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      • SCISCIESCOPUS

        STELLAR MASSES FROM THE CANDELS SURVEY: THE GOODS-SOUTH AND UDS FIELDS

        Santini, P.,Ferguson, H. C.,Fontana, A.,Mobasher, B.,Barro, G.,Castellano, M.,Finkelstein, S. L.,Grazian, A.,Hsu, L. T.,Lee, B.,Lee, S.-K.,Pforr, J.,Salvato, M.,Wiklind, T.,Wuyts, S.,Almaini, O.,Coope IOP Publishing 2015 The Astrophysical journal Vol.801 No.2

        <P>We present the public release of the stellar mass catalogs for the GOODS-S and UDS fields obtained using some of the deepest near-IR images available, achieved as part of the Cosmic Assembly Near-infrared Deep Extragalactic Legacy Survey project. We combine the effort from 10 different teams, who computed the stellar masses using the same photometry and the same redshifts. Each team adopted their preferred fitting code, assumptions, priors, and parameter grid. The combination of results using the same underlying stellar isochrones reduces the systematics associated with the fitting code and other choices. Thanks to the availability of different estimates, we can test the effect of some specific parameters and assumptions on the stellar mass estimate. The choice of the stellar isochrone library turns out to have the largest effect on the galaxy stellar mass estimates, resulting in the largest distributions around the median value (with a semi interquartile range larger than 0.1 dex). On the other hand, for most galaxies, the stellar mass estimates are relatively insensitive to the different parameterizations of the star formation history. The inclusion of nebular emission in the model spectra does not have a significant impact for the majority of galaxies (less than a factor of 2 for similar to 80% of the sample). Nevertheless, the stellar mass for the subsample of young galaxies (age <100 Myr), especially in particular redshift ranges (e.g., 2.2 < z < 2.4, 3.2 < z < 3.6, and 5.5 < z < 6.5), can be seriously overestimated (by up to a factor of 10 for <20 Myr sources) if nebular contribution is ignored.</P>

      • BENTHIC AMPHIPOD FAUNA (CRUSTACEA) OF THE PORTUGUESE COAST: BIOGEOGRAPHICAL CONSIDERATIONS

        Bellan-Santini,Denise,Marques,Joao Carlos 嶺南大 海洋科學硏究所 1990 Marine Nature Vol.3 No.1

        Biogeographic affinities of the Amphipod fauna from the Portuguese Coast were analysed. The Portuguese Coast appeared as a transition zone where faunas from the Mediterranean and of northern affinities become mixed. The biogeographic affinities between the Portuguese Coast and the Mauritanian and Senegalese regions still remained difficult to interpret. The comparison of the life cycles between several populations of Echinogammarus marinus (Leach), under different environmental constraints, showed that Gammarids can have large intraspecific variations in their reproductive patterns, which might have an important role in marine amphipods speciation.

      • SCIESCOPUS

        Comparative study on dynamic analyses of non-classically damped linear systems

        Greco, Annalisa,Santini, Adolfo Techno-Press 2002 Structural Engineering and Mechanics, An Int'l Jou Vol.14 No.6

        In this paper some techniques for the dynamic analysis of non-classically damped linear systems are reviewed and compared. All these methods are based on a transformation of the governing equations using a basis of complex or real vectors. Complex and real vector bases are presented and compared. The complex vector basis is represented by the eigenvectors of the complex eigenproblem obtained considering the non-classical damping matrix of the system. The real vector basis is a set of Ritz vectors derived either as the undamped normal modes of vibration of the system, or by the load dependent vector algorithm (Lanczos vectors). In this latter case the vector basis includes the static correction concept. The rate of convergence of these bases, with reference to a parametric structural system subjected to a fixed spatial distribution of forces, is evaluated. To this aim two error norms are considered, the first based on the spatial distribution of the load and the second on the shear force at the base due to impulsive loading. It is shown that both error norms point out that the rate of convergence is strongly influenced by the spatial distribution of the applied forces.

      • A FRF-based algorithm for damage detection using experimentally collected data

        Garcia-Palencia, Antonio,Santini-Bell, Erin,Gul, Mustafa,Catbas, Necati Techno-Press 2015 Structural monitoring and maintenance Vol.2 No.4

        Automated damage detection through Structural Health Monitoring (SHM) techniques has become an active area of research in the bridge engineering community but widespread implementation on in-service infrastructure still presents some challenges. In the meantime, visual inspection remains as the most common method for condition assessment even though collected information is highly subjective and certain types of damage can be overlooked by the inspector. In this article, a Frequency Response Functions-based model updating algorithm is evaluated using experimentally collected data from the University of Central Florida (UCF)-Benchmark Structure. A protocol for measurement selection and a regularization technique are presented in this work in order to provide the most well-conditioned model updating scenario for the target structure. The proposed technique is composed of two main stages. First, the initial finite element model (FEM) is calibrated through model updating so that it captures the dynamic signature of the UCF Benchmark Structure in its healthy condition. Second, based upon collected data from the damaged condition, the updating process is repeated on the baseline (healthy) FEM. The difference between the updated parameters from subsequent stages revealed both location and extent of damage in a "blind" scenario, without any previous information about type and location of damage.

