생체분해성 고분자를 이용한 사시수술용 제형개발 및 효용성에 대한 연구

민병무,김용백,김승영,김창식,박근성,길숙종,조항진,이성복,노승무,송규상,강대영,조준식,양준묵,정경수,최선웅,이진호,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

A new device, muscle clamping system was developed to facilitate exact quatifying technique A strabismus surgery, and reduce the risk of complications. The device is composed of a lower fixing body with three jaws and an upper supporting body. They are used to clip an extraocular muscle and fix it to the sclera with a single bite. Superior rectus recession on 16 rabbit eyes were performed with this new device. Conjunctival injection, muscle adhesion strength, and light microscopic findings were examined at 1, 2, 4 and 8 weeks postoperatively. The Conjunctival injection were minimal, adhesion power ranged from 420 to 600 gram gravity, which is sufficient in withstand the normal pull of human extraocular muscle. In microscopic exam, some Inflammatory cells and fibrosis were found. The new device was technically easy, fast, and accurate, so it may be useful in stabismus surgery.

재한줌머공동체의 ‘실금’과 한국사회의 다문화 수용력

유승무(Ryu, Seung-Moo),신종화(Shin, Jong-Hwa),박종일(Park Jong-il),이태정(Lee, Tae-Jeong),박수호(Park, Su-Ho) 고려대학교 아세아문제연구소 2013 亞細亞硏究 Vol.56 No.1

The purpose of this paper is to highlight, with the help of the Jumma community, a refugee community in Korea, the way in which the immigrant community is affected by the combination of the two factors, the adaptibility of the immigrants and the receptibility of Korean society. The main argument is to identify the fact that the components of the pre-state identities, which detonates the refugeefication, lead the internal differentiation of the refugee community due to the refugee’s strategy of adaptation, on the one hadn, and the characteristics of supporting organizations of the protection states, on the other. In this paper, first, the special aspects of refugees in their development are investigated, and, second, the Jumma community’s effort to keep their pre-state identities and the formative process of the Jumma community in Korea are evaluated. Thu authors identify the phenomenon of differentiation among refugees through the relationship with the supporting organizations in Korea. This division process of the refugee community possibly accelerates the dissolution and break-up of immigrant community. For this reason, the systematic management of refugees is also required. The outcome of this research includes: first, the immigrant community, which has been assumed as the united and homogeneous community, is internally evolved to different directions; second, the evolution of the immigrant community is led or strengthened by the supporting organizations in Korea which is relate to their own interests; third, the research on refugees, which has been alienated in the immigration and multiculturalsim studies for a long time, is evoked loudly; the importance of religion for the refugees’ adaptation process to the protecting country; last but not least, the Korean society is asked for its multicultural receptive policies to respect the tradition of the immigrant community and to manage their internal differentiation.

Rat의 복강에 삽입한 Filorouracil-Polyglycolic acid제형의 Fluorouracil용출에 관한 연구

노승무,정경수,오정연,김진향,양준묵,강대영,송규상,최정목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

A common form of relapse in adenocarcinoma of the stomach is intraperitioneal dissemination, in fact, among gastric adenocarcinoma patients who have undergone surgery intended to cure, approximately 50% of the patients develope initial recurrence in the peritoneal cavity regardless of the anatomic site of the primary tumor within the stomach. The efficacy of systemic postoperative chemotherapy to prevent peritoneal recurrence of gastrric adenocarcinoma is not satisfactory. There is still a great need for improved therapeutic strategies on the disseminated microscopic disease and small miliary nodules remaining on the peritoneal surface or lymphatics after operation. The authers have made fluorouracil-polyglycolic acid composite disks(Fu-PGA disks) with fluorouracil and biodegradable polymer: polyglycolic acid for more effective intraperitoneal chemotherapy. We inserted the Fu-PGA disk(s) in the peritoneal cavity of rat and pharmacokinetic study was performed to measure fluorouracil concentration in the peritoneal fluid, plasma, liver, kidney and heart tissue at 24 hour, 72 hour and 168 hour after insertion of Fu-PGA disk(s). Myelosuppressive action of this composite also was determined following its administration. The data of this study suggested that Fu-PGA composite will be a new device releasing drugs in a controlled manner and having targetability to peritoneum, and this device will be improving the efficacy of intraperitoneal chemotherapy for gastric adenocarcinoma.

