흰쥐에서 심정지후 Pentoxifylline이 뇌의 허혈-재관류 손상에 미치는 효과

정시경,김영민,오동렬,최경호,박승현,이운정,박규남,유은영,이원재,김세경 大韓應急醫學會 1999 대한응급의학회지 Vol.10 No.2

Background: Two major events occurring in the cerebral hemodynamics after successful resuscitation from cardiac arrest are reactive hyperemia and postischemic hypoperfusion. In this study, we examined the effect of Pentoxifylline(PTX) on the rat brain following cardiac arrest. Methods: Fourteen rats were anesthetized and artificially ventilated. Cardiac arrest was produced by chest compression and clamping of tracheal tube for 3 minutes in ketamine anesthetized rats. Circulation was restored by standard cardiopulmonary resuscitation methods. In 7 rats, PTX 10mg/kg was infused at 10min after cardiac arrest(PTX group). In the other 7 rats, same amount of normal saline was infused(control group). Results: In both groups, hemodynamic variables, neurologic deficit(ND) score and histopathologic findings of hippocampal CA1 neurons were observed. Hemodynamic variables and ND score were not significantly different between two groups. Delayed ischemic neurons of hippocampal CA1 were decreased in PTX group(2.2±2.4%) compared with control group(9.1±1.2%). Conclusions: We conclude that PTX prevented development of delayed ischemic neurons in hippocampal CA1 after cardiac arrest. PTX may be useful in emergency situations following cardiac arrest.

건국신화의 제의적 서사구조 연구

오세정 한국고전연구학회 2003 한국고전연구 Vol.9 No.-

本論에서의 논의 방향을 간략히 소개하자면, 肅宗 당대에 다대한 정치적인 波瀾을 야기했던 장희빈의 쟁총과 몰락이라는 정치적인 사건이 王昭君을 읊는 작품에 어떤 영향을 주었는지에 대해, 한편으로는 個我的인 層位에서 한편으로는 集團的인 層位에서 살펴본다. 이어서 역시 해당 시기에 彌滿했던 黨色이 영사시의 창작이나 영사시에 대한 평가에 어떤 작용을 하였는지를 검토하도록 한다. 숙종 연간에 왕소군을 소재로 쓰여진 시편이 빈출하고 있다는 사실은 후궁에게 탐닉한 숙종의 행태에 대해 당대인들이 강한 불만을 가지고 있었으며 그러한 불만이 直敍되는 것은 곧바로 임금에 대한 不敬이기에 仁顯과 이력이 겹쳐지는 王昭君을 詩 空間에 포섭하여 당대 정치에 대한 우회적인 비판을 토로한 것으로 정리할 수 있겠다. 한편 前代에 산출된 영사시편에 투영된 정조에 대한 불만 때문에 대용작을 짓고 所懷를 피력하고 있는 점도 현상인 것으로 판단된다. 이와 함께 金萬重의 한시 시편 검토를 통해 南征記가 돌출적으로 산출된 것이 아니라는 사실을 확인할 수 있었다. 나아가 비단 김만중 개인만이 아니라 당대 조야의 분위기 일반이 南征記의 胚胎를 추동하고 있음을 그들이 남긴 영사시편을 통해 유추해 볼 수 있었다. 이를 통해 남정기의 창작 정황에 대한 보다 곡진한 이해에 일조할 수 있을 것으로 보인다. This thesis amis to investigate the structure of the Foundation Myth of Korea: <Tangun-myth(檀君神話)>, <Haemosoo-myth(解慕漱神話)>, <Sooro-myth(首露神話)>, <Hyeokgeose-myth(赫居世神話)>, <Choomong-myth(朱蒙神話)>, <Talhae-myth(脫解神話)>. The Korean myths have specific context of performance, that is the ritual. The myth is the message of ritual, the ritual is the field or the frame of communication. As a matter of course the features of myth are related to ritual. The foundation myths of Korea are composed of ritual events or ritual actions, these are called ritual mytheme. These myths have life-crisis rituals: a ritual of birth or appearance, a ritual of marriage, a ritual of coronation......etc. The situations surroundings of each countries make some difference among myths. Some are focused upon appearance or birth dthers are marriage. But there is a common priciple of the narrative-composition, that is ruled by pemoral order. This principle make myths sacred and natural. Theses myths is not simple fictional and interseting stories but sacred and true histories of origin. These features of myths are realated to effective mechanims of ritual which are a specific type of communication.

