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        • SCIESCOPUSKCI등재

          Review : Application of MALDI Tissue Imaging of Drugs and Metabolites: A New Frontier for Molecular Histology

          ( Selina Rahman Shanta ), ( Young Jun Kim ), ( Young Hwan Kim ), ( Kwang Pyo Kim ) 한국응용약물학회 2011 Biomolecules & Therapeutics(구 응용약물학회지) Vol.19 No.2

          Matrix assisted laser desorption ionization (MALDI) mass spectrometry is commonly used to analyze biological molecules such as proteins, peptides and lipids from cells or tissue. Recently MALDI Imaging mass spectrometry (IMS) has been widely applied for the identification of different drugs and their metabolites in tissue. This special feature has made MALDI-MS a common choice for investigation of the molecular histology of pathological samples as well as an important alternative to other conventional imaging methods. The basic advantages of MALDI-IMS are its simple technique, rapid acquisition, increased sensitivity and most prominently, its capacity for direct tissue analysis without prior sample preparation. Moreover, with ms/ms analysis, it is possible to acquire structural information of known or unknown analytes directly from tissue sections. In recent years, MALDI-IMS has made enormous advances in the pathological field. Indeed, it is now possible to identify various changes in biological components due to disease states directly on tissue as well as to analyze the effect of treated drugs. In this review, we focus on the advantages of MALDI tissue imaging over traditional methods and highlight some motivating findings that are significant in pathological studies.

        • SCIESCOPUSKCI등재

          Application of MALDI Tissue Imaging of Drugs and Metabolites: A New Frontier for Molecular Histology

          Shanta,,Selina,Rahman,Kim,,Young-Jun,Kim,,Young-Hwan,Kim,,Kwang-Pyo The Korean Society of Applied Pharmacology 2011 Biomolecules & Therapeutics(구 응용약물학회지) Vol.19 No.2

          Matrix assisted laser desorption ionization (MALDI) mass spectrometry is commonly used to analyze biological molecules such as proteins, peptides and lipids from cells or tissue. Recently MALDI Imaging mass spectrometry (IMS) has been widely applied for the identification of different drugs and their metabolites in tissue. This special feature has made MALDI-MS a common choice for investigation of the molecular histology of pathological samples as well as an important alternative to other conventional imaging methods. The basic advantages of MALDI-IMS are its simple technique, rapid acquisition, increased sensitivity and most prominently, its capacity for direct tissue analysis without prior sample preparation. Moreover, with ms/ms analysis, it is possible to acquire structural information of known or unknown analytes directly from tissue sections. In recent years, MALDI-IMS has made enormous advances in the pathological field. Indeed, it is now possible to identify various changes in biological components due to disease states directly on tissue as well as to analyze the effect of treated drugs. In this review, we focus on the advantages of MALDI tissue imaging over traditional methods and highlight some motivating findings that are significant in pathological studies.

        • KCI등재

          On Conditions of Phytoplankton Blooms in the Coastal Waters of the North-Western East/Japan Sea

          Zuenko,,Yury,Selina,,Marina,Stonik,,Inna The Korean Society of Oceanography 2006 Ocean science journal Vol.41 No.1

          Seasonal changes of abundance of the main phytoplankton groups of species (diatoms, dinoflagellates, chrysophytes, small flagellates and cryptophytes) and a set of environmental parameters were investigated in coastal and pre-estuarine waters of Peter the Great Bay (East/Japan Sea) in May-October of 1998 and 1999. Three periods of mass development were revealed: spring, summer and autumn blooms, with successive change of species. The conditions favourable for each group of species were determined. Driving mechanisms of the succession include nutrients transport through seasonal pycnocline by turbulent mixing, terrestrial nutrients supply by monsoon floods, nutrients supply by upwellings, and light control by the thickness of upper mixed layer. Summer succession could be explained by a simple SST-MLD diagram similar to Pingree S-kh diagram with sea surface temperature as indicator of stratification (S) and mixed layer depth as indicator of light availability (kh).

