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Difficulty Estimation of Number Place Puzzle and Its Problem Generation Support
Satoshi Ono,Ryuji Miyamoto,Shigeru Nakayama,Kazunori Mizuno 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
This paper proposes a method forestimating difficulty of number place puzzle problem. The proposed method formulates a number place problem as a graph colorability(COL) problem, solvesit by a general COL solver, and ranks its difficulty from the search cost the solver spends until a solutionis found. Compared to previous work, the method is quite fast and pluraltrials are not necessary due to no stochastic process init. This paperal soproposes a tool for supporting number place problem design. The tool uses the proposed difficulty estimation method, and is implementedon mobile phone platform“Google And roid.” Experiments have shown that the proposed method could roughly estimate difficulty of number place problem instances.
Chemical variation in molecular cloud cores in the Orion A cloud. II.
Tatematsu, Ken'ichi,Ohashi, Satoshi,Umemoto, Tomofumi,Lee, Jeong-Eun,Hirota, Tomoya,Yamamoto, Satoshi,Choi, Minho,Kandori, Ryo,Mizuno, Norikazu Astronomical Society of Japan 2014 Publications of the Astronomical Society of Japan Vol.66 No.1
김현덕,김귀년,Jung Keun Ahn,Masayuki Igashira,Satoshi Mizuno,Tae-Ik Ro,Toshiro Ohsaki,Won-Chung Chung 한국물리학회 2004 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.45 No.3
The neutron capture cross-sections and capture-ray spectra of 161;162;163;164Dy were measuredat a neutron energy of 550 keV by using the 3-MV Pelletron accelerator of the Research Laboratoryfor Nuclear Reactors at the Tokyo Institute of Technology. A neutron time-of-ight method wasadopted with a 1.5-ns pulsed neutron source using the 7Li(p,n)7Be reaction, and a large anti-Compton NaI(Tl)-ray spectrometer was used. A pulse-height weighting technique was applied tothe observed capture-ray pulse-height spectra to derive the capture yields. The measured capturecross-sections were 0.221 0.016, 0.110 0.007, 0.119 0.008, and 0.037 0.005 (barn) for 161Dy,162Dy, 163Dy, and 164Dy, respectively. The present results were in good agreement with previousmeasurements. However, the evaluated values of ENDF/B-VI for 162;164Dy were more than threetimes higher than our measurements. The capture-ray spectra were obtained by unfolding theobserved capture-ray pulse-height spectra. The neutron capture cross-sections and capture -ray spectra of 161;162;163;164Dy were measured at a neutron energy of 550 keV by using the 3-MV Pelletron accelerator of the Research Laboratory for Nuclear Reactors at the Tokyo Institute of Technology. A neutron time-of- ight method was adopted with a 1.5-ns pulsed neutron source using the 7Li(p,n)7Be reaction, and a large anti- Compton NaI(Tl) -ray spectrometer was used. A pulse-height weighting technique was applied to the observed capture -ray pulse-height spectra to derive the capture yields. The measured capture cross-sections were 0.221 0.016, 0.110 0.007, 0.119 0.008, and 0.037 0.005 (barn) for 161Dy, 162Dy, 163Dy, and 164Dy, respectively. The present results were in good agreement with previous measurements. However, the evaluated values of ENDF/B-VI for 162;164Dy were more than three times higher than our measurements. The capture -ray spectra were obtained by unfolding the observed capture -ray pulse-height spectra.
