Mast Cells in Allergic Asthma and Beyond

Sebastian Reuter,Michael Stassen,Christian Taube 연세대학교의과대학 2010 Yonsei medical journal Vol.51 No.6

Mast cells have been regarded for a long time as effector cells in IgE mediated type I reactions and in host defence against parasites. However, they are resident in all environmental exposed tissues and express a wide variety of receptors, suggesting that these cells can also function as sentinels in innate immune responses. Indeed, studies have demonstrated an important role of mast cells during the induction of life-saving antibacterial responses. Furthermore, recent findings have shown that mast cells promote and modulate the development of adaptive immune responses, making them an important hinge of innate and acquired immunity. In addition, mast cells and several mast cell-produced mediators have been shown to be important during the development of allergic airway diseases. In the present review, we will summarize findings on the role of mast cells during the development of adaptive immune responses and highlight their function, especially during the development of allergic asthma.

Body Part Detection in Smoky Environments with Thermal Camera Using Deep Learning

Sebastian Gelfert 제어로봇시스템학회 2022 제어로봇시스템학회 국제학술대회 논문집 Vol.2022 No.11

Human victim detection in smoky indoor environments during search and rescue missions is still challenging. This situation is due to the fact that fire fighters are on the one hand exposed to unstable building structures and on the other hand their cognitive fatigue, due to long search missions, reduce the efficient victim detection in these hazardous environments. In this paper, an approach to detect victims in real time with a thermal camera assisting fire fighters in their search and rescue mission, is presented. Thereby, a low resolution thermal camera is mounted on a remote-controlled mobile robot with a human hand detection using deep learning and display the detection in real time to an operator outside the danger zone. Experiments show that this approach enables an efficient victim detection in smoky indoor environments. The human hand detection model achieves a real time detection rate of above 90% in a dense smoke indoor environment.

Modification of Cellulose and Rutile Welding Electrode Coating by Infiltrated TiO2 Nanoparticles

Sebastian Balos,Leposava Sidjanin,Miroslav Dramicanin,Danka Labus,Branka Pilic,Mirjana Jovicic 대한금속·재료학회 2016 METALS AND MATERIALS International Vol.22 No.3

In this paper, a novel method of infiltration of TiO2 nanoparticles into the coating of the cellulose and rutile shielded metal arc welding electrode is shown. Tensile properties and strength of weld metals were correlated to the chemical composition of the weld metals, ferrite type, and non-metallic inclusion type, size and composition. As infiltration time is increased in the cellulose electrodes, the non-metallic inclusion count increases and their size decreases. They act as inoculants and lead to the replacement of Widmanstaetten with the finegrained acicular ferrite which increases the mechanical properties of the welds. The modification of rutile electrodes with low and medium infiltration time also refines the microstructure and increases the mechanical properties. Specimens welded with rutile electrodes infiltrated at maximum duration exhibited the lowest mechanical properties due to the relatively large non-metallic inclusions that act as void nucleation sites and the appearance of large grain allotriomorphic ferrite in the weld metal.

Visual Tropes in the Ancient Mediterranean: The Case of Situla Art (c. 600–400 BC)

Sebastian Müller 한국세계문화사학회 2017 세계 역사와 문화 연구 Vol.0 No.45

Situla art occurring in northern Italy and the southeast alpine area from 600 B.C. has been an intensively discussed phenomenon. The figurative scenes on the eponymous bronze vessels are often understood as direct representations of the local people’s customs, lifestyle or even of historical events in the area of their discovery. An examination of the scenes based on their general themes demonstrates, however, that despite the inclusion of regional elements, there is a huge similarity with motifs of Etruscan art and even with older visual artwork from Anatolia and Mesopotamia. Although it is possible that the depicted images were connected locally with individual narratives, their main function was to communicate the affiliation of the owner of the decorated objects to the elite stratum of the society. There is no doubt that regional and cultural elements as well as the purpose of the decorated object influenced the visual content, there are, however, recurring themes or visual tropes that connect different civilizations and cultures through space and time. These similarities might be explainable by their universal character that applied to the ideals, but also to the reality of lives of the elite members in the prehistoric and ancient Mediterranean. (Busan University of Foreign Studies)

Sex Differences in Serum C-Reactive Protein Course after Total Hip Arthroplasty

Sebastian Rohe,Eric Röhner,Christoph Windisch,Georg Matziolis,Steffen Brodt,Sabrina Böhle 대한정형외과학회 2022 Clinics in Orthopedic Surgery Vol.14 No.1

Background: Gender-specific medicine has become an important part in investigating the course of various diseases. C-reactive protein (CRP) is used as an inflammatory marker for detecting inflammations and even infections after total hip arthroplasty (THA). The general course of CRP after THA is well known, but there is controversy about its association with sex. Therefore, we aimed to investigate if there is an influence of sex on the CRP after THA in the first 10 days after operation in a complication-free course in male and female patients and to re-evaluate the specific postoperative CRP course with its maximum on the second to third postoperative days. Methods: We retrospectively reviewed patients who had been treated with THA due to primary osteoarthritis through the same approach using an equal model of a cementless stem and a cup and complication-free between 2013 and 2016. Patients with active inflammation, rheumatoid arthritis, secondary arthrosis, active cancer disease, and documented postoperative complications were not included. The CRP values before THA and up to 10 days after THA were recorded and tested for sex discrepancy. Factor analyses were performed, and CRP values were adjusted for confounders (age, operation time, diabetes mellitus, and body mass index [BMI]). Results: A total of 1,255 patients (728 women and 527 men) were finally analyzed. Men were younger and had a longer operation time and a higher BMI compared to women. The prevalence of overweight was higher in men, while obesity (BMI > 40 kg/m²), diabetes mellitus, renal failure, and American Society of Anaesthesiologists status showed no significant difference between men and women. Men had significantly higher CRP values than women between the 2nd and the 7th postoperative days, with the largest difference on the 4th postoperative day (men, 130.48 mg/L; women, 87.26 mg/L; p = 0.018). Conclusions: Based on the results of more precise sex-specific evaluation of the postoperative CRP course after THA, the present study showed for the first time that there was a gender discrepancy in the CRP course after complication-free THA in the first 7 postoperative days. Furthermore, this study confirmed the postoperative CRP course with its maximum on the third postoperative day.

