Interleukin-5 저해 활성 chalcone 화합물의 유효 입체 구조

이기철,김민석,P. Thanigaimalai,Vinay K. Sharma,박경래,김영수,정상헌 충남대학교 약학대학 의약품개발연구소 2010 藥學論文集 Vol.25 No.-

Interleukin(IL)-5 appears to be one of the main proinflammatory mediators among the growing number of cytokines and chemokines that induce eosinophilic inflammation. Previously, our group synthesized a number of chalcone derivatives to determine their inhibitory activity against IL-5. However, the structure-activity relationship (SAR) of these chalcones was somewhat unclear, robably due to presence of three free rotatable bonds. To further, explore the SAR of these chalcones, we synthesized eight 2-(benzylidene)-2,3-dihydroinden-1-ones and 2- benzylidene)-3,4-dihydronaphthalen-1(2H)-ones 6 and evaluated for their inhibitory activity against IL-5. These rigidified chalcones 6 exhibited very weak inhibitory activity against IL-5 compared to chalcones 2. The structures of 6 closely resemble to the stretched conformations of chalcone 2, not effective conformation for the inhibition on IL-5 function.

액상정액을 이용한 인공수정시 품종, 계절, 인공수정 횟수 및 정자농도가 번식성적에 미치는 영향

김인철,박창식,이규승,서길웅,한성욱 충남대학교 농업과학연구소 2001 농업과학연구 Vol.28 No.2

돼지에서 액상정액을 이용한 인공수정이 번식성적에 미치는 영향을 구명하기 위하여 축산기술연구소 종축개량부 (충남, 성환) 돼지 인공수정센터에서 사육중인 인공수정용 종모돈을 이용하여 1995년부터 2000년까지 액상정액을 이용한 인공수정시 종모돈의 품종, 인공수정횟수, 계절 및 정자농도가 번식성적에 미치는 영향을 조사하여 돼지 인공수정시 번식성적 향상과 실용화에 기여하고자 본 연구를 실시하였다. 액상정액 인공수정시 정액을 생산한 종모돈의 품종 (Landrace, Yorkshire, Duroc)간 번식성적은 유의차가 인정되지 않았다. 발정당 2회 또는 3회 인공수정 시에도 번식성적에 차이가 없었다. 인공수정을 실시한 계절별로 번식성적을 조사하였으나 계절간 차이점은 발견할 수 없었다. 액상정액 인공수정시 1회 주입정자의 최저농도를 구명코자 활력 70% 이상인 정자수를 기준으로 80 ml 병당 정자농도를 3.0, 2.5, 2.0 및 1.5×10^(9)로 조절하여 인공수정한 결과 수태율, 분만율, 총산자수 및 생존산자수에서 통계적인 유의차가 인정되지 않아 1회 주입정자농도는 운동성 정자 기준으로 1.5×10^(9)/80 ml 이상으로 조절하면 인공수정에 실용적으로 사용 할 수 있음을 보였다. This study was carried out to investigate the effects of liquid boar semen on reproductive performance in swine artificial insemination Many factors, which were breeds, time of insemination, breeding season, sperm per dose etc. have been tried to improve reproductive efficiency. Boars were raised at Swine Artificial Insemination Center in National Livestock Research Institute. Sunghwan, Chungnam, Korea. This experiment was carried out from 1995 to 2000. There were no differences in the fertility results compared with 3 breeds (Landrace, Yorkshire and Duroc), frequencies of artificial insemination (double and triple) per estrus cycle and different seasons by using liquid boar semen. There were no significant differences in conception rate, farrowing rate and litter size using 4 trials of 3.0, 2.5, 20 and 1.5×10^(9)/80㎖ in liquid boar semen with 70% of motile sperm cells. We confirmed that the sperm number per dose of 1.5×10^(9)/80㎖ could be used for commercial artificial insemination.

