안동호 주변 수계 저서성대형무척추동물의 군집변동 및 생물학적 수질평가

김순환,이지연,서을원,이종은 7개 국립대학교 환경연구 논문집 공동발행 위원회 2003 공업기술연구 Vol.3 No.-

A biological assessment of water quality was carried out in stream of the near Andong lake from June 2002 through March 2003. The benthic macroinvertebrates collected seasonally from 5 field sites were indentified mostly up to species level. The benthic macroinvertebrates collected from the surveyed sites were composed of 77 species, 62 genera, 44 families, 13 orders, 5 class, 4 phyla. Among these phyla, aquatic insects in Arthropoda were 69 species, 37 families, 8 orders. Dominant species occurring in all the field sites were mostly Chironomidae sp. 1, Baetiella fuscatus and Rhopalopsole mahunkai. The dominance indices(DI) showed the highest as 0.929 at site 3 and the lowest as 0.758 at site 5. The species diversity indices(H´) showed the highest as 1.964 at site 5 and the lowest as 1.128 at site 3. Ecological score of benthic macroinvertebrate(ESB) showed the highest as 33.3 at site 5 and the lowest as 17.8 at site 1. It was α-mesosaprobic in site 1 and site 3 the others was β-mesosaprobic that the water quality estimated by ecological score of benthic macroinvertebrate community.

Natto의 텍스쳐 및 관능적평가

오성천,서연희,조정순 명지대학교 자연과학연구소 1997 자연과학논문집 Vol.16 No.-

To make Natto, traditional Japanese food fermented by Bacillus natto, acceptable to Koreans, garlic(2%) and ginseng(2%) were added. General soybean Natto(S₁), 2% garlic Natto(S₂), 2% ginseng Natto(S₃) and black soybean Natto(S₄) were prepared. The proximate composition revealed the most moisture content in S₂ among the all samples. The most cmde protein, crude fat and ash were found in S₄. The non-fibrous and fiber contents were the most in S₁ and S₃. In the texture characteristics, hardness and gumminess were the highest in S₄. The highest springness and cohesiveness were found in S₁. Adhesiveness and chewing were the best in S₂ and S₃. In the sensory evaluation, S₃ showed the best preference, appearance and color. In the aspects of taste and texture, S₄ was mostly prefered. Flavor and viscosity of S₂ were the best among the all samples. The general soybean Natto(S₁) without any addition showed low values in most examinations and tests. In the sensory evaluation, S₃ has the best overall acceptability among the all experimental Nattos.

식도를 포함한 전위장관을 침범한 전이성 악성 흑색종 1예

최정영,김준기,신성하,고영춘,조상욱,서강석,강명원,임연근,여향순,김경수 全南大醫大 2001 전남의대학술지 Vol.37 No.1

Clinical Significance of the Detection of Antinuclear Antibodies in Patients with Acute Hepatitis A

( Yeon Seok Seo ),( Kwang Gyun Lee ),( Eun Suk Jung ),( Hyong Gin An ),( Ji Hoon Kim ),( Jong Eun Yeon ),( Kwan Soo Byun ),( Hyung Joon Yim ),( Hong Sik Lee ),( Soon Ho Um ),( Chang Duck Kim ),( Ho Sa 대한소화기기능성질환·운동학회 2011 Gut and Liver Vol.5 No.3

Background/Aims: The findings of several recent studies suggest that antinuclear antibodies (ANAs) are frequently detected in patients with acute hepatitis A (AHA). However, the clinical significance of a positive ANA test remains uncertain. This study was performed to evaluate the clinical significance of ANAs in AHA patients. Methods: All patients admitted with AHA were consecutively enrolled in this study. An ANA assay was performed by indirect immunofluorescence during hospitalization. ANA positivity was defined as an ANA titer ≥1:80. The peak international normalized ratio (INR), peak alanine aminotransferase (ALT) and peak bilirubin levels were assessed over the duration of the hospitalization, and the incidence of AHA complications was evaluated. Results: A total of 422 patients were enrolled in this study (age, 31±7 years), of which 260 (61.6%) were men. ANAs were detected in 179 AHA patients (42.4%). The proportion of ANA-positive patients varied significantly with AHA status on the day of the ANA assay (4.7% during the prodromal period vs 52.1% during the icteric or recovery period, p<0.001) and sex (56.2% in women vs 33.8% in men, p<0.001). The ANAs became undetectable in all ANA-positive patients within 3 months. The incidence of complications, including mortality, fulminant hepatic failure, renal dysfunction, relapse, and cholestatic hepatitis, did not differ significantly between ANA-positive and ANA-negative patients. Conclusions: ANAs were detected frequently and transiently in patients with AHA, especially after their peak-ALT day. The presence of ANAs may not be associated with the clinical outcome of AHA, but simply with AHA status on the ANA assay day. (Gut Liver 2011;5:340-347)