        • KCI등재후보

          Huawei's Thirty Years: From Phone Switch Resellers to Global Telecom Equipment and Service Giant

          Kevin,Han,Huang,Selina,Juehua,Su,Lulu,Ouyang Academy of Asian Business (AAB) 2017 Academy of Asian Business Review Vol.3 No.2

          This case study aims to analyse the success story of Huawei, a leading Chinese telecommunication company, best known for its infrastructure equipment manufacturing and its smartphone production. The report is presented in three parts. The first part examines the events and turning points in the years prior to Huawei's current market leadership. Market conditions and competitors at the key junctures are analysed, and Huawei's corresponding strategies and consequent performance are discussed. The second part looks into the factors behind Huawei's success, categorised in terms of internal management and external strategies. Distinct Asian-business features are highlighted and analysed in the context of the markets they are being applied to. The third part examines the current position and future potential of Huawei's three major business groups in the context of market trends. This is followed by a discussion of the challenges faced by Huawei and recommended solutions. Market conditions underpinning the challenges are explored, while the effects and feasibility of solutions are analysed with specific examples. Finally, the conclusion examines what can be learned from Huawei's success. As the world embraces rapid technological advancement in all spheres, this case study, by analysing the success story of a technological giant, hopes to offer insights for emerging Asian technological enterprises. Moreover, the many uniquely Asian-style business strategies, while not universally applicable, present valuable lessons for Asian enterprises wishing to succeed in the globalised world. Huawei's revolutionary management structure, unique marketing strategies and devotion to research and development are particular aspects of its success that are worth examining.

        • KCI등재SCOPUS

          Kinetic Model for Simultaneous Saccharification and Fermentation of Brewers' Spent Grain Liquor Using Lactobacillus delbrueckii Subsp. lactis

          Alexander,Akermann,Jens,Weiermüller,Selina,Lenz,Jens,Christmann,Roland,Ulber 한국생물공학회 2021 Biotechnology and Bioprocess Engineering Vol.26 No.1

          Brewers' spent grain (BSG) liquor can be obtained by pressing fresh BSG and was recently proposed as a fermentation medium. A kinetic model was established, that can predict lactate formation and cell growth of Lactobacillus delbrueckii subsp. lactis with three BSG liquors of different origin in a simultaneous saccharification and fermentation approach. The kinetic model assumes a multi-substrate dependence of glucose and several nitrogencontaining molecule classes on cell growth, substrate uptake, and lactate formation. Furthermore, the model contains terms for the enzymatic degradation of 1,4-α-bond glucose oligomers. The nutrient content of the fermentation media, based on BSG liquor, varied broadly in terms of total carbohydrates (26.27 g·L-1 to 107.17 g·L-1), amino acids (1.52 g·L-1 to 6.78 g·L-1), and proteins (0.16 g·L-1 to 0.46 g·L-1). The deviation between experiment and simulation was - in relation to the large differences in media composition - quite small and ranged from 1.6% to 12.9% (final cell density) and from 5.0% to 24.8% (total lactate concentration). Both the experiment and the simulation showed that serine and alanine play an essential role in the metabolism of the organism. In general, the ratio of carbohydrates to amino acids in the fermentation medium is very important for L. delbrueckii subsp. lactis. Therefore, the model can contribute to control the bioprocess and assess fermentation kinetics for unknown BSG liquors.

