Multi‑tissue lipotoxicity caused by high‑fat diet feeding is attenuated by the supplementation of Korean red ginseng in mice

Seon‑A Jang,Seung Namkoong,이성률,Jin Woo Lee,Yuna Park,Gyeongseop So,Sung Hyeok Kim,Mi‑Ja Kim,Ki‑Hyo Jang,Alberto P. Avolio,Sumudu V. S. Gangoda,Hyun Jung Koo,Myung Kyum Kim,Se Chan Kang,Eun‑Hwa Sohn 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.1

Background Excessive intake of fat, one of the causes of obesity, is associated with low-grade infammation in various susceptible organs and eventually causes tissue toxicity. This study examines the multifaceted suppressive efects of Korean red ginseng extract (KRG) on high-fat diet (HFD)-induced lipotoxicity and infammatory responses in the aorta, liver, and brain. Methods Male C57BL/6 mice were fed HFD with or without KRG for 12 weeks. The improvement efect in KRG on lipotoxicity and infammatory potential was determined in the blood and the aorta, liver, and brain tissues. Results KRG signifcantly inhibited 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity by >20% in vitro. KRG supplementation suppressed HFD-associated body weight gain, lipid profle changes, and excessive fat deposition in the liver and increased leptin, insulin, and ALT levels in the blood. Infammatory markers in the aorta, liver, and brain were also signifcantly reduced by KRG treatment. In microvascular endothelial cells, the 15% cyclic stretch-mediated upregulation of ICAM-1 and vascular cell adhesion protein-1 (VCAM-1) expression was signifcantly attenuated in the presence of KRG. Conclusion KRG supplementation attenuates HFD-mediated body weight gain, lipid profle changes, and multi-tissue infammatory responses.

어머니의 내현적 자기애 성향과 유아의 부적응 행동과의 관계

이미선 ( Mi Sun Lee ),최명선 ( Myung Seon Choi ) 한국놀이치료학회 2009 한국놀이치료학회지(놀이치료연구) Vol.12 No.1

본 연구에서는 어머니의 성격특성인 자기애적 성향이 유아의 부적응 행동에 어떠한 영향을 미치는지 살펴보았다. 연구 대상은 광주광역시에 있는 어린이집에 다니는 만 4~6세의 취학 전 유아를 가진 어머니 252명을 대상으로 하였다. 측정도구로는 어머니의 내현적 자기애를 측정하기 위해 강선희와 정남운(2002)의 내현적 자기애 척도를 사용하였고, 유아의 부적응 행동을 측정하기 위해 TBC 척도를 사용하였다. 수집된 자료는 SPSS 12.0 통계프로그램을 사용하여, 빈도와 백분율, Cronbach α계수, 상관분석, 중다회귀분석을 실시하였다. 본 연구 결과는 첫째, 어머니의 내현적 자기애 성향이 여아보다 남아의 부적응 행동과 상관이 높게 나타났다. 둘째, 어머니의 내현적 자기애 성향이 유아의 부적응 행동의 모든 영역에 영향을 주는 것으로 나타났다. 특히 어머니의 착취/자기중심성이 성별에 관계없이 공격성, 심리적 불안, 미성숙, 반항행동, 주의력 결핍, 위축행동에 대해 영향을 주는 것으로 나타났다. This study examined the relation between mothers` personality characteristics of covert narcissism and young children`s maladjustment behaviors. The participants were 252 mothers whose children were preschoolers aged four through six in Gwangju. The instruments consisted of Covert Narcissism Scale(Seon-Heui Gang & Nam-Woon Chung, 2002) for measuring mothers` covert narcissism and TBC for measuring young children`s maladjustment behaviors. Collected data were analyzed using SPSS 12.0. Frequencies, percentages, Cronbach α, correlations, and multiple regressions were conducted. The results of the study were as follows. First, there were significant correlations between mothers` covert narcissism and young children`s maladjustment behaviors. Second, mothers` covert narcissism was correlated with male children`s maladjustment behaviors more significantly than those of female children. Third, the effects of mothers` covert narcissism on subscals of children`s maladjustment behaviors were significant except for defiance. Especially, mothers` self-centeredness greatly affected young children`s aggression, anxiety, immaturity, defiant behavior, attention deficit, withdrawing behavior.

