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      • SCOPUSKCI등재

        Alterations of Proteins in Artificially Induced Chronic Myocardial Infarction in Rats

        Mi-Jin Lee,Hyun-Jin Tae,Do-Hyeon Yu,Ying-Hua Li,Jong-Hyun Lee,Ji-Seon Yoon,Seok-Won Lee,In-Shik Kim,Jin-Ho Park 한국임상수의학회 2008 한국임상수의학회지 Vol.25 No.3

        We investigated the changes of protein in chronic MI which was occurred with long-term ischemia, without reperfusion. Sprague Dawley (SD) rats were divided into the sham group and the experimental groups (MI groups). The sham group was treated only thoracotomy without ligation for left main descending artery (LMDA) of left coronary artery (LCA), and the experimental groups (MI7d, ligation of LMDA for 7 days and MI30d, ligation of LMDA for 30 days) were conducted an artificial chronic MI. The change of proteins according to passage of times was compared and analyzed on first and second dimension (1 and 2D) sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) analysis. Among total 46 spots expressed differentially in the sham group versus MI7d and MI30d groups on 2D gel, we selected proteins that the volume of spot was increased in the MI7d and MI30d groups compared with the sham group. After that, the proteins were identified through liquid chromatography/tandem mass spectrometry (LC-MS/MS) analysis. In result, we could obtain many proteins as follows; albumin, glucose regulated protein 58 KDa, similar to tripartite motif protein 50, ubiquinol-cytochrome c reductase core protein Ⅱ, sarcomeric mitochondrial creatine kinase, ATP synthetase alpha chain (mitochondrial precursor) and creatine kinase. In conclusion, we suggest many changed proteins shown at chronic ischemia after artificial MI and consider that these proteins play an important role in the function of heart after MI.

      • KCI등재

        Multi‑tissue lipotoxicity caused by high‑fat diet feeding is attenuated by the supplementation of Korean red ginseng in mice

        Seon‑A Jang,Seung Namkoong,이성률,Jin Woo Lee,Yuna Park,Gyeongseop So,Sung Hyeok Kim,Mi‑Ja Kim,Ki‑Hyo Jang,Alberto P. Avolio,Sumudu V. S. Gangoda,Hyun Jung Koo,Myung Kyum Kim,Se Chan Kang,Eun‑Hwa Sohn 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.1

        Background Excessive intake of fat, one of the causes of obesity, is associated with low-grade infammation in various susceptible organs and eventually causes tissue toxicity. This study examines the multifaceted suppressive efects of Korean red ginseng extract (KRG) on high-fat diet (HFD)-induced lipotoxicity and infammatory responses in the aorta, liver, and brain. Methods Male C57BL/6 mice were fed HFD with or without KRG for 12 weeks. The improvement efect in KRG on lipotoxicity and infammatory potential was determined in the blood and the aorta, liver, and brain tissues. Results KRG signifcantly inhibited 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity by >20% in vitro. KRG supplementation suppressed HFD-associated body weight gain, lipid profle changes, and excessive fat deposition in the liver and increased leptin, insulin, and ALT levels in the blood. Infammatory markers in the aorta, liver, and brain were also signifcantly reduced by KRG treatment. In microvascular endothelial cells, the 15% cyclic stretch-mediated upregulation of ICAM-1 and vascular cell adhesion protein-1 (VCAM-1) expression was signifcantly attenuated in the presence of KRG. Conclusion KRG supplementation attenuates HFD-mediated body weight gain, lipid profle changes, and multi-tissue infammatory responses.