Serum cystatin C level is a good prognostic marker in patients with cirrhotic ascites and normal serum creatinine levels

Seo, Yeon Seok,Jung, Eun Suk,An, Hyonggin,Kim, Jeong Han,Jung, Young Kul,Kim, Ji Hoon,Yim, Hyung Joon,Yeon, Jong Eun,Byun, Kwan Soo,Kim, Chang Duck,Ryu, Ho Sang,Um, Soon Ho Blackwell Publishing Ltd 2009 Liver International Vol.29 No.10

<P>Abstract</P><P>Background/Aims</P><P>Serum creatinine (Cr) is not a reliable marker for early detection of renal dysfunction in patients with cirrhotic ascites. Several reports have suggested that cystatin C (CysC) is more sensitive than Cr for detecting reduced renal function in these patients. This study evaluated the clinical significance of CysC in patients with cirrhotic ascites and a normal serum Cr level.</P><P>Methods</P><P>We enrolled patients with ascites and a normal serum Cr level (<1.2 mg/dl). Liver function tests, international normalized ratio (INR) and serum Cr and CysC levels were measured on the same day for all patients. CysC levels were measured using the automated latex-enhanced immunonephelometric method. The endpoint of follow-up was the development of hepatorenal syndrome (HRS) or mortality.</P><P>Results</P><P>Seventy-eight patients with cirrhotic ascites were enrolled in the study (58 men and 30 women; age, 53±11 years). The underlying liver diseases in these patients were chronic hepatitis B (37%), chronic hepatitis C (4%), alcoholic liver disease (53%) and others (6%). Forty-six (59%) and 32 (41%) patients were in Child–Pugh classes B and C respectively. HRS developed in 14 patients during the follow-up period (349±241 days), with cumulative incidences of 10.2% and 20.4% at 6 and 12 months respectively. The CysC level was the only independent predictive factor for HRS. Twenty-three patients died during the follow-up period. CysC level and INR were independent factors for predicting mortality.</P><P>Conclusion</P><P>Serum CysC level is a good marker for predicting HRS and survival in patients with cirrhotic ascites and a normal Cr level.</P>

Full-dose sofosbuvir plus low-dose ribavirin for hepatitis C virus genotype 2-infected patients on hemodialysis

Hee Yeon Seo,Myeong-Sook Seo,Sun-Young Yoon,Jong Wook Choi,Soon Young Ko 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.3

Background/Aims: New direct-acting antivirals have shown surprising success in the treatment of hepatitis C, not only in the general population, but also in difficult- to-treat cohorts. However, there is still limited data regarding direct-acting antivirals, including sofosbuvir (SOF), in the context of hemodialysis. The aim of this study was to investigate the safety and outcome of administering full-dose SOF (400 mg/day) plus low-dose ribavirin (RBV, 100 to 200 mg/day) in hemodialysis patients with hepatitis C virus (HCV) genotype 2 (GT2) infection. Methods: Patients with chronic HCV GT2 infection and end-stage renal disease on maintenance hemodialysis treated with full-dose SOF plus low-dose RBV were retrospectively identified from a database of patients with HCV GT2 who were treated in Konkuk University Chungju Hospital between February 2017 and February 2018. Medical records were reviewed for demographics, medical history, laboratory data, and radiologic and electrocardiographic findings. Results: All nine patients completed a full course of 12 weeks of treatment with a full-dose SOF plus low-dose RBV regimen. Two had compensated cirrhosis. Seven patients were treatment-naïve, and two had a relapse following previous interferon-based therapy. All patients had a sustained viral response at 12 weeks post-treatment. There was no discontinuation of treatment because of side effects. Conclusions: In hemodialysis patients with HCV GT2 infection, the full-dose SOF plus low-dose RBV regimen appears to be safe and well tolerated, and yields high rates of sustained virologic response.

