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Sang-Wook Park(박상욱),Jong-Bae Kim(김종배) 대한의생명과학회 1999 Biomedical Science Letters Vol.5 No.1
갑상선 질환의 진단에 필요한 갑상선 호르몬의 측정시 thyroxine (T₄) 농도 측정방법이 가장 흔히 이용되고 있다. 과거에 많이 활용되어 온 방사면역측정법 (RIA)이 폐기물 처리 및 관리인원 등의 인적, 물적인 문제가 크게 대두되고 있는 점을 감안하면 효소결합면역측정법의 확립은 큰 의미가 있다고 하겠다. 본 연구에서는 thyroxine (T₄)에 대한 단클론 항체 (monoclonal antibody)를 이용하여 T₄에 horseradish-peroxidase를 화학적으로 결합시킨 microtiter plate에 HRP-conjugate T₄와 혈청 내의 T₄간의 서로 경쟁적인 반응을 이용한 표준곡선을 얻었다. 그리고 이렇게 확립한 기법을 임상적인 갑상선 질환 환자의 혈청을 기존의 chemiluminescence 방법을 이용하여 얻은 결과와 비교하여 본 실험에서 확립한 ELISA 검사 수치의 유용성을 검토하였으며 이 방법의 임상이용 가능성을 검토하였다. Thyroxine (3,5,3',5'-L-tetraiodothyronine; T₄) is the most commonly measured thyroid hormone for the diagnosis of various thyroid disorders. Although radioimmunoassay (RIA) is still considered as the reference technique for the measurement of T₄, it is generally regarded that RIA has its primary disadventages in handling the wastes and controling the human and material resources. Therefore, establishment of enzyme-linked immunosorbent assay (ELISA) has of great significance. To verify the usefulness of our enzyme immunoassay, we have obtained the standard dose response curve of T₄ in patient's sera which is inversely proportional to the amount of horseradish peroxidase (HRP) conjugated monoclonal antibody of T₄ bound to the wells. The correlation coefficient (r) between the ELISA and chemiluminescent assay was 0.444 (n=38). Thus we have investigated the establishment of rapid and sensitive competitive ELISA assay method for detection of T₄ in patient's sera.
The role of Egr-1 in IL-17F-induced psoriasin expression in human keratinocytes
( Sang Hoon Jeong ),( Min Gun Yoo ),( Seong Kyu Jeong ),( San Geun Lee ),( Hee Hoo Kim ),( Kyung Goo Lee ),( Sang Min Yi ),( Eun