거제도(경상남도, 거제시)의 거미상

김주필(Joo Pil Kim),김대희(Dae Hee Kim),지승환(Seung Hwan Ji),지성현(Sung Hyun Ji) 한국거미연구소 2017 한국거미 Vol.33 No.2

2017년 7월 4일부터 6일까지 경상남도 거제시 거제도 일대를 김주필, 김대희, 지승환, 지성현, 최라미, 이영경 등 한국거미연구소 회원들이 주야로 채집한 결과, 총 23과 56속 75종이 조사 연구되어 이에 발표하는 바이다. 채집한 표본은 주필거미박물관에 보관하였다. From July 4 to 6 in 2017. Joo-Pil Kim, Dae-Hee Kim, Seung-Hwan Ji, Sung-Hyun Ji, Ra-Mi Choi, Yeong-Gyeong Lee, the members of The Arachnological Institute of Korea investigated the spiders in the whole area of Geoje city, Geoje-do, Gyeongsangnam-do and report 23 Family 56 Genus 75 Species of spiders. The collected spiders are placed (stored) in the Joo-Pil Spider museum.

자궁경부암종에서 신생혈관 형성과 증식세포 핵항원 및 Ki-67 표지지수의 예후적 의의

박찬필,박문향,이승연 대한병리학회 1997 Journal of Pathology and Translational Medicine Vol.31 No.1

OOP를 이용한 배전자동화복구시스템의 설계

김필석,이승재 명지대학교 대학원 1997 대학원논문집 Vol.1 No.-

This paper proposes the OOP design for development of the service restoration system in DAS. It utilizes the Booch Method and has features of high reusability, expansion and manatenance capability.

심한 저칼륨혈증을 동반한 갑상선 중독성 주기성 마비 2례

유승진,최승필,최경호,오동렬,황주일,나병호,김세경 대한응급의학회 1996 대한응급의학회지 Vol.7 No.2

Thyrotoxic periodic paralysis occurs primarily in Orientals with an overwhelming male preponderance and a higher association of specific HLA antigens. Clinical manifestations include onset after high carbohydrate ingestion or heavy exertion with progressive symmetric weakness leading to flaccid paralysis of the extremities and other muscle groups, lasting several hours. Other precipitating facters include trauma, infection, administration of epinephrine, thyroid hormone, or corticosteroid. If hypokalemia is present, potassium administration may help abort the attack. Although propranolol can be efficacious in preventing further episodes, the only definitive treatment is euthyroid state. The pathophysiology is still controversal, but reflects altered potassium and calcium dynamics as well as certain morphologic characteristics within the muscle unit itself. We discribed two patients with thyrotoxic periodic paralysis who had a no familial history of paralysis and had a decreased level of serum potassium during attack.

Creutzfeldt-Jacob병 1례

홍승철,한진희,정종현,김소양,허균,이성필 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

저자들은 Creutzfeldt-Jacob병 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. 환자는 약 4개월에 걸친 비교적 짧은 기간 동안 중증의 인지 기능 장애와 시각 장애, 보행장애와 하지의 약화, 불수의적 운동 등과 함께 섬망상태에까지 이르게 되어 본원 정신과에 입원하게 되었다. 정신상태 검사상, 반응시간의 지체, 언어장애와 보속증, 시간에 대한 지남력 장애, 주의 집중력 장애, 단기 및 장기 기억 장애, 추상적 사고능력 장애 등의 소견을 보였고, 이러한 증상들은 입원후 치료에도 불구하고 빠르게 악화되었다. 뇌파검사상 지속적인 다발초점성 서파가 모든 전극에서, 특히 우측 전두부에서 현저하게 나타나는 소견을 보였고, 병리조직학적 검사상 대뇌 피질에 신경손실을 동반한 해면화와 신경교 증식증을 나타냈다. 이상의 소견들은 모두 CJD의 진단에 합당하였다. We report a case of Creutzfeldt-Jacob disease and review the relevant literatures. This 56-year-old male patient was admitted to our hospital with a history of rapidly progressing cognitive dysfunction, visual disturbance, gait disturbance, weakness, involuntary movement of lower extremities, and the symptoms of delirium. On mental status examination, he showed psychomotor retardation, speech disturbance, perseveration, disorientation, impairment of short-term and long-term memory, and inability of abstract thinking. He had a rapid downhill course, along with shakiness of trunk, rigidity of the limbs, myoclonus, confusion, and finally, inability to speak or move on the bedside. On electroencephalogram(EEG), continuous multifocal show delta activities were found in all leads, especially in the right frontal areas. Brain biopsy showed, spongiosis with neuronal loss and gliosis noted at the cerebral cortex. These findings were compatible with Creutzfeldt-Jacob disease.

