정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

우관상동맥 개구부 완전 폐쇄가 동반된 대동맥 판상부 협착증 1례

임상현,김종진,김희열,진승원,전희경,노태호,채장성,김재형,홍순조,최규보,윤정섭,김치경 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

자발성 뇌교출혈 환자의 예후에 관한 임상 분석

조재영,석종식,민병국,권정택,최덕영,황성남,김영백,박승원 중앙대학교 의과대학 의과학연구소 2002 中央醫大誌 Vol.27 No.1

Patients with spontaneous pontine hemorrhage very often develop setvere disturbances of consciousness,pupilary abnormalities, respiratory and motor. They have high mortality rate. Therefore, I analyzed the correlation between the Glasgow outcome scale(GOS)and clincial manifestations or computed tomographic(CT)findings in 48 patients with spontaneous pontine hemorrhage to clarify factors predicting the prognosis. I examined 48 Patients with spontaneous pontine hemorrhage; 33 males and 15 females, age 54.6±8.99(mean±S.D.;range 39 to 68)brought to our hospital between January 1995 and December 1999, retrospectively. Correlations between the clinical manifestations, CT findings and the GOS was assessed with multivariate regression analysis. The results were as follow: 1) Patients with the pontine hemorrhage were of 8.8% in those with intracerebral hemorrhage. The ratio of male and female was 33 to 15. The incidence of age is eqial to 40,50 and 60. Total mortality was 41.6%. 2) The poor prognostic factor were that; Glasgow coma scale(GCS)3∼8, irregular respiration. pupilary abnormality, quadriplegia, Brain CT typeⅠ(massive), hydrocephalus, extrapontine extension, Intraventricular hemorrhage(IVH). These clinical analysis should be useful in determining the level of care and future resuscitative efforts.

中年期婦人에서 흔히 발생하는 婦人科 疾患

金丞兆 대한가정의학회 1984 Korean Journal of Family Medicine Vol.5 No.2

쾌적한 도시환경 조성을 위한 어메니티자원 조사 및 발굴에 관한 연구 : 부산광역시 서구를 중심으로

김승환,박승범,강영조,남정칠,도창희 東亞大學校 1997 東亞論叢 Vol.34 No.-

This study tries to survey and extract amenity resources for the creation of urban amenities Seo-Gu at Pusan city was selected due to abundant amenity resources in the region. The process of research methodology as follows; Firstly, various types of amenity resources were collected by literature and preliminary survey. The resources were classified into 5 categories as park and greenery, natural, historic, cultural and life resources. These were reclassified such three types of detailed frames existing, potential and extractable forms. Secondly, the detailed information on amenity resources in the site was gathered by visiting all Dongs in Seo-Gu. Furthermore, careful amenity watching survey was carried out to extract potential in citizen`s common behavior. Then, amenity resources was evaluated through the assessment survey of landscape architects and other professionals. Finally, amenity resources maps were produced based on the evaluation of the selected amenity resources. The total amenity resources in Seo-Gu amount 169, which comprised of 81 existing resources, 22 potential resources, and 66 extracted resources. In order to create and maintain the best quality of urban amenity, it`s important to have this kind of amenity resources map. Citizen, planners and policy makers can use these to make better urban environment by providing the information of existing, potential and extractable amenity resources which may enhance the pride and affection for the citizen.

부가가치생산성 측정법의 기업단위 적용방식에 대한 새로운 접근

조승제,김승용 조선대학교 경영경제연구소 2000 經營經濟硏究 = Management and economics research Vol.23 No.2

