Pyrantel Pamoate(Combantrin)에 依한 蛔蟲症의 減量療法

徐丙卨,李純炯,趙昇烈,姜信榮,梁龍石,黃邱一,朴定圭,李水月 中央醫學社 1973 中央醫學 Vol.25 No.4

The mass treatment trial with low dosage of pyrantel pamoate against Ascaris lumbricoides infection was conducted to school children in rural areas of Korea. A comparative trial in the use of piperazine salt, santonin-kainic acid complex in the treatment of ascariasis was also attempted to evaluate the efficacy of' pyrantel pamoate. A total of 804 Ascaris infected school children selected out of 822-positives, who were screened from the total 1, 699 collected specimens, were classified into 7 groups. One of the three kinds of anthelmintics, i.e., pyrantel pamoate, piperazine adipate and santonin-kainic acid complex was administered to each group according to the planned regimen. For the evaluation, the egg negative conversion rate(cure rate) and egg reduction rate were calculated 4 weeks after treatment on 623 follow-up cases with the obtained results from the stool examinations (Cellophane Thick Smear Method and Stoll's Egg Counting Technique). The results obtained were; 1. The egg negative conversion rate was the highest in pyrantel treated groups (Group 1, 2, 3), santonin-kainic acid complex treated group (Group 7) coming next, and the lowest in piperazine treated groups (Group 4, 5, 6). 2. The reduction rates were also obtained just as the same order of the above results. 3. Among the pyrantel pamoate treated groups, the low dosage groups (Group 2 8: 3) showed 90.6% and 85.7% of negative conversion rate, and 99. 2% and 98. 2% of reduction rate respectively, while 94.1% of negative conversion rate and 97.9% of reduction rate were obtained in the conventional dosage group (Group 1). 4. On the analysis of efficacy in the groups treated with piperazine adipate, the best results were. shown in 2 or 3 consecutively treated groups (Group 4 &.- 6) under the supervision of qualified doctors, and the worst was in the group treated with 2 consecutive administration by teachers without supervision (Group 5). 5. The side reactions were so negligible in all the trial groups that none of the treated cases complained about the known side effect of those anthelmintics. From the present study, it can be suggested that the pyrantel pamoate is the most effective among three drugs, and also be recommended to apply the low dosage schedule of pyrantel pamoate in the masstreatment of ascariasis to reduce the expense of masstreatment.

후방십자인대 손상과 동반된 내측 측부 인대 손상의 치료 결과 : 내측부의 안정성은 후방 안정성에 의해 영향을 받는가 MCL Stability depends on PCL Status