單獨住宅地의 地區特格 및 住居規模에 따른 住民意識構造에 관한 硏究

安相哲 동아대학교 공과대학 부설 한국자원개발연구소 1986 硏究報告 Vol.10 No.2

This study in analyzied the attribution of the social character in the of dwelling style of site inhabitants the human relation of inhabitants, dwelling sense and site sense of inhabitants according to the change of dwelling size and district character in a private housing site. The object of this is selected private housing among the survey area have constructed in Busan, and the method of examination depends on enquete, field survey, statical data.

컴퓨터과학 교육을 중심으로 한 중등 컴퓨팅 교육과정 설계

신상국,권대용,김형신,염용철,유승욱,이원규 한국컴퓨터교육학회 2005 컴퓨터교육학회 논문지 Vol.8 No.3

山淸地方의 梅實 開花期 및 發育段階 調査

安相烈,李英喆 진주산업대학교 농업기술연구소 1991 農業技術硏究所報 Vol.4 No.-

山淸地方에 植栽된 梅實品種의 肥培管理 및 收穫期의 基礎資料를 알기 위하여 開花期 및 發育段階를 調査한 結果는 다음과 같다. 1. 開花期는 백가하가 3月 13日에 시작하여 3月 19日에 滿開하였고 화향실, 남고 等은 3月 18日에 시작하여 3月 23日에 滿開하였으며, 풍후는 3月 20日에 시작하여 3月 24日에 滿開하였다. 2. 梅實 發育段階에서 종경은 풍후가 3.93cm로 가장 크고 백가하, 남고, 화향실, 順이었으며, 횡경은 풍후, 백가하, 화향실 順이었다. 3. 果重과 乾物重은 풍후, 백가하, 남고, 화향실 順이었으며, 풍후, 백가의 後期 發育이 旺盛하였다. 4. 果肉率은 풍후가 88.9%로 가장 높고 백가하, 남고 順로 높았으며, 화향실이 82.6%로 가장 낮았다. The investigation on bloossom time and developmental stage of Japanese apricot is carried out in San Chung district with 4 cultivals. The results of this investigation were summarized as follows; 1. The bloossom time is no March the 13th and the ful bloom is the 19th with Sirokaga. It is March the 18th and the 23th with Nankoro and Hanakami. Also, It is March the 20th and the 24th with Bungo. 2. The fruit hights of Bungo, Sirokaga, Nankoro, Hanakami are high in order and the fruit hight of Bungo, is 3.93cm. Also, the fruit width is similar to the fruit hight. 3. The fruit weight and the weight of dried fruit are similar and they are heavy in order of Bungo, Sirokaga, Nankoro and the late stage of development of Bungo and Sirokaga are vigorous. 4. The flesh ratio of Bungo is 0.889 and Sirokaga, Nangoro and less than Bungo and Hanakami is least.

十二經脈의 經脈名에 관한 考察

구성태,조명수,황재호,변기원,김경식,손인철 한국전통의학연구소 2002 한국전통의학지 Vol.12 No.1

In the present study, we aimed. to consider the name of twelve main Meridian in order to understand the concept of the Meridian system and to applicate acupuncture theory in the clinical field properly and fundamentally. We referred to several literatures on the matter and we found out that the name of present twelve Meridian was not settled until the period of Yellow Emperor's Classic. In the time of Yellow Emperor's Classic, the two theory of Internal Organ and Meridian system were combined and added new theory of 'WoonGi'. The general rule of combination is that the component of name of Meridian consist of 'Hand' or 'Foot', 'three Eum and Yang' and internal organ. The internal organ coupled with the root ki or middle ki of 'three Eum and Yang' and the 'Hand' or 'Foot' depend on the location of internal organ that belongs to meridian. The name of Twelve Meridian is a kind of system formed to analyze the two concepts organically and dynamically. One is material internal organ and the other is immaterial meridian system.

