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        • KCI등재

          Statistical Characterization of the Multi-Charged Fragment Ions in the CID and HCD Spectrum

          Sangeetha,Ramachandran,and,Tessamma,Thomas,Tessamma,Thomas 사단법인 한국질량분석학회 2021 Mass spectrometry letters Vol.12 No.2

          Collision-induced dissociation (CID) and higher-energy collisional dissociation (HCD) are the widely used fragmenta- tion technique in mass spectrometry-based proteomics studies. Understanding the fragmentation pattern from the tandem mass spectra using statistical methods helps to implement efficient spectrum analysis algorithms. The study characterizes the frequency of occurrence of multi-charged fragment ions and their neutral loss events of doubly and triply charged peptides in the CID and HCD spectrum. The dependency of the length of the fragment ion on the occurrence of multi-charged fragment ion is characterized here. Study shows that the singly charged fragment ions are generally dominated in the doubly charged peptide spectrum. However, as the length of the product ion increases, the frequency of occurrence of charge 2 fragment ions increases. The y- ions have more tendencies to generate charge 2 fragment ions than b- ions, both in CID and HCD spectrum. The frequency of occurrence of charge 2 fragment ion peaks is prominent upon the dissociation of the triply charged peptides. For triply charged peptides, product ion of higher length occurred in multiple charge states in CID spectrum. The neutral loss peaks mostly exist in charge 2 states in the triply charged peptide spectrum. The b-ions peaks are observed in much less frequency than y-ions in HCD spectrum as the length of the fragment increases. Isotopic peaks are occurred in charge 2 state both in doubly and triply charged peptide's HCD spectrum.

        • KCI등재

          Characterization of the Fragmentation Pattern of Peptide from Tandem Mass Spectra

          Sangeetha,Ramachandran,and,Tessamma,Thomas,Tessamma,Thomas 사단법인 한국질량분석학회 2019 Mass spectrometry letters Vol.10 No.2

          The fragmentation statistics of ion trap CID (Collision-Induced Dissociation) spectra using 87,661 tandem mass spectra of doubly charged tryptic peptides are analyzed here. In contrast to the usual method of using intensity information, the frequency of occurrence of fragment ions, with respect to the position of the cleavage site and the residues at these sites is stud-ied in this paper. The analysis shows that the frequency of occurrence of fragment ion peaks is more towards the middle of the peptide than its ends. It was noted that amino acid with an aromatic and basic side chain at N- & C- terminal end of the peptide stimulates more peaks at the lower end of the spectrum. The residue pair effect was shown when the amide bond occurs between acidic and basic residues. The fragmentation at these sites (D/E-H/R/K) stimulates the generation of the y-ion peak. Also, the cleavage site H–H/R/K stimulates the generation of b-ions. K-P environment in the peptide sequence has more tendency to gen-erate y-ions than b-ions. Statistical analysis helps in the visualization of the CID fragmentation pattern. Cleavage pattern along the length of the peptide and the residue pair effects, enhance the knowledge of fragmentation behavior, which is useful for the better interpretation of tandem mass spectra.

        • KCI등재

          Does hotel attributes impact customer satisfaction: A sentiment analysis of online reviews

          Sangeetha,Gunasekar,Sooriya,Sudhakar 한국마케팅과학회 2019 마케팅과학연구 Vol.29 No.2

          User-generated content is a major source of information particularly in tourism industry where consumers seek unbiased and unregulated information. While making their hotel booking decisions, consumers refer to the previous guests' experiences expressed in the hotel reviews across social media. Studies in the literature have focused on enhancing the understanding of what makes customers satisfied or dissatisfied. They have analyzed the text reviews and the patterns in the overall rating and ranking of the hotels given by hotel guests. While most emerging destinations have been studied in the literature, studies related to India, a fast-growing leisure destination are scant. The present study tries to understand the hotel attributes that contribute towards customer satisfaction or dissatisfaction using online reviews for all hotels of Andaman & Nicobar Islands in India. Among the eight attributes identified from the most frequently used words in the text reviews, the study finds that while the location has a significant probability of increasing the ratings of both highand low-rated reviews, rooms seem to have the most significant impact on lowering the probability of high scores irrespective of positive or negative sentiment review. The study also finds that guests of luxury hotels rate the hotels significantly higher than the guests of midrange and budget hotels.

