P168 : Split-face comparison study of new hyaluronic acid filler for efficacy and safety of HA-IDF versus Restylane® for correction of nasolabial folds

( Jie Hyun Jeon ),( Joo Ha Kim ),( Jung Woo Lee ),( Kui Young Park ),( Seong Jun Seo ),( Hae Jun Song ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2

Background: After successive trials and failures of various injectable materials such as bovine collagen, polyacryamide, calcium hydroxylapatite, etc., hyaluronic acid (HA) has become the most popular filling material. Many new HA fillers are being produced for the purpose of correcting wrinkles and augmentation of soft tissue. Objectives: This study aimed to test the efficacy, tolerability, and safety of a new HA filler, HA-IDF (Yvoire Classic s touch-up, LG Life Sciences, Inc., Seoul, South Korea) and compare HA-IDF with Restylane (Q-Med, Uppsala, Sweden). Methods: Fifty-eight subjects with visible nasolabial folds (NLFs) were enrolled in a randomized, multi-center, single-blind, active-controlled, matched-pair clinical study. Each subject was injected with HA-IDF in one NLF and Restylane in the other. All participants were assessed for cosmetic change at 2, 10, 18, and 26 weeks. Results: At screening, the average Wrinkle Severity Rating Scale (WSRS) for both right and left NLFs was 3.24±0.43. After 26 weeks, the results were 2.56±0.09 for both groups. There was no significant difference in WSRS scores for wrinkle improvement and in incidence of adverse events for both HA filler treatments. Conclusion: The new HA filler HA-IDF is effective and safe for correcting NLFs.

Bloodstream Infections and Clinical Significance of Healthcare-associated Bacteremia: A Multicenter Surveillance Study in Korean Hospitals

Son, Jun Seong,Song, Jae-Hoon,Ko, Kwan Soo,Yeom, Joon Sup,Ki, Hyun Kyun,Kim, Shin-Woo,Chang, Hyun-Ha,Ryu, Seong Yeol,Kim, Yeon-Sook,Jung, Sook-In,Shin, Sang Yop,Oh, Hee Bok,Lee, Yeong Seon,Chung, Doo The Korean Academy of Medical Sciences 2010 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.25 No.7

<P>Recent changes in healthcare systems have changed the epidemiologic paradigms in many infectious fields including bloodstream infection (BSI). We compared clinical characteristics of community-acquired (CA), hospital-acquired (HA), and healthcare-associated (HCA) BSI. We performed a prospective nationwide multicenter surveillance study from 9 university hospitals in Korea. Total 1,605 blood isolates were collected from 2006 to 2007, and 1,144 isolates were considered true pathogens. HA-BSI accounted for 48.8%, CA-BSI for 33.2%, and HCA-BSI for 18.0%. HA-BSI and HCA-BSI were more likely to have severe comorbidities. <I>Escherichia coli</I> was the most common isolate in CA-BSI (47.1%) and HCA-BSI (27.2%). In contrast, <I>Staphylococcus aureus</I> (15.2%), coagulase-negative <I>Staphylococcus</I> (15.1%) were the common isolates in HA-BSI. The rate of appropriate empiric antimicrobial therapy was the highest in CA-BSI (89.0%) followed by HCA-BSI (76.4%), and HA-BSI (75.0%). The 30-day mortality rate was the highest in HA-BSI (23.0%) followed by HCA-BSI (18.4%), and CA-BSI (10.2%). High Pitt score and inappropriate empirical antibiotic therapy were the independent risk factors for mortality by multivariate analysis. In conclusion, the present data suggest that clinical features, outcome, and microbiologic features of causative pathogens vary by origin of BSI. Especially, HCA-BSI shows unique clinical characteristics, which should be considered a distinct category for more appropriate antibiotic treatment.</P>

돈분뇨 액비 시용이 양파의 생육, 양분흡수량 및 토양 화학성에 미치는 영향

이종태(Jong Tae Lee),하인종(In Jong Ha),김희대(Hee Dae Kim),문진성(Jin Seong Moon),김우일(Woo Il Kim),송원두(Won Doo Song) 한국원예학회 2006 원예과학기술지 Vol.24 No.2