서승석,곽희철 대한슬관절학회 2002 대한슬관절학회지 Vol.14 No.2

목적: 본 연구의 목적은 후방 십자 인대 손상과 동반된 내측 측부 인대 손상의 치료 결과를 분석하여 내측 측부 인대 손상의 치료 후 예후에 미치는 요소를 파악하고자 하는데 있다. 대상 및 방법: 1994년 12월부터 1999년 4월까지, 후방 십자 인대 손상과 내측 측부 인대 손상이 동시에 발생하여 본원에서 치료를 받았던 13예의 환자중에서 2년 이상 추시가 가능하였던 10에를 연구대상으로 하였다. 환자의 평균 나이는 33.6세이었고 손상 원인은 스포츠 손상이 2예, 교통사고가 8예였다. 후방 십자인대의 치료는 복원술이 3예, 재건술이 7예에서 시행되었고, 내측 측부 인대의 치료는 복원술이 8예, 보존적인 치료가 2예에서 시행되었다. 수술 후 5내지 6주간 석고고정을 한 후에 보조기 착용을 하고 재활 치료가 시행되었다. 결과: Lysholm 평가 점수에서 우수가 2예, 양호가 2예, 보통 3예, 불량 3예였다. IKDC 판정기준에 따르면 A등급 2예, B등급 2예, C등급 4예, D등급 2예였다. 술 후 스트레스 부하 방사선상에서 후방 십자 인대 이완 정도에 따라 이완이 5 mm 이내인 경우를 제 1군, 6 mm 경우를 제 2군으로 하였을 때 제1군이 4예, 제 2군이 6예였다. 후방 십자 인대 이완 정도에 따른 내측 측부 인대의 이완 정도는 제 1군에서 평균 1.6 mm였고 제 2군에서 평균 3.0 mm였다(P=0.05). 후방 십자 인대의 치료 방법에 따른 내측 측부인대의 이완 정도는 복원술을 시행한 군에서 평균 2.5 mm였고, 재건술을 시행한 군에서 평균 2.4 mm였다(P>0.05). 내측 측부 인대의 치료방법에 따른 내측 측부 인대 이완 정도는 보존적인 치료를 시행한 군에서 평균 2.8 mm였고, 복원술을 시행한 군에서 평균 2.4 mm였다(P>0.05). 결론: 내측 측부 인대 손상이 후방 십자 인대 손상과 동반되었을 때 내측 측부 인대의 이완 정도는 후방십자 인대나 내측 측부 인대의 치료 방법보다는 후방 십자 인대의 이완 정도와 관련이 있었다. 따라서 후방 십자 인대 손상과 동반된 내측 측부 인대 손상의 치료에 있어 우수한 외반 안정성을 얻기 위해서는 정확한 후방 십자 인대 손상의 치료가 필요할 것으로 사료된다. Purpose: The purpose of this study is to evaluate the results fo treatment of combined injury of PCL and MCL and to analysis the facotors affecting the MCL stability. Materials and Methods: The 10 patients of combined injury of posterior cruciate ligament and medial collateral ligament was evaluated after an average duration of follow up of 62.3 months. The age of the patients at the time of injury had twenty five to fifty five years (average 33.6 years) Posterior cruciate ligament were treated reconstructed (7case) or repaired (3case) Medial collateral ligament were treated repaired (8case) of nonoperatively (2case) of repaired (3case) Medial collateral ligament were treated repaired (8case) of nonoperatively (2 case) Postoperatively, all knees had been immobilized for 5~6weeks in 30degrees flexion with a plaster of cast. Results: Lysholm knee score were revealed Excellent (2), good (2). fair (3) poor (3). IKDC knee evaluation form were classified A (2), B (2), C (4), D(2). Materials were grouped according to posterior laxity on the stress x-ray. Group Ⅰ- less than 5 mm posterior translation (4 case), Group Ⅱ-more than 6 mm posterior translation (6case). MCL laxity were average 1.6 m in group Ⅰand 3.0 mm in group Ⅱ (P=0.05). The MCL laxity of PCL repair group was 2.5 mm and that of PCL reconstruction group was 2.4 mm (p>0.05). The MCL laxity of MCL non-operative group was 2.8 mm and that of MCL repair group was 2.4 mm (P>0.05). Conclusion: Lsxity of medial collateral ligament was more related to the PCL laxity than method of treatment PCL and MCL on combined injury of PCL and MCL. To obtain the excellent medial stability on the combined injury MCL and PCL needs a more sophisticated PCL reconstruction.

퇴행성 관절염의 반월상 연골에서 구역에 따른 Apoptosis, Fas, NO, Ki-67, MMP-1발현의 면역분석학적 차이

서승석 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.5

Purpose : The purposes of this study were to examine whether there were a regional difference of the occurrence of apoptosis, nitrotyrosine, Fas, Ki-67 and MMP-1 in the human osteoarthritic(OA) meniscus. Materials and Methods : The 15 cases of menisci were obtained from OA patients undergoing total knee replacement arthroplasty. Apoptotic cells were identified by TUNEL method and electron microscopy. Meniscal sections were analyzed by immunohistochemistry for the regional difference of nitrotyrosine, Ki-67, MMP-1 and Fas expression in the central(medial 2/3) and peripheral(lateral 1/3) portions. Results : The number of apoptotic cells, Nitrotyrosine, MMP-1 were significantly increased in the central portion rather than the peripheral in OA meniscus(p<0.05). The number of apoptotic cells were increased with tissue degeneration. The number of Fas-expressing cells did not have the regional difference in both portions(p<0.05). Ki-67 was significaltly increased in the peripheral portion rather than the cantral portion(p<0.05). Conclusion : Apoptosis was increased in the central portion of the degenerative meniscus in OA. The nitrotyrosine showed the similar result, but the Fas expression was not. This moaned that the NO pathway was more affective to apoptosis in the peripheral portion. We observed that the cellular proliferation occurred in the periphera portion when the degerative change developed in the meniscus. According to the our experiments, we knew the different response when the degeneration occurred in thecentral and peripheral portions.