Naoyuki Takashima,Hisatomi Arima,Yoshikuni Kita,Takako Fujii,Sachiko Tanaka-Mizuno,Satoshi Shitara,Akihiro Kitamura,Yoshihisa Sugimoto,Makoto Urushitani,Katsuyuki Miura,Kazuhiko Nozaki 대한뇌졸중학회 2020 Journal of stroke Vol.22 No.3
Background and Purpose Although numerous measures for stroke exist, stroke remains one of the leading causes of death in Japan. In this study, we aimed to determine the long-term survival rate after first-ever stroke using data from a large-scale population-based stroke registry study in Japan. Methods Part of the Shiga Stroke and Heart Attack Registry, the Shiga Stroke Registry is an ongoing population-based registry study of stroke, which covers approximately 1.4 million residents of Shiga Prefecture in Japan. A total 1,880 patients with non-fatal first-ever stroke (among 29-day survivors after stroke onset) registered in 2011 were followed up until December 2016. Five-year cumulative survival rates were estimated using the Kaplan-Meier method, according to subtype of the index stroke. Cox proportional hazards models were used to assess predictors of subsequent allcause death. Results During an average 4.3-year follow-up period, 677 patients died. The 5-year cumulative survival rate after non-fatal first-ever stroke was 65.9%. Heterogeneity was present in 5-year cumulative survival according to stroke subtype: lacunar infarction, 75.1%; large-artery infarction, 61.5%; cardioembolic infarction, 44.9%; intracerebral hemorrhage, 69.1%; and subarachnoid hemorrhage, 77.9%. Age, male sex, Japan Coma Scale score on admission, and modified Rankin Scale score before stroke onset were associated with increased mortality during the chronic phase of ischemic and hemorrhagic stroke. Conclusions In this study conducted in a real-world setting of Japan, the 5-year survival rate after non-fatal first-ever stroke remained low, particularly among patients with cardioembolic infarction and large-artery infarction in the present population-based stroke registry.
Yasunori Nakamura,Jun Sano,Kohji Ohki,Toshimasa Higuchi,Kotaro Aihara,Seiichi Mizuno,Osami Kajimoto,Satoshi Nakagawa,Yoshitaka Kajimoto 한국식품영양과학회 2005 Journal of medicinal food Vol.8 No.4
Casein hydrolysate, prepared with Aspergillus oryzaeprotease, contains angiotensin I-converting enzyme in-hibitory peptides, such as Val-Pro-Pro and Ile-Pro-Pro. We conducted a randomized, double-blind, placebo-controlled studyto evaluate the effect of casein hydrolysate on the blood pressure of 144 subjects with high-normal blood pressure (n . 104)and mild hypertension (n . 40). Subjects were randomly assigned to two groups for a 12-week intake period. In the test group,both systolic (SBP) and diastolic (DBP) blood pressure decreased significantly compared with the placebo group: SBP/DBPsignificantly decreased from 138.2. 6.5/84.4. 5.3 mm Hg at week 0 to 132.3. 7.3 (P. .001)/81.2. 4.8 mm Hg (P..001) at week 12. In the stratified analysis, the test product showed an antihypertensive effect in both the subject group withhigh-normal blood pressure and that with mild hypertension. No side effect was observed in any subjects in this study. Theseresults demonstrate that the casein hydrolysate, prepared with A. oryzaeprotease, produced a significant reduction in bloodpressure in a population of subjects with high-normal blood pressure or mild hypertension without an adverse event.
Takasawa Ken,Asada Ken,Kaneko Syuzo,Shiraishi Kouya,Machino Hidenori,Takahashi Satoshi,Shinkai Norio,Kouno Nobuji,Kobayashi Kazuma,Komatsu Masaaki,Mizuno Takaaki,Okubo Yu,Mukai Masami,Yoshida Tatsuya 생화학분자생물학회 2024 Experimental and molecular medicine Vol.56 No.-
DNA methylation is an epigenetic modification that results in dynamic changes during ontogenesis and cell differentiation. DNA methylation patterns regulate gene expression and have been widely researched. While tools for DNA methylation analysis have been developed, most of them have focused on intergroup comparative analysis within a dataset; therefore, it is difficult to conduct cross-dataset studies, such as rare disease studies or cross-institutional studies. This study describes a novel method for DNA methylation analysis, namely, methPLIER, which enables interdataset comparative analyses. methPLIER combines Pathway Level Information Extractor (PLIER), which is a non-negative matrix factorization (NMF) method, with regularization by a knowledge matrix and transfer learning. methPLIER can be used to perform intersample and interdataset comparative analysis based on latent feature matrices, which are obtained via matrix factorization of large-scale data, and factor-loading matrices, which are obtained through matrix factorization of the data to be analyzed. We used methPLIER to analyze a lung cancer dataset and confirmed that the data decomposition reflected sample characteristics for recurrence-free survival. Moreover, methPLIER can analyze data obtained via different preprocessing methods, thereby reducing distributional bias among datasets due to preprocessing. Furthermore, methPLIER can be employed for comparative analyses of methylation data obtained from different platforms, thereby reducing bias in data distribution due to platform differences. methPLIER is expected to facilitate cross-sectional DNA methylation data analysis and enhance DNA methylation data resources.