한국인에게 적절한 기관삽관 위치

이승한,최옥경,정구영,정성필 대한응급의학회 1995 대한응급의학회지 Vol.6 No.1

Endotracheal intubation is one of the important procedures in ED and various fields. Endobronchial intubation can lead to hypoxemia secondary to tension pneumothorax of intubated side and atelectasis of contralateral side. The placement of tube beyond the vocal cords may results in inadvertent extubation, larygeal spasm and aspiration pneumonia. The conformation methods of endotracheal intubation are auscultation of the chest, observation of a vapor trail, oximetry and capnography, and radiologic evaluation. Owen and associates recommended that oral intubation tubes at the upper incisor teeth at the 23cm in men and the 21cm in women of average adult size would have led to proper placement. We studied that whether the proper depth of endotracheal tube in American is appropriate to Korean. We studied adult patients admitted to ED (of both hospitals during March in 1995. Endotracheal tubes in men were positioned at the 23cm and women had positioned at the 21cm at the upper incisor teeth. The distance of the tip of the endotracheal tube to the tracheal carina on the postintubation chest X-ray then determined. Correct placement of intubation was defined with the tip of the tube≥3cm above the carina and below the level of the larynx. Fifty adult patients were enrolled in the study ; 29 men (58%) and 31 women (42%). Mean height and weight were 170±5.2cm, 68±9kg in men and 158±6.5cm, 56±10kg in women. Reasons for intubation were ; respiratory failure(38%), trauma(16%), increased intracramial pressare(16%), drug intoxication(12%), shock(8%), cardiac arrest(7%)and others(3%). The mean distance from the tip to carina on chest X-ray was 4.13±1.5cm in men and 3.45±2.1cm in women. Proper position was 27/29(93%) in men, 14/21(67%) in women or 41/50(82%). this means the placement of endotracheal tube of our patients was positioned deeper than prion study group(97.6%).(p<.05) We recommend that the 22cm tube mark for men and 20cm tube mard for women at upper incisor teeth would have led to proper placement in Korean adult patient.

PC12를 이용한 신경세포 허혈모델에서 irp94 유전자의 발현

김승환,양영모,하영록,정성필,유인술,김인병 대한응급의학회 2001 대한응급의학회지 Vol.12 No.3

Background: The ischemia responsive protein 94 kDa(irp94) gene belongs to the heat shock protein 110 family and was isolated in 1999 from rat brain by transiently induced forebrain ischemia. The PC12 cell is the pheochromocytoma cell line of rat, which is differentiated to a sympathetic neuron-like cell by the stimulation of a nerve growth factor. This study is to determine whether irp94 is expressed when an ischemia-like condition is induced by ATP depletion in cultured PC12 cells in vitro. Methods: PC12 cells were maintained as monolayer cultures in RPMI-1640 medium(Sigma) supplemented with 10% horse serum, 5% fetal bovine serum, 5 mg/ml transferrin, and 1 mg/ml insulin in a humidified 5% CO2 incubator at 37℃. The ATP depleting agent antimycin A was added at concentrations of 1, 2.5, and 5 μM to simulate ischemia, and 10 μg/ml of tunicamycin, which is expected to express heat shock protein maximally, was used as a positive control. The cells were harvested after a 60-minute incubation, and the total RNA was extracted. The reverse transcription polymerase chain reaction(RT-PCR) was performed to use 501 bp irp94 cDNA as a molecular probe, and the expression of irp94 mRNA was analyzed by northern blotting. Results: The irp94 mRNA expression was enhanced, compared to the negative control group, as the concentration of antimycin A was increased. Conclusion: This study suggests that irp94 mRNA expression is enhanced as the severity of ischemia is increased. Thus, it is possible to investigate the mechanism of ischemic neuronal injury indirectly by using this in-vitro model of neuronal ischemia.