      • KCI등재후보

        어머니의 내현적 자기애 성향과 유아의 부적응 행동과의 관계

        이미선 ( Mi Sun Lee ),최명선 ( Myung Seon Choi ) 한국놀이치료학회 2009 한국놀이치료학회지(놀이치료연구) Vol.12 No.1

        본 연구에서는 어머니의 성격특성인 자기애적 성향이 유아의 부적응 행동에 어떠한 영향을 미치는지 살펴보았다. 연구 대상은 광주광역시에 있는 어린이집에 다니는 만 4~6세의 취학 전 유아를 가진 어머니 252명을 대상으로 하였다. 측정도구로는 어머니의 내현적 자기애를 측정하기 위해 강선희와 정남운(2002)의 내현적 자기애 척도를 사용하였고, 유아의 부적응 행동을 측정하기 위해 TBC 척도를 사용하였다. 수집된 자료는 SPSS 12.0 통계프로그램을 사용하여, 빈도와 백분율, Cronbach α계수, 상관분석, 중다회귀분석을 실시하였다. 본 연구 결과는 첫째, 어머니의 내현적 자기애 성향이 여아보다 남아의 부적응 행동과 상관이 높게 나타났다. 둘째, 어머니의 내현적 자기애 성향이 유아의 부적응 행동의 모든 영역에 영향을 주는 것으로 나타났다. 특히 어머니의 착취/자기중심성이 성별에 관계없이 공격성, 심리적 불안, 미성숙, 반항행동, 주의력 결핍, 위축행동에 대해 영향을 주는 것으로 나타났다. This study examined the relation between mothers` personality characteristics of covert narcissism and young children`s maladjustment behaviors. The participants were 252 mothers whose children were preschoolers aged four through six in Gwangju. The instruments consisted of Covert Narcissism Scale(Seon-Heui Gang & Nam-Woon Chung, 2002) for measuring mothers` covert narcissism and TBC for measuring young children`s maladjustment behaviors. Collected data were analyzed using SPSS 12.0. Frequencies, percentages, Cronbach α, correlations, and multiple regressions were conducted. The results of the study were as follows. First, there were significant correlations between mothers` covert narcissism and young children`s maladjustment behaviors. Second, mothers` covert narcissism was correlated with male children`s maladjustment behaviors more significantly than those of female children. Third, the effects of mothers` covert narcissism on subscals of children`s maladjustment behaviors were significant except for defiance. Especially, mothers` self-centeredness greatly affected young children`s aggression, anxiety, immaturity, defiant behavior, attention deficit, withdrawing behavior.

      • 일부 응급구조과 학생과 간호과 학생의 안락사에 대한 태도조사 연구

        김미선,박미화,황선영 한국응급구조학회 2002 한국응급구조학회지 Vol.6 No.1

        This descriptive study was conducted to identify the attitude toward euthanasia of EMT and nursing students and to compare their attitude before and after clinical practice. The convenience sample was comprised of 40 first grade and 40 second grade EMT students attended at G college in G-city, and 40 first grade and 40 third grade nursing students attended at C college in C-province. The variable was tested with an euthanasia attitude scale developed by Kim Ae Kyoung(2001). The valid responses were obtained and analyzed by using SPSS PC+ from November 25 to December 6.2002. The results showed that most of the respondents agreed to have positive attitude toward euthanasia in terms of client's right and client's quality of life. Also, they thought that euthanasia should be legalized and the right to die with dignity should be guaranteed. The EMT respondents having a clinical experience showed significantly higher score than respondents having no experience in the subarea of medical ethics and nursing respondents who had a clinical practice showed significantly higher score than others no experience in the subarea of quality of life. But, the other sub-areas had no significant difference between the respondents before and after clinical practice.