벼와 양파 2모작 논토양에서 효율적인 돈분뇨 액비 시용을 위하여 액비 시용에 따른 양파의 생육, 양분흡수량 변화와 토양의 이화학적 특성을 조사하였다. 사용된 액비의 질소, 인산 및 칼륨 함량은 각각 4.2, 0.34, 1.2g kg⁻¹ 등이었다. 추비용 액비는 시용 10일 전에 물로 2배 희석하여 월 2회씩 4회와 6회로 나누어 시용하였다. 기비는 질소표준시비량 기준으로 19,280kg ha⁻¹로 시용하였으며 추비에 사용된 액비량은 101,910kg ha⁻¹이었다. 양파의 초장은 정식 136일 후부터 186일까지 급격히 증가하였으며 화학비료구, 액비기비+화학비료 추비구 및 액비기비+액비 4회 추비구 간에는 차이가 없었으나 무비구와 액비전량 기비구는 양분부족으로 생육이 저조하였다. 구 비대초기의 구경은 무비구에서 가장 컸으나 그 이후 화학비료구와 액비시용구에서 크게 증가하였다. 엽 생체중의 변화는 초장과 유사한 경향을 보인 반면 구 생체중은 구경과 비슷한 경향을 나타내었다. 초장과 엽중은 화학비료구와 액비전량 기비구 및 액비기비+액비 6회 추비구간 다소 작았으나 구경, 구중 및 엽수는 처리간 차이가 뚜렷하지 않았다. 양파 구와 잎의 양분흡수량은 전 생육기간에 시그모이드 형을 나타내었으며 잎과 구의 양분흡수량은 각각 잎과 구의 생육이 진전됨에 따라 증가하는 경향이었다. 화학비료구와 액비기비+화학비료 추비구 및 액비 4회 추비구간에 양분흡수량의 차이는 없었고 액비전량 기비구에서 잎의 질소와 칼륨흡수량이, 구의 질소흡수량이 화학비료구보다 적었다. 무비구는 질소, 칼륨 및 마그네슘 흡수량이 다른 처리구보다 적었다. 액비기비+액비 4회 추비구에서 질소와 인산이용률이 각각 23.5%, 13.2%로 가장 높았으나 액비기비+액비 4회 추비구에서 칼륨이용률이 높았고 상품 수량도 55.0Mg ha⁻¹로 가장 많았다. 구의 질소, 인산 및 칼륨함량은 생육이 진전됨에 감소하는 경향이었고 잎의 질소함량은 생육초기에 가장 많은 반면 칼륨함량은 구비대 초기에 가장 많았다. 수확 후 토양 pH, 질산태 질소, 교환성 칼륨 및 EC 농도는 화학비료구보다 액비시용구에서 약간 증가하였다. 본 연구 결과를 종합해 볼 때 돈분뇨 액비를 기비로 시용하고 3배 희석한 액비를 2월과 3월에 4회 추비하면 균형적인 양분공급이 가능하고 적정 수량도 확보할 수있었다. This study was carried out to evaluate the effect of liquid pig manure (LPM) on the nutrient uptake, yield of onion and soil properties. The LPM applied to onion field contained 4.2 g kg⁻¹ N, 0.34 g kg⁻¹ P, 1.2 g kg⁻¹ K and it was diluted with water by 1:2 for top-dressing, which was applied separately 4 or 6 times from February to April. The LPM application rate for basal fertilization was 19,280 kg ha⁻¹ which included 80 kg N, 6.6 kg P, and 22 kg K. The application rate for top-dressing was 101,910 kg ha⁻¹ which included 160 kg N, 13 kg P, and 53 kg K. The plant height was not almost different among treatments until 136 days after planting. Thereafter, it enlarged abruptly until 186 days, on May 4. The significant difference among CF and LPM + top-dressing by CF or LPM I was not shown, but no fertilizer and LPM only (it was applied totally as basal fertilization) made plant height of onion lessen at the maximum growth stage because of insufficient nutrients. The plant diameter increased after 136 days, and there was a significant difference between CF or LPM and no fertilizer from 186 days after planting. The leaf weight was similar tendency to plant height while bulb weight was similar to plant diameter. The amount of nutrient uptake in leaf coincided with leaf growth and the nutrient uptake in bulb swelled simultaneously with bulb growth. The difference between CF and LPM + top-dressing by CF or LPM I was not significant in nutrient uptake of onion leaf and bulb. But LPM only decreased in nitrogen and potassium of leaf and in nitrogen of bulb. And no fertilizer made a remarkable difference to others in nitrogen, potassium and magnesium of leaf and bulb. The utilization of nitrogen and phosphorus in LPM + top-dressing by CF were 23.5%, 13.2% respectively, more than the others. The LPM + top-dressing by LPM I was most available with potassium, and it leaded the most abundant marketable yield by 55.0 t ha⁻¹ as well. The nitrogen, phosphorus, and potassium contents in bulb were inclined to decrease with progress of onion growth. The nitrogen contents in leaf maximized at the initial growth stage while potassium contents increased at the initial bulbing stage. The LPM application increased pH, nitrate nitrogen, potassium and EC in soil more than chemical fertilizer (CF) did.

