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      • HCC : Transient Elastography can Predict Recurrence after Radiofrequency Ablation for Hepatocellular Carcinoma

        ( Sang Hoon Lee ), ( Sang Hun Lee ), ( Seung Up Kim ), ( Beom Kyung Kim ), ( Jun Yong Park ), ( Do Young Kim ), ( Sang Hoon Ahn ), ( Kwang Hyub Han ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1

        Background/ Aims: Liver stiffness (LS) values measured using transient elastography (TE) can accurately assess the degree of liver fibrosis. The degree of liver fibrosis is significantly associated with the risk of hepatocellular carcinoma (HCC) development. Thus, this study investigated whether LS values at radiofrequency ablation (RFA) can predict HCC recurrence after RFA. Methods: Between May 2005 and April 2011, a total of 56 patients with HCC who underwent RFA and LS value measurement at the same day were analyzed in this retrospective study. All were followed up for monitoring the development of HCC recurrence until March 2013. Results: The mean age of the patients (40 men, 16 women) was 62.1 years, and the median LS value was 23.0 kPa. During the follow-up period (median 27.9 [range, 1.1-77.3] months), 33 (58.9%) patients experienced HCC recurrence and 18 (32.1%) were dead. Median time to recurrence was 17.1 (range, 2.5-67.8) months and median time to mortality was 27.9 (range, 1.1-77.3) months. Patients with recurrence showed significantly higher prevalence of liver cirrhosis, spleen size, multiple tumors, and LS values, whereas they had significantly lower platelet count than patients without recurrence (all P<0.05). On multivariate analysis, together with previous anti- HCC treatment history, patients with a higher LS value >13.0 kPa were at a significant greater risk for HCC recurrence after RFA with a hazard ratio of 6.981 (P<0.05; 95% confidence interval, 1.650-28.782) compared with those with LS value ≤13.0 kPa. However, LS values were not predictive for overall survival (P=0.237). Conclusions: Our data suggest that LS values measured using TE can be a useful predictor of HCC recurrence after RFA. Further studies with large sample size are warranted for the validation of our results.

      • In Vitro Developmental Competence of Porcine SCNT Embryos is improved by m-Carboxycinnamic Acid Bishydroxamide, Histone Deacetylase Inhibitor

        Sang-Hoon,Park,Mi-Ran,Lee,Tae-Suk,Kim,Sang-Ki,Baek,Sang-Jin,Jin,Jin-Wook,Kim,Sang-Gon,Jeon,Ho-Baek,Yoon,Joon-Hee,Lee 한국동물번식학회 2014 Reproductive & developmental biology Vol.38 No.4

        Differentiated nuclei can experimentally be returned to an undifferentiated embryonic status after nuclear transfer (NT) to unfertilized metaphase II (MII) oocytes. Nuclear reprogramming is triggered immediately after somatic cell nucleus transfer (SCNT) into recipient cytoplasm and this period is regarded as a key stage for optimizing reprogramming. In a recent study (Dai et al., 2010), use of m-carboxycinnamic acid bishydroxamide (CBHA) as a histone deacetylase inhibitor during the in vitro early culture of murine cloned embryos modifies the acetylation status of somatic nuclei and increases the developmental competence of SCNT embryos. Thus, we examined the effects of CBHA treatment on the in vitro preimplantation development of porcine SCNT embryos and on the acetylated status of histone H3K9 on cloned embryos at the zygote stage. We performed the three groups SCNT: SCNT (NT), CBHA treatment at the porcine fetus fibroblast cells (PFFs) used as donor cells prior to SCNT (CBHA-C) and CBHA treatment at the porcine SCNT embryos during the in vitro early culture after oocyte activation (CBHA-Z). The PFFs were treated with a 15 μM of CBHA (8 h) for the early culture and the porcine cloned embryos were treated with a 100 μM concentration of CBHA during the in vitro early culture (10 h). Cleavage rates and development to the blastocyst stage were assessed. No significant difference was observed the cleavage rate among the groups (82.6%, 76.4% and 82.2%, respectively). However, the development competence to the blastocyst stage was significantly increased in CBHA-Z embryos (22.7%) as compared to SCNT and CBHA-C embryos (8.6% and 4.1%)(p<0.05). Total cell numbers and viable cell numbers at the blastocyst stage of porcine SCNT embryos were increased in CBHA-Z embryos as compared to those in CBHA-C embryos (p<0.05). Signal level of histone acetylation (H3K9ac) at the zygote stage of SCNT was increased in CBHA-Z embryos as compared to SCNT and CBHA-C embryos. The results of the present study suggested that treatment with CBHA during the in vitro early culture (10 h) had significantly increased the developmental competence and histone acetylation level at the zygote stage.

