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Identification of Antioxidant and Antimicrobial Compounds of Lippia Species by Bioautography
Rodrigo Luiz Fabri,Mauro Silva Nogueira,Jussara dos Reis Moreira,Maria Lúcia Morcef Bouzada,Elita Scio 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.7
The methanolic extracts of the leaves of Lippia species (L. pseudo-thea, L. hermannioides, L. alba, L. rubella, and L. sidoides) were tested for their antibacterial, antifungal, and antioxidant activity. Cytotoxicity was determined by using brine shrimp lethality bioassay. Phytochemical screening was also performed. The extracts showed a minimum inhibitory concentration (MIC) ranging from 78 to 5000 μg/mL for antibacterial activity against at least 2 species of bacteria, although none was active against Escherichia coli. Antifungal activity was found only for L. pseudo-thea (MIC, 625 μg/mL for Candida albicans) and L. sidoides (MIC, 625 μg/mL for both C. albicans and C. neoformans). The bioautography showed that flavonoids and coumarins are responsible for the antioxidant activity of the extracts and that the antimicrobial properties are due to flavonoids and terpenoids. The cytotoxic activity was stronger for L rubella extract. To our knowledge, this is the first report of the biological and chemical constituents of L. pseudo-thea, L. hermannioides, and L. rubella.
Maurizio Bellavia,Giuseppe Damiano,Vincenzo Davide Palumbo,Gabriele Spinelli,Giovanni Tomasello,Antonio Marrazzo,Silvia Ficarella,Antonio Bruno,Antonino Sammartano,Tiziana Fiorentini,Antonio Scio,Caro 한국유방암학회 2012 Journal of breast cancer Vol.15 No.3
Granulomatous mastitis is a rare benign inflammatory disease of the breast with multiple etiologies such as tuberculosis, sarcoidosis, foreign body reaction, and mycotic and parasitic infections. In contrast, idiopathic granulomatous mastitis (IGM) is characterized by the presence of chronic granulomatous lobulitis in the absence of an obvious etiology. Clinically and radiologically it may mimic breast carcinoma and so awareness of surgeons,pathologists, and radiologists is essential to avoid unnecessary mastectomies. Cases of IGM are reported during antidepressant therapy in patients also showing high levels of prolactinemia. In these cases, we believe that surgical excision must be avoided being replaced with a conservative management of the pathological condition based on a corticosteroid treatment.
An Incremental, Iterative and Interative Ontology Matching Approach
Fernando Wagner,Jose A.F.Macedo,Bernadette Lóscio 한국엔터프라이즈아키텍처학회 2012 정보기술아키텍처연구 Vol.9 No.4
Ontologies are being used in order to define common vocabularies to describe the elements of schemas involved in a particular application. The problem of finding correspondences between ontologies concepts, called ontology matching, consists in the discovery of correspondences between terms of vocabularies (represented by ontologies) used by various applications. The majority of solutions proposed in the literature, despite being fully automatic, has heuristic nature and may produce nonsatisfactory results. The problem intensifies when dealing with large data sources. The goal of this paper is to propose a method for generation and incremental refinement of correspondences between ontologies. The proposed approach uses filtering techniques, as well as user feedback to support the generation and refinement of such matches. For validation purposes, a tool was developed and some experiments were conducted.