Rat의 복강에 삽입한 Fluorouracil-Polyglycolic acid 제형의 Fluorouracil 용출에 관한 연구

노승무,정경수,오정연,김진향,양준묵,강대영,송규상,최정목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 忠南大學校 癌共同硏究所 1998 癌共同硏究所 硏究誌 Vol.2 No.1

A common form of relapse in adenocarcinoma of the stomach is intraperitoneal dissemination, in fact, among gastric adenocarcinoma patients who have undergone surgery intended to cure, approximately 50% of the patients develope initial recurrence in the peritoneal cavity regardless of the anatomic site of the primary tumor within the stomach. The efficacy of systemic postoperative chemotherapy to prevent peritoneal recurrence of gastrric adcnocarcinoma is not satisfactory. There is still a great need for improved therapeutic strategies on the disseminated microscopic disease and small miliary nodules remaining on the peritoneal surface or lymphatics after operation. The authers have made fluorouracil-polyglycolic acid composite disks(Fu-PGA disks) with fluorouracil and biodegradable polymer: polyglycolic acid for more effective intraperitoneal chemotherapy. We inserted the Fu-PGA disk(s) in the peritoneal cavity of rat and pharmacokinetic study was performed to measure fluorouracil concentration in the peritoneal fluid, plasma, liver, kidney and heart tissue at 24 hour, 72 hour and 168 hour after insertion of Fu-PGA disk(s). Myelosuppressive action of this composite also was determined following its administration. The data of this study suggested that Fu-PGA composite will be a new device releasing drugs in a controlled manner and having targetability to peritoneum, and this device will be improving the efficacy of intraperitoneal chemotherapy for gastric adenocarcinoma.

무연(無緣) 사회 현상의 사회학적 이해

유승무(Lew, Seung-Moo),박수호(Park, Su-Ho),신종화(Shin, Jong-Hwa),이민정(Lee, Min-Jung) 한국이론사회학회 2015 사회와 이론 Vol.27 No.-