      • LabVIEW를 활용한 선박 전기 추진 제어 및 계측 시스템

        남상대(Sang-Dae Nam), 김성훈(Sung-Hoon Kim), 손상혁(Sang-Hyuk Son), 박흥주(Heung-Ju Park), 손지훈(Ji-Hoon Son), 최상섭(Sang-Sub Choi), 장낙원(Nak-Won Jang) 한국항해항만학회 2008 한국항해항만학회 학술대회논문집 Vol.2008 No.공동학술

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

        The marine transportation business will increase along with safe and economical shipping services. To make an effective electric propulsion system, we need to use an advanced software like a LabVIEW because the LabVIEW can contain all types of electric signals perfectly. Particularly, we designed a flexible electric propulsion system to protect the safe shipping service. In this paper, We propose a flexible control and measurement of electric propulsion system using LabVIEW.

      • KCI등재후보

        폐렴구균 수막뇌염 이후 급성 미만성 백질 병변으로 진행한 6개월 영아 1례

        이훈상(Hoon Sang Lee), 김경민(Kyung Min Kim), 남상욱(Sang Ook Nam), 김영미(Young Mi Kim), 연규민(Gyu Min Yeon), 이윤진(Yun Jin Lee) 대한소아신경학회 2016 대한소아신경학회지 Vol.24 No.4

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

        폐렴구균 같은 세균성 뇌수막염은 소아나 성인에서 높은 사망률과 심각한 신경학적 합병증을 초래할 수 있다. 6개월의 여아가 3일간의 발열과 의식 쳐짐을 주소로 내원하였다. 내원 당시 시행한 뇌척수액 검사에서 세균성 뇌수막염이 의심되는 소견이 관찰 되어 항생제(vancomycin, cefotaxime)를 즉각적으로 투여 하였고,. 혈액과 뇌척수액 배양 검사에서 폐렴구균(S.pneumoniae )이 동정되었다. MRI 소견에서는 백질에 광범위한 다발성의 고음영 소견이 관찰되어 gammaglobulin (5-day course of 0.4 g/kg/day)와 고용량의 methylprednisolone (30 mg/kg/day)을 정맥 투여하였다. 하지만, 이런 치료에도 불구하고, 호흡이 불안정하게 되어 기계환기 치료를 하였고, 상태가 점점 악화되어 환아는 입원 60일경에 사망하였다. 저자들은 급속하게 비가역적인 미만성 백질의 침범이 있는 폐렴구균수막뇌염의 6개월 어린 영아를 경험하였기에 보고하는 바이다. Acute bacterial meningitis such as Streptococcus pneumoniae (S. pneumonia) continues to be a major cause of morbidity and mortality in both children and adults. A rapid aggravating invasion of diffuse white matter following bacterial meningoencephalitis may be a rare occurrence depending on patient's immune response. A 6-month-old girl was referred to our hospital after 3-days of fever and appeared lethargic at the time of visit. Lumbar puncture was performed with the results of white blood cells of 60/mm3 (70% neutrophil), total protein 415 mg/dL, and glucose 51 mg/dL. Brain MRI showed very widely spreading signal abnormalities of diffuse white matters, basal ganglia and corpus callosum. Intravenous vancomycin and high dose cefotaxime as well as intravenous immunoglobulin (0.4 g/kg/day for 5 days), and high-dose methylprednisolone (30 mg/kg/day) were started on the first and third day after admission, respectively. On the 4th day after admission, the patient was intubated for ventilator care and despite aggressive treatment, the patient deteriorated rapidly and died after 60 days since admission. S. pneumoniae growth was noted from both blood and cerebrospinal fluid. We report this case with rapidly aggravating white matter lesion due to S. pneumoniae meningoencephalitis, as one of the youngest patient reported to date, with a fatal outcome.

