Adiponectin Attenuates the Inflammation in Atopic Dermatitis-Like Reconstructed Human Epidermis

( Hee-seok Seo ),( Ki Hyun Seong ),( Chang-deok Kim ),( Seong Jun Seo ),( Byung Cheol Park ),( Myung Hwa Kim ),( Seung-phil Hong ) 대한피부과학회 2019 Annals of Dermatology Vol.31 No.2

Background: Atopic dermatitis (AD) is a chronic disorder, with a vicious cycle of repetitive inflammation and deterioration of the epidermal barrier function. Adiponectin, an adipokine, has anti-inflammatory effects on various metabolic and inflammatory disorders. Recently, its level was found to be reduced in serum and tissue samples from AD patients. Objective: We aimed to investigate the effects of adiponectin on epidermal inflammation and barrier structures in AD skin. Methods: A three-dimensional in vitro epidermal equivalent model mimicking AD was obtained by adding an inflammatory substance cocktail to normal human epidermal equivalents (HEEs). The expression of epidermal differentiation markers, primary inflammatory mediators, and lipid biosynthetic enzymes was compared between adiponectintreated AD-HEEs, untreated control AD-HEEs, and normal HEEs. Results: Adiponectin co-treatment 1) inhibited the increase in mRNA expression of major inflammatory mediators (carbonic anhydrase II, neuron-specific NEL-like protein 2, thymic stromal lymphopoietin, interleukin-8, tumor necrosis factor-alpha, and human beta-defensin-2) from keratinocytes in AD-inflammatory HEEs, 2) enhanced the expression of lipid biosynthetic enzymes (fatty acid synthase, HMG CoA reductase, and serine-palmitoyl transferase), and 3) promoted the expression of differentiation factors, especially filaggrin. We also found that the expression of adiponectin receptor-1 and -2 decreased in the epidermis of chronic AD lesion. Conclusion: Activation of the adiponectin pathway is expected to enhance epidermal differentiation and barrier function as well as attenuate inflammatory response to AD as a therapeutic approach. (Ann Dermatol 31(2) 186∼195, 2019)

Study on the Weldability and Mechanical Characteristics of Dissimilar Materials (Al5052-DP590) by TIG Assisted Hybrid Friction Stir Welding

Hee‑Seon Bang,Seong Min Hong,Atanu Das,Han‑Sur Bang 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.5

Hybrid friction stir welding, adopting an external pre-heat source in front of the friction stir welding (FSW) tool, is knownas a way of overcoming the disadvantages of conventional FSW; lack of plastic flow and excessive tool wear. In joining ofaluminum alloy to steel, presence of intermetallics (IMC) is essential, but its excessive growth can degrade the joint qualityby its brittleness. In this study, joining of 2.5 mm thick Al5052 aluminum alloy and 1.4 mm thick DP590 high strength steelhas been carried out by FSW and TIG assisted hybrid friction stir welding (HFSW) through experiments and numericalanalysis. Joints characteristics of two process was compared to optimize the process parameters. A 3-D model was developedto estimate the thermal elastic–plastic characteristics of the joints. It was confirmed that the joint efficiency of HFSW jointshas been improved to 84% than that of FSW (74%). 2.74 μm thickness of IMC layer was formed in HFSW joints and satisfiedthe permissible thickness (under 10 μm). The maximum residual stress (σzz) in welding direction was slightly higherat the HFSW joints than at the FSW joints. The overall results from experiment and simulation confirmed that HFSW is aneffective way of joining Al5052 to DP590.