ELISA에 의한 뇌척수액내 Fibronectin의 측정과 임상적 의의

김숙희,박충서,이병헌,조준승 慶北大學校 醫科大學 1990 慶北醫大誌 Vol.31 No.3

신경계 질환의 진단은 임상 소견과 뇌척수액 검사소견 등을 기초로 하고 있다. 그러나 이들 소견이 각 질환간의 감별에 분명한 도움을 주고 있지는 못하고 있다. 이에 본 연구에서는 뇌척수액 fibronectin을 측정하여 여러 신경계 질환과의 관련을 조사하고 나아가 이들 질환의 감별에 도움을 얻고자 하였다. Fibronectin은 뇌척수액내 미량으로 존재하므로 이의 측정을 위하여 먼저 측정능이 좋은 ELISA를 개발하였다. 그 결과 농도가 10 ng/ml에서부터 100 ng/ml의 범위내에서 뇌척수액 fibronectin 농도를 측정할 수 있었다. 결핵성 뇌막염 9례, 바이러스성 뇌막염 5례, 세균성 뇌막염 2례를 포함한 기타 신경계 질환 8례 및 정상대조군 18례 등 총 40례를 대상으로 뇌척수액내 fibronectin농도를 조사한 결과, 결핵성 뇌막염군은 4.21±2.32 ㎍/㎖, 바이러스성 뇌막염군은 0.9±0.79 ㎍/㎖, 기타 질환군은 2.05±2.48 ㎍/㎖, 그리고 정상대조군은 1.35±0.84 ㎍/㎖의 평균값을 보여 결핵성 뇌막염군이 기타 질환군을 제외한 타 질환군들에 비해 통계적으로 유의하게 높은 값을 보였다(p<0.01). 결핵성 뇌막염의 경우 1례를 제외하고는 모두 2.9 ㎍/㎖ 이상이었고, 3례(38%)에서는 4.6 ㎍/㎖ 이상이었던 반면, 바이러스성 혹은 무균성 뇌막염에서는 1례에서만 2.2 ㎍/㎖이고 나머지는 모두 1 ㎍/㎖ 이하로 나타났다. 이상의 결과로 보아 뇌척수액내 fibronectin농도의 측정은 결핵성 뇌막염과 바이러스성 뇌막염의 감별진단에 유용하리라 생각된다. The diagnosis of neurologic diseases is based on the clinical symptoms and cerebrospinal fluid findings. These findings, however, are often ambiguous. This study aims to evaluate the diagnostic value of cerebrospinal concentration of fibronectin. Fibronectin level in cerebrospinal fuid was measured by ELISA which could detect fibronectin in the range from 10 ng/ml to 100 ng/ml. Nine cases of tuberculous menigitis, 5 cases of viral meningitis, 8 cases of miscellaneous neurologic conditions and 18 cases of normal controls were studied. The mean value of fibronectin level in cerebrospinal fluid in tuberculous meningitis was 4.21±2.32 ㎍/㎖, in viral meningitis 0.9±0.79 ㎍/㎖, in miscellaneous neurologic conditions 2.05±2.48 ㎍/㎖ and in controls 1.35±0.84 ㎍/㎖. The fibronectin level in tuberculous meningitis was significantly higher than in other groups except the miscellaneous neurologic conditon(p<0.01). Cerebrospinal fluid fibronectin level appeared to be useful to differentiate tuberculous meningitis fro viral meningitis. Those levels were higher than 2.9 ㎍/㎖ in all except one case and higher than 4.6 ㎍/㎖ in 38% of tuberculous meningitis cases, but, 2.2 ㎍/㎖ in only one case of viral meningitis and lower than 1.0 ㎍/㎖ in all except one case of viral meningitis. It is suggested that measurement of fibronectin level in cerebrospinal fluid is a useful test for diagnosis of tuberculous meningitis, especially for differential diagnosis between tuberculous and viral meningitis.