      • LabVIEW를 활용한 선박 전기 추진 제어 및 계측 시스템

        남상대(Sang-Dae Nam), 김성훈(Sung-Hoon Kim), 손상혁(Sang-Hyuk Son), 박흥주(Heung-Ju Park), 손지훈(Ji-Hoon Son), 최상섭(Sang-Sub Choi), 장낙원(Nak-Won Jang) 한국마린엔지니어링학회 2008 한국마린엔지니어링학회 학술대회 논문집 Vol.2008 No.-

        The marine transportation business will increase along with safe and economical shipping services. To make an effective electric propulsion system, we need to use an advanced software like a LabVIEW because the LabVIEW can contain all types of electric signals perfectly. Particularly, we designed a flexible electric propulsion system to protect the safe shipping service. In this paper, We propose a flexible control and measurement of electric propulsion system using LabVIEW.

      • In Vitro Developmental Competence of Porcine SCNT Embryos is improved by m-Carboxycinnamic Acid Bishydroxamide, Histone Deacetylase Inhibitor

        Park,,Sang-Hoon,Lee,,Mi-Ran,Kim,,Tae-Suk,Baek,,Sang-Ki,Jin,,Sang-Jin,Kim,,Jin-Wook,Jeon,,Sang-Gon,Yoon,,Ho-Baek,Lee,,Joon-Hee The Korean Society of Animal Reproduction 2014 Reproductive & developmental biology Vol.38 No.4

        Differentiated nuclei can experimentally be returned to an undifferentiated embryonic status after nuclear transfer (NT) to unfertilized metaphase II (MII) oocytes. Nuclear reprogramming is triggered immediately after somatic cell nucleus transfer (SCNT) into recipient cytoplasm and this period is regarded as a key stage for optimizing reprogramming. In a recent study (Dai et al., 2010), use of m-carboxycinnamic acid bishydroxamide (CBHA) as a histone deacetylase inhibitor during the in vitro early culture of murine cloned embryos modifies the acetylation status of somatic nuclei and increases the developmental competence of SCNT embryos. Thus, we examined the effects of CBHA treatment on the in vitro preimplantation development of porcine SCNT embryos and on the acetylated status of histone H3K9 on cloned embryos at the zygote stage. We performed the three groups SCNT: SCNT (NT), CBHA treatment at the porcine fetus fibroblast cells (PFFs) used as donor cells prior to SCNT (CBHA-C) and CBHA treatment at the porcine SCNT embryos during the in vitro early culture after oocyte activation (CBHA-Z). The PFFs were treated with a $15{\mu}M$ of CBHA (8 h) for the early culture and the porcine cloned embryos were treated with a $100{\mu}M$ concentration of CBHA during the in vitro early culture (10 h). Cleavage rates and development to the blastocyst stage were assessed. No significant difference was observed the cleavage rate among the groups (82.6%, 76.4% and 82.2%, respectively). However, the development competence to the blastocyst stage was significantly increased in CBHA-Z embryos (22.7%) as compared to SCNT and CBHA-C embryos (8.6% and 4.1%)(p<0.05). Total cell numbers and viable cell numbers at the blastocyst stage of porcine SCNT embryos were increased in CBHA-Z embryos as compared to those in CBHA-C embryos (p<0.05). Signal level of histone acetylation (H3K9ac) at the zygote stage of SCNT was increased in CBHA-Z embryos as compared to SCNT and CBHA-C embryos. The results of the present study suggested that treatment with CBHA during the in vitro early culture (10 h) had significantly increased the developmental competence and histone acetylation level at the zygote stage.