      • KCI등재
      • KCI등재

        익명표현의 자유에 대한 헌법적 검토

        장선미,성기용 梨花女子大學校 法學硏究所 2016 法學論集 Vol.20 No.4

        This study evaluated the constitutional significance of the freedom of anonymous speech or, in other words, the freedom and limitation of anonymous speech related to the freedom of expression defined in the Constitution article 21 with focusing on the recent decision of the Constitutional Court. The essence of the freedom of anonymous speech is the freedom of expression. Limiting the freedom of anonymous speech means to force someone to speak after revealing one’s identity and make people consider the responsibility of a speech before they express themselves. Restricting the freedom of anonymous speech, which means regulating the freedom of expressing and delivering one’s thoughts and opinions anonymously and freely, eventually limits expressing opinions and actions. In this regards, guaranteeing the anonymity strengthens the implementation of the freedom of expression. Moreover, the choice of whether one expresses oneself anonymously or not is a choice of the person on how to combine an opinion with his or her personality to what extent. This is ultimately linked with the self-determination and personality revelation, which is the reason of guaranteeing the freedom of expression. Consequently, ‘the regulation of confirming the real name’ or ‘the regulation of identity verification’, which limits the freedom of anonymous speech by allowing people to express themselves upon identification, restricts the foundation of the freedom of expression rather than limiting the contents and methods of expression. It reduces the protection territory of the freedom of expression by inducing the public values such as the welfare of the public to limit the core and assurance of freedom of expression. In particular, ‘the regulation of Identifying Real Names’ or ‘the regulation of identity verification’ in the online environment determines the degree of the guaranteed expression and differentiates the degree of restriction with considering the characteristics of internet media. In other words, it determines the level of freedom due to the needs of restriction. It should be abolished because the principle and exception are reversed. 본 연구는 익명표현의 자유의 헌법상 의의, 즉 헌법 제21조가 규정하는 표현의 자유와 관련하여 익명표현의 자유와 그 제한을 최근의 헌법재판소의 결정을 중심으로 검토하였다. 익명표현의 자유는 그 본질이 표현의 자유이다. 익명표현에 대한 제한은 자신의 정체를 밝히고 표현 할 것을 강제하는 것이고, 발화된 표현에 대한 책임을 표현 전에 고려하도록 강제하는 것이다. 익명으로 사고와 견해를 자유롭게 표명하고 전달할 자유인 익명표현의 자유를 제한하는 것은 결국 표현의사 및 표현행위 자체를 위축시키는 것이다. 이렇게 볼 때 익명성의 보장은 표현의 자유의 실현을 강화한다. 또한 익명표현 여부에 대한 선택은 표현자가 자신의 표현과 자신의 인격을 어떠한 방식으로, 어느 정도로 결합시킬 것인가에 대한 선택이기도 하다. 이는 궁극적으로 표현의 자유를 보장하는 본질적인 이유인 개인의 자기결정 및 인격발현과 연결된다. 따라서 본인확인을 거칠 것을 전제로 표현을 허용함으로써 익명표현의 자유를 제한하는 ‘실명확인제’ 또는 ‘본인확인제’는 표현의 내용과 방법의 제한이 아닌 그 이전 단계에 대한 제한이며, 표현의 자유의 본질과 표현의 자유의 보장목적에서 표현의 자유의 제한원리인 공공복리 등의 공익적 가치를 개입시켜 표현의 자유의 보호영역을 축소시키는 것이다. 또한 인터넷 ‘실명확인제’ 또는 ‘본인확인제’는 인터넷이라는 매체의 특성을 고려하여 표현의 보장 정도를 결정하고 제한의 정도를 달리하는 규제이며, 제한의 필요에 의해 보장의 수준을 결정하는 원칙과 예외가 전도된 규제이다.