초등교사의 과학과 환경 교육에 대한 수업실태 분석 및 인식도

조태호,서승조,백남권,김성규,박강은,박원석 한국환경과학회 2002 한국환경과학회지 Vol.11 No.7

The purpose of this study was to analyze the elementary school teachers' perception toward the environment-related subjects in science education and to investigate their instructional methods in delivering the subjects in the classroom. The participants of this study were 300 elementary school teachers sampled from elementary schools in Kyung Nam Province. The findings of this study were as follows; First, more than half of the teachers surveyed showed that the environment-related units and contents in the science textbook were insufficient to the existing issues. Second, the large portion of teachers responded that the teaching materials in the textbook were insufficient to deliver the contents. Third, the largest portion of respondents replied that their preferred instructional method was a teacher-directed instruction followed by a case study approach. Fourth, in terms of the effectiveness of environmental education, both male and female teachers showed negative responses. Furthermore, male teachers were more negative than female teachers. Fifth, total means of their preference of the environment-related units was 3.13. The unit for sixth graders titled 'Environmental Pollution and Protecting Nature' showed the highest preference, whereas the unit for fifth graders titled 'Structure and Functions of Plants' showed the lowest preference. Sixth, there was no statistically significance in gender and their working areas. Seventh, there was statistically significant differences between male and female teachers in terms of teaching experience. In detail, the teachers with 5 to 9 teaching experience showed the lowest scores, while the teacher with more than 15 years teaching experience showed the highest scores in their perception of the units. Eighth, there was a significant difference between two groups in terms of their educational background. For example, two-year college graduates showed higher preference than four-year college graduates.

안검에 발생한 단발성 성인형 근섬유종 1예

김성준,박현수,서승리,이용석,전덕규 대한피부과학회 2003 대한피부과학회지 Vol.41 No.2

Solitary myofibroma is an uncommon myofibroblastic neoplasm, presenting as an asymptomatic nodule of the skin, which mainly occurrs in adults. It was thought to be the adult counterpart of infantile myofibromatosis. Although it has histopathological similarity to infantile myofibromatosis, it shows a discrete clinicopathological entity compared with infantile form on the basis of its much later onset, superficial location, invariable solitary occurrence and uniformly benign behavior. A 45-year-old woman had a skin lesion on the right upper eyelid for 2 years, which was a solitary, painless nodule with eyelid retraction. The excised tumor was diagnosed as myofibroma by light microscopy and immunohistochemistry. (Korean J Dermatol 2003;41(2) : 272∼275)

RAW264.7 세포에서 interferon-r 및 LPS에 의해 유도되는 NO생성에 미치는 TALT-35의 영향

박종일,박경석,김종석,박지훈,윤은진,송경섭,서강식,김훈,윤완희,박승길,임규,황병두 충남대학교 생물공학연구소 2006 생물공학연구지 Vol.12 No.-

TALP-35 purified from human term placenta is known to increase microtubule polymerization and stabilize the polymerized microtubule. To examine the effect of TALP-35 on immune system this study was performed. MTT assay was performed to investigate the effect of TALP-35 on the proliferation of RAW264.7 cells. TALP-35 dose dependently suppress the proliferation of RAW264.7 cells at high concentration (above 1 μM) in unstimulated cells, in case of 10 μM TALP-35 treated cells the suppression was 25% but in stimulated cells it was only 15%. Cosedimentation assay was carried out to investigate whether TALP-35 can bind to tubulin of RAW264.7, monocyte/macrophage lineage of mouse, and polymerize it. TALP-35 polymerize the tubulin of RAW264.7 cells and sedimented in dose-dependent manner. To investigate the effect of TALP-35 on the expression of iNOS protein western blotting was performed. The expression level of iNOS was decreased dose dependently in high concentration of TALP-35 treatment. To examine the activity of iNOS, secreted NO was determined by method based on Griess reaction. Interferon-γ and LPS-stimulated production of NO from RAW264.7 cells was decreased dose dependently above 0.1 μM concentration of TALP-35 and 50% is decreased at 10μM of it. This study shows TALP-35 can control cytokine induced-iNOS expression therefore it might control inflammatory diseases.