      • KCI우수등재

        관광에 의한 생활공간의 젠트리피케이션 과정

        이상훈 ( Lee Sang-hoon ), 강상훈 ( Kang Sang-hoon ) 한국관광학회 2018 관광학연구 Vol.42 No.2

        본 연구는 관광에 의해서 생활공간이 관광지로 변형되어가는 과정 그리고 지역주민이 그 변화과정에 대해 가졌던 태도를 질적 연구 방법의 하나인 심층 면접을 적용해서 조사했다. 연구 결과를 요약하면, 생활 공간인 감천문화마을은 관광에 의해서 젠트리피케이션 현상이 진행되고 있는 것을 알 수 있었다. 젠트리피케이션 진행 과정은 크게 지방자치단체와 마을 협의회의 관광지화 찬성 단계, 지역주민 간의 관계변화 단계, 지역주민 이전 강요와 지역주민과 외부자원의 압박 단계, 그리고 젠트리피케이션에 의한 마을 공동화의 4 단계로 구분되었다. 또한 지역주민이 살고 있는 생활공간이 관광지로 변화된 이후에 발생하고 있는 관광의 부정적 영향에 관해서도 알아봤다. 특히, 선행 연구에서 젠트리피케이션의 결과물로서 제시했던 비자발적 외부이주현상과 더불어 ‘자발적' 외부이주 현상과 비자발적 ‘내부' 이주현상이 관광지화된 생활공간에서는 동시에 진행되고 있다는 것을 밝힘으로써 기존 젠트리피케이션 연구의 이론적 발전에 기여를 했고, 실무적 시사점을 결론에서 제시했다. This study examined the transformation process of living space to tourism space and local residents' attitudes toward the transformation process by applying in-depth interviews as a qualitative research methodology. Findings show that gentrification has hastened the transformation of living space to tourism space. More specifically, four steps were identified: 1) approvement for being a tourism space by local government and community council; 2) changes in the relationships between/among community residents; 3) transfer of community residents' living space by demand; and 4) community decline as a result of gentrification. While previous studies have revealed mandatory transfer by gentrification, this study found that both voluntary transfer to other communities and mandatory transfer within local residents' communities have been happening together. Based on the results, theoretical and practical implications are discussed to advance the current knowledge of gentrification research.

      • KCI등재

        비만지표(肥滿指標)와 사상인체질분포(四象人體質分布)와의 관계(關係)에 관한 림상보고(臨床報告)

        유호상 ( Ho Sang You ), 최승훈 ( Seung Hoon Choi ), 오민석 ( Min Seok Oh ), 송태원 ( Tae Won Song ) 한방재활의학과학회 2002 한방재활의학과학회지 Vol.12 No.3

        Objectives:To find out the correlation between indices related with obese and sa-sang constitutional distribution Methods:This study was done with 38 persons, who had taken the tests for obese and sa-sang constitutional distribution in oriental medical hospital of Dae Jeon university from 22 February 2002 to 2 April 2002.Then, the data of % body fat, obesity degree, BMI, WHR and BMR was analyzed by sex, age and sa-sang constitutional distribution.Results:The correlation between % body fat, obesity degree, WHR and BMI & sex had no significance with a exception of BMR (Sig.=0.000).and the habit of drinking had no significant correlation with the indices but smoking did with BMR(Sig.=0.011).In obesity degree, Taeeum-in had significant differences compared with soyang-in and soeum-in, in BMI and WHR Taeeum-in compared significantly with soeum-in and in BMR Taeeum-in did with soyang-in.Conclusions:Indices for obesity with a exception of % body fat had significance with sa-sang constitutional distribution especially for Taeeum-in.