Der Schuldnerverzug als eigenständiger Tatbestand im Recht der Leistungsstörungenmobile

Sebastian Lohsse 충남대학교 법학연구소 2008 法學硏究 Vol.19 No.2

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프랑스의 작업중지권 : 규제와 현황

Sebastian Schulze-Marmeling 한국노동연구원 2015 국제노동브리프 Vol.13 No.7

Is Sacral Extension a Risk Factor for Early Proximal Junctional Kyphosis in Adult Spinal Deformity Surgery?

Sebastian Decker,Renaud Lafage,Christian Krettek,Robert Hart,Christopher Ames,Justin S. Smith,Douglas Burton,Eric Klineberg,Shay Bess,Frank J. Schwab,Virginie Lafage,International Spine Study Group 대한척추외과학회 2020 Asian Spine Journal Vol.14 No.2

Study Design: Retrospective cohort study. Purpose: To investigate the role of sacral extension (SE) for the development of proximal junctional kyphosis (PJK) in adult spinal deformity (ASD) surgery. Overview of Literature: The development of PJK is multifactorial and different risk factors have been identified. Of these, there is some evidence that SE also affects the development of PJK, but data are insufficient. Methods: Using a combined database comprising two propensity-matched groups of fusions following ASD surgery, one with fixation to S1 or S1 and the ilium (SE) and one without SE but with a lower instrumented vertebra of L5 or higher (lumbar fixation, LF), PJK and the role of further parameters were analyzed. The propensity-matched variables included age, the upper-most instrumented vertebra (UIV), preoperative sagittal alignment, and the baseline to 1 year change of the sagittal alignment. Results: Propensity matching led to two groups of 89 patients each. The UIV, pelvic incidence minus lumbar lordosis, sagittal vertical axis, pelvic tilt, age, and body mass index were similar in both groups (p>0.05). The incidence of PJK at postoperative 1 year was similar for SE (30.3%) and LF (22.5%) groups (p=0.207). The PJK angle was comparable (p=0.963) with a change of −8.2° (SE) and −8.3° (LF) from the preoperative measures (p=0.954). A higher rate of PJK after SE (p=0.026) was found only in the subgroup of patients with UIV levels between T9 and T12. Conclusions: Instrumentation to the sacrum with or without iliac extension did not increase the overall risk of PJK. However, an increased risk for PJK was found after SE with UIV levels between T9 and T12.

Mounded Mnemonics: Tumuli and Collective Memory in Old Silla

Sebastian Muller 고려대학교 한국사연구소 2021 International Journal of Korean History Vol.26 No.1

본고는 한반도 남동부 지역 경주에 위치한 마립간 시대(356-514년)의 고분이 고신라 정권의 집단 기억에 미치는 영향에 대하여 논의한다. 독일의 문화학자 얀 야스만의 의사 소통과 문화적 기억을 구별하는 연구를 토대로 삼아 본고의 이론적 틀을 세웠다. 장례식 과정에서 기억에 남을 수 있는 사건들을 만듬으로써 의사소통의 기억을 조작하는데 이는 기념비적이며 화려한 무덤을 짓게한 동기 중 하나라고 주장하는 바이다. 고분 형태의 무덤을 지으면 공간적 기준점이 생겨나 훗날 집단적이며 장기적인 혹은 문화적 기억에 영향을 끼친다. 결과적으로 고분의 건설은 문화적 기억을 위한 연상 기호적 장치가 되었고, 그러므로 국가의 형성과 안정화에 주요한 요소라고 가정할 수 있다. The present article discusses the mounded tombs of the Maripkan period (356-514) located in the city of Kyŏngju in the southeastern part of the Korean Peninsula regarding their impact on the collective memory of the early Silla polity. The theoretical framework for the following considerations draws from the seminal research of the cultural scientist Jan Assmann, who distinguishes between a communicative and cultural memory. It is being argued that one of the motivations for constructing the monumental and lavishly equipped graves was the manipulation of communicative memory by creating memorable events in the course of the funerary process. The construction of the graves as mounds created spatial reference points in the landscape which affected subsequently the collective long-term or cultural memory. Consequently, it is assumed that the mounds became mnemonic devices for cultural memory and, therefore, crucial factors for the formation and stabilization of the kingdom.

Another Mega-Regional Trade Bloc under Construction? The Case of the European Union (EU) - Japan Free Trade Agreement (FTA)

( Sebastian Bobowski ) 한국EU학회 2017 Asia-Pacific Journal of EU Studies Vol.15 No.2

The aim of the paper is to study the implications of the EU - Japan FTA, accounting for 28.36 percent of the global GDP and 34.72 percent of the global exports. Japan is the EU’s second largest trade partner from Asia, while the EU is the largest investor in Japan. Both for the EU and Japan the proposed FTA is an opportunity to set multilateral rules of trade in the 21st century and challenge hegemonic ambitions of the United States and China at both regional and global levels. The paper addresses the concept of mega-regionalism in trade, delivers a comprehensive study of bilateral trade relations between the EU and Japan, the genesis of the proposed FTA and important stages in trade talks, as well as implications of the agreement.