한국인 알코올 의존 환자에서 알코올 대사 효소 유전자형 빈도의 남녀 차이

김성곤,김철민,이덕기,황인복,이현숙,김성연,전은숙,송영상,박제민,최병무,김명정 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.2

Objectives : There are a number of preceding epidemiological studies reporting gender differences in the genetic etiology of alcohol dependence. The author investigated gender difference in the frequencies of ADH2 and ALDH2 genoypes between the patients with alcohol dependence and normal control. Methods : The subjects were 141 alcohol dependent patients (104 males, 37 females) and 138 normal control (79 males, 59 females). The frequencies of 1/1 and 1/2+2/2 (2+ afterward) genotypes for ADH2 and ALDH2 were investigated in male and female between alcohol dependence and normal control group. DNA was extracted from WBC in peripheral venous blood and PCR-RFLP method was used out for genotyping. Results : First, the frequency of ADH2 1/1 genotype was significantly higher in alcohol dependent patients than normal control in both genders. Second, while there was no gender difference in the frequency of ADH2 1/1 genotype in normal controls, in the patient group however, the frequency was significantly higher in females than males. Third, in male subjects with alcohol dependence, the frequency of ALDH2 1/1 genotype was significantly higher than in male normal control subjects. On the other hand, in female subjects with alcohol dependence, the frequency of ALDH2 2+ genotype was significantly higher than in female normal control subjects. Conclusion : These results suggest that while the risk of alcohol dependence is predominantly affected by ALDH2 1/1 geno-type in male, the female ADH2 1/1 genotype is mainly associated with the risk of alcohol dependence. This means that there are gender differences in the genetic etiology of alcohol dependence.

24주간 추적하는 임상 연구에서 한국인 남자 알코올 의존 환자의 비재발률

강철중,김성곤,남궁기,조동환,이병욱,최인근,최용성,박성봉,제영묘,김현경,김성연 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.1

Objetives : In order to provide useful data tbr the further clinical studies with Korean alcohol-dependent patients, enrollment and non-relapse rates were investigated while alcohol-dependent patients wcre followed up for 24 weeks. Methods : The subjects of this study were alcohol-dependent male patients who, for the first time, visited a hospital among 3 groups of hospitals, University Hospital, General Hospital or Mental Hospital, or those who needed to be followed up after discharge from those hospitals. After assigning 12 subjects to each hospital, we investigated enrollment and non-relapse rates while cognitive-behavioral therapy and pharmacotherapy were provided. Results : 1) Forty-eight patients were enrolled and the rate of enrollment was 36.4%. The enrollment rate in the University Hospital group was 52.1%, in the General Hospital group 50.0%. and in the Mental Hospital group 10.4%. 2) In 48 patients, non-relapse rate was 27.1% at 12 week and 18.8% at 24 weeks after starting follow-up. It was 24.4% and 20.0% at 12 and 24 weeks, repectively, in the University Hospital group while the General Hospital group showed 33.3% and 16.7%, respectively, and the Mental Hospital Group showed 20.0% at both 12 and 24 weeks. Conclusion : These results provide important data for further clinical studies of Korean alcohol-dependent patients.

헤어리베치 신품종 조생종 콜드그린과 중만생종 청파의 생육특성 및 수량성

신정남(Chung Nam Shin),고기환(Ki Hwan Ko),김종탁(Jong Tak Kim),이종경(Joung Kyong Lee),서성(Sung Seo),성병렬(Byung Ryul Seong),최기준(Gi Jun Choi),김종덕(Jong Duk Kim),오명곤(Myung Gon Oh) 한국초지조사료학회 2007 한국초지조사료학회지 Vol.27 No.4

