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Iron Reshapes the Gut Microbiome and Host Metabolism
Botta Amy,Barra Nicole G.,Lam Nhat Hung,Chow Samantha,Pantopoulos Kostas,Schertzer Jonathan D.,Sweeney Gary 한국지질동맥경화학회 2021 지질·동맥경화학회지 Vol.10 No.2
Compelling studies have established that the gut microbiome is a modifier of metabolic health. Changes in the composition of the gut microbiome are influenced by genetics and the environment, including diet. Iron is a potential node of crosstalk between the host-microbe relationship and metabolic disease. Although iron is well characterized as a frequent traveling companion of metabolic disease, the role of iron is underappreciated because the mechanisms of iron's influence on host metabolism are poorly characterized. Both iron deficiency and excessive amounts leading to iron overload can have detrimental effects on cardiometabolic health. Optimal iron homeostasis is critical for regulation of host immunity and metabolism in addition to regulation of commensal and pathogenic enteric bacteria. In this article we review evidence to support the notion that altering composition of the gut microbiome may be an important route via which iron impacts cardiometabolic health. We discuss reshaping of the microbiome by iron, the physiological significance and the potential for therapeutic interventions.
Bacterial Postbiotics as Promising Tools to Mitigate Cardiometabolic Diseases
Anhê Fernando F.,Jensen Benjamin A. H.,Perazza Lais Rossi,Tchernof André,Schertzer Jonathan D.,Marette André 한국지질동맥경화학회 2021 지질·동맥경화학회지 Vol.10 No.2
Gut microbes dictate critical features of host immunometabolism. Certain bacterial components and metabolites (termed postbiotics) mitigate cardiometabolic diseases whereas others potentiate pathological processes. In this review, we discuss key aspects related to the usefulness of bacterial-related molecules strategically positioned as promising treatment strategies for cardiometabolic diseases.