        • KCI등재SCOPUS

          Copy Number Variation Burden on Asthma Subgenome in Normal Cohorts Identifies Susceptibility Markers

          Sangeetha,Vishweswaraiah,Avinash,M,Veerappa,Padukudru,A,Mahesh,Sareh,R,Jahromi,Nallur,B.,Ramachandra 대한천식알레르기학회 2015 Allergy, Asthma & Immunology Research Vol.7 No.3

          Purpose: Asthma is a complex disease caused by interplay of genes and environment on the genome of an individual. Copy number variations (CNVs) are more common compared to the other variations that disrupt genome organization. The effect of CNVs on asthma subgenome has been less studied compared to studies on the other variations. We report the assessments of CNV burden in asthma genes of normal cohorts carried out in different geographical areas of the world and discuss the relevance of the observation with respect to asthma pathogenesis. Methods: CNV analysis was performed using Affymerix high-resolution arrays, and various bioinformatics tools were used to understand the influence of genes on asthma pathogenesis. Results: This study identified 61 genes associated with asthma and provided various mechanisms and pathways underlying asthma pathogenesis. CCL3L1, ADAM8, and MUC5B were the most prevalent asthma genes. Among them, CCL3L1 was found across all 12 populations in varying copy number states. This study also identified the inheritance of asthma-CNVs from parents to offspring creating the latent period for manifestation of asthma. Conclusions: This study revealed CNV burden with varying copy number states and identified susceptibility towards the disease manifestation. It can be hypothesized that primary CNVs may not be the initiating event in the pathogenesis of asthma and additional preceding mutations or CNVs may be required. The initiator or primary CNVs sensitize normal cohorts leading to an increased probability of accumulating mutations or exposure to allergic stimulating agents that can augment the development of asthma.

        • KCI등재

          Pathological Status of Pyricularia angulata Causing Blast and Pitting Disease of Banana in Eastern India

          Sangeetha,Ganesan,Hari,Shankar,Singh,Srinivas,Petikam,Debasish,Biswal 한국식물병리학회 2017 Plant Pathology Journal Vol.33 No.1

          Incidence of leaf blast on nursery plants and pittingdisease on maturing banana bunches has beenrecorded in banana plantations during rainy seasonin Eastern India during 2014 to 2015. Taxonomicalidentification as well as DNA sequence analysis of theinternal transcribed spacer region of fungus isolatedfrom affected tissue culture derived plantlets andfruits confirmed the pathogen to be Pyricularia angulataHashioka “in both the cases”. Koch's postulateswere proved on young plantlets as well as on maturingfruits of cv. Grand Naine under simulated conditions. Evolutionary history was inferred and presented forour P. angulata strain PG9001 with GenBank accessionno. KU984740. The analysis indicated that theP. angulata is phylogenitically distinct from other relatedspecies related to both Pyricularia and Magnaporthe. Detailed symptoms of blast lesions on youngleaves, transition leaves, mid rib, petioles, peduncle,maturing bunches, bunch stalks and cushions weredocumented. Notably, the distinct small pitting spotson maturing bunches reduced the visual appeal of maturefruits. Appearance of pitting symptoms on fruitsin relation with age of fruits and their distributionpattern on bunch and fingers was also documentedin detail. Further, the roles of transitory leaves, weedhosts, seasonality on disease occurrence have also beendocumented.

        • SCISCIESCOPUS

          Strain induced optical properties of exciton in a CdTe/ZnTe quantum dot

          Sangeetha,,R.,John,Peter,,A.,Lee,,C.W. Academic Press 2014 Superlattices and microstructures Vol.66 No.-

          The influence of strain on the binding energies of heavy and light hole is obtained in a Zn<SUB>x</SUB>Cd<SUB>1-x</SUB>Te/ZnTe quantum dot taking into account the phonon confinement effect. The band offsets are calculated using model-solid approach. The dielectric mismatch effect is introduced between the dielectric constants of dot and the barrier. The strain induced energies of excitonic transitions in a CdZnTe quantum dot with ZnTe barrier are brought out considering the internal electric field induced by the spontaneous and piezoelectric polarizations. Calculations have been obtained using Bessel function as an orthonormal basis for different confinement potentials of barrier height, strain induced linear and third-order nonlinear optical absorption coefficients and the changes of refractive index with the incident photon energy are observed. Our results show that the exciton binding energy is enhanced with the inclusion of potential taking into account the effects of dielectric mismatch and the geometry of quantum dot with various Zinc alloy content has a great influence on the optical properties of the dot.