      • KCI등재

        제주마 고환내 세균의 16S rRNA 염기서열 분석을 이용한 동정

        박용상(Yong-Sang Park), 김남영(Nam-Young Kim), 한상현(Sang-Hyun Han), 박남건(Nam-Geon Park), 고문석(Moon-Suck Ko), 조원모(Won-Mo Cho), 채현석(Hyun-Seok Chae), 조인철(In-Chul Cho), 조상래(Sang-Rae Cho), 우제훈(Jae-Hoon Woo), 강태영(Tae-Young Ka) 한국임상수의학회 2014 한국임상수의학회지 Vol.31 No.1

        Many bacteria colonized in the horse semen affect quality of the sperm and some may cause infection in the mare reproductive tract and infertility of susceptible mare. This study was initiated to determine the prevalence of bacteria in testes of Jeju horses by determining rRNA sequence. The samples were swabed from the testes of nine Jeju horses (aged from 8 to 12 months after birth). Bacteria isolated from testes were identified by 16S rDNA sequencing. 1.6-kbp PCR products for 16S rRNA coding region were obtained using the universal primers. The PCR products were further purified and sequenced. Maximum similar species were found by BLAST search in the GenBank DNA database. BLAST results showed that the sequences were similar to those of Acinetobacter sp (A. schindleri, A. ursingii)., Bacillus cereus, Corynebacterium glutamicum, Escherichia coli, Gamma proteobacterium, Micrococcus luteus, Pseudomonas mendocina, Shigella sonnei, Sphingomonas sp., Staphylococcus sp (S. cohnii, S. saprophyticus, S. xylosus)., and Stenotrophomonas maltophilia. DNA sequences for 16S rRNA is provided useful informations for species identification of pathogenic microorganisms for the reproductive organs in horses.

      • KCI등재

        A Comparison of m-Carboxycinnamic Acid Bishydroxamide with Trichostatin A as Histone Deacetylase Inhibitor on the Developmental Competence of Somatic Cell Nuclear Transfer Porcine Embryos

        Mi-Ran,Lee,Sang-Hoon,Park,Tae-Suk,Kim,Sang-Ki,Baek,Sang-Jin,Jin,Yeoung-Gyu,Ko,Hwan-Hwoo,Sung,Ho-Baek,Yoon,Jin-Wook,Kim,Joon-Hee,Lee 경상대학교 농업생명과학연구원 2014 농업생명과학연구 Vol.48 No.6

        The cloning efficiency is extremely low despite successful somatic cell nuclear transfer (SCNT) method producing cloned animals in several mammals. In general, faulty epigenetic modifications underlying the incomplete reprogramming of donor cell nuclei after SCNT mainly results in low cloning efficiency. The nuclear reprogramming process involves epigenetic modifications, such as DNA demethylation and histone acetylation, which may be an important factor in enhancing the cloning efficiency. Recently, the histone deacetylase inhibitors (HDACi), such as trichosatin A (TSA) and m-carboxycinnamic acid bishydroxamide (CBHA), to increase histone acetylation have been used to improve the developmental competence of SCNT embryos. Therefore, we compared the effects of TSA with CBHA on the in vitro developmental competence and pluripotency-related gene expression (Oct4, Nanog and Sox2) in porcine cloned blastocysts and histone acetylation pattern (H3K9ac). The porcine cloned embryos were treated with a 50nM concentration of TSA and 100μM concentration of CBHA during the in vitro early culture (10h) after cell fusion and then were assessed to cleavage rate, development to the blastocyst stage and pluripotency-related gene expression in NT blastocyst also, level of histone acetylation in zygote, 2cell, 4cell stage. As results, Although NT, TSA and CBHA treated NT embryos were not different between all groups for cleavage rates, the developmental competence to the blastocyst stage was significantly increased in CBHA treated embryos (22.7%) compared to that of normal NT and TSA treated NT embryos (8.1% and 15.4%)(p<0.05). In addition, all of pluripotent transcription factors (Oct4, Nanog and Sox2) were expressed in the CBHA treated NT embryos, however, Sox2 and Oct4 were expressed in TSA treated NT embryos and expression pattern of CBHA treated NT embryos is particularly similar to that of IVF embryos. Also, CBHA treated NT embryos were increased in level of histone acetylation (H3K9ac) at the zygote, 2-cell, 4-cell stage compared to those of NT and TSA treated NT embryos. In conclusion, the treatment of CBHA as a histone deacetylase inhibitor significantly increased the developmental competence of porcine NT embryos and pluripotency-related gene expressions(Oct4, Nanog and Sox2) in NT blastocysts and level of histone acetylation (H3K9ac).

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