환자의 비강으로부터 분리된 메티실린 내성 황색 포도알균의 분자 아형 분석

Sang-Ha Kim,Sung-Bae Park,Heechul Park,Jun Seong Kim,Jungho Kim,Jiyoung Lee,임재원,Young Kwon Kim,Sunghyun Kim 대한임상검사과학회 2020 대한임상검사과학회지(KJCLS) Vol.52 No.2

Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterium that causes infections in different parts of the body and causes skin and soft tissue infections (SSTI). The present study examined the antimicrobial resistance patterns and molecular epidemiological characteristics of MRSA isolated from nasal swabs in clinical patients. SCCmec type of MRSA isolates from clinical patients were analyzed: 24 cases were SCCmec type-II; two cases were type-II/IVa; one case was type-II/V; one case was type-IVa; 11 cases were not-typeable. The mec complex type of MRSA isolates from clinical patients were analyzed: 29 cases were mec complex type A, and 10 cases were not-typeable, but type B was not found in the present study. In conclusion, SCCmec type-II and mec complex type A were the most dominant MRSA subtypes among the MRSA isolates from a nasal swab of patients, and the results were similar to other studies on hospital-acquired MRSA (HA-MRSA). These results can not only provide basic data for hospital infection management but also be a good guideline for MRSA infections in the Republic of Korea. 본 연구에서는 환자의 비강으로부터 분리 배양된 총 39건의 MRSA 분리 배양 균주를 이용해 mecA 유전자 검출, SCCmec typing과 mec complex typing을 분석해 보고자 하였다. 임상 환자의 비강으로부터 분리 배양된 MRSA 총 39주 중 SCCmec type-II가 24건, type-II/IVa가 2건, type-II/V가 1건, type-IVa가 1건, not-typeable이 11건으로 분석되었으며, mec complex type A가 29건, not-typeable이 10건이었으며, type B는 없는 것으로 분석 되었다. 결론적으로, 환자의 비강으로부터 분리된 MRSA 분리 배양 균주 중 SCCmec type-II와 mec complex type A 아형이 가장 많이 분포하고 있었으며, 이 결과는 의료기관 획득 MRSA에 관한 다른 연구결과와 유사한 결과를 나타냈다. 이후 환자의 비강으로부터 분리 배양된 not-typeable 아형의 MRSA 균주를 대상으로 국내에서 발견되는 새로운 MRSA 아형 규명에 관한 추가 연구가 필요할 뿐만 아니라, MRSA 분리 배양 균주의 아형을 분석함으로써 그 분자적 특성을 분석한 결과를 바탕으로 병원 감염관리를 위한 기초자료를 제공할 수 것으로 사료된다.