본 시험의 목적은 대구 경북에 자생하는 헤어리베치로 다수성 조생품종과 중만생품종을 개발하기 위하여 수행하였다. 경북 성주와 경남 사천에서 1998년부터 2006년까지 자료수집 및 순화, 생육이 왕성한 조생 및 중만생계통선발, 상호교잡의 단순순환선발법으로 조생종인 콜드그린과 중만생종인 청파를 육성하였다. 육성종자는 2004년부터 2006년까지 경북성주와 경남사천에서 생육특성과 수량을 평가하였다. 줄기의 털은 콜드그린과 청파는 있었으나, 헤이메이커프러스와 라티고는 없었다. 잎의 모양은 콜드그린은 엽폭이 넓은 장타원형이고, 청파, 헤이메이커프러스, 라티고는 좁은 장타원형이었다. 꽃색은 콜드그린은 자주색이고 청파는 보라색이었다. 내한성은 성주에서 콜드그린, 청파, 라티고가 헤이메이커프러스 보다 높았으며 사천에서는 차이가 적었다. 개화기는 콜드그린과 헤이메이커프러스가 조생종으로 유사했고 중만생종인 청파는 라티고 보다 다소 빨랐다. 성주에서 건물수량은 콜드그린이 다른 품종 보다 높았으며 청파와 헤이메이커프러스는 라티고 보다 높았다(P<0.05). 2005년 사천에서는 콜드그린과 헤이메이커프러스는 다른 품종보다 높았으며, 청파는 라티고 보다 높았다(P<0.05). 베치의 조단백질 함량은 높고 ADF의 함량은 낮았다. The objective of this research was to develop a high yielding, early and medium-late flowering new hairy vetch(Vicia villosa Roth) varieties derived from an accession in Korea. Most vigorous early and medium-late flowering hairy vetch lines were selected and crossed by open pollination and their seeds were bulked and plants were reselected at Seongju in the Keongbuk and at Sacheon in the Keongnam. A performance trial was conducted to evaluate agronomic characteristics, forage quality and dry matter(DM) yield of new hairy vetch early-maturing 'Cold green' and medium-late maturing variety 'Cheong pa' at Seongju and Sacheon. 'Cold green' and 'Cheong pa' are hair but 'Haymaker plus' and 'Latigo' are nearly hairless. 'Cold green' has purple flowers while 'Cheong pa' has violet. The cold tolerance of 'Cold green,' 'Cheong pa' and 'Latigo' was higher than 'Haymaker plus' at Seong-ju, Keongbuk province, in inland region but there were a little differences at Sacheon, Keongnam province in southern coast region. Fifty percent-flowering dates of 'Cold green' and 'Haymaker plus' had earlier than others and 'Cheong pa' was earlier than 'Latigo'. The DM yield of 'Cold green' was higher than that of others, but 'Cheong pa' and 'Haymaker plus' had higher than 'Latigo' at Seong-ju(P<0.05). In Sacheon, The DM yield of 'Cold green' and 'Haymaker plus' was higher than others and 'Cheong pa' had higher than 'Latigo'.

긴 관동맥병변에서 긴 스텐트삽입에 대한 임상경과 및 재협착율

김영학,박성욱,정상식,박훈기,이상곤,이일수,이철환,김재중,홍명기,박승정 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.6

스포츠와 攻擊性 : 定義的·理論的 考察 Definitional and Theoretical Considerations

김승곤 제주대학교 1992 논문집 Vol.35 No.1

Human agression is a problem in society as well as in sport. Agression is any form of behavior directed to the goal of harming or injuring another being. The key element in this defintion is the notion of intent to harm. We have identified two basic kinds of aggression. In hostile aggression, the primary goal is the injury of another humaning. In instrument aggression, the reinforcement is an external reward such as winnig. Assertive behavior involves the use of legitimate physical or verbal force to achieve one's purpose. Aggression may be measured in terms of the personality trait of aggressiveness or through situation-specific state measures of aggression. Trait measures of aggression are genearlly ascertained through projective techniques and pencil-and-paper tests. State measures of aggression include laboratory test such as the shock box and field test such as behavior observation and archival studies. There are three major theories that attempt to explain why athletes are aggressive. These theoretical positions are extremely important because they make some very basic assumptions aboot the origin of aggressive behavior and the prospects for changing it. Accoding to instinct theory, aggression was unavoidable since it was innate, but as with any drive it could be regulated through dischage or fulfillment. Frustration-aggression theory proposes that aggression occurs as a result of frustration. Social learning theory regards aggression as a learned response. Findings from examination of aggression-performance relationships have yielded more conflicting results. The problems associated with investigation aggression-performance relationship can be classified as conceptual, methodological, or interpretive. Based upon the research problems outlined, the following suggestions are made for future research. First, Future studies not only should be based upon a theoretical framework but also should test the theory or some aspect of it Second, Studies should distinguish between aggressive and assertive behavior as well as beteween instrumental and reactive aggression. Third, Researchers should attempt to determine how the level and type of sport, as well as the gender, mediate aggression-performance relationships. Fourth, Conclusions about causality should not be drawn from correlation data.