靈芝버섯 栽培方法 改善에 關한 硏究

金成朝,李甲湘,李基炫,白承和 圓光大學校 1993 論文集 Vol.27 No.2

靈芝載培에 있어서 一般的인 栽培法을 改善하여 靈芝의 收穫量을 높이고 品質向上을 시킬 目的으로 菌絲의 活着條件, 種菌接種 時期 및 方法, 버섯培養地의 土養種類 등을 달리하고, 栽培舍 構造設備을 改良하여 靈芝를 栽培한 結果는 다음과 같다. 種菌接種短木에 菌接種時期가 1月, 12月, 2月, 3月, 4月, 順으로 氣溫이 올라 갈수록 菌絲活着 期間이 빨라져 버섯培養할 때 까지의 菌絲培養 期間을 10日 以上 短縮할 수 있었다. 菌絲培養床의 크기 中 菌絲培養床 幅을 各各 0.8m,1.2m로 하였을 때 같은 菌絲培養期間 동안의 菌絲活着率은 89.6%, 96.4%, 91.2%가 되어 菌絲培養床 幅이 1.0m에서 菌絲活着率이 가장 높았다. 接種短木에 種菌을 接種 後 密封方法은 스치로폴을 막은 後 파라핀으로 密封한 것이 菌絲培養條件에 關係없이 푸른곰팡이 發生率이 가장 낮았고, 스치로폴만 막은것도 新聞紙를 材料로 菌絲培養 條件을 改善하여 푸른곰팡이의 發生率을 파라핀으로 完全히 密封 것과 거의 같은 水準으로 抑制 시킬 수 있었다. 二重 비닐하우스 栽培舍內의 內部 하우스에 遮光幕을 設置함으로서 一般 裁培舍 하우스의 6個月 水準의 靈芝生育 適溫期間을 8個月 以上 까지 延長할 수 있었고, 收穫回數를 年 2回에서 4回로 늘릴 수 있었다. 內部 하우스에 遮光幕을 設置하여 改善한 栽培舍에서는 버섯培養 後 2年次에 目標水準 收穫量의 96.9% 까지 收穫할 수 있었는데 一般 栽培舍에서는 目標 收量의 89.1%만 收穫할 수 있었다. 收穫量에서도 改良 栽培舍의 上品靈芝收量이 一般 載培舍에 比하여 1.5倍의 增收를 보였다. 粘土含量이 가장 많고 모래 含量이 적은 E 土壤에서 雜菌發生이 가장 甚하여 靈芝의 收穫量 및 品質이 가장 低調하였다. To increase the yield and to obtain much better the quality on grown Ganoderma lucidum cultured, these experiments were conducted under carefully controlled in greenhouse with the following conditions on spawn spread related with tentative planting time of short timber inoculated, sealing methods with styrofoam only used and with sealing wax after styrofoam used, soil textures of planting sites, temperatures and growing time as the outside shield was commonly culture method and the inside shield was one of the methods improved itself in these experiments with double vivyl greenhouse. The results were as follow: Speeds of spawn spreading on inoculating Ganoderma lucidum to the short timber were faster when the temperatures were increasing as Jan.<Dec.<Feb.<Mar.<Apr., and it could be short more than 10 days for tentative planting time with inoculation. During the same time of tentative planting the rate of spawn was the highest at the width of 1.0m when the widths of tentative planting hotbets were 0.8, 1.0, and 1.2m, and the rates were 89.6, 96.4, 91.2%, respectively. Occurrences of green mold on inoculated timbers were the lowest as the sealing wax after styrofoam used without the conditions of tentative planting, and when there were surrounding the pile of timbers with styrofoam only used to seal inoculating holes with the second hand newspapers, those were almost the same level as the sealing wax after styrofoam used. When the shield over the roof of the inside greenhouse in the double greenhouse was set, the time on growing could be prolonged until more than 8 months and the yield could be increased 2 times more from 2 to 4 times as compared with the outside shielding over the vinyl that was the common culture method to be known. The culture with inside shielding could improve to be possible that the 96.9% of objective yield was done during two years only and that the amount of the best qualities was 1.5 times than in the common culture, the outside shielding, there was 89.1% of yield only at the same time. In sandy caly that was the least sand and was the most clay of the soils experimented there was the least of yield, there were the plenty of various germs occurred and there was not good in the quality.