Risk Factors for Severe Diverticulitis in Computed Tomography-Confirmed Acute Diverticulitis in Korea

( Nark Soon Park ),( Yoon Tae Jeen ),( Hyuk Soon Choi ),( Eun Sun Kim ),( Young Jin Kim ),( Bora Keum ),( Yeon Seok Seo ),( Hoon Jai Chun ),( Hong Sik Lee ),( Soon Ho Um ),( Chang Duck Kim ),( Ho Sang 대한소화기학회 2013 Gut and Liver Vol.7 No.4

Background/Aims: Acute complicated diverticulitis can be subdivided into moderate diverticulitis and severe diverticulitis. Although there have been numerous studies on the risk factors for complicated diverticulitis, little research has focused on severe diverticulitis. This study was designed to identify the risk factors for severe diverticulitis in an acute diverticulitis attack using the modified Hinchey classification. Methods: Patients were included if they had any evidence of acute diverticulitis detected by computed tomography. The patients were subdivided into severe diverticulitis (Hinchey class Ib; abscesses or peritonitis) and moderate diverticulitis (Hinchey class Ia; pericolic inflammation) groups. Results: Of the 128 patients, 25 exhibited severe diverticulitis, and 103 exhibited moderate diverticulitis. In a multivariate analysis, age >50 years (odds ratio [OR], 5.27; p=0.017), smoking (OR, 3.61; p=0.044), comorbidity (OR, 4.98; p=0.045), leukocytosis (OR, 7.70; p=0.003), recurrence (OR, 4.95; p=0.032), and left-sided diverticulitis (OR, 6.92; p=0.006) were significantly associated with severe diverticulitis. Conclusions: This study suggests that the risk factors for severe diverticulitis are age >50 years, smoking, comorbidity, leukocytosis, recurrent episodes, and left-sided diverticulitis. (Gut Liver 2013; 7:443-449)

Endoscopic submucosal tunnel dissection salvage technique for ulcerative early gastric cancer.

Choi, Hyuk Soon,Chun, Hoon Jai,Seo, Min Ho,Kim, Eun Sun,Keum, Bora,Seo, Yeon Seok,Jeen, Yoon Tae,Lee, Hong Sik,Um, Soon Ho,Kim, Chang Duck,Ryu, Ho Sang WJG Press 2014 WORLD JOURNAL OF GASTROENTEROLOGY Vol.20 No.27

<P>Endoscopic submucosal dissection is an effective treatment modality for early gastric cancer (EGC), though the submucosal fibrosis found in ulcerative EGC is an obstacle for successful treatment. This report presents two cases of ulcerative EGC in two males, 73- and 80-year-old, with severe fibrosis. As endoscopic ultrasonography suggested that the EGCs had invaded the submucosal layer, the endoscopic submucosal tunnel dissection salvage technique was utilized for complete resection of the lesions. Although surgical gastrectomy was originally scheduled, the two patients had severe coronary heart disease, and surgeries were refused because of the risks associated with their heart conditions. The endoscopic submucosal tunnel dissection salvage technique procedures described in these cases were performed under conscious sedation, and were completed within 30 min. The complete en bloc resection of EGC using endoscopic submucosal tunnel dissection salvage technique was possible with a free resection margin, and no other complications were noted during the procedure. This is the first known report concerning the use of the endoscopic submucosal tunnel dissection salvage technique salvage technique for treatment of ulcerative EGC. We demonstrate that endoscopic submucosal tunnel dissection salvage technique it is a feasible method showing several advantages over endoscopic submucosal dissection for cases of EGC with fibrosis. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.</P>

How Should We Assign Large Infiltrative Hepatocellular Carcinomas for Staging?