이 논문은 최근 한국 사회에서 점차사회문제로 부상하고 있는 무연 사회 현상을새로운 관점에서 이해하기 위한 이론적프레임의 모색을시도하였다. 이러한 문제의식의 기저에는 일본 NHK가 무관계 사회 혹은 무연고 사회로 정의한 ‘무연 사회’라는 개념이 사회학적 맥락에서 성립 불가능한 모순된 개념임에도 불구하고 무비판적으로 사용되고 있다는 인식과 고령화나 가족 및 공동체의 해체 등을 무연 사회의 원인으로 규정하는 선행 연구들의 피상성을 극복해야 할 필요성이 자리하고 있었다. 이와 같은 문제의식을 해결하는 과정은 무연 사회 현상의 바탕에 마음의 멀어짐과 닫힘이 있음을 확인하는 것에서부터 출발하였다. 2000년 이후 14년 동안 주요 4개 일간지에 사용된 단어들의 활용 빈도와 그들 사이의 상관성을 통해 사회적 관계로서 의연(緣) 현상이 마음과 일정한 상관관계를 가지고 있으며, 연줄과 절연 및 무연고라는 단어의 사용이 정적인 관계를 보이고 있음도 확인하였다. 그리고 절연과 무연 사회 현상에는 갈등이나 트라우마 같은 마음고생의 계기가 존재하며, 관계 회복을 위한 의지와 마음의 강도에 따라 절연 상태의 유지 여부가 달라질 수 있음을 구체적 사례들을 통해 알 수 있었다. 이상의 사실들을 통해 ‘연’이라는 사회적 현상이 구체적 사회관계의 잠재성으로서 ‘포함과 배제의 상즉상입 과정’과 ‘관심과 무관심의 상즉상입’이라는 마음의 매개과정이 일정한 방식으로 결합함으로써 친근과 소원이라는 두 가지 유형의 관계로 발현하며, 대인관계와 집단관계라는 관계적 차원에 따라 모두 네 가지의 ‘연’ 유형이 나타남을 모델화하였다. 그리고 내재적, 외재적요인에 의해 촉발된 갈등상황이 축적됨으로써 발생한 마음의 실금이 관계 회복을 위한 노력의 정도에따라 우호적 관계를 복원하거나 절연상태로 전개되며, 다양한 관계에서 절연 현상이 중첩적으로 나타날때 무연 사회 현상이 나타남을 도식화할 수 있었다. 마지막으로 이 논문의 연구결과는 마음을 사회적 배제의 요인으로 도입해 사회적 배제 이론의 지평을 확장하고, ‘마음의 사회학’을 발전시키는 데 기여하고, 사회관계의 회복을 통해 무연 사회 현상의 예방 및 무연 상태의 사회적 약자들이 사회에 기여할 수 있는 방안을 모색하는 계기가 될것으로 기대한다. This paper aims at building a theoretical framework for newly understanding so-called ‘no-relationship’ society, which is emerging as a social problem in the Korean society recently. This purpose is based on the necessity of overcoming superficiality of the term, ‘no-relationship’ society from a Japanese broadcasting company, NHK, on the one hand, and of the previous literature which poins out aging society or the fragmentation of family and community as the main cause of rising ‘no-relationship’ society, on the other. Authors get this study started where there is a social fact that one’s heart(마음, 心) is distantiated from a relation with the others and closed finally, under the phenomenon of ‘no-relationship’ society. Authors also identify, with a longitudinal study of daily newspaper on the text mining technique, that the phenomenon of Yeon(연, 緣) as the social relation in the to some extent correlation with heart, at first, relational line(연줄, yeon-jool), cutting relation(절연, 切緣, jeol-yeon), and no-relationalbackground(무연고, 無緣古, moo-yeon-goh), these three words show positive relations each other in the correlation test of a statistical approach, at second. By the way, authors recognize that there are motives of psychological heart troubles, for example conflict, trauma, in the phenomenon of cutting relation and no-relationship society, on the one hand, and whether the state of cutted-relation is maintained or not, namely relationship is restored, is dependent on the strength of will and heart for reviving relations. Authors build two research models: the first one shows that two types of relations, closenss and estrangement are developed as a combinational consequence of ‘the mutual process of inclusion and exclusion’ and ‘the mutual penetration and wayout of concern and indifference’. The second one has four type of ‘relation(yeon)’ on the relational dimension of individual and group relations. Besides, draw a picture that no-relationship society appears when the cutting-relation phenomena in several relations are overlapped. There are two ways: the state of cutted-relation and the restoration of friendship. These are the result of effort to revive relations overcoming micro fragmentation of heart occurred by the accumulation of conflict caused by internal and external factors. Authors expect with the paper that the theory of social exclusion and the sociology of heart are connected by the way of introducing ‘heart’ as the factor of social exclusion and it would promote to find solutions for social minorities in the state of no-relationship and prevent them from other phenomena of no-relationship society through the restoration of social relations.