문학 작품 감상 교육의 연구 방안 : 시 감상 교육의 이론과 수용자의 반응을 중심으로

이희중,강성도,정성모,이창호,조성리 전주대학교 교육문제연구소 2000 敎育論叢 Vol.15 No.-

國內飼育 犬에 있어서 心臟絲狀蟲의 感染率에 관한 調査 硏究

Ji Hee Seong(成知禧),Hwa Joong Yoon(尹和重),Won Chang Lee(李元暢),Kwang Ho Kim(金光浩),Seung Won Kang(姜承遠) 한국예방수의학회 1996 예방수의학회지 Vol.20 No.2

The purpose of this study was carried out an epidemiological survey on the prevalence rate of the canine heartworms in Seoul City and the districts of Pa-Ju, Seong-Nam and Po-Chon in Kyonggi province of Korea from September 1994 to the end of September 1995. The blood samples from 292 male and 193 female dogs (pet, 363 ; fighting dogs, 60 ; working dogs, 62) were examined for the adult heartworms cuticle antibodies using the enzyme-linked immunosorbent assay (ELSA) kits. The test was designed to detect the antibodies of the host against the specific cuticle antigens produced with the adult heartworms.

Algal bioassay 에 의한 조류생장 제한영양염류 결정

오희목(Hee Mock Oh),이석준(Seog June Lee),김성빈(Seong Bin Kim),박미경(Mi Kyung Park),윤병대(Byung Dae Yoon),김도한(Do Han Kim) 한국하천호수학회 1998 생태와 환경 Vol.31 No.2

Determination of Limiting Nutrient for Algal Growth by Algal Bioassay. Oh, Hee-Mock, Seog June Lee, Seong-Bin Kim, Mi- Kyung Park, Byung-Dae Yoon and Do-Han Kim (Environmental Microbiology Research Unit, Korea Research Institute of Bioscience and Biotechnology, Taejon 305-333, Korea and Water Resources Research Institute, Korea Water Resources Corporation, Taejon 305-390, Korea) Water quaiity and algal growth potential (AGP) using Microcystis aeruginosa were investigated from April to September 1997 in Daechung Reservoir. Secchi disk transparency was 1.1 m in August. Chlorophyll-a concentrations were higher than 10㎍/l at all samples. Total phosphorus concentration was in a range of 0.020∼0.027mg/l which is at the approximate value of 0.03 mg/l, the general critical level of eutrophication. These results indicate that Daechung Reservoir is in an eutrophic state except some temporary times and restricted sites. Phosphorus uptake rate of M. aeruginosa was higher in the water from the epilimnion than in the hypolimnion and also higher under light condition than under dark condition. Therefore, phosphorus uptake rate appears to depend on cellular phosphorous content and light condition, a meaning of endergonic process. Phosphorus was the most frequently limiting nutrient: phosphorus was limiting algal gowth in April and May, nitrogen, phosphorus and trace elements were the limiting factors for algae in August, and trace elements in September. If a fast growing alga, M, aeruginosa, is used as a test organism for assaying AGP, in vivo fluorescence instead of dry weight can be measured for algal biomass and incubation period can be reduced from traditional 14 days to 7 days.

京畿道 安城郡 농촌의 乳兒영양법 실태조사

李星熙,李賢子 안성산업대학교 1983 論文集 Vol.15 No.-

an ecological survey of early childhood nutrition was conducted from June 1 to July 16, 1983, to study the feeding method and weaning practice in An Seong-Gun, Kyonggi-do. This study covered a total of 197 children. The followings are the results of this survey. 1) Breast feeding was 70.6% of infants, bottle feeding, 12,9% and mixed feeding, 16.5%. 2) Only 29.4% of the subjects included began to be fed supplementary food before the age of 6 months. 3) The supplementary food used most frequently by the majority of children at the beginning of weaning was plain cooked rice; rarely preparation not so different from the food eaten by the family. 4) The infants of high educate mother's were greatly faster in the period of weaning and stopping of breast feeding than those of low educated mother's. 5) 55.3% of the subjects were before 12 months, 24.7% were between 13 and 18 months of age, 8.2% were between 19 and 24 months of age, 5.9% of the subjects were before 6months and after 25 months. 6) As for methods of stopping breast feeding 51.8% of the subjects were naturally terminated while 32.9% were forced to terminate by the application of sticking plaster or medicins to the mother's nipples. 7) The remarkable recognition is that the mother's of this rural area shows more high interest in the proper period and the reason for supplementary foods tan those of any other ares. As the result of the above survey, the mother's of this rural area require the nutrition education to improve the weaning practice.