전국 단위 감시체계의 현황과 전망

강성규,안연순,지영구,김형옥,하미나,권호장,백남종,김성아,홍윤철,김재용,강대희,정혜선,하은희 대한산업의학회 2001 대한직업환경의학회지 Vol.13 No.2

EG/AD 모형빙 정도 향상을 위한 콜드룸에서의 생성기법 및 계측기법 연구

조성락(Seong-Rak Cho),정성엽(Seong-Yeob Jeong),하정석(Jung-Seok Ha1),강국진(Kuk-Jin Kang) 대한조선학회 2013 大韓造船學會 論文集 Vol.50 No.6

Interaction between Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Recent Negative Stressor in Harm Avoidance

Kim, Seog Ju,Cho, Seong-Jin,Jang, Ha Min,Shin, Jonghan,Park, Pil-Whan,Lee, Yu Jin,Cho, In Hee,Choi, Jung-Eun,Lee, Heon-Jeong S. Karger AG 2009 Neuropsychobiology Vol.61 No.1

<P>There have been controversial results regarding the association between brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and anxiety-related traits such as harm avoidance (HA). We aimed to investigate the interaction between <I>BDNF</I> Val66Met polymorphism and negative life stressors in HA. <I>BDNF</I> Val66Met polymorphism was genotyped in 391 community-dwelling Koreans (152 males, 239 females; 43.2 ± 14.1 years old). The Temperament and Character Inventory (TCI) and the Center for Epidemiological Studies for Depression Scale (CES-D) were self applied. The Structured Clinical Interview for DSM-IV axis I disorders and face-to-face interviews investigating negative life stressors within the last 6 months were also performed. There was no significant difference in TCI score, major depressive disorder prevalence and CES-D score among the 3 genotypes (94 Met/Met, 188 Val/Met and 109 Val/Val subjects). There was no significant difference in TCI scores between subjects with stressors and those without stressors, while more common major depressive episodes (p = 0.03) and higher CES-D scores (p < 0.001) were found in subjects with stressors. However, there was a significant interaction between the <I>BDNF</I> genotype and negative life stressors in HA (p = 0.02). Only subjects with the Val/Val genotype showed higher HA with recent negative stressors. Our finding suggests that <I>BDNF</I> Val66Met polymorphism might influence HA by interacting with recent negative stress experience.</P><P>Copyright © 2009 S. Karger AG, Basel</P>

우리나라 지역 직업성질환 감시체계의 현황과 전망

임종한,장성실,김성아,문재동,채창호,홍윤철,김수영,김진석,김영욱,한상환,이혜숙,원종욱,송동빈,하은희,강성규 대한산업의학회 2001 대한직업환경의학회지 Vol.13 No.2

기존의 특수건강진단과 작업환경측정을 통한 직업병 관리가 진폐증, 소음성난청 등의 소수 특정질환에 국한되고 실제 직업병 발생 규모 파악이나 신종 직업병의 발견에 한계를 보인다는 사실은 산업의학전문가들 사이에서도 공감을 이루고 있다. 미국과 영국 등에서의 직업성질환 감시체계에 대한 경험은 우리 나라의 직업성질환 감시체계 구축에도 새로운 자극제가 되면서, 1998년이후 인천, 대전, 여천, 구미, 부울경 지역에서 지역 직업성질환감시체계를 산업보건관리의 중요한 시스템으로 구축하려는 노력이 확산되고 있다. 새로이 구축되어지는 이들 지역 직업성질환 감시체계는 감시하고자 하는 대상질환, 활용 가능한 인적자원 및 자료원, 지역 의료체계의 특수성 등에 따라서 목적과 방법을 달리하면서 독특한 형태로 발전을 하고 있다. 각 지역단위 감시체계들이 그 상황에 맞게 독특한 목적과 전략들을 발전 시키면서도, 향후 발전할 국가적인 차원의 직업성질환 감시체계 구축을 위하여 직업성질환 감시의 기본 전략 등을 공유하는 등의 노력이 필요하다. 환례 정의 및 기본적인 등록 서식의 공유, 직업성질환 감시 자료원의 발굴, 공동의 정보 네트워크 및 직업성질환 감시 데이터베이스 구축 등 직업성질환 감시활동을 지원하기 위한 여러 기초 인프라 구축에 힘을 모아야 할 것이다. 우리 나라에서 직업성질환 감시체계를 성공적으로 구축하기 위해서는 수집된 자료의 질 관리를 위한 직업성질환 감시의 원칙 제정과 감시 전략의 공유 등이 필요하며, 전국적인 직업성질환 감시체계의 하부구조라고 할 수 있는 지역감시체계의 기초 토대 마련과 강화작업이 절실하게 필요하다.