동일한 혈관 내에 발생한 이식형 약제 주입기 카테터의 위치이상

오대석,김영재,김명훈,조광래,임세훈,이정한,이근무,정순호,신치만 仁濟大學校 白病院 2010 仁濟醫學 Vol.31 No.-

저자들은 56세 여성 환자의 왼쪽 쇄골 하 정맥에 시행한 이식형 약제주입기 카테터의 삽입 후 발생한 비정상 위치에 대한 증례를 보고하고자 한다. 카테터의 끝은 환자의 늘 어진 가슴, 체위, 신체의 움직임, 카테터의 유동성 등의 영향으로 천자된 정맥 내에서 견인되고 뒤쪽으로 이동하였다. 환자는 어떠한 증상도 호소하지 않았지만 비정상 위치의 카테터는 심각한 합병증을 유발할 수 있기 때문에 제거되었다. 따라서 시술자는 약제주입기 삽입 전에 환자의 신체 상태와 단순 흉부 촬영상을 확인하고 카테터의 비정상 위치가 발생할 수 있는 위험 징후를 알아차려야 하겠다.

Methoprene이 매미나방(Lymantria dispar) 6령유충의 단백질 함량과 패턴에 미치는 영향

오세원,강정호 광주보건대학 1993 論文集 Vol.18 No.-

The effects of methoprene, juvenile hormone analogue, protein contents and patternes of 6th larval stages in the gypsy moth, Lymantria dispar were studied. Methoprene has been shown to effects of protein in the hemolymph both topical and ingestion treatment group. Protein contents of the topical treatment group were lower than those of the control group, but ingestion groups were increased. In male, protein concentrations were higher than those on the female. For significance level 10%(p<0.1), there exist difference control and methoprene treatment group in female. Protein patterns make a differences between control and methoprene treatment group.

폐부종과 심정지가 발생한 페노바비탈 중독환자

오동렬,이운정,박규남,김세경,김영민,이환,유은영,최경호,정시경 大韓應急醫學會 1999 대한응급의학회지 Vol.10 No.2

Phenobarbital is a long-acting barbiturate causing generalized depression of neuronal activity in the brain. Its effect is primarily achieved through enhanced GABA-mediated synaptic inhibition. Its use as an antiepileptic agent was first described in 1912. Before the introduction of phenytoin, phenobarbital is used as sedative-hypnotics. It is used for the treatment of epilepsy and status epilepticus. All barbiturates, including phenobarbital, have a high potential for abuse. They were frequently used for suicide attempts in the past, but they have in large part been replaced by benzodiazepines. The onset of symptoms depends on the drug and the route of administration. Mild to moderate barbiturate intoxication resembles ethanol inebriation with slurred speech, ataxia, and lethargy. Severe acute barbiturate intoxication is life threatening. Early deaths are generally cardiovascular-related. Hypotension, shock, pulmonary edema, and cardiac arrest that occurs with large doses are caused by depression of central sympathetic tone and as well as by direct depression of cardiac contractility. The potentially fatal oral dose of phenobarbital is 6-10g. We describe an 23-year-old woman with pulmonary edema, and cardiac arrest ingestion of 18grams of phenobarbital. She was completely recovered by successful cardiopulmonary resuscitation and homoperfusion. We report a case with literature review.