      • KCI등재

        The Global Histone Modification Patterns of Osteosarcoma

        도성임,임성직,김윤화,Liliana G. Olvi,Eduardo Santini-Araujo,박용구 대한병리학회 2011 Journal of Pathology and Translational Medicine Vol.45 No.2

        Background: Epigenetic alteration may affect a patient’s prognosis by altering the development and progression of the tumor. Some recent reports have identified a correlation between histone modification and patient outcome. However, no studies have been conducted on global histone modification in osteosarcomas. Methods: We investigated histone modification in 54 cases of osteosarcoma by performing immunohistochemical staining. The immunohistochemical expres­sion of four histone modification markers, acetylated H4 lysine 12 (H4K12Ac), acetylated H3 ly­sine 18, trimethylated H3 lysine 27, and dimethylated H3 lysine 4 were evaluated. Results: High H4K12Ac expression was correlated with patient age (p=0.011). However, the other histone mod­ification markers showed no correlation with any of the clinicopathological data such as survival, tumor grade, tumor site, metastasis, age, or gender. Conclusions: Our study showed that all four histone modification markers are expressed in osteosarcoma (median expression rate, 40 to 60%). However, we did not find a correlation with the clinicopathological factors except for age. Further study to evaluate the reason for the association between H4K12Ac and patient age is needed.

      • KCI등재

        IDH Mutation Analysis in Ewing Sarcoma Family Tumors

        나기용,박용구,노병주,성지윤,김윤화,Eduardo Santini Araujo 대한병리학회 2015 Journal of Pathology and Translational Medicine Vol.49 No.3

        Background: Isocitrate dehydrogenase (IDH) catalyzes the oxidative decarboxylation of isocitrate to yield α-ketoglutarate (α-KG) with production of reduced nicotinamide adenine dinucleotide (NADH). Dysfunctional IDH leads to reduced production of α-KG and NADH and increased production of 2-hydroxyglutarate, an oncometabolite. This results in increased oxidative damage and stabilization of hypoxia-inducible factor α, causing cells to be prone to tumorigenesis. Methods: This study investigated IDH mutations in 61 Ewing sarcoma family tumors (ESFTs), using a pentose nucleic acid clamping method and direct sequencing. Results: We identified four cases of ESFTs harboring IDH mutations. The number of IDH1 and IDH2 mutations was equal and the subtype of IDH mutations was variable. Clinicopathologic analysis according to IDH mutation status did not reveal significant results. Conclusions: This study is the first to report IDH mutations in ESFTs. The results indicate that ESFTs can harbor IDH mutations in previously known hot-spot regions, although their incidence is rare. Further validation with a larger case-based study would establish more reliable and significant data on prevalence rate and the biological significance of IDH mutations in ESFTs.

      • KCI등재

        14-bp Insertion/Deletion Polymorphism of the HLA-G Gene in Osteosarcoma Patients

        문아림,김수강,정주호,나기용,Liliana G. Olvi,Eduardo Santini-Araujo,김윤화,박용구 대한병리학회 2011 Journal of Pathology and Translational Medicine Vol.45 No.5

        Background: The major histocompatibility complex class I, G (human leukocyte antigen-G [HLA-G]) gene plays a vital role in the suppression of immune responses. Recently, a number of studies have reported an association between HLA-G and diseases (pregnancy complications, organ transplantation, and tumors). Some of the studies have revealed that the 14-bp insertion/deletion polymorphism might be associated with various diseases. The aim of the present study was to explore a possible influence of the 14-bp insertion/deletion polymorphism on osteosarcoma. Methods: Genomic DNA was extracted from 75 formalin-fixed, paraffin-embedded tumor tissues derived from patients with conventional osteosarcoma (OSA) and 183 peripheral blood samples of healthy controls. Fifty-eight cases were South Korean patients with OSA and 17 cases were Argentine patients with OSA. The HLA-G 14-bp insertion/deletion polymorphism at exon 8 of the HLA-G locus was analyzed by polymerase chain reaction. Results: There was a significantly different distribution profile for the 14-bp genotypes between the Korean OSA and Korean control groups. Specifically, there were more heterozygote 210 bp/224 bp genotypes in the Korean OSA group when compared to the Korean control group (62.1% vs 40.4%, p=0.002). Conclusions: The results suggest that HLA-G heterozygote patients may be more susceptible to OSA in the Korean population.

      • SCISCIESCOPUS

        Expression of heat shock proteins in osteosarcomas

        Moon, Ahrim,Bacchini, Patrizia,Bertoni, Franco,Olvi, Liliana G.,Santini-Arawo, Eduardo,Kim, Youn Wha,Park, Yong-Koo Elsevier 2010 Pathology Vol.42 No.5

        <P>Aims: Heat shock proteins (HSPs) protect cells against stress-associated injuries and are overexpressed in several malignant tumours. We investigated the potential roles of HSP27, HSP60, and HSP70 in conventional and low grade central osteosarcoma. Methods: Expressions of HSP27, HSP60, and HSP70 were analysed using immunohistochemistry on tissue sections from 52 cases of conventional osteosarcoma and 21 cases of low grade central osteosarcoma. We evaluated the expression of each protein and examined its relationship with clinicopathological parameters. Results: We found significantly different expressions of HSP27 and HSP70 between conventional and low grade central osteosarcoma [34.6% versus 4.8% (p = 0.008), 88.5% versus 14.3% (p < 0.001)]. However, HSP60 was highly expressed in both kinds of osteosarcoma (92.3% versus 85.7%). In conventional osteosarcoma, a higher expression of HSP27 was significantly related to distant metastasis (p = 0.034) and histological subtype [osteoblastic versus non-osteoblastic (p = 0.041)]. The expressions of HSP60 and HSP70 were not significantly related to any tested clinicopathological parameter. Conclusions: HSP27 and HSP70 may be used as differential markers to distinguish conventional and low grade central osteosarcoma. HSP27 may be used as a possible prognostic marker in conventional osteosarcoma cases.</P>

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