PET/CT를 이용하여 진단한 구강암의 증례

김영희,양병은,조영민,김성곤 대한구강악안면방사선학회 2006 Imaging Science in Dentistry Vol.36 No.2

PET/CT is a new imaging technology that combines high-quality Positron Emission Tomography (PET) and Computed Tomography (CT). This imaging provides simultaneous anatomical and metabolic information. Therefore PET/CT is useful diagnostic modality for early detection of malignant tumor, accurate staging, decision on therapeutic plan, monitoring response to therapy and rapid detection of recurrence. We report oral and maxillofacial cancers diagnosed by using PET/CT and the usefulness of PET/CT in the evaluation of postoperative recurrence.

엘리트 스포츠에 대한 제주도민의 의식 조사 연구

김승곤,정찬식 濟州大學敎 體育科學硏究所 1998 체육과학연구 Vol.4 No.-

The purpose of this study is to present the desirable ways of elite sport through the research of the consciousness of elite sport in Cheju-do To achieve the above.539 Cheju people were asked 56 questions about elite sport through questionnaires. And in this paper. T- test. ANOVA and x2(chi-squares) test methods through the use SAS were used to statistical significance. The concrete problem drawn from such an analysis are summarized as follows: 1. It is certain that most of the Cheju people trend to have a negative reply in the role of elite sport about promotions of sports itself or social relation. Most Cheju islanders think that elite sports seldom influence the social union, and the sound atmosphere of our nation. Therefore, to solve this problem, elite sport must be connected with the School sports and sport for all. 2. Cheju islanders consciousness about influence of sports activity is changing toward affirmative attitude after eighty-decade years. This result seems to be desirable to develop elite sport. 3. In a question of a sports administrative organization for athletes. most of cheju islanders trend to have a negative attitude about the chief of government or businessmen centered sports administrative activities. only physical directors sympathize with the leading role of an athletic organization. And both of them have no interest in relation to between the system of an local sport council and financial support from an local self-governing. 4. From the viewpoint of caring for student athletes. they dont think about many schools make an effort to cut down on a loss of student athletes schoolwork. and they also take preferential treatments and a scholarship for entering upon schooling as a matter of course. Especially they have a high opinion of school costs and offering lodging and boarding in the benefits of student athletes schoolwork. 5. Cheju islanders have not answer affirmative answer toward the local representative athletes or teams, but they agree to the necessity of the exchange between the elites from the different area and camp training. And they also know that the system of prize for elite athletes should be improved. 6. It is shown that an event or all-round games contribute to the activation of local athletics. and rearing for elite athletes. either. In relation to the managing a tournament, they note that the point to be considered are general indifference, an excessive competition. government-centered management, an excessive expenses in finance. the time fixed for an athletic meeting, managing an event. manpower mobilization, and a very extensive scale. 7. As regards the influence of community development through inducing or joining a nation athletic meet, they emphasize the progress of the athletes ability. After all. our cheju islanders think that the cooperation of mass communication must be needed to develop elite sports. And they question the problem of connection between the scientific program for elite sport and sports for all. Lastly they call for the conversion of understanding elite sport, the local dispersion of central sports event, and the reorganization of the sport government setups for elite.

靑少年의 餘暇環境 實態 調査 硏究 : 濟州道 북제주군 中·高等學生을 中心으로 Centering on Buk-Cheju-Gun Junior and high school students

김승곤 제주대학교 1992 논문집 Vol.35 No.1

The purpose of this study was to investigate actual states on the youth leisure environment (i.e, an outlook on leisure, leisure participation pattern, leisure facilities, and soundness of leisure), and further to determine the leisure functioning of the youth leisure participation and provide some basic information for the relevant authorities to devise basic plan for establish the youth discipline center For this study, the questionnaires were given to 500 young boys and girls who were chosen at cluster sampling among the youth at Buk-Cheju-Gun in Cheju-do. The major findings obtained from this study were followings. First, with regard to leisure, cognition, a large percentage of they youth thought of leisure as a creative activities for self-culture or an opportunity for enjoyment through the art and sport/physical activities. But as regards leisure satisfaction, most of the students unsatisfied on leisure activities Second, with regard to relation leisure to health, the majority of young people perceived that leisure has a function of importance for physical and mental health. Such activities for improve physical and mental health included active sport activities, such as table tennis, jogging, fishing, camping/climing, and soccer etc. Third, the primary leisure activities participated in leisure time were table tennis, badminton. rid bicycle, skipping etc. If the circumstances permit, the young students were hoping for participate in table tennis, tennis, hangglider, riding, camping/climbing, windsurfing etc. Fourth, with regard to leisure facilities frequently use in ordinary times, a playground was the first to use and followed by pingpong house, library/private library, roller, skate, electronic game room, theaters, all sorts of exercise hall, basketball court etc. The students usually perceived insuffcient facilities as gymnasium, playground, table tennis hall, swimming pool, badminton court, etc. Fifth, if the circumstances permit, sport related facilities hope for investment included gymnasium, swimming pool, table tennis hall, ski, riding course, rooler skate space etc. In cultural facilities departement, the students had a desire for facilities such as library, youth-theather, dilettante room, computer room, bikeroad, stroll road etc. This survey result discussed in terms of leisure fscilities/space, education, and leisure values. More specifically, acquisition of space and facilities for the conduct of leisure/sport activities is one of the most urgent needs. Thus, on the national level, the public authorities should efforts to make leisure and sport facilities available to the youth. also schools should offering more opportunities for diversified leisure education, and organizes out-of-class programs. Finally, we should reconsider the value of physical actitvity programs including games and sports for the teen-agers.