혈중 콜레스테롤과 음독자실시도

최승필,권태욱,황주일,김세경 대한응급의학회 1995 대한응급의학회지 Vol.6 No.2

Objective: Several studies suggest that a low cholesterol concentration is associated with a greater than normal risk of mortality from suicide. The authors sought to determine whether a low cholesterol level is associated with a history of serious suicide attempts among drug ingested ED patients. Method: serum cholesterol levels of attempted suicide of 89 patients, aged 20-72 years, were obtained from the ED admission biochemical profiles. Results: The seriousness of suicide attempt was associated with low serum cholesterol concentration in all age subgroups. Conclusions: Low cholesterol concentration should be futher investigated as a potential biological marker of suicide risk.

말쥐치 기름의 投與가 흰쥐의 血淸 및 肝臟의 콜레스테롤 濃度수준에 미치는 影響

鄭承鏞,黃淑子,姜晋順,朴畢淑 慶尙大學校 1985 論文集 Vol.24 No.2

Sprague Dawley계 숫 흰쥐에 eicosapentaenoic acid 및 docosahexaenoic acid둥 고도불포화지방산을 함유하고 있는 말쥐치커기름과 monoenoic acid를 많이 함유하고 있는 올리브기름을 각각 10% 씩 첨가하고 또한 vitamin E를 식이 100g당 5, 50, 100 I. U.로 첨가한 사료로서 2주간 사육한 후 혈청 및 간장 중의 cholesterol 농도, 과산화지질 및 α-tocopherol의 농도를 측정한 바 다음과 같은 결과를 얻었다. 1. 증체량 및 사료섭취량은 전 시험군 간에 있어 유의적인 차이는 없으나 말쥐치기름 투여군이 약간 낮은 경향이었다. 2. 혈청 중의 총 cholesterol 농도는 올리브기름 및 말쥐치기름 투여 군 모두 vitamin E의 첨가량을 증가시킴에 따라 낮아지는 경향이었으며, 말쥐치기름 투여군 은 올리브기름 투여군에 비해 유의적으로 그 농도가 낮았다 (P<0.05). 3. 혈청 중의 HDL-cholesterol 농도 및 총cholesterol 농도에 대한 HDL-cholesterol 농도의 비율은 말쥐치기름 투여군이 올리브기름 투여군에 비해 대체로 높은 경향이었다. 4. 간장 중의 총 cholesterol 농도는 말쥐치기름 투여군이 올리브기름 투여군에 비해 약간 낮은 경향이었다. 5. 혈청 및 간장 중의 과산화지질의 농도는 말쥐치기름 투여군이 유의 적으로 높았으며 (P<0.05) vitamin E의 첨가량을 증가시킴에 따라 감소되는 경향이었다. 6. 혈청 및 간장 중의 α-tocopherol 농도는 말쥐치기름 투여군이 유의적으로 낮았다 (F<0.05). The Sprague Dawley male rats were fed experimental diets containing 10% file fish oil or 10% olive oil, and three graded levels of vitamin E(5,50 and 100 I.U./l00g diet) were provided for each test oil group. After two weeks feeding, the concentration of cholesterol, lipid peroxide and a-tocopherol in serum and liver of rats were determined. The results were summarized as follows. 1. The amount of body weight gain and food intake of rats were not significantly different among all the experimental groups but tended to slightly be low in rats fed file fish oil diet. 2. Total cholesterol concentrations in serum tended to be decreased as vitamin E level increased all of the file fish oil and olive oil diet groups, serum total cholesterol concentrations of the file fish oil diet groups were significantly lower than those of the olive oil diet groups. 3. HDL-cholesterol concentrations and the ratio of HDL-cholesterol to total cholesterol in serum generally tended to be higher on the file fish oil diet groups than those of the olive oil diet groups. 4. Total cholesterol concentrations in liver tended to slightly be lower on the file fish oil diet groups than those of the olive oil diet groups. 5. Lipid peroxide values in serum and liver were significantly high on the file fish oil diet groups and tended to be decreased as vitamin E level increased. 6. The concentrations of α-tocopherol in serum and liver were significantly low on the file fish oil diet groups.