생체분해성 망막압정을 이용한 망막고정에 대한 실험적 연구

김용백,민병무,김창식,박근성,김승영,길숙종,조항진,이성복,노승무,송규상,강대영,조준식,양준묵,정경수,최선웅,이진호,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Biodegradable retinal fixation devices obtain mechnical fixation of the retina with desirable chorioretinal scarring and with the potential for local, sustained release of antimetabolites and steroids to inhibit proliferative vitreoretinopathy. We manufactured a biodegradable retinal tack with barb that was designed in order to prevent intrusion from implantation of retinal tacks. This study was carried to evaluate the efficacy for retinal fixation and the capability for sustained release of drugs with a newly designed biodegradable retinal tack Biodegradable retinal tacks were made of polymers of glycolic acids and were designed with barbs in a shape to prevent the disinsertion. Biodegradale retinal tacks are divided into 3 parts, a conical portion that is inserted into the sclera, a cylinder portion that remains in the vitreous, and a neck portion between the pin and the cylinder. The tapered conical end was manufactured to allow easy insertion through the retina and choroid into the sclera. A cylinder portion was manufactured with a tapered angle that fixes firmly into the orifice of 19 gauge spinal needle. A neck portion, 0.4 mm in diameter, was designed to prevent disinsertion from following implantation of retinal tack. The applicator was a 19 gauge spinal needle and its orifice was prepared to 15°angle to accept the tapered cylinder portion of the retinal tack. The retinal tacks, secured in the needles, were passed through the formed vitreous and inserted into the retina, choroid, and sclera and were released by pushing the internal needle, usually within 2-3mm of the medullary ray of the posterior rabbit retina A retinal tack was placed in each of 8 pigmented rabbit eyes. Slit-lamp biomicroscopy, indirect ophthalmoscopy and fundus photography were performed periodically from 1 day to 8 weeks after surgery. Eight eyes were enucleated and studied by light microscopy at 8 weeks. Biomicroscopic evaluation of the animals revealed edemas adjacent to the retinal surfaces immediately after insertion of the biodegradable retinal tacks in all the animals. These edemas disappeared after 1 week. The first noticeable change in the size of retinal tacks was shown after 2weeks. The size of the retinal tacks gradually got smaller, decreasing to about one-half at 4 weeks and about one-third at 8 weeks. All retinal tacks remained in inserted places without any movement for an 8 week period. On light microscopy, epiretinal proliferations were seen to extend into the vitreous cavity. Cellular capsules that lined the inner aspect of the scleral defect caused by tack insertion were found. However the adjacent retina had a normal cytologic appearance and architecture in all specimens. We manufactured a biodegradable retinal tack that is designed to prevent intrusion from implantation of retinal tacks. All biodegradable retinal tacks reduce in size with time, but no retinal tacks extruded from the inserted place. The newly designed biodegradable retinal tack can be used for retinal fixation and may be used as a vehicle for the introduction of pharmacologic agents to prevent the cellular events that promote proliferative vitreoretinopathy.

백서의 복강내에 투여한 Mitomycin-C-Polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

송규상,강대영,최정목,노승무,정경수,오정연,김진향,양준목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

To evaluate the in-vivo effects of mitomycin-C-polyglycolic acid composite(MMC-PGA) the disk: shaped composite were implanted into the peritoneal cavity of the Sprague-Dawley rats. The pathologic changes were examined at various time points up to 12 weeks. Initially the soft tissue around the inserted disks showed capillary congestion at 3 days. Inflammatory infiltrates with foreign body giant cells appeared from the 2nd week and reached peak response at 6-8 weeks. These reaction diminished prominently at 12 weeks. No specific pathologic change was found in the liver, the kidneys, and the heart. The above results suggest that the MMC-PGA composite can serve as a new device for intraperitoneal chemotherapy of various types of cancers.

Rat의 복강내에 투여한 5-fluorouracil-polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

강대영,송규상,최정목,노승무,정경수,오정연,김진향,양준묵,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