교육 지도자들이 지각하는 스포츠 가치 지향

김승곤,이세형,양명환 濟州大學敎 體育科學硏究所 1997 체육과학연구 Vol.3 No.-

The purpose of this survey research was to examine the value orientations as perceived by physical education teachers & coaches, community sport leaders and other academic teachers. Specifically. the research problems were twofold, First, to investigate whether differences on selected sport values were significantly related to gender, age, and educational leaders. Second, to investigate what social values emphasized by physical education teachers & coaches, community sport leaders and other academic teachers during educational training. Subjects were 229 educational leaders(l52 male and 77 female leaders) selected from the 4 high schools, a community sport club and '97 community sport leaders training course in Cheju National University. Data for the study were collected by menas of 10 items questionnaire and focus group interview. A 5-point Likert scale, strongly disagree(1)~strongly agree(5). was used to measure the value orientation of sport. Frequency analysis, t-test, one-way ANOVA were used for statistical analysis. The major findings of this study were as follows. First. Male leaders rated significantly higher patriotism score than did female leaders. while female leaders showed significantly higher cultivation of leadership score than did male leaders. Second, Sport related leaders perceived significantly higher level of social development. good citizenship, respect for authority. self-discipline, leadership. prevention of social deviation. composite value scores than did the other academic teachers. Third, twenties leaders showed significantly higher social development, respect for authority, leadership scores than did thirties leaders and above forties leaders. Also. twenties leaders rated significantly higher competition in good faith and cooperation, self-discipline scores than did above forties leaders. Fourth, sport related leaders emphasized attitudes of do one's best, honesty and sincerity. perseverance. spirit of fair play, self-regulation and responsibility, consideration for others. the rules of etiquette, mental health, positivity, and physical health. Academic teachers stressed attitudes of honesty and sincerity, self-regulation and responsibility, do one's best, consideration for others, positivity.