삼환계 항우울제(Dothiepin)가 우울증 환자의 수면에 미치는 영향 : 수면 다원 검사에 의한 연구 A Polysomnographic Study

홍승철,한진희,이성필,방승규 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.4

우울증환자군에서 삼환계 항우울제인 dothiepin 투여 후의 수면이 변화양성을 알아보며, 치료 후의 호전정도를 예측할 수 있는 치료 전과 치료 후의 수면변인을 조사하기 위하여 본 연구를 시행하였다. 수면상태는 수면다원검사를 실시하여 평가하였고, 우울증상의 심각도와 임상양상의 정도는 Hamilton 우울척도를 이용하여 평가하였다. 연구대상은 최소 14일 이상 약물을 투여 받지 않은 우울증 환자 16명(남자 7명, 여자 9명, 연령분포 23∼64세)으로 구성되었다. 수면다원검사는 약물을 투여하기 전과 약물투여 후 1주와 3주에 시행하여 다음과 같은 결과를 얻었다. 1) 항우울제 투여 1주와 3주 후 수면 연속성은 기준수면에 비하여 총수면 시간이 유의하게 증가하였고 수면잠재기는 단축되었으며, 수면도중 각성시간은 감소하였고, 수면효율은 증가되었다. 2) 항우울제 투여 1주와 3주 후 수면구조에서는 기준수면에 비하여 2단계 수면이 유의하게 증가하였다. 3) 항우울제 투여 1주와 3주 후 급속안구운동 수면은 기준수면에 비하여 유의하게 감소하였고, 급속안구운동 수면잠재기는 증가하였다. 4) 항우울제 투여 1주 후와 3주 후의 수면을 비교시 수면잠재기가 3주에 유의하게 감소된 외에는 수면 변인의 차이를 보이지 않았다. 5) 우울증상의 평가를 위하여 약물투여 1주 후와 3주 후에 시행한 Hamilton 우울척도 점수는 약물투여 전에 비하여 줄어들어 우울증상이 호전됨을 나타내었다. 6) 항우울제 투여 3주 후 치료반응이 좋았던 군의 수면특징은 기준수면에서 수면도중 각성시간이 증가된 경향을 나타내었고, 약물투여 1주 후의 수면에서는 4단계 수면의 양이 유의하게 감소되었다. 이상의 결과를 볼 때, 우울증환자에서 삼환계 항우울제인 dothiepin 투여 후의 수면변화는 치료초기에 나타났다. 기준수면에서 각성기간의 증가와 1주 후의 수면에서 4단계 수면의 감소는 약물치료에 좋은 반응과 관련된 수면변인으로 생각되었다. Objectives : This study was designed to investigate 1) sleep changes after antidepressant (dothiepin) treatment, and 2) sleep variables which seem to be associated with clinical response in the depressed patients. Methods : The subjects consisted of 16 patients who fullfilled the criteria for major depression by the Diagnostic and statistical Manual, (4th edition). Their sleep was recorded using polysomnography at the baseline and after one week and three weeks of dothiepin treatment. All subjects were further interviewed using Hamilton Rating Scale for Depression (HRSD) to rate the severity of their depression. High response to the drug was defined as a reduction of more than 50% of the HRSD score. Results : The results were as follows : 1) Depressed patients after dothiepin treatment showed more total sleep time(p=0.019), shorter sleep latency(p=0.05), less awake time(p=0.033), more sleep efficiency(p=0.018), more stage 2 sleep(p=0.002), less REM time(p=0.000), and longer REM sleep latency(p=0.004) than before treatment. 2) There were no differences in sleep variables between those who received 1 week and 3 weeks of dothiepin treatment except for the shortening of sleep latency after 3 weeks(p<0.05). 3) Depressive symptom scores on HRSD were reduced after 1 week and 3 weeks of dothiepin treatment as compared with the baseline. 4) High responders showed a tendency of increased wake time(p=0.054), while their stage 4 sleep decreased after 1 week of dothiepin treatment as compared with the low responders(p=0.0136). Conclusion : These results suggest that sleep of the depressed patients after dothiepin treatment tends to be normalized and sleep changes seem to appear early in the treatment phase. In addition, clinical response might be associated with greater wake time at the baseline and lesser stage 4 sleep after 1 week of dothiepin treatment.