인터넷 조사를 이용한 구성원 정보 데이터베이스 시스템 설계 및 구현

곽난희,남기성,문덕희,박희창 창원대학교 정보통신연구소 2000 精報通信論文集 Vol.4 No.-

A system that designed and implemented in this paper was composed of database system, online survey system, OLAP system, and online report system. Data of this system put in online survey system, and summated past saved database data. And OLAP system analyzed input data. Online report system prints output at real time that composed of basic information(tables and graphs etc.) for policy determine. All system operate on WWW. Also this data are using in high class statistics program.

전국 단위 감시체계의 현황과 전망

강성규,안연순,지영구,김형옥,하미나,권호장,백남종,김성아,홍윤철,김재용,강대희,정혜선,하은희 대한산업의학회 2001 대한직업환경의학회지 Vol.13 No.2

우리나라 지역 직업성질환 감시체계의 현황과 전망

임종한,장성실,김성아,문재동,채창호,홍윤철,김수영,김진석,김영욱,한상환,이혜숙,원종욱,송동빈,하은희,강성규 대한산업의학회 2001 대한직업환경의학회지 Vol.13 No.2

기존의 특수건강진단과 작업환경측정을 통한 직업병 관리가 진폐증, 소음성난청 등의 소수 특정질환에 국한되고 실제 직업병 발생 규모 파악이나 신종 직업병의 발견에 한계를 보인다는 사실은 산업의학전문가들 사이에서도 공감을 이루고 있다. 미국과 영국 등에서의 직업성질환 감시체계에 대한 경험은 우리 나라의 직업성질환 감시체계 구축에도 새로운 자극제가 되면서, 1998년이후 인천, 대전, 여천, 구미, 부울경 지역에서 지역 직업성질환감시체계를 산업보건관리의 중요한 시스템으로 구축하려는 노력이 확산되고 있다. 새로이 구축되어지는 이들 지역 직업성질환 감시체계는 감시하고자 하는 대상질환, 활용 가능한 인적자원 및 자료원, 지역 의료체계의 특수성 등에 따라서 목적과 방법을 달리하면서 독특한 형태로 발전을 하고 있다. 각 지역단위 감시체계들이 그 상황에 맞게 독특한 목적과 전략들을 발전 시키면서도, 향후 발전할 국가적인 차원의 직업성질환 감시체계 구축을 위하여 직업성질환 감시의 기본 전략 등을 공유하는 등의 노력이 필요하다. 환례 정의 및 기본적인 등록 서식의 공유, 직업성질환 감시 자료원의 발굴, 공동의 정보 네트워크 및 직업성질환 감시 데이터베이스 구축 등 직업성질환 감시활동을 지원하기 위한 여러 기초 인프라 구축에 힘을 모아야 할 것이다. 우리 나라에서 직업성질환 감시체계를 성공적으로 구축하기 위해서는 수집된 자료의 질 관리를 위한 직업성질환 감시의 원칙 제정과 감시 전략의 공유 등이 필요하며, 전국적인 직업성질환 감시체계의 하부구조라고 할 수 있는 지역감시체계의 기초 토대 마련과 강화작업이 절실하게 필요하다.

고등학교 지구과학 실험·실습 요목 비교 분석

정원우,이윤종,기우항,김영호,양승영,강용희,안병호,임성규,윤일희,김중욱,윤성효,강동진 경북대학교 과학교육연구소 1997 科學敎育硏究誌 Vol.21 No.-

The purpose of this study is to investigate the status of the experimental and practical education in high school earth. The present status and reasonable management of the experimental and practical education in high school earth science have been grasped from the questionaires. To do this, eighty eight earth science teachers in Korea are administered questionaires. The frequency of the experimental and practical items in the seven kind of earth science text books were investigated. The problems and the reasonable management for experimental and practical education were proposed in this paper.