        • KCI등재

          Protocol: Testing the Relevance of Acupuncture Theory in the Treatment of Myofascial Pain in the Upper Trapezius Muscle

          Dale,S.,Elsdon,Selina,Spanswick,Chris,Zaslawski,Peter,C.,Meier 사단법인약침학회 2017 Journal of Acupuncture & Meridian Studies Vol.10 No.1

          A protocol for a prospective single-blind parallel four-arm randomized placebo-controlled trial with repeated measures was designed to test the effects of various acupuncture methods compared with sham. Eighty self-selected participants with myofascial pain in the upper trapezius muscle were randomized into four groups. Group 1 received acupuncture to a myofascial trigger point (MTrP) in the upper trapezius. Group 2 received acupuncture to the MTrP in addition to relevant distal points. Group 3 received acupuncture to the relevant distal points only. Group 4 received a sham treatment to both the MTrP and distal points using a deactivated acupuncture laser device. Treatment was applied four times within 2 weeks with outcomes measured throughout the trial and at 2 weeks and 4 weeks posttreatment. Outcome measurements were a 100-mm visual analog pain scale, SF-36, pressure pain threshold, Neck Disability Index, the Upper Extremity Functional Index, lateral flexion in the neck, McGill Pain Questionnaire, Massachusetts General Hospital Acupuncture Sensation Scale, Working Alliance Inventory (short form), and the Credibility Expectance Questionnaire. Two-way analysis of variance (ANOVA) with repeated measures were used to assess the differences between groups.

        • KCI등재

          Mass spectrometry based cellular phosphoinositides profiling and phospholipid analysis: A brief review

          김영준,Li-Hua,Zhou,Selina,Rahman,Shanta,김광표 생화학분자생물학회 2010 Experimental and molecular medicine Vol.42 No.1

          Phospholipids are key components of cellular membrane and signaling. Among cellular phospholipids,phosphoinositides, phosphorylated derivatives of phosphatidylinositol are important as a participant in essential metabolic processes in animals. However,due to its low abundance in cells and tissues, it is difficult to identify the composition of phosphoinositides. Recent advances in mass spectrometric techniques,combined with established separation methods, have allowed the rapid and sensitive detection and quantification of a variety of lipid species including phosphoinositides. In this mini review, we briefly introduce progress in profiling of cellular phosphoinositides using mass spectrometry. We also summarize current progress of matrices development for the analysis of cellular phospholipids using matrix-assisted laser desorption/ionization mass spectrometry. The phosphoinositides profiling and phospholipids imaging will help us to understand how they function in a biological system and will provide a powerful tool for elucidating the mechanism of diseases such as diabetes, cancer and neurodegenerative diseases. The investigation of cellular phospholipids including phosphoinositides using electrospray ionization mass spectrometry and matrix-assisted laser desorption/ionization mass spectrometry will suggest new insights on human diseases,and on clinical application through drug development of lipid related diseases.

        • KCI등재

          Identification of Protein Markers Specific for Papillary Renal Cell Carcinoma Using Imaging Mass Spectrometry

          나찬현,홍지혜,김완섭,Selina,Rahman,Shanta,방주용,박동민,김학균,김광표 한국분자세포생물학회 2015 Molecules and cells Vol.38 No.7

          Since the emergence of proteomics methods, many proteins specific for renal cell carcinoma (RCC) have been identified. Despite their usefulness for the specific diagnosis of RCC, such proteins do not provide spatial information on the diseased tissue. Therefore, the identification of cancerspecific proteins that include information on their specific location is needed. Recently, matrix-assisted laser desorption ionization (MALDI) mass spectrometry (MS) based imaging mass spectrometry (IMS) has emerged as a new tool for the analysis of spatial distribution as well as identification of either proteins or small molecules in tissues. In this report, surgical tissue sections of papillary RCC were analyzed using MALDI-IMS. Statistical analysis revealed several discriminative cancer-specific m/z-species between normal and diseased tissues. Among these m/z-species, two particular proteins, S100A11 and ferritin light chain, which are specific for papillary RCC cancer regions, were successfully identified using LC-MS/MS following protein extraction from independent RCC samples. The expressions of S100A11 and ferritin light chain were further validated by immunohistochemistry of human tissues and tissue microarrays (TMAs) of RCC. In conclusion, MALDI-IMS followed by LCMS/ MS analysis in human tissue identified that S100A11 and ferritin light chain are differentially expressed proteins in papillary RCC cancer regions.

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