위장질환에 따른 H.pylori 감염빈도와 검사방법의 비교분석

김대현,조재현,금민수,최성곤,이창형,탁원형,권영오,김성국,최용환,정준모 慶北大學校 醫科大學 1997 慶北醫大誌 Vol.38 No.2

목적 : H. pylori가 위장관 질환의 병인에 깊은 관련이 있어 이의 적절한 진단 및 치료가 중요하게 대두되고 있다. 이에 저자들은 소화기 증상을 주소로 내원한 환자들을 대상으로 내시경 검사를 실시하여 H. pylori검출을 위한 CLO검사, IgG 항체검사 및 H&E 염색 등을 시행하여 각 질환별로 H. pylori 감염의 양성율을 알아보고 검사법에 따른 민감도 및 특이도를 그 유용성에 대하여 조사하였다. 대상 및 방법 : 1996 4월에서 8월까지 경북대학교병원에 소화기증상을 주소로 내원한 총 313명의 환자를 대상으로 내시경 검사를 실시하여 H. pylori 검출을 위한 CLO 검사, IgG 항체검사, 조직염색 검사를 실시하였다. 결과 : 전체 대상 환자수는 313명이었고 연령별 분포는 16세부터 80세 까지 다양하였으며 그중40대, 50대, 60대가 각각 69예(22%), 73예(23.3%), 65예(20.8%)로 전체 환자중 66%를 차지하였다. 남녀비는 2.07 대 1로 남자가 많았다. 대상환자의 평균나이는 52±15세였고, 전체 대상환자에서 H. pylori 양성군과 음성군의 평균나이는 각각 50±15세, 54±15세 였고, 궤양환자군에서 H. pylori 양성군과 음성군사이의 평균나이는 각각 49±14.8세, 55±13.8세로 나타났다. 각 질환별분포는 위염이 72명(23%), 십이지장 궤양이 85명(27.2%), 위궤양이 80명(25.6%), 위암이 20명(6.4%), 비궤양성 소화불량이 13명(4.2%), 기타가 43명(13.7%)이었으며, H. pylori 감염 양성율은 위염이 71%, 십이지장 궤양이 86.8%, 위궤양이 58.3%, 위암이 75%, 비궤양성 소화불량이 75%였으며 특히 유문륜 궤양에서는 100%의 양성율을 보였다. 소화성 궤양군과 비궤양군에서의 H. pylori 양성율을 비교해 본 결과 궤양군에서는 73.1%, 비궤양군에서는 72%로 통계학적으로 차이는 없었다(P=0.91). 소화성 궤양환자에서 출혈이 동반된 군과 동반되지 않은 군에서의 H. pylori 양성율을 비교해 본 결과 출혈이 동반된 군에서의 양성율은 54.5%였고, 출혈이 동반되지 않은 군에서는 77.5%의 양성율을 보여 출혈이동반되지 않은 군에서 통계학적으로 유의하게 높았다(P=0.014). 나이에 따른 양성율을 알아본 결과 50세 이하에서는 78.5%였고, 50세 이상에서는 67.5%로서 양성율이 낮았으나 통계학적으로 유의성은 없었다(P=0.052). 각 검사법에 따른 민감도 및 특이도는 전체 환자중에서는 CLO검사가 88.9%, 96.1%, IgG항체검사 90.8%, 58.5%, H&E 염색검사 86.9%, 79.2%로서 민감도는 비슷하게 나왔으나 CLO검사는 상대적으로 특이도가 다른 검사법에 비해 높았다. 궤양군에서의 CLO검사의 민감도와 특이도는 92.0%, 95.6%였고, 비궤양군에서의 민감도와 특이도는 84.3%, 96.8%로서 비궤양군에서는 CLO검사의 민감도는 약간 낮았다. 나이에 따른 CLO 검사의 민감도 및 특이도는 50세 이하에서는 91.5%, 93.1% 였고, 50세 이상에서는 86.3%, 97.9%로서 50세 이상에서는 상대적으로 CLO검사의 민감도가 낮았다. 결론 : 본 연구에서는 위장질환에 따른 H. pylori 양성율을 알아보았는데, 다른 보고에서 처럼 높게 나왔으며, 진단 방법으로 사용한 CLO검사, IgG항체 검사, 조직염색검사 등은 모두 비교적 높은 예민도를 나타냈고, 그중 CLO검사가 간편하고 경제적이라는 면에서 임상적으로 유용한 검사로 여겨지나 상대적으로 CLO검사의 민감도가 낮은 비궤양성 질환과 50세 이상의 환자군에서는 CLO검사 외에 다른 검사방법을 병행함으로써 H. pylori의 진단율을 높일 수 있을 것으로 사료된다. Background: Gastric colonization by Helicobacter. pylori is common among patients with peptic ulcer and gastritis. And various diagnostic tests are available in confirming H. pylori infection. The aim of this paper is to estimate the prevalence of H. pylori infection in Gastroduodenal disorders and compare the sensitivity and specificity of the most widely available tests. Methods: A total of 313 patients were tested for H. pylori infection by IgG Ab, CLO test and H&E stains. Results: The prevalence of H. pylori infection was significantly higher in duodenal ulcer(86.8%) than in gastric cancer(75%), gastritis(71%) and gastric ulcer(58.3%)(P=0.009). The sensitivity and specificity of each test was as follows: CLO test(88.9%, 96.1%), IgG Ab test(90.8%, 58.5%), H&E stain(86.9%, 79.2%). Sensitivity of CLO test in peptic group was 92.0%, whereas in non-peptic group, it was 86.3%. Sensitivity of CLO test in age under 50 was 91.5%, that over 50 it was 86.3%. Conculsions: There is a strong association between H. pylori and gastrointestinal disorders. CLO tests have relatively high sensitivity and specificity, especially in peptic group and younger age(below 50 yr)group. But in those patients in which CLO tests are less sensitive (age>50 or non-peptic group), more than one test may be necessary to diagnose the presence of the organism.