편백 잎(葉) 정유 성분의 항균(抗菌)활성 물질 분석

조종수,김사익,윤승락,노정관,나종범,김동귀,최길동 진주산업대학교 산업과학기술연구소 2007 산업과학기술연구소보 Vol.- No.14

To investigate the antimicrobial effects of essential oil in the leaves of Chamaecyparis obtusa extractives by paper disc method, the extractives were fractionated into four portions. In antimicrobial test, essential oil in the leaves of Chamaecyparis obtusa was found to have strong inhibitory effects against the growth of Bacillus subtilis and Staphylococcus aureus. A part of analyzed inhibition components of essential oil in the leaves of Chamaecyparis obtusa from GC-MS was supposed to be α,β-pinene, α-terpinolene, camphor, β-myrcene, 1-α-terpinolene, 4-thujen-2-α-yl, limonene, Cardinene.

부인과 영역의 오진(誤診)

김승조 大韓法醫學會 1991 대한법의학회지 Vol.15 No.2

The type of misdiagnosis in gynecological diseases can characteristically derived from various sorts of technical and analogic errors dealing with various informations from menstrual disorders, infertility, abnormal vaginal bleeding, infections, neoplasms, pregnancy related disorders, congenital anomalies, pelvic pains, and psychosomatic diseases, it is important that misdiagnoses are not less often be fatal in gynecological than in other patients. It's because the diseases themselves are mostly related with hemorrhage, septic infection and pregnancy related immune deficiency. Recently, there have appeared so many mordern untrafashionable medical instruments which can dramatically reduce the misdiagnoses such as ultrasonography, and MRI etc. and otherwise physicochemical methods. In our neighborhood, however, we can see so many occasions with negative aspects of medical environment including misdiagnoses, medical accidents and medicolegal conflicts. As a fundamental reason, negligence to develop abilities that human can achieve in the power of attention and concentration to reduce errors can easily be considered. Another important thing for medical doctors to make misdiagnosis is failure in maintaining a good para-medical human relationship, the rapport and the cooreariton with the patients. Furthermore, indirect influences deriver from so many unreasonable political and medicososcial environments such as restricting medical insurance systems which can cause down regulation of the quality of medical treatment must be corrected or abolished, and , on the other hand, establishment of national political and socioenvironmental atmosphere to secure the adequate treatment will also be important to reduce misdiagnosis.

부산시 가로수 현황과 토양환경개선에 관한 연구

김석규,박승범,남정칠,김승환,강영조 동아대학교 건설기술연구소 1999 硏究報告 Vol.23 No.2

The purpose of this study is to analyze the correlation between soil hardness, soil acidity, and the vitality of street trees. This data was investigatived in 40 areas on 10 main street routes of Pusan; Chungang-ro, Naktong-ro, Suyeong-ro, Taejong-ro, Konghang-ro, Kudeok-ro, Kumjeong-ro, Mandeok-ro, Kaya-ro, Chungjang-ro. The findings are as follows : 1. The average soil hardness where tree grates have been built was shown to be 22.23㎜. In the absence of tree grates, the average soil hardness was 24.60㎜. These figures do not exceed the accepted parameters for acceptable soil hardness when rearing trees (22∼25㎜). However, soil hardness was measured higher in areas where tree grates were absent. Consequently, tree grates are necessary. 2. Soil acidity was measured as satisfactory(pH 5.5), mediocre(pH 5.5∼5.0), inferior(pH 5.0∼4.5), very inferior(pH 4.5). No areas were measured as satisfactory soil acidity. Four areas were measured as mediocre(10%), 19 areas as inferior(47.5%), and 17 areas as very inferior (42.5%). This indicates a requirement to improve soil acidity as about 90% of the investigatived areas were measured as either inferior or very inferior. 3. The following is an analysis of correlation between soil hardness, soil acidity and the vitality of the Ginkgo biloba ; The Ginkgo biloba was found to have a positive correlation was measured with the diagram (R²). In conclusion, the results of the analysis show a strong influence of soil hardness and soil acidity upon the vitality of Street Tree.