SUB>2</SUB>S plasma to facilitate ALD reaction elucidated from DFT calculation. </LI> <LI> Excellent uniformity and conformality of PEALD-WS<SUB>2</SUB> on 3 dimensional Ni-foam. </LI> <LI> Applications as a binder and carbon-free anode in SIBs and catalyst for HER. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Deep Learning Model for Predicting Airway Organoid Differentiation
Lim Mi Hyun,Shin Seungmin,Park Keonhyeok,Park Jaejung,Kim Sung Won,Basurrah Mohammed Abdullah,Lee Seungchul,Kim Do Hyun 한국조직공학과 재생의학회 2023 조직공학과 재생의학 Vol.20 No.7
BACKGROUND: Organoids are self-organized three-dimensional culture systems and have the advantages of both in vitro and in vivo experiments. However, each organoid has a different degree of self-organization, and methods such as immunofluorescence staining are required for confirmation. Therefore, we established a system to select organoids with high tissue-specific similarity using deep learning without relying on staining by acquiring bright-field images in a nondestructive manner. METHODS: We identified four biomarkers in RNA extracted from airway organoids. We also predicted biomarker expression by image-based analysis of organoids by convolution neural network, a deep learning method. RESULTS: We predicted airway organoid-specific marker expression from bright-field images of organoids. Organoid differentiation was verified by immunofluorescence staining of the same organoid after predicting biomarker expression in bright-field images. CONCLUSION: Our study demonstrates the potential of imaging and deep learning to distinguish organoids with high human tissue similarity in disease research and drug screening.
( Seungmin Yu ),( Jong Hun Choi ),( Hun Jung Kim ),( Soo Hyun Park ),( Gwang-woong Go ),( Wooki Kim ) 한국미생물생명공학회(구 한국산업미생물학회) 2017 Journal of microbiology and biotechnology Vol.27 No.9
Dietary approaches using structured lipids, including medium-chain fatty acids and diacylglycerols, have been adopted for the prevention of obesity-induced chronic inflammation. In an extension to previous studies, medium-chain fatty acid-diacylglycerol enriched dietary oil (MCDG) was prepared by interesterification of canola oil and medium-chain fatty acid-triacylglycerols. The consequent MCDG product was applied to RAW264.7 macrophages followed by the assessment of multiple inflammatory responses. Compared with conventionally used canola and olive oil controls, MCDG suppressed macrophage phagocytosis, as assessed by the uptake of microsphere beads. Furthermore, the production of IL-6 and TNF-α, transcription of COX-2 and iNOS, and expression of CD80 on cell surfaces were downregulated by MCDG in LPS-stimulated macrophages. Subsequently, differentiated 3T3-L1 adipocytes were evaluated for proinflammatory cytokine production and lipid accumulation. IL-6 production was marginally affected and lipid accumulation was inhibited by MCDG. Taken together, these results suggest that MCDG has potential as an alternative oil for cooking in order to prevent obesity-induced inflammation.