      • KCI등재

        국제인권규범을 통한 사회적 기본권의 구체화 가능성 검토

        장선미,성기용 梨花女子大學校 法學硏究所 2018 法學論集 Vol.22 No.4

        사회적 기본권을 헌법에서 직접 규정하고 있는 우리 헌법의 해석론으로 가장 타당한 것은 구체적 권리설이라고 할 수 있다. 그러나 구체적 권리설을 취할 때, 개별 기본권 규정에서 직접 도출될 수 있는 사회적 기본권의 구체적 내용이 무엇이냐에 대한 논의가 필요하다. 사회적 기본권 규정들을 어떤 방식으로 해석하여야 하는지에 대한 문제는 여전히 남아 있기 때문이다. 헌법상 사회적 기본권 규정들의 경우, 사회적 기본권이라는 주관적 권리에 대응하는 국가의 의무에 대한 내용을 함께 규정하고 있는데, 개별 규정에서 규정하고 있는 사회적 기본권의 구체적 내용은 무엇인지, 개인의 권리와 국가의 의무를 함께 규정하고 있는 이유 내지 의미는 무엇인지, 이때의 국가의 사회적 기본권 실현의무의 구체적 내용은 무엇인지를 규명하는 것 또한 구체적 권리설의 과제인 것이다. 사회적 기본권의 주관적 권리성 및 구체적 권리성 인정만으로 사회적 기본권이 개인의 기본권으로 보장되는 정도 내지 구속력이 객관설에 비해 크게 강화되는 것은 아니다. 사회적 기본권의 구체적 내용과 보장의 범위에 대한 더 나아간 논의가 없다면, 객관설이 지적하는 바와 같이 명목상 권리에 그치게 될 수 있다. 이러한 연구과제와 관련하여 생각해 볼 수 있는 연구의 방향은 사회적 기본권이 자유권적 기본권과 마찬가지로 그 토대를 인권에 두고 있다는 점에 주목하여, 국제인권규범 분야에서 사회적 기본권과 동일하거나 유사한 인권에 관한 규범과 그 해석론을 사회적 기본권의 구체적 내용 파악에 활용하는 것이다. 이 가운데 사회권의 최소핵심을 실현하지 않는 국가작용에 대하여는 사법심사의 대상으로 삼아 권리의 침해를 인정하여야 한다는 사회권에 특유한 심사기준인 최소핵심의무는 사회적 기본권에서도 핵심적 내용을 판단하는 기준이 될 수 있다. 최소핵심의무뿐만 아니라 기본권의 구체적인 내용을 규정하고 있는 국제인권규범은 헌법재판소의 심사 과정에서도 사회적 기본권을 구체화시키는 기능을 할 수 있다. The most reasonable interpretation of the Constitution which social rights are directly defined in it is to accept such a right as a subjective right. However, there remains the further question as to whether social rights have their own scope and to what they are and to what extent they need to protect constitutionally. These are the questions related to how to interpret the constitutional provisions to entrench social rights in the constitutional law. Many theories try to solve these problem. Some theories assert that social rights have just the objective value like the constitutional principles or that they have the character as weak subjective rights. But it is not accepted because the constitutional law explicitly has provisions related to social rights. Social rights must be understood as subjective rights like freedom or liberties and the state has to owe the positive obligation to protect the rights when the constitutional law stipulates social rights provision. The constitutional court does not review cases related to social rights positively. It claims that it is difficult to materialize social rights and the legislator has to solve the difficulty because the constitutional law authorize legislator to materialize social rights. These claims are very plausible. Actually democratic legitimacy of legislator is stronger than the constitutional court. But the constitutional law authorize the constitutional court to protect people by interpreting the constitutional law at the trial. So the constitutional court has to try to seek reliable criteria. International human rights norms can suggest direction for the court. Especially the minimum core of economic, social and cultural rights or the minimum core obligation of the state help the court suggesting effective criteria.

