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제조업 근로자들의 혈청 Perfluorooctanoic Acid (PFOA) 농도와 생활습관 및 직업적 관련요인
장상환,이채관,김대환,김권복,안진홍,김휘동,이창희,김정호,이종태 大韓産業醫學會 2008 대한직업환경의학회지 Vol.20 No.3
목적: PFOA에 노출이 가능한 제조업 근로자들을 대상으로 혈청 PFOA농도를 조사하고 생활습관, 직업적 요인, 간기능 및 혈청 지질과의 관련성을 연구하고자 하였다. 방법: 2007년 8월부터 12월까지 부산지역 1개 대학병원 산업의학과에서 건강진단을 받은 PFOA노출 가능성이 있는 제조업 사업장 근로자 남자 203명과 여자112명의 총315명을 대상으로 하였다. 생활습관 및 직업적 요인을 설문조사 하였고, 혈청 PFOA 농도를 LC-MS/MS로 분석하였으며, 간기능 및 혈청 지질 검사를 실시하였다. 결과: 혈청 PFOA 농도의 평균은 전체가 8.0 ng/mL이었으며, 남자가 9.0 ng/mL, 여자가 6.3 ng/mL로 남자가 여자보다 통계적으로 유의하게 높았다(p<0.001). 다중회귀분석을 시행한 결과 성, 연령, 체질량지수, 총 콜레스테롤 등이 유의하게 나타났으며, 성별로는 남성에서, 연령이 많을 수록, 총 콜레스테롤이 높을 수록, 체질량지수가 낮을 수록 혈청 PFOA의 농도가 통계적으로 유의하게 높았다. 로지스틱 회귀분석을 실시하여 성과 연령을 보정한 교차비를 산출한 결과, 섬유제품 염색, 정리 및 마무리 가공업(OR 6.16)이 통계적으로 유의하게 높았고, 주형 및 금형 제조업(OR 4.84), 선박 구성부분품 제조업 (OR 3.87), 플라스틱 합성피혁 제조업 (OR 10.05) 등이 상대적으로 높았다. 결론: 제조업 근로자들의 혈청 PFOA 농도는 성, 연령 및 총 콜레스테를 등과 관련성이 있었고, 업종별로는 섬유제품 염색, 정리 및 마무리 가공업에서 높은 것으로 조사되었다. 이러한 결과는 PFOA의 인체 위해성을 조사하기 위한 기초자료로 활용가치가 있을 것이다. Objectives: The objective of this study was to determine serum perfluorooctanoic acid (PFOA) concentrations and to investigate the relationship of lifestyle, health status and work-related factors among workers at manufacturing companies with possible occupational exposure to PFOA. Methods: The study subjects were 315 workers (male 203, female 112) of manufacturing companies with possible exposure to PFOA from August to December, 2007. A questionnaire was administered to investigate lifestyle and work-related factors. Serum PFOA concentrations were analyzed by LC-MS/MS, and liver function and total cholesterol were also tested. Results: Serum PFOA concentrations ranged from 1.0 to 40.9 ng/mL (mean 8.0 ng/mL). Serum PFOA concentrations increased with age. Male workers had higher PFOA concentration than female workers (male 9.0 ng/mL; female 6.3 ng/mL). According to stepwise multiple regression analysis, factors significantly associated with PFOA concentration were male, being older, higher total cholesterol, and lower body mass index. Adjusted for age and gender by logistic regression, dyeing and finishing textiles had significantly higher odds ratio (OR) of 6.16, and moulding patterns, moulds and industrial patterns (OR=4.84), sections for ships (OR=3.87), and plastics synthetic leather (OR=1O.05) had marginally significantly high odds ratios. Conclusions: This study demonstrated the factors affecting serum PFOA concentration of workers at manufacturing companies. Further study is needed to ensure the effect of occupational exposure on serum PFOA concentration.
등속성 운동 시 근전도 주파수 분석에서 얻은 피로지수의 특성
권오윤,이충휘,조상현,이영희,원종임,박정미 한국전문물리치료학회 2001 한국전문물리치료학회지 Vol.8 No.3
In rehabilitation programs involving muscle re-education and endurance exercise, it is necessary to confirm when fatigue occurs. It is also necessary to quantify fatigue, to confirm whether the muscle has been exercised sufficiently. In general, as fatigue occurs, the force-generating ability of the muscle is reduced. If the median frequency (MDF) obtained from electromyograrn (EMG) power spectrum is correlated highly with work, then the timing and degree of fatigue may be confirmed. This study examined the relationship between work and MDF obtained from the EMG power spectrum during repetitive isokinetic exercise. Surface EMG signals were collected from biceps brachii and vastus lateralis of 52 normal subjects (26 males, 26 females) at 120˚/sec and 60˚/sec while performing an isokinetic exercise. The exercise was finished at 25% of peak work. MDF data was obtained using a moving fast Fourier transformation (FPT), and random noise was removed using the inverse FPT, then a new MDF data was obtained from the main signal. There was a high correlation between work and MDF during repetitive isokinetic exercise in the biceps brachii and vastus lateralis of males and the biceps Brachii of temales (r=.50∼.77). However, there was a low correlation between work and MDF in the vastus lateralis of females (r=.06∼.19).
