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β-NaFeO2 nanoparticles have been synthesized by sol–gel method and their morphological, structural and optical propertiesinvestigated. Transmission electron microscope study reveals that the size of the synthesis nanoparticles is 37 nm and theyare possessing spherical symmetry. X-ray diffraction pattern shows the orthorhombic crystal structure of nanoparticles withspace group Pn21a. UV–visible spectra of β-NaFeO2 divulges that these nanoparticles have direct band gap 2.35 eV. Theobserved Fourier transform infrared spectroscopy spectra confirms the presence of Fe–Na bonding at 1074 cm−1. The photoluminescencestudy of these nanoparticles shows that these nanoparticles possesses various transition in the visible spectrum.
The abrasive reinforcement present in ‘Metal matrix composites’ (MMCs) is responsible for numerous machining challenges for the research fraternity. The increase in tool wear, burr formation, surface roughness, and increase in cutting forces are few of such machining challenges during the drilling of MMCs. The present research investigation explores the effect of change in drill point geometry on the drilling Quality characteristics (QCs) of the drilled hole wall. The drilling QCs under investigation are, Specific cutting pressure (SCP) and Surface roughness (SR) of the drilled hole wall. The levels of the input process parameters for optimum values of the output responses were established by Taguchi’s methodology. SEM images and contour plots of drilled hole wall have been used to qualitatively explain the drilling behavior of MMCs. The chip formation mechanism observed during drilling establishes the cutting behavior of the different cutting edges of the modified drill point geometry. It has been observed that the single conical chips were produced by primary cutting edge and single ring type chips were produced by secondary cutting edge. The step diameter is the main factor which influences the SCP followed by the feed and point angle. The surface roughness of the drilled hole wall has been governed by the cutting speed, feed and step diameter. Burnishing and honing effect were observed on the drilled hole wall surface because of entrapped free SiC particles using SEM.
Singh, Sarbjit,Goo, Ja-Il,Noh, Hyojin,Lee, Sung Jae,Kim, Myoung Woo,Park, Hyejun,Jalani, Hitesh B.,Lee, Kyeong,Kim, Chunsook,Kim, Won-Ki,Ju, Chung,Choi, Yongseok Elsevier 2017 Bioorganic & medicinal chemistry Vol.25 No.4
<P><B>Abstract</B></P> <P>Astrocytes play a key role in brain homeostasis, protecting neurons against neurotoxic stimuli such as oxidative stress. Therefore, the neuroprotective therapeutics that enhance astrocytic functionality has been regarded as a promising strategy to reduce brain damage. We previously reported that ciclopirox, a well-known antifungal <I>N</I>-hydroxypyridone compound, protects astrocytes from oxidative stress by enhancing mitochondrial function. Using the <I>N</I>-hydroxypyridone scaffold, we have synthesized a series of cytoprotective derivatives. Mitochondrial activity assay showed that <I>N-</I>hydroxypyridone derivatives with biphenyl group have comparable to better protective effects than ciclopirox in astrocytes exposed to H<SUB>2</SUB>O<SUB>2</SUB>. <I>N</I>-hydroxypyridone derivatives, especially <B>11g</B>, inhibited H<SUB>2</SUB>O<SUB>2</SUB>-induced deterioration of mitochondrial membrane potential and oxygen consumption rate, and significantly improved cell viability of astrocytes. The results indicate that the <I>N</I>-hydroxypyridone motif can provide a novel cytoprotective scaffold for astrocytes via enhancing mitochondrial functionality.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Chronic spontaneous urticaria (CSU) is characterized by typically short-lived and fleeting wheals, angioedema or both, which occur spontaneously and persist for longer than 6 weeks. This term is applied to the most common subtype of chronic urticaria. The underlying pathophysiology for CSU involves mast cell and basophil degranulation with release of histamine, leukotrienes, prostaglandins and other inflammatory mediators. Although a variety of treatments exist, many patients do not tolerate or benefit from the existing therapies and even require more effective treatments. Omalizumab is currently the only licensed biologic for antihistamine-refractory CSU, and novel drugs are under development. This article reviews its current status regarding pathogenesis and approach to treatment as well as therapeutic agents that are under development for the treatment of CSU.
Naik, Haladhara,Singh, Sarbjit,Goswami, Ashok,Kumar Manchanda, Vijay,Suryanarayana, S. V.,Raj, Devesh,Ganesan, Srinivasan,Shakilur Rahman, Md.,Sook Kim, Kyung,Woo Lee, Man,Kim, Guinyun,Cho, Moo-Hyun,S Springer-Verlag 2011 The european physical journal. A, Hadrons and nucl Vol.47 No.3
A novel series of hydrazide derivatives were synthesized as potential diacylglycerol acyltransferase (DGAT) inhibitors. Among them, compounds 8u and 8v exhibited selective and potent DGAT-1 inhibitory activities. In addition, compound 8u dose-dependently inhibited triglyceride synthesis in HepG2 cell lines. Furthermore, treatment with compound 8u for an oral lipid tolerance test showed a significant decrease in plasma triglyceride levels compared with vehicle-treated control animals, indicating delayed absorption of triglyceride after an acute lipid challenge.
Naik, Haladhara,Kim, Guinyun,Goswami, Ashok,Singh, Sarbjit,Manchanda, Vijay Kumar,Raj, Devesh,Ganesan, Srinivasan,Oh, Young Do,Lee, Hee-Seock,Kim, Kyung Sook,Lee, Man-Woo,Cho, Moo-Hyun,Ko, In Soo,Namk Springer-Verlag 2010 JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY Vol.283 No.2