일부 응급구조과 학생과 간호과 학생의 안락사에 대한 태도조사 연구

김미선,박미화,황선영 한국응급구조학회 2002 한국응급구조학회지 Vol.6 No.1

This descriptive study was conducted to identify the attitude toward euthanasia of EMT and nursing students and to compare their attitude before and after clinical practice. The convenience sample was comprised of 40 first grade and 40 second grade EMT students attended at G college in G-city, and 40 first grade and 40 third grade nursing students attended at C college in C-province. The variable was tested with an euthanasia attitude scale developed by Kim Ae Kyoung(2001). The valid responses were obtained and analyzed by using SPSS PC+ from November 25 to December 6.2002. The results showed that most of the respondents agreed to have positive attitude toward euthanasia in terms of client's right and client's quality of life. Also, they thought that euthanasia should be legalized and the right to die with dignity should be guaranteed. The EMT respondents having a clinical experience showed significantly higher score than respondents having no experience in the subarea of medical ethics and nursing respondents who had a clinical practice showed significantly higher score than others no experience in the subarea of quality of life. But, the other sub-areas had no significant difference between the respondents before and after clinical practice.

『잊혀진 구두 왕 Olvidado Rey Gudu』의 환상성

권미선 ( Kwon Mi Seon ) 한국스페인어문학회 2003 스페인어문학 Vol.0 No.29

Ana Mari´a Matute es una de los escritores que han construi´do un mundo auto´nomo con su atmo´sfera propia y reconocible en sus novelas y en sus cuentos. Por eso, ella es considerada una´nimamente por los investigadores y cri´ticos como una escritora de difi´cil clasificacio´n. Asi´, el cara´cter muy peculiar y homoge´neo de su produccio´n se define con frecuencia como `otro mundo literario`. Lo que aleja a Matute de `los escritores del medio siglo` es su modo de escribir, distinto del tipo de narrativa basada en realismo social, realismo objetivo o literatura testimonial. Frente a ella, la obra de Matute adquiere dimensiones mi´ticas y simbo´licas a trave´s de su exacerbado lirismo subjetivo, es decir, la fantasi´a. Y la continua repeticio´n de temas y personajes da a su mundo de ficcio´n una unidad y un acento personales. Su reciente novela, Olvidado Rey Gudu´(1996), ha sido clasificada como una novela fanta´stica, pero en mi opinio´n, ma´s que eso, es una novela con mucha fantasi´a donde se reflejan casi todas sus obras anteriores, otras literaturas y cuentos de hadas. Olvidado Rey Gudu´ es la obra cumbre de Ana Mari´a Matute, en la que ella ha trabajado gran parte de su vida, segu´n sus propias palabras. Se trata de un libro ambientado en la Edad Media, que tiene un gran componente de fabulacio´n y fantasi´a, y narra la creacio´n y expansio´n del Reino Olar. Pero no es u´nicamente una novela de aventuras, sino esta´ plagada de simbologi´a, que todo parece tener una segunda lectura, desde los personajes hasta el propio paisaje. Todo remite a una gran meta´fora sobre el hombre, su vida y su memoria.

보문 : Polyethylene Film포장이 포도 Sheridan의 저장력에 미치는 영향

남상영(Sang Young Nam),김경미(Kyoung Mi Kim),박종천(Jong Chun Park),주선종(Seon Jong Joo),정재현(Jai Hyun Jung) 한국식품저장유통학회(구 한국농산물저장유통학회) 1997 한국식품저장유통학회지 Vol.4 No.1

지르코니아 clwP 세라믹의 착색 처리조건이 색조변화에 미치는 영향 : Effect of Treatment Condition on Coloring of Zirconia Dental Ceramics

오선미, 이채현 배재대학교 공학연구소 2011 공학논문집 Vol.13 No.1

The Effect of treatment condition on the coloring of zirconia dental ceramics were studied. Four liquid coloring agents and different dipping time, and different sintering condition were chosen. Variety of colors from Al to C4 according to shade guide, were observed by spectrophotometer. Therefore it can be concluded that the color of zirconia core can be controlled by controlling treatment condition such as dipping time, sintering temperature, sintering time, coloring agent, and so on.