컴퓨터 법에 있어서의 책임에 관한 연구

鄭鎭世,鄭在晃,方碩皓,河泰勳,李成德,崔鳳哲 홍익대학교 1995 弘大論叢 Vol.27 No.-

This paper, coauthored by Chin-Se Chung, as well as other 5 faculty members at Hong-Ik University Department of Law (Jea-Hwang Jeong, Suk-Ho Bang, Tae-Hoon Ha, Seong-Deog Yi and Bong-Chul Choi), deals with liability issuses surrounding constitutional law, administrative law, civil law (contracts, torts), commercial law, criminal law, international law and philosophy & law. Professor of Law Jea-Hwang Jeong makes a comparative analysis of privacy protection and disclosure of information legal issues, appeared at current Korean law and draft of law in case of the latter one. He suggestes some desirable ways of legislation through revision process and operation of legal rules at his paper. Professor of Law Suk-Ho Bang makes a brief survey of civil liability issues arising out of contracts and torts in English and American law, first. He tries to show that many Parts of arguments in such legal world are attributed to Statute of Frauds tradition, unique to such legal world. New developments in the area of torts, including computer malpractice and computer virus, are shown and analysed in terms of application possibility under our current law. But, as even the Anglo-American courts are found very reluctant to accept those arguments as new grounds for torts liability, it seems more plausible and practicable to refer to contractual approach, basically, rather than to torts approach even under English American law. Professor of Law Chin-Se Chung suggests in his paper on EFT that the allocation of liability under EFT be made under the new and most relevant principle, working for useful transmission way of fund, not solely under traditional legal principles. If such new principle works with high return of risk to users, it makes imminent problems against the goats of consumer protection, and eventually will be hardly refered to. Conversely, if it requires too much sacrifice from the side of banks, then the convenience in such system will not be utilized. So, it may be natural that EFT be discarded even without proper functioning under market system. In conclusion, Professor Chung points out that, only when banks fond that the economy out of cost-saving at tasks outweighs the risk undertaken by the banks, the banks will operate the system. But, if this system makes more return of benefits to the banks with the burden of users, it is against the idea of equity. Consequently, the banks should bear the aggeviated risks in return for the cost saved under this system Professor of Law Tae-Hoon Ha focuses his research paper on criminal liability under EFT. He draws his conclusion out of current criminal statutes that illegal fund transfer under automatic teller machines, cash cards and information system can not be penalized due to lack of proper statutory provision. So, the criminal provision on computer crime, newly made on December of 1995, can be positively appreciated. But, he anticipates that the question whether such new provision will be successful in regulating all illegal activites at fund transfor system without any operation defects in criminal code, or will cause new problem in interpretation of criminal code remains unsolved. Professor of Law Seong-Deog Yi examines the international legal issues which may be given rise to by direct satellite broadcasting. In his paper, the issue of national jurisdiction in relation to direct satellite broadcasting is firstly dealt with. Secondly, the possible ways in which direct satellite broadcasting is regulated by international law are examined with special emphasis of two different approaches, that is, freedom of information approach and state sovereignty approach. In this context, many international conventions concerning direct satellite broadcasting in Particular, and international regulatory regime of outer space in general are broadly reviewed. Thirdly, the types of activities which may be a violation of international legal regime of direct satellite broadcasting are suggested and the possible lethal remedies for these violations are proposed with the traditional international state responsibility law in mind. Professor of Law Bong-Chul Choi explores the relations of computerized society to its laws throughout his paper as a kind of conclusion of this whole paper. Computerized society is one that the technical, scientific, informational knowledge prevails. With correspondence to the structural change in knowledge, the law of such a society has suffered transformation, and the knowledge and techniques distributing and computing legal responsibility has also changed. However, he does not insist that the diffusion of technical knowledge is the sole factor of the transformation of legal responsibility. It is only one of the various factors. Moreover, he does not deny the continuation between the classical techniques distributing legal responsibility and the contemporary ones. In this era, the law realizes fairness and community values at the expense of singularities. In addition, he proposes that legal scholars take the diagnosis of law from the perspective of the technology/knowledge shifts seriously.