발달지연 아동 및 뇌성마비 아동의 평가실태와 물리치료사들의 평가에 대한 인식도 조사
박혜정,이충휘,조상현,권혁철 한국전문물리치료학회 2000 한국전문물리치료학회지 Vol.7 No.1
The purpose of this study were to research the current stat of evaluation of children with delayed development and cerebral palsy and determine pediatric physical therapists's knowledge of assessment tools and their use. The subjects were 130 pediatric physical therapists (general hospitals, university-related hospitals, rehabilitation centers, etc.). Data was obtained form August 24, 1999 to October 18, 1999 by means of a survey questionnaire. The results were as follows: 1. the current state of pediatric physical therapist evaluation of children with delayed development and cerebral palsy. 1) Tools used to assess functional areas of children with cerebral palsy were: subjective description format-128 (47.1%); the GMFM-58 (21.3%); facility-generated tool-51 (18.8%); and DDST-15 (5.5%) 2) Tools used to assess developmentally delayed children were: subjective description format-121 (50.6%); the GMFM-43 (18.0%); facility-generated tool-41 (17.2%); and DDST-14 (5.9%). 3) After their college or university study, therapists who had attended lectures on evaluation were 113 (86.9%); 13 (10.0%) therapists had not attended any lectures on evaluation. 2. Test scores of physical therapists' professional knowledge of evaluation procedures: high (more than 36 points)-74 (56.9%); moderate (18~35 points)-39 (30.0%); and low (below 17 points)-none. 1) For therapists treating cerebral palsied children, 73 (65.2%) were in the high range, 39 (34.8%) were in the moderate rage and none were in the low range. 2) For therapists treating children with delayed development, 71 (65.7%) were in the high range, 37 (34.3%) were in the moderate range and none were in low range. Although the general degree of professional knowledge of evaluation was quite high, there was a lack of variety in the assessment tools used with a large number of therapists depending on subjective description. Possible reasons for the low rate of objective assessment tool use: 1) Poor clinical environment: Too many clients and limited treatment time. 2) Lack of any medical insurance fee category for specific assessment tools. 3) Lack of continuing education opportunities in pediatric evaluation skills during or after either college-based(3 year) or university-based(4 year) education programs. Based on the study results, provision of more extended educational opportunities would promote the use of a greater variety of objective assessment tools by pediatric physical therapists.
Pharmaceutical Evaluation of Genistein-loaded Pluronic Micelles for Oral Delivery
Kwon, Suk-Hyung,Kim, Sun-Young,Ha, Kyoung-Wook,Kang, Myung-Joo,Huh, Jin-Seo,Im, Tae-Jong,Kim, Yong-Min,Park, Young-Mi,Kang, Kyoung-Hoon,Lee, Sang-Kil,Chang, Jung-Yun,Choi, Young-Wook,Lee, Jae-Hwi 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.9
The purpose of the present study was to determine whether Pluronic F127 polymeric micelles could improve the oral bioavailability of a poor water-soluble drug, such as genistein. Genistein is a phytoestrogen that has estrogenic activity. F127 triblock copolymer consists of $PEO_{100}-PPO_{65}-PEO_{100}$. Genistein was incorporated in the Pluronic F127 polymeric micelles by a solid dispersion method. The genistein release of genistein-loaded polymeric micelles was studied in vitro (in pH 1.2 and pH 6.8). And the oral bioavailabilities of genistein powder and genisteinloaded micelles were estimated at a dose of 4.0 mg/kg as genistein in rats. Drug loading amount and drug loading efficiency were 11.18% and 97.41%, respectively. The average size of the genistein-loaded polymeric micelles was 27.76 nm. And genistein release of the genistein-loaded polymeric micelles in vitro was 58% (pH 1.2) and 82% (pH 6.8). The bioavailability of genistein-loaded polymeric micelles was better than genistein powder. Consequently, Pluronic F127 polymeric micelles are an effective delivery system for the oral administration of genistein.