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Seokhwi Kim,장기택,배현식,최미순,김빛나리,허진석,김호성,최승희 대한병리학회 2016 Journal of Pathology and Translational Medicine Vol.50 No.4
IgG4-related disease (IgG4-RD) may involve multiple organs. Although it usually presents as diffuse organ involvement, localized mass-forming lesions have been occasionally encountered in pancreas. However, the same pattern has been seldom reported in biliary tract. A 61-year-old male showed a hilar bile duct mass with multiple enlarged lymph nodes in imaging studies and he underwent trisectionectomy under impression of cholangiocarcinoma. Gross examination revealed a mass-like lesion around hilar bile duct. Histopathologically, dense lymphoplasmacytic infiltration and storiform fibrosis were identified without evidence of malignancy. Immunohistochemical stain demonstrated rich IgG4-positive plasma cell infiltration. Follow-up imaging studies disclosed multiple enlarged lymph nodes with involvement of pancreas and perisplenic soft tissue. The lesions have been significantly reduced after steroid treatment, which suggests multi-organ involvement of systemic IgG4-RD. Here, we report an unusual localized mass-forming IgG4-related cholangitis as an initial presentation of IgG4-RD, which was biliary manifestation of systemic IgG4-related autoimmune disease.
ChatGPT 시대, 의료 인공지능이 의사를 대신할 수 있을까?
김석휘 ( Seokhwi Kim ) 대한내과학회 2023 대한내과학회지 Vol.98 No.3
Whether artificial intelligence (AI) can replace the role of doctors has seriously been discussed since the appearance of Chat Generative Pretrained Transformer (ChatGPT). Unlike past expectations that limit the role of AI in the medical field, doctors seem to both admire and be threatened by recent advances in AI models. Because previously developed and approved AI models have been managed and reviewed by medical experts during the preparation, refining, annotation, and verification of data, those systems can be considered to be based on evidence-based medicine. However, the current version of the ChatGPT model derives the most meaningful results from unverified open data. This approach enhances the accessibility to new information but is significantly different from the methodology of evidence-based medicine. Like all AI models developed to date, ChatGPT needs a system that can be rigorously verified and regulated by doctors to facilitate its use in the medical field. (Korean J Med 2023;98:99-101)
Ji‑Hyun Kim,Sang Youp Hwang,Jung Eun Park,Gi Bbum Lee,Ho Kim,Seokhwi Kim,Bum Ui Hong 한국탄소학회 2019 Carbon Letters Vol.29 No.3
To prepare activated carbon with a high specific surface area, oxygen functional groups (OFGs) that can serve as useful electron donors during KOH activation were treated with nitric acid and incorporated into activated carbon. OFGs are incorporated differently according to the surface characteristics of starting materials. Up to 22.46% OFGs are incorporated into wood-based activated carbons (WACs), the C=O, COOH contents was 1.90, 17.05%, respectively. Whereas up to 12.82% OFGs are incorporated into coconut shell-based activated carbons, the C=O, COOH contents was 4.12, 6.15%, respectively. The OFGs used for increasing the specific surface area are the carbonyl group, and as the content of the functional group increases, the carbonyl group spreads to the carboxyl group. The specific surface area of activated carbons increased by 10–68% with an increase in the carbonyl group up to 6% (maximum point of carbonyl group). On the other hand, the specific surface area for WACs increased when the carboxyl group was 10% or below, but decreased by 6–15% when it increased to 10% or excess.
최선희 ( Sunhee Choi ),김석휘 ( Seokhwi Kim ),김원장 ( Wonjang Kim ),강창현 ( Changhyun Kang ),김강주 ( Kangjoo Kim ) 한국농공학회 2009 한국농공학회 학술대회초록집 Vol.2009 No.-
새만금수역에서의 영양염류와 염분농도의 관계에서 볼 때 만경강과 동진강으로부터 유입되는 담수와 해수의 혼합 정도가 가장 큰 요인으로 관찰되었다. 즉, 담수 하천을 통해 유입되는 담수의 양에 의해 영양염류의 농도가 상당부분 결정되는 것으로 해수-담수 혼합효과가 가장 중요한 영양염 농도 제어인자라고 할 수 있는 것이다. 이에 의한 영향이 제대로 평가된다면 새만금수질에 있어 가장 중요한 부분이 해결된 것이고 이후에는 플랑크톤의 활동과 저층 영양염 용출 효과만을 생각 하면 될 것이다. 그런데, 담수유입에 의한 효과를 정량화하기 위해서는 상류의 유입유량, 새만금호내의 저수량, 그리고 배수갑문의 통수유량 자료가 필요하다. 그러나 현재 배수갑문의 개폐에 따른 통수 유량 데이터는 산출되어 있지 않고, 상류하천으로부터의 유입되는 유량모델도 담수유입에 의해 급변하는 새만금호의 수질변화를 적절하게 표현하는데 한계가 있다. 이에 본 연구에서는 단순히 강수량을 기준으로 새만금호의 염분농도가 얼마인지를 예측할 수 있는 모델을 개발하였으며, 염분농도는 곧 담수의 유입을 직접적으로 지시하는 변수이기 때문에, 이를 바탕으로 담수에 의한 수질영향 부분은 근사적으로 예측할 수 있을 것이다. 만약 영양염의 저층용출부분과 플랑크톤에 의한 영향을 추가적으로 정량화한다면 이에 더하여 종합적인 수질을 예측할 수 있을 것이다. We could quantitatively evaluate the role of factors controlling the temporal variation of nutrient concentrations in a saline lake recently constructed by tideland reclamation using multivariate statistical techniques. Factors affecting water quality were identified from factor analysis and their contributions to the concentrations of nutrient species were estimated based on multiple linear regression analysis. The objectives of the investigation are monitoring on the present status of water qualities of the lake and establishment of counter-measures to minimize the environmental impacts, especially on the water qualities. From the factor-analysis to identify the key parameters on the water qualities, fresh-water input and biological activities are the most important factors on the surface water qualities, but in addition to the fluvial water, underground water should be considered as another important factor on the bottom water quality.
Comparison of by‑product gas composition by activations of activated carbon
Gi Bbum Lee,Jung Eun Park,Sang Youp Hwang,Ji Hyun Kim,Seokhwi Kim,Ho Kim,Bum Ui Hong 한국탄소학회 2019 Carbon Letters Vol.29 No.3
In this study, commercial activated carbons (ACs) were upgraded by different activation methods, and the gases generated during the activations were defined and quantified. The chemical activation commonly applied for upgrading ACs uses complex reactions, involving pyrolysis, physical, and chemical reactions. The ACs based on wood materials were characterized by elemental analysis, N2 physisorption, Fourier-transform infrared spectroscopy, X-ray photoelectron spectroscopy, and temperature-programmed desorption mass spectrometry. The patterns and composition of the generated gases were analyzed by gas chromatography and X-ray diffraction; high-resolution scanning electron microscopy was also used to characterize the activated carbon. The AC was mostly decomposed to CO2 by pyrolysis and physical activation, while CO was mainly detected during chemical activation from the K2CO3 produced by the reactions between CO2 and K2O. The detected amounts of generated gases were differed at various KOH ratios and residence times. The highest surface area obtained in this study was 2000 m2/g at the optimum ratio of AC and KOH (1:2).