국제인권규범을 통한 사회적 기본권의 구체화 가능성 검토

장선미,성기용 梨花女子大學校 法學硏究所 2018 法學論集 Vol.22 No.4

사회적 기본권을 헌법에서 직접 규정하고 있는 우리 헌법의 해석론으로 가장 타당한 것은 구체적 권리설이라고 할 수 있다. 그러나 구체적 권리설을 취할 때, 개별 기본권 규정에서 직접 도출될 수 있는 사회적 기본권의 구체적 내용이 무엇이냐에 대한 논의가 필요하다. 사회적 기본권 규정들을 어떤 방식으로 해석하여야 하는지에 대한 문제는 여전히 남아 있기 때문이다. 헌법상 사회적 기본권 규정들의 경우, 사회적 기본권이라는 주관적 권리에 대응하는 국가의 의무에 대한 내용을 함께 규정하고 있는데, 개별 규정에서 규정하고 있는 사회적 기본권의 구체적 내용은 무엇인지, 개인의 권리와 국가의 의무를 함께 규정하고 있는 이유 내지 의미는 무엇인지, 이때의 국가의 사회적 기본권 실현의무의 구체적 내용은 무엇인지를 규명하는 것 또한 구체적 권리설의 과제인 것이다. 사회적 기본권의 주관적 권리성 및 구체적 권리성 인정만으로 사회적 기본권이 개인의 기본권으로 보장되는 정도 내지 구속력이 객관설에 비해 크게 강화되는 것은 아니다. 사회적 기본권의 구체적 내용과 보장의 범위에 대한 더 나아간 논의가 없다면, 객관설이 지적하는 바와 같이 명목상 권리에 그치게 될 수 있다. 이러한 연구과제와 관련하여 생각해 볼 수 있는 연구의 방향은 사회적 기본권이 자유권적 기본권과 마찬가지로 그 토대를 인권에 두고 있다는 점에 주목하여, 국제인권규범 분야에서 사회적 기본권과 동일하거나 유사한 인권에 관한 규범과 그 해석론을 사회적 기본권의 구체적 내용 파악에 활용하는 것이다. 이 가운데 사회권의 최소핵심을 실현하지 않는 국가작용에 대하여는 사법심사의 대상으로 삼아 권리의 침해를 인정하여야 한다는 사회권에 특유한 심사기준인 최소핵심의무는 사회적 기본권에서도 핵심적 내용을 판단하는 기준이 될 수 있다. 최소핵심의무뿐만 아니라 기본권의 구체적인 내용을 규정하고 있는 국제인권규범은 헌법재판소의 심사 과정에서도 사회적 기본권을 구체화시키는 기능을 할 수 있다. The most reasonable interpretation of the Constitution which social rights are directly defined in it is to accept such a right as a subjective right. However, there remains the further question as to whether social rights have their own scope and to what they are and to what extent they need to protect constitutionally. These are the questions related to how to interpret the constitutional provisions to entrench social rights in the constitutional law. Many theories try to solve these problem. Some theories assert that social rights have just the objective value like the constitutional principles or that they have the character as weak subjective rights. But it is not accepted because the constitutional law explicitly has provisions related to social rights. Social rights must be understood as subjective rights like freedom or liberties and the state has to owe the positive obligation to protect the rights when the constitutional law stipulates social rights provision. The constitutional court does not review cases related to social rights positively. It claims that it is difficult to materialize social rights and the legislator has to solve the difficulty because the constitutional law authorize legislator to materialize social rights. These claims are very plausible. Actually democratic legitimacy of legislator is stronger than the constitutional court. But the constitutional law authorize the constitutional court to protect people by interpreting the constitutional law at the trial. So the constitutional court has to try to seek reliable criteria. International human rights norms can suggest direction for the court. Especially the minimum core of economic, social and cultural rights or the minimum core obligation of the state help the court suggesting effective criteria.