肉鷄飼育에 있어서 外國鷄種과 國內改良 交雜種과의 經濟性 分析

吳世正,尹熙燮 건국대학교 1980 學術誌 Vol.24 No.2

The experiment was conducted to compare economic performance at 8 weeks of age on 9 breeds. Three locally developed breeds were compared with three of existing imported breeds and three of newly imported breeds. Four hundred chicks of each breed was used in this experiment. The results obtained are as follows: 1.There was no significant difference in viability between local and imported broiler breeds. 2.High mortality was showed due to the Infection of staphylococosis and peritionitis which accounted for 40.3% of total occurrence. It was found that chicks of newly imported breeds were more resistant to these types of infections than other breeds. 3.Body weight at 8 weeks of age of local and, existing and newly imported breeds were 1676.93g, 1709.92g and 1755.69g. respectively. There was no difference in body weight gain among 3 groups during the first 4 weeks but difference was observed in body weight gain during 5-6 weeks of age between local and imported breeds. Therefore, it may be desirable to select the local broiler breeds on the basis of body weight at 6 weeks of age. 4.The feed requirement per 1 kg body weight gain of local and, existing and newly imported breeds were 2.59, 2.55 and 2.49, respectively. The feed conversion rate of newly imported breeds was superior to other breeds. 5.The highest net income at 8 weeks of age was obtained by newly imported breeds that rendered 402.26 Won per bird.

교통사고로 발생한 대량 환자의 중증도 분류와 이송의 분석

오세현,정용택,김병철,이부수 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4

Background: Triage and transportations are important and life-saving medical task performed at the site of mutiple-casualty incidents(MCIs). We pursued three road traffic accidents victims to find out any problem in triaging and transporting them, and to provide an information for equipping an local disaster planning. Methods: The medical records of 70 consecutive patients who were transported to five emergency facilities in Kangnung, on three MCIs from 1998 to 2000, were analysed, retrospectively. The intervals and types of transport vehicles were analysed. We compared the prehospital time between severity-based groups, which were graded into 3 groups according to the Triage score(0,1~8,9). Results: Among the 70 patients, 33 patients(47.1%), 21 patients(30%), and 16 patients(22.9%) were transported to Level I, Level II, and Level III trauma centers, respectively. The time elapsed from scenes to the Level I trauma center was significantly shorter(p=0.003) than to others, but no differences in the mean Triage score between trauma centers were seen(p>0.05). The 119 rescue services transported 58.6%(41 patients) of victims to emergency facilities, and 58.5%(24 patients) of them was concentrated to Level I. There were no significant differences in the prehospital time between three Triage score groups(p>0.05). Conclusion: There was no medical control such as triage and transportation in the cases of three MCIs. In the construction of emergency medical service system(EMSS) preparing MCIs or disasters, we suggest the integration and unification of 119 rescue services and emergency medical information centers for effective medical control. We propose to making a new and simple triage guideline. The prehospital personnel should be educated and disaster drills should be performed under the guideline.

肉鷄飼料에 있어 抗生物質 添加效果와 經濟性에 관한 硏究

吳世正 건국대학교 1982 學術誌 Vol.26 No.2

These studies were performed to investigate the efficiency and economic value of 5 antibiotic produts served from 3 different companies on 800 cobb-color broiler chicks for 8 weeks. Which were carried out with 8 groups of 800 chicks through 5 times repeat system. Results obtained were as follows. 1.In weight gain, 1) The groups with antibiotic had better results than those of the ones not added, (0.77-5.58%) 2) T3 group with 0.1% of antibiotic was increased 3.7% of weight gain more than T2 group with 0.04%. 3) Adding different companies antibiotic, T5 with 0.05% was increased 21% of weight more than T7 with 0.01%. It revealed that the effects of the antibiotic products produced by the different companies were not same. 2.In the volume of feed intake, Groups with antibiotic were increased by-0.7-2.04%. 3.In feed efficiency, Most of groups were increased by 0.78-5.08% except T1 (0.94%). 4.In the number of dead chicks, Most of groups with antibiotic had more numbers than the contrast groups except T4. 5.In the rate of meat coloring, T7 was best but T2 was white color. It was thought that according to the kinds of antibiotic products, the effect was different. 6.In economic value, T6, T1 and T2 had a loss of 113.27 won, 9.47won and 1.43won per one chick respectively, comparing to the contrast grow. But T4, T5, T3 and T7 made a profit of 94.14, 54.72, 24.91, and 13.09 won respectively (0.2-15.4% of loss, 1.8-12.80 of profit). It suggested that the correct of antibiotic products made great role in making a profit. Under the good environmental condition, there were little differences in weight gain and feed efficiency, but the kinds, adding rate and the companies of antibiotic had much influences on loss and profit in economic value. It was thought that under the bad condition, loss and profit seemed much more depend on the effect of antibiotic.