Clinical Results Comparing Transtibial Technique and Outside in Technique in Single Bundle Anterior Cruciate Ligament Reconstruction

( Seung Suk Seo ),( Chang Wan Kim ),( Jeon Gyo Kim ),( Sung Yub Jin ) 대한슬관절학회 2013 대한슬관절학회지 Vol.25 No.3

Purpose: To compare the clinical results of single-bundle anterior cruciate ligament (ACL) reconstruction using the conventional transtibial technique and the anatomical outside-in technique for femoral tunneling. Materials and Methods: From 2007 to 2011, 89 patients who received ACL reconstruction were followed for ≥1 year were enrolled in the study. The conventional transtibial technique was used in 41 patients and the outside-in technique, in 48 patients. Femoral tunnel angle measurement and three-dimensional computed tomography (3D CT) were used for radiologic assessment of the location of femoral tunnel and Lysholm score and other tests were used for clinical assessment. Results: Both techniques did not reveal statistical differences in the clinical assessment. However, in International Knee Documentation Committee subjective knee evaluation, the sum of two questionnaire items regarding instability showed a statistically significant difference (p=0.01). In the pivot shift test, the anatomical outside-in technique showed outstanding rotational stability over the transtibial technique (p=0.04). The mean femoral tunnel inclination in coronal plane were 69.2o and 30.3o, respectively, for both techniques, and 21.6o and 50.8o, respectively in sagittal plane, showing statistically significant differences on simple radiography (p=0.04, 0.05). A 3D CT was performed in 17 patients with the conventional transtibial technique and 25 patients with the outside-in technique. Coefficients of variation were 0.33 and 0.13, respectively, from dorsal border of the condyle and 0.67 and 0.24, respectively, from the roof of intercondylar notch. Conclusions: Femoral tunnels created with the outside-in technique have superior knee joint rotational stability compare to the transtibial technique. Therefore, the outside-in technique could be considered as a valuable technique in single-bundle ACL reconstruction.

A Comparison of Patella Retention versus Resurfacing for Moderate or Severe Patellar Articular Defects in Total Knee Arthroplasty: Minimum 5-year Follow-up Results

( Seung Suk Seo ),( Chang Wan Kim ),( Sang Won Moon ) 대한슬관절학회 2011 대한슬관절학회지 Vol.23 No.3

Purpose: The purpose of this study is to assess the clinical and radiological results of patients who underwent patellar retention or resurfacing for moderate or severe patellar articular defects during total knee arthroplasty and evaluate the clinical efficacy of patellar resurfacing according to the articular defect of the patella. Materials and Methods: From May 2003 to March 2006, 252 patients (277 cases) underwent total knee arthroplasty by one surgeon. Intraoperatively, we divided these patients into a moderate articular defect group (50-75%: group I) and a severe articular defect group (75-100%: group II) and randomly performed patellar resurfacing. The average age was 67.2 years. There were 234 female and 17 male patients. The average follow-up period was 74.6 months. Clinical outcomes were analyzed using the Knee Society (KS) knee score. Functional score, Hospital for Special Surgery (HSS) score, Feller patellar score and range of motion (ROM). Radiological outcomes were analyzed using the congruence angle, Insall-Salvati ratio and patella tilt angle. Results: The KS knee score and functional score at the last follow-up were 84.4/73.1 in the retention group and 85.2/71.8 in the resurfacing group (p=0.80, p=0.63) in group I. In group II, the values were 82.1/75.1 and 87.0/71.2, respectively (p=0.51, p=0.26). The HSS score and Feller patella score were 86.7/20.3 in the retention group and 84.3/21.7 in the resurfacing group (p=0.31, p=0.29) in group I. In group II, the values were 91.6/21.2 and 85.5/22.1, respectively (p=0.37/p=0.30). The knee ROM (p=0.36/p=0.41), congruence angle (p=0.22/p=0.16), Insall-Salvati ratio (p=0.16/p=0.21) and patella tilt angle (p=0.12/p=0.19) were not statistically different between the two groups. Conclusions: In this study, we could not find any correlations between the degree of patellar articular defect and patellar resurfacing in terms of the clinical and radiological results. Therefore, patellar articular defects is thought to be less meaningful in determining patellar resurfacing.

Avulsion fracture of the tibial tuberosity with patellar ligament rupture in an adolescent patient

Seung Suk Seo,Do-Hun Kim,Moo-Won Kim,Jin-Hyeok Seo 대한정형외과 스포츠의학회 2015 Arthroscopy and Orthopedic Sports Medicine Vol.2 No.1

Avulsion fracture of the tibial tuberosity generally occurs in the adolescent patient during sports activities. However, avulsion fracture of the tibial tuberosity combined with patellar ligament rupture is a rare occurrence. Here, we present the diagnosis and treatment of this rare case in an adolescent male.