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- 저자 : Sergio Gonzalez-Munoz (검색결과 2 건)
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Angelica S. Gonzalez-Garibay,Alfonso Lopez-Vazquez,Jesus Garcıa-Banuelos,Sergio Sanchez-Enrıquez,Ana S. Sandoval-Rodrıguez,Susana Del Toro Arreola,Miriam R. Bueno-Topete,Jose F. Munoz-Valle,Mercedes E 한국식품영양과학회 2020 Journal of medicinal food Vol.23 No.3
Excess of visceral adipose tissue (VAT) characteristic of obesity leads to a proinflammatory state disrupting the insulin signaling pathway, triggering insulin resistance (IR) and inflammation, the main processes contributing to obesity comorbidities. Ursolic acid (UA), a pentacyclic triterpenoid occurring in a variety of plant foods, exhibits anti-inflammatory properties. The aim of this study was to evaluate UA effects on IR, hyperinsulinemia, and inflammation in experimental diet-induced obesity. Forty male Wistar rats were randomly assigned to eight groups (n = 5). One group was used for time 0. Three groups were labeled as OBE (control): receiving high-fat diet (HFD; fat content 45.24% of energy) during 3, 6, or 9 weeks; three groups UA-PREV: exposed to simultaneous HFD and UA during 3, 6, or 9 weeks to evaluate UA preventive effects; one group UA-REV: receiving HFD for 6 weeks, followed by simultaneous HFD and UA for three additional weeks to analyze UA reversal effects. Measurements were performed after 3, 6, or 9 weeks of treatment. Adiposity was calculated by weighing VAT after sacrifice. Serum markers were quantified through colorimetric and enzyme-linked immunosorbent assay methods. VAT adipokines RNAm expression was evaluated by quantitative reverse transcriptase–polymerase chain reaction. Data were analyzed by Kruskal–Wallis and Mann–Whitney U tests. UA significantly decreased adiposity, IR, hyperinsulinemia, triacylglycerides, and cholesterol levels, and also VAT mRNA expression of MCP-1 (monocyte chemoattractant protein-1), IL (interleukin)-1β and IL-6, concomitantly increasing adiponectin levels. UA metabolic effects demonstrated in this study support its potential therapeutic utility to improve IR, hyperinsulinemia, and inflammation observed in obesity and diabetes.
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Growth performance and health of nursing lambs supplemented with inulin and Lactobacillus casei
Marco A Ayala-Monter,David Hernandez-Sanchez,Sergio Gonzalez-Munoz,Rene Pinto-Ruiz,Jose A Martinez-Aispuro,Nicolas Torres-Salado,Jeronimo Herrera-Perez,Adrian Gloria-Trujillo 아세아·태평양축산학회 2019 Animal Bioscience Vol.32 No.8
Objective: This experiment was designed to evaluate the effects of Agave tequilana inulin and Lactobacillus casei (L. casei) on growth performace, hematological variables, serum metabolites, and total coliforms in nursing lambs. Methods: The experimental design was completely randomized; treatments were T1, control (pre-starter concentrate, PC), T2: T1+2% inulin, and T3: T1+2% inulin+L. casei; treatments were compared with Tukey test (p≤0.05); and 45 new born Kathadin×Dorset lambs (4.8±0.8 kg birth weight) were the experimental units (15 per treatment). The variables were daily weight gain (DWG), dry matter intake and diarrheas incidence (%) during 56 d. Twenty-four hours after birth and at the end of the experiment, blood samples were collected to evaluate hematological variables and serum metabolites. Besides, the populations of total coliforms and lactobacilli were estimated in fecal samples. Results: Addition of agave inulin and L. casei increased (p≤0.05) DWG 356, 384, and 415 g/d, weaning weight 24.92, 26.18, and 28.07 kg, as well as lactobacilli population 5.79, 6.32, and 6.48 Log10 cfu/g, for T1, T2, and T3, respectively. Lambs fed L. casei had decreased (p≤0.05) populations of total coliforms (T1 = 6.18, T2 = 5.77, and T3 = 5.07 Log10 cfu/g), diarrheas incidence (T1 = 11.67%, T2 = 8.33%, and T3 = 5.0%), and serum cholesterol concentration (11% in T2 and 13% in T3, compared to control). Conclusion: The combination of Agave tequilana inulin and L. casei increases weight gain and improves intestinal health by reducing coliforms and diarrheas incidence in Katahdin× Dorset lambs during the pre-weaning period.
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