환경불확실성에 따른 품질경영 활동과 경영성과에 관한 연구

정상철,오세구 충남대학교 경상대학부설 경영경제연구소 1997 경영논집 Vol.13 No.2

본 연구는 품질경영에 대한 이론적 배경을 고찰하고, 우리나라 제조업체의 실질적인 품질 경영활동과 경영성과간의 관계에 대하여 분석하였다. 본 연구는 기존의 대다수의 연구들이 취하던 품질경영의 성과측정에 그치지 않고 변수들간의 구조분석을 통하여 실제 어떤 활동이 성과에 주된 역할을 하는지에 대하여 살펴보았다. 실증분석결과 동기부여, 신기술개발등이 재무성과, 비재무성과에 공통적으로 큰 영향을 미치는 활동으로 확인되었다.

토양으로부터 항세균성 물질을 생산하는 Streptomyces sp. 의 분리

오현정,정완석,김세재,김창진,고영환 제주대학교 생명과학연구소 1999 제주생명과학연구 Vol.2 No.-

제주도의 토양에서 분리된 방선균 307주를 대상으로, paper disc법과 시험관 희석 배양법을 사용하여 항세균성 물질을 생산하는 균주를 선별하였다. 약 3.3%에 상당하는 분리주들이 Escherichia coli 8749, Staphylococcus aureus 6538 그리고 Pseudomonas solanacearum 10692에 대해 항균효과를 나타냈고, 그 중에서 가장 높은 항균활성을 나타내는 BL93 균주를 최종선별하여 동정하였다. BL93 균주의 배양학적, 형태학적, 생리학적, 생화학적 그리고 화학분류학적 특성을 기준으로 볼 때 Streptomyces violaceus와 유사하였기에, Streptomyces sp. BL93으로 명명하였다. 이 균주가 생산하는 항세균성 물질은 butanol보다도 물에 더 잘 녹는 극성화합물로 chloroform이나 ethylacetate에는 거의 용해되지 않았다. 100℃에서 30분간 가열 처리해도 활성의 소실이 거의 없었고, pH 3∼9범위에서 안정하였다. 분리균주 BL93은 aspartocin을 생산하는 Streptomyces violaceus와 유사함으로, BL93이 생산하는 항세균성 물질의 동정 및 aspartocin과의 비교 검토가 선행되어야 할 것이다. Three hundred and seven isolates of Actinomycetes were isolated and purified from soil samples in Cheju Is. to screen antibacterial compounds. About 3.3% of the isolates showed antibacterial activity, and one of them, BL93, showed relatively higher antibacterial activity against Escherichia coli 8749, Staphylococcus aureus 6538 and Pseudomonas solanacearum 10692 by both paper disc method and tube dilution incubation method. The isolate BL93 was similar to Streptomyces violaceus based upon its cultural, morphological, physiological, biochemical and chemotaxanomic characteristics. It was designated as Streptomyces sp. BL93. The antibacterial substance produced by the isolate BL93 had higher affinity for water than butanol and was insoluble in chloroform or ethylacetate. Most of its antibacterial activity was retained even after heating at 100℃ for 30min and was stable at pH ranges 3 to 9. As the isolate BL93 was tentatively identified to be Streptomyces violaceus, the antibacterial substance preferentially need to be identified and compared with aspartocin, an antimicrobial compound produced by Streptomyces violaceus.