맥주박 바이오차 처리가 암모니아 배출량에 미치는 영향 평가

이재한(Jae-Han Lee),최하연(Ha-Yeon Choi),박성용(Seong-yong Park),천진혁(Jin-Hyuk Chun),강윤구(Yun-Gu Kang),윤여욱(Yeo-Uk Yun),이기범(Gibum Yi),오택근(Taek-Keun Oh) 한국토양비료학회 2021 한국토양비료학회 학술발표회 초록집 Vol.2021 No.11

암모니아(NH₃)는 대기 중 황산화물(SOx), 질소산화물(NOx) 등과 반응하여 황산암모늄, 질산암모늄과 같은 2차 미세먼지를 생성하는 주요 미세먼지 원인물질이다. 2017년 기준 국내에서 NH₃는 총 308,298 ton year<SUP>-1</SUP> 배출되었으며, 농업부문에서 약 79.3%의 비율로 가장 많이 배출되었다. 토양에 질소질 비료의 시용 시 발생되는 NH₃의 대기로 배출은 토양 내 질소 손실의 원인이 되기도 한다. 바이오차는 넓은 표면적과 표면의 작용기를 가지고 있어 토양 내에서 중금속이나 오염물질 등을 제거하는 특징이 있다. 본 연구는 다양한 온도에서 열분해된 맥주박 바이오차 처리가 NH₃ 배출량에 미치는 영향을 평가하기 위해 실시하였다. 바이오차는 충분히 건조된 맥주박을 300, 500, 700°C에서 각각 1시간 동안 열분해하여 제조하였다. 각 바이오차를 토양에 3% (w w<SUP>-1</SUP>)씩 혼합 후 NH₃ 포집을 위해 자체 제작한 아크릴컬럼에 작토층 높이인 20 cm 까지 토양을 채웠으며, 토양 수분함량은 20%로 조절하였다. 질소질 비료는 작물별 시비처방기준의 배추를 기준으로 요소를 각 처리구에 320 kg ha<SUP>-1</SUP>로 처리하였다. NH₃의 포집은 요소 처리 후부터 약 30일간 실험실 내에서 실시하였다. 배출되는 NH₃는 0.05 N H₂SO₄으로 포집하여, Indophenol blue method로 비색정량하였다. 그 결과, 시험 기간 중 총 NH₃ 배출량은 BB<SUB>700</SUB>처리구가 약 11.83 kg ha<SUP>-1</SUP>로 가장 높게 나타났다. BB<SUB>300</SUB>처리구의 총배출량은 약 7.34 kg ha<SUP>-1</SUP>로 가장 낮았으며, N처리구에 비해 약 30.5% 저감 되었다. BB<SUB>700</SUB>처리구는 N처리구에 비해 NH₃ 총배출량이 약 12% 증가하였는데, 이는 바이오차의 높은 pH에 의한 alkali effect로 판단된다. 실험 후 토양 분석 결과, 모든 바이오차 처리구에서 pH, EC, Av. P₂O<SUB>5</SUB>, T-C, T-N 등이 증가하였다. 특히, BB<SUB>700</SUB>처리구는 처리된 바이오차의 높은 탄소 함량으로 인하여, 토양 내 탄소 함량이 약 3.44%로 가장 높았다. 따라서, 비교적 낮은 온도에서 열분해한 BB<SUB>300</SUB>의 토양 처리가 농경지에서 배출되는 NH₃를 감축할 수 있으며, 본 연구 결과는 실제 농경지에서 배출되는 NH₃를 감축하기 위한 기초자료로 사용될 수 있을 것으로 판단된다.