하악 우측 측절치에 발생한 선양 치성 종양

박미선,박호원,서현우,이주현 大韓小兒齒科學會 2011 大韓小兒齒科學會誌 Vol.38 No.4

선양 치성 종양(adenomatoid odontogenic tumor)은 악골에 드물게 발생하는 치성 기원의 종양이다. 이전에는 법랑모세 포종(ameloblastoma)의 한 종류로 여겨졌으나 양성이며 재발되는 경우는 극히 드물다. 상악 견치에 호발하며 대개는 무증 상이지만 크기가 천천히 커져 무통성 종창을 일으킬 수 있다. 방사선학적으로 함치성 낭종(dentigerous cyst) 및 단방성 법 랑모세포종(unicystic ameloblastoma)과 매우 유사하다. 일반적으로 보존적인 소파술(curettage) 및 적출술(enucleation) 을 통해 치료한다. 본 증례는 하악 우측 측절치 미맹출을 주소로 내원한 10세 여자 환아에서 방사선 사진 검사를 통해 치아의 매복 및 병소를 확인하고 적출술을 시행하였다. 치아에는 브라켓을 부착하여 교정적 정출을 유도하였다. 조직학적 검사를 통해 선양 치성 종 양으로 확진되었으며 양호한 치료 결과를 보였기에 보고하는 바이다. Adenomatoid odontogenic tumor(AOT) is an infrequent odontogenic tumor which arise in the jaw. It was considered as a variant of ameloblastoma. The adenomatoid odontogenic tumor is clearly benign and, in contrast to the ameloblastoma, present a very low recurrence. It most often appears in the canine region of the maxilla. The adenomatoid odontogenic tumor is frequently asymptomatic, however it may cause painless swelling. The radiological findings of adenomatoid odontogenic tumor frequently share characteristics of dentigerous cyst and unicystic ameloblastoma. Conservative surgical enucleation and curettage are the treatment of choice. In this case a 10-year-old child was presented with mandibular right lateral incisor in unerupted. Radiographically, the tooth was impacted and a radiolucency was seen in the area. The lesion was enuclated without extraction of the tooth. Bracket was attached on the tooth for orthodontic extrusion installed. Histopathologically adenomatoid odontogenic tumor was revealed.

응급구조과 학생의 윤리적 가치관에 관한 연구

김미선 한국응급구조학회 2001 한국응급구조학회지 Vol.5 No.1

This study is aimed at examining the ethical values of EMT students. The results below are based on the revised questionnaires, which can be applicable to EMT from the original questionnaires developed by Lee(1990), with a sample of 124 students consisting of 63 first and 61 second year students, conducted November 2-8. 2001. Data were analyzed using SPSS in terms of means, standard deviations, t-test, ANOVA, Pearson's correlation coefficient. The results are as follows: 1. In the area of Human life, all subjects showed utilitarian disposition. All respondents perceived the item "When patients recognizing there is no hope for survival ask for euthanasia, it is ethically right to accomodate their opinions." as the most utilitarian item, whereas they perceived the item "When an hopeless patient is on cardiac arrest, it is ethically right to do CPR as the most deontoogical item. 2. In the area of patient relationship, all students of two groups took on deontoogical characteristics, but there were no statistically significant differences between two groups. All students perceived an item "EMT have to keep it secret if patients disclose their suicide intentions and ask for absolute secrecy" the most utilitarian item, whereas they perceived an item "Even though patients act and speak in a very rude manner, EMT people should do their best to provide care for patients." as the most deontoogical item. 3. In the area of task relationship, first year students perceived an item "Given time iimitations, it is ethically right to give priority to the patients who can be rehabilitated over the paients who can't be fully recovered." as the most utilitarian item, whereas second year students perceived an item "Under no circumstances should any placebo be administered to patients." as the most utilitarian item. All students perceived an item "When EMT students see an unconscious person lying in the street, they have to give him/her emergency treatment." as the most deontoogical item. 4. In the area of coworker relationship, all students of two groups took on deontoogical disposition, but there were no significant differences between two groups. All students of two groups perceived an item "Suppose you are regaded as the person who would be promoted. However, you think that your coworker is more competent than you. In that case you should tell your supervisor about your coworker." as the most utilitarian item. First year students perceived an item, whereas second year students perceived an item "When you observe coworkers' misconduct at work, it is ethically right to ignore their misdeeds." as the most deontoogical item. 5. This study demonstrated that for the first year students, there is a correlational relationship between areas of human life and task relationship, and between areas of human life and task relationship and coworker relationship, whereas for the second year students, there is a correlational relationsip between areas of human life and task relationship. 6. In areas of human life and task relationship, there are significant differences according to attitudes toward EMT and attendance at ethics training sessions. In the area of coworker relationship, there are significant differences according to religion, attendance at ethics training sessions, and a code of ethics. Recommendations for future research, 1. Sample items to measure ethical values and the instrument tailored to the needs of EMT should be developed. 2. A longitudinal study to track ethical value changes according to the amount of work experience is needed. 3. A code of ethics and/or ethics training, which could apply in actual situations, should be implemented.

인터넷을 기반으로 한 보건정보 검색도구 특성 및 탐색방법에 관한 연구

김미선 광주보건대학 1999 論文集 Vol.24 No.-