접촉즉흥(Contact Improvisation) 교육적가치와 순환구조에 관한 연구

최상철 韓國舞踊敎育學會 2008 韓國舞踊敎育學會誌 Vol.19 No.2

The pace of changes in all disciplines is accelerated to respond and adapt to radical social changes in the 21st century. Dance education is no exception to those changes. Dance education has been treated as a professional education that selective few receive as non-major or that special groups to be professional dancers can get. There have been significant changes in dance art during last decade: increased interactivity due to emergence of new media, pursuit of interactivity through leveraging digitalized multimedia in dance discipline, blurring and collapse of disciplinary boundaries due to disintegration of genre striving new communication, de-authoritarianism and inducing audience participation by narrowing the distance between audience and dancers, narrowing the distance between audience and dancers by utilizing every space as stages and so on. Under the logic of deconstruction and reconstruction, those changes in dance arts are rapidly flowing to somewhere else. Today, it does not make any sense to differentiate pure arts from popular arts. Arts and everyday life coexist today. In this context, dance art seems to be making a huge progress. In the 21st century, cultural competitiveness has emerged as a significant agenda and it is required that artists and creators in art fields have innovative mind based on imagination and creativity. The purpose of this study is divided in to two category; First, identifying implications and educational values of contact improvisation. Second, formulating a model of recursive structure of contact improvisation based on the author7 s teaching experience in the educational field.

Halliwick Method 중재가 자폐성행동장애아의 수영지도에 미치는 효과

이성철 창원대학교 체육과학연구소 2003 경남 체육연구 Vol.8 No.2

본 연구는 Halliwick Method 중재가 자폐성행동장애아의 수영지도에 미치는 영향을 알아본 것이다. 연구에 참여한 대상자는 9세에서 15세까지의 자폐성행동장애아 14명(남7,여7)으로 구성하였다. 사전중재단계는 개개인을 위하여 2가지 자료 수집을 포함하였다. 각 수영프로그램은 개개인에게 24주 동안 지속되었고, 그 빈도는 1주에 2회 시간은 40분이었다. 그 첫 번째 수영프로그램은 Halliwick Method의 10가지 내용의 부분 활동들이 포함되었으며, 그 수영프로그램은 Halliwick Method의 각 학습에 있어서도 똑 같이 개개 학생들이 실행하였고, 보다 더 나은 성취를 위해 학생들에게 모든 수영학습 속에 행동처리기법을 이용한 명백한 강화를 이용하였다. 연구 결과 Halliwick Method가 자폐성행동장애아들의 수영지도를 위해 개별화 교육 접근법과 교수법 자체의 구성 요소에서의 차별화된 과제분석을 사용함으로써 훨씬 향상되고 발전할 수 있다는 것을 보여주었으며, 아울러 현장교육에서의 수영지도에 있어서 유의해야 할 점은 다음과 같다. 첫째, Halliwick Method가 자폐성행동장애아를 위한 체육교육에 보다 큰 기여를 했다. 하지만 수영치료교육을 자발적으로 운영하는 Halliwick Method 지지 교사들은 구체적인 신체적 지식 없이 행하는 맹목적 교사가 되지 않도록 철저히 분석한 후 적용해야 함을 잊지 말아야한다. 둘째, Halliwick Method가 실행되는 현장에 있는 대부분의 지도자들은 전문적인 특수체육교사가 아니기 때문에 자폐성행동장애아들을 위한 체육교육이 Halliwick Method의 순기능 속에서 담당할 수 있는 수영프로그램을 가르치는 방법과 구성을 위한 교육자로서의 책임에 대한 역할에 대한 재정의가 필요하다.