        • Effects of strain on the band alignment and the optical gain of a CdTe/ZnTe quantum dot

          Sangeetha,,R.,Peter,,A.,John,Yoo,,Chang,Kyoo Canadian Science Publishing 2014 Canadian journal of physics Vol.92 No.5

          <P> The band lineups at the strained layer interfaces, in ZnxCd1-xTe/ZnTe quantum dot nanostructure for various Zn alloy content, are computed using model solid theory with an example of CdTe/ZnTe interface. The effects of strain, due to hydrostatic and biaxial strain, and the internal electric fields, due to the spontaneous and piezoelectric polarization, are taken into consideration. The dielectric mismatch, through the effective potential, is introduced between the dielectric constants of the dot and the barrier materials. The interband emission energy as a function of dot radius is computed for various Zn alloy content. The optical gain spectra of heavy hole exciton for various Zn concentration are studied. Calculations are obtained for different confinement potentials with the inclusion strain effect. Our results show that (i) the potential taking into account the effects of PB potential due to the dielectric mismatch enhances the exciton binding energy and (ii) the geometry of quantum dot, the strain effects and the Zinc alloy content have great influences on the electrical and optical properties of the dot. Our results are in good agreement with the previous investigators. </P>

        • Hospital Record Search using RDF based Information Retrieval

          K.,Sangeetha,S.,Santhiya 보안공학연구지원센터 2016 International Journal of Software Engineering and Vol.10 No.8

          In Today's World, the usage of Web is increased in a very fast manner. The User who is surfing the Web always wants to extract the meaningful information from the resources. As the number of user increased, the Web is diffusing day-by- day. Due to this diffusion, there is enormous lacking in retrieving the relevant information. To overcome this, Semantic Web Technologies such as Resource Description Framework along with Document Object Model are used to bring the clear answers to user queries by taking advantage of the availability of precise semantics of information in the context of the search engines. The Resource Description Framework (RDF) is defined by the World Wide Web Consortium (W3C) which is one of the enrich entity which is mainly used to encode the meaning of the data.

        • SCOPUSKCI등재

          Characterization of the Fragmentation Pattern of Peptide from Tandem Mass Spectra

          Ramachandran,,Sangeetha,Thomas,,Tessamma Korean Society for Mass Spectrometry 2019 Mass spectrometry letters Vol.10 No.2

          The fragmentation statistics of ion trap CID (Collision-Induced Dissociation) spectra using 87,661 tandem mass spectra of doubly charged tryptic peptides are analyzed here. In contrast to the usual method of using intensity information, the frequency of occurrence of fragment ions, with respect to the position of the cleavage site and the residues at these sites is studied in this paper. The analysis shows that the frequency of occurrence of fragment ion peaks is more towards the middle of the peptide than its ends. It was noted that amino acid with an aromatic and basic side chain at N- & C- terminal end of the peptide stimulates more peaks at the lower end of the spectrum. The residue pair effect was shown when the amide bond occurs between acidic and basic residues. The fragmentation at these sites (D/E-H/R/K) stimulates the generation of the y-ion peak. Also, the cleavage site H-H/R/K stimulates the generation of b-ions. K-P environment in the peptide sequence has more tendency to generate y-ions than b-ions. Statistical analysis helps in the visualization of the CID fragmentation pattern. Cleavage pattern along the length of the peptide and the residue pair effects, enhance the knowledge of fragmentation behavior, which is useful for the better interpretation of tandem mass spectra.

        • SCIEKCI등재

          Pathological Status of Pyricularia angulata Causing Blast and Pitting Disease of Banana in Eastern India

          Ganesan,,Sangeetha,Singh,,Hari,Shankar,Petikam,,Srinivas,Biswal,,Debasish The Korean Society of Plant Pathology 2017 Plant Pathology Journal Vol.33 No.1

          Incidence of leaf blast on nursery plants and pitting disease on maturing banana bunches has been recorded in banana plantations during rainy season in Eastern India during 2014 to 2015. Taxonomical identification as well as DNA sequence analysis of the internal transcribed spacer region of fungus isolated from affected tissue culture derived plantlets and fruits confirmed the pathogen to be Pyricularia angulata Hashioka "in both the cases". Koch's postulates were proved on young plantlets as well as on maturing fruits of cv. Grand Naine under simulated conditions. Evolutionary history was inferred and presented for our P. angulata strain PG9001 with GenBank accession no. KU984740. The analysis indicated that the P. angulata is phylogenitically distinct from other related species related to both Pyricularia and Magnaporthe. Detailed symptoms of blast lesions on young leaves, transition leaves, mid rib, petioles, peduncle, maturing bunches, bunch stalks and cushions were documented. Notably, the distinct small pitting spots on maturing bunches reduced the visual appeal of mature fruits. Appearance of pitting symptoms on fruits in relation with age of fruits and their distribution pattern on bunch and fingers was also documented in detail. Further, the roles of transitory leaves, weed hosts, seasonality on disease occurrence have also been documented.

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