( Chung Gyo Seo ),( Sun Young Yim ),( Yoo Jin Lee ),( Tae Hyung Kim ),( Na Yeon Han ),( Yeon Seok Seo ),( Hyung Joon Yim ),( Ji Hoon Kim ),( Young Dong Yu ),( Dong Sik Kim ),( Soon Ho Um ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

Aims: Infiltrative gross morphology of hepatocellular carcinoma (HCC) is known to be associated with poor prognosis. To date, there has been no study that fully addressed the potential role of tumor morphology in staging HCC, although it requires further clarification. Therefore, we analyzed the prognostic impact of the infiltrative type HCC by evaluating patients who underwent liver resection for HCC, and attempted to clarify how to assign this HCC subtype in the current staging systems to increase their discriminatory ability. Methods: A total of 774 HCC patients who underwent curative liver resection were retrospectively reviewed and the prognostic significance of infiltrative type HCC was assessed using the Barcelona Clinic Liver Cancer (BCLC) and American Joint Committee on Cancer (AJCC) staging systems. The infiltrative type HCC is defined as a mass with foci varying in size which fuse to form a larger foci without a distinct margin or a mass with a permeative appearance which blends into the background of the cirrhotic liver with an indistinct margin. The cumulative incidence of OS was determined according to the AJCC T-stage and BCLC staging system and the impact of the infiltrative type HCC on each staging system was evaluated using Kaplan-Meier plots (log-rank test), censoring the patients who were lost to follow-up. The Akaike information criterion (AIC) and concordance index (c-index) were calculated to compare the prognostic powers of each staging systems. Results: Seventy-four patients (9.6%) had infiltrative HCCs with a higher proportion of multifocal tumors, larger tumors, vessel invasion, increased tumor marker levels, and advanced T-stages than those with nodular HCC (all, P<0.01). Infiltrative morphology was independently associated with lower overall survival (OS), but its impact was significant when the tumor size was ≥4cm (P<0.001). Under current AJCC and BCLC staging criteria, these large infiltrative HCCs were associated with significantly worse OS in early AJCC T-stages (T1b/T2, P<0.001) and BCLC stage A/B (P=0.01) but not in advanced AJCC (T3/T4) and BCLC C (Fig 1 & 2). The reassignment of this subtype to T3 and T4 increased the discriminatory ability of AJCC T-staging with lower AIC values (3086.9 and 3084 vs. 3103.6) and higher c-index (0.69 and 0.69 vs. 0.67), respectively (both, P<0.05) (Table 1). For BCLC staging sequential reassignment of large infiltrative HCC from BCLC A to BCLC B and from BCLC B to BCLC C also improved the prognostic performance. Conclusions: Large infiltrative type HCC should be assigned to the advanced stages beyond T1 or T2 of the AJCC staging or beyond BCLC stage A or B. We recommend assuming the large unifocal infiltrative type HCCs on surgical specimen as tumors with multiple foci and reassign them from AJCC-T1 and T2 to AJCC-T3, or assuming all large infiltrative HCCs staged AJCC-T1 to T3 as those with macrovascular invasion and reassigning them to AJCC-T4. Second, for BCLC staging, we recommend any large unifocal-looking infiltrative type HCCs staged BCLC-A on imaging studies to be reassigned to BCLC-B while definitely multifocal HCCs initially staged BCLC-B to BCLC-C. This enable finer stratification of HCC patients and provide more accurate prognostic competence.

A case of ovarian choriocarcinoma mimicking ectopic pregnancy

( Yeon Jee Lee ),( Hyun Kyoung Seo ),( Seon Mi Lee ),( Jae Yoon Jo ),( Hee Jung Lee ),( In Ae Cho ),( Jeong Kyu Shin ),( Won Jun Choi ),( Jong Hak Lee ),( Won Young Paik ),( Soon Ae Lee ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-

Choriocarcinoma of the ovary is rare. This tumor can arise from gestational tissue or pure germ cells of the ovary, the former results in gestational choriocarcinoma. We experienced a case of ovarian choriocarcinoma mimicking ectopic pregnancy. We describe a case of a 32-year-old woman, initial diagnosis based on ultrasonography and b-hCG were ectopic pregnancy with hemoperitoneum. Laparoscopic left ovarian cystectomy and dilatation curettage biopsy was done. Biopsy results were reported as ovarian choriocarcinoma. Three times of b-hCG became normal range followed surgery. Ovarian choriocarcinoma should be included in the differential diagnosis of ovarian lesion. The early stage of an ovarian choriocarcinoma can be treated surgry.