For more effective intraperitoneal chemotherapy, the authers made 5-fluorouracil-polyglycolic acid composite disks(FU-PGA disks) with 5-fluorouracil and polyglycolic acid, a biodegradable polymer. We inserted the FU-PGA disk into the peritoneal cavites of Sprague-Dawley male rats, the control and three experimental groups; one FU-PGA disk insert group(300mg/kg), two FU-PGA disk insert group(600mg/kg), and three FU-PGA disk insert group(900mg/kg). The control group received a similar number of PGA disk inserts. A pharmacokinetic study was performed to measure the 5-fluorouracil concentration in the peritoneal fluid, blood, and tissues(liver, kidney and heart) at 24 hours, 72hours and 168 hours after insertion of the FU-PGA disk. Light and electron microscopic studies were done. The results were as follows: 1) The number of white blood cells and platelets decreased after FU-PGA insertion. The degree was proportional to the duration and amounts inserted. The change in the number of red blood cells varied slightly. 2) Light microscopically, slight changes were noted at 168 hours in the 3 disk insert group (900mg/kg). Mild fatty change and hepatocyte degeneration around the central veins of the liver were noted, with vacuolar degeneration in the proximal convoluted tubules of the kidney. 3) Electron microscopically,the liver showed focal increases of lipid droplets in the hepatocytes, and irregular nuclear membrane with focal nucleolar segregation of the fibrillar and granular elements. Also the double membranous structure of the hepatocytes and Kupffer cells was widened with bleb formation. The kidney showed wide separation of the nuclear double membrane in the proximal convoluted tubular cells and mesangial cells, with vacuolation and myelin figure formation in the mitochondria of the proximal convoluted tubular cells, at 72 hours and 168 hours in the 2 to 3 FU-PGA insert groups. The heart showed focal loss of cristae,vacuolation and myelin figure formation in the mitochondria of the 2 to 3 FU-PGA insert groups. In conclusion, despite the large amont of FU-PGA inserted, the histopathological changes in the liver, kidney and heart were slight, and consonant with the very low amount of 5-fluorouracil concentrations detected in the liver, kidney and heart. The above results suggest that the FU-PGA composite can serve as a new device for releasing drugs in a controlled manner and easily targeted to intraperitoneal organs. This device can improve the efficacy of intraperitoneal chemotherapy for gastric cancer.

Berkshire 種과 Landrace 種의 産仔能力의 比較에 관한 調査 硏究

文勝式 건국대학교 1976 論文集 Vol.4 No.1

This study was carried out to determine the breed differences in some reproductive performances between Berkshire and Landrace pigs. The reproductive records of 284 Berkshire and 383 Landrace sows at Sacheon Branch, National Livestock Breeding Station, Korea from 1970 to 1975 were analysed statistically, 1. The average length of gestation was 115.89 + 0.51 days in Berkshires and 114.94 + 0.11 days in Landraces. The breed difference in gestation length was not significant in both or either of farrowing seasons. The sows which farrowed in the spring had a little longer gestation period. 2. The average litter size at birth was 8.97 +0.13 pigs in Berkshires and 9.87+0.13 pigs in Landraces. The litter size at birth of Landrace sows was significantly larger in both or either of farrowing seasons than that of Berkshires. Berkshire sows farrowed a little more pigs in the spring but Landrace ones did in the fall. The little size at birth of Landraces was significantly larger in any farrowing number than that of Berkshires. In both the breeds it was increased slightly as the farrowing advanced. 3. The average birth weight per litter and pig was 11.24 + 0.20 kg and 1.25 + 0.01 kg in Berkshires and 13.16 + 0.16 kg and 1.33 + 0.01 kg in Landraces. The birth weight per litter and pig in Landraces was significantly heavier in both or either of farrowing seasons than that of Berkshires. In any farrowing number breed difference was observed but the breed difference in birth weight per pig was not significant in the sows over the fourth farrowing. 4. The average litter size at weaning was 7.50 + 0.11 pigs in Berkshires and 7.91 +0.09 pigs in Landraces. The litter size at weaning of Landraces was significantly larger in both the seasons than that of Berkshires. Landrace sows had significantly larger litter size at weaning in the third farrowing and a little larger in the other farrowing number than that of Berkshires. The average percentage of pigs raised to weaning was 78.48% in Berkshires and 75.85 in Landraces. The breed difference of this trait was significant in both the farrowing seasons. The more pigs were raised to weaning in Berkshire sows of the first to the fourth farrowing but in Landrace sows over the fifth farrowing. However the breed difference of this trait was significant only in the fourth and the fifth farrowing. 5. The average weaning weight per litter and pig was 106.18 + 1.90 kg and 14.09 + 0.21 kg in Berkshires and 130.65 + 1.65 kg and 16.52 + 0.11 kg in Landraces. The weaning weight of litter and pig of Landraces was significantly heavier in both or either of farrowing seasons than that of Berkshires. In both the breeds the sows which farrowed in the spring clad the heavier weaned litters and pigs. In any farrowing numbers the Landrace sows had the significantly heavier litters and pigs.

항문직장 기형에 대한 임상적 고찰

노승무,장일성 대한대장항문학회 1989 Annals of Coloproctolgy Vol.5 No.1