      • KCI등재

        하악 우측 측절치에 발생한 선양 치성 종양

        박미선,박호원,서현우,이주현 大韓小兒齒科學會 2011 大韓小兒齒科學會誌 Vol.38 No.4

        선양 치성 종양(adenomatoid odontogenic tumor)은 악골에 드물게 발생하는 치성 기원의 종양이다. 이전에는 법랑모세 포종(ameloblastoma)의 한 종류로 여겨졌으나 양성이며 재발되는 경우는 극히 드물다. 상악 견치에 호발하며 대개는 무증 상이지만 크기가 천천히 커져 무통성 종창을 일으킬 수 있다. 방사선학적으로 함치성 낭종(dentigerous cyst) 및 단방성 법 랑모세포종(unicystic ameloblastoma)과 매우 유사하다. 일반적으로 보존적인 소파술(curettage) 및 적출술(enucleation) 을 통해 치료한다. 본 증례는 하악 우측 측절치 미맹출을 주소로 내원한 10세 여자 환아에서 방사선 사진 검사를 통해 치아의 매복 및 병소를 확인하고 적출술을 시행하였다. 치아에는 브라켓을 부착하여 교정적 정출을 유도하였다. 조직학적 검사를 통해 선양 치성 종 양으로 확진되었으며 양호한 치료 결과를 보였기에 보고하는 바이다. Adenomatoid odontogenic tumor(AOT) is an infrequent odontogenic tumor which arise in the jaw. It was considered as a variant of ameloblastoma. The adenomatoid odontogenic tumor is clearly benign and, in contrast to the ameloblastoma, present a very low recurrence. It most often appears in the canine region of the maxilla. The adenomatoid odontogenic tumor is frequently asymptomatic, however it may cause painless swelling. The radiological findings of adenomatoid odontogenic tumor frequently share characteristics of dentigerous cyst and unicystic ameloblastoma. Conservative surgical enucleation and curettage are the treatment of choice. In this case a 10-year-old child was presented with mandibular right lateral incisor in unerupted. Radiographically, the tooth was impacted and a radiolucency was seen in the area. The lesion was enuclated without extraction of the tooth. Bracket was attached on the tooth for orthodontic extrusion installed. Histopathologically adenomatoid odontogenic tumor was revealed.

      • 지르코니아 clwP 세라믹의 착색 처리조건이 색조변화에 미치는 영향 : Effect of Treatment Condition on Coloring of Zirconia Dental Ceramics

        오선미, 이채현 배재대학교 공학연구소 2011 공학논문집 Vol.13 No.1

        The Effect of treatment condition on the coloring of zirconia dental ceramics were studied. Four liquid coloring agents and different dipping time, and different sintering condition were chosen. Variety of colors from Al to C4 according to shade guide, were observed by spectrophotometer. Therefore it can be concluded that the color of zirconia core can be controlled by controlling treatment condition such as dipping time, sintering temperature, sintering time, coloring agent, and so on.

      • 石顚 禪詩의 受容美學

        金美善 청주대학교 학술연구소 2004 淸大學術論集 Vol.4 No.-

        - Sukjon Park-Hanyoung was a Buddhist monk(禪僧) who had virtues throughout "recitation"(講), "commandment"(律), "zen/Buddhist meditation"(禪), "poetry(詩)". And he was also one of the well-known intellectuals in Korea at that time. There is no doubt that he was a great authority who had been respected by not only the Buddhist society but also great scholars of those days. That fact makes us conclude that the level of his intelligence and personality was so high. In order that the study of Sukjon be made fully and properly, we need to study with diversified aspects related to him. In this chapter, on account of limited space, I would raise the necessity of research of his poetry in the first place. Therefore, in order to investigate the background of forming his poetry, we studied his life, "法脈" are, and the sense of poetry. His sense of poetry was, in other words, "Wha-Um", and for him, "Wha-Um" was nature, and the nature became well-organized zen-poetry getting out of concept itself. Here are the summary of his literary work. 1. Among his 禪事詩, those poems with themes of "temples" are prominent. By sublimating human word into zen-word, he expressed the zen-world with symbolical method. 2. Sukjon himself wrote poems as a Buddhist monk(禪僧), and the poetry which he was pursuing was located in the world of "the inseparable"(不二) which was not distinguished from zen and accorded with the nature. It also imply the perfection of self throughout spiritual enlightenment with samadhi(三味) of "no wickedness in thinking"(思無邪) and the stage of being Bodhisattva(菩薩) for mankind. That means 禪理詩 made by the result of ascetic exercises is another feature of 石顚詩. 3. We can find that his zen-poetry(禪詩) is namely, the mark of samadhi(禪定) and attained a stage of "poetry and zen are accorded"(詩禪一如). The followings are the tasks remaining in this chapter. 1. the study of his diversified thought(idea) 2. Besides his zen-poetry, I am going to deal with nature-poetry(自然詩), greeting-poetry(人事詩), journey-poetry(紀行詩) later, and hope to have your full participation.

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