결절성 및 괴상성 간세포암에서 역동적 전산화단층촬영 소견에 따른 경동맥화학색전술결과의 예측

이성문,김홍,지성우,우성구,이정형,서수지,손철호 啓明大學校 醫科大學 1997 계명의대학술지 Vol.16 No.2

Purpose: To evaluate retrospectively whether it is possible to predict the transarterial chemoembolization(TACE) result with the pre-TACE dynamic CT findings. Materials and Methods: The dynamic CT findings of 33 patients with 35 nodular and 8 massive hepatocellular carcinoma(HCCs) who was taken follow up CT after TACE, were reviewed retrospectively. After excluding the diffuse or infiltrative HCCs, the mass was classified into two groups of nodular and massive types. The size, location, degree of enhancement, pseudocapsule, portal vein(PV) thrombosis and arterioportal(AP) shunt were evaluated on the dynamic CT scans. The vascularity, multiple or parasitic blood supply, AP shunt and the possibility of superselection were considered on the angiography. After TACE, the pattern of lipiodol uptake and residual enhancing nodules were evaluated on the follow-up CT scans. Results: The good TACE results could be obtained in 18 of 35 nodular HCCs with dynamic CT findings of small size(mean=2.94cm), peripheral location, hyper-or iso-enhancement, and absence fo PV thrombosis, with angiographic finding of possible superselection, but the pseudocapsule did not give important effect on the result. Most of the massive HCCs had poor TACE results. Conclusion: The prediction of the TACE results of nodular and massive HCCs was possible with dynamic CT findings. If the good prognostic factors were not observed on the pre-TACE dynamic CT, the multiple TACE and/or combination therapy with percutaneous ethanol injection(PEI), surgical resection or others should be considered for the effective control of the HCCs.

골반내에 발생한 Proximal-type 유상피성 육종 1예

길준철,이상수,전병화,김성훈,손우석,목정은,박양순,강길현 대한부인종양 콜포스코피학회 2003 Journal of Gynecologic Oncology Vol.14 No.4

유상피성 육종은 매우 드문 악성 연조직 육종으로, 전형적인 경우들은 주로 젊은 남성의 수부, 전완부와 같은 신체의 원위부에 피하 혹은 심재성 피부 종괴로 발생하며, 조직학적 소견상 적은 비정형성을 나타내는 유상피성 세포와 방추형 세포의 증식에 의한 다발성 결절 형태의 배열을 보인다. 최근에 전형적인 유상피성 육종과 조직학적 유사성을 가지나 더 공격적인 형태인 proximal-type 유상피성 육종이 보고되었으며, proximal-type은 전형적인 유상피성 육종에 비하여 현저한 유상피성 세포의 발현과 매우 심한 비정형성을 나타내며, 세포가 매우 크고, 소포성 핵과 뚜렷한 핵소체를 보이며, 자주 rhabdoid 세포의 양상을 띈다. 임상적으로는 전형적인 형태에 비하여 호발 연령이 조금 늦고, 주로 체간부에, 특히 골반, 회음부, 생식기 등과 같은 심부에 발생하고, 더욱 공격적인 양상을 나타낸다. 저자들은 13세 소녀에서 원발부위를 알 수 없는, 골반내에 발생한 proximal-type 유상피성 육종 1예를 경험하여, 문헌 고찰과 함께 보고하는 바이다. Epithelioid sarcoma is a rare malignant soft-tissue sarcoma with an unknown histiogenesis, typically presenting as a subcutaneous or deep dermal mass lesion in the distal portions of the extremities of young adults. Recently, a more aggressive, so-called 'proximal-type' epithelioid sarcoma has been reported. In contrast to conventional epithelioid sarcoma, the proximal type is characterized by a predominantly large cell epithelioid cytomorphology, marked cytologic atypia, and frequent occurrence of rhabdoid features in most patients. Proximal-type epithelioid sarcoma has a predilection for appearing in the genitalia, especially the vulva, penis, pelvis and buttocks. Also this lesion appears to be somewhat more aggressive or at least metastasizes earlier than the conventional epithelioid sarcoma. We report a 13-year-old girl who presented with a buge mass filling the pelvic cavity which was painful, hard and fixed on palpation, and was radiologically diagnosed as a malignant germ cell tumors on the CT scan. The mass was surgically excised and pathologically proved to be an proximal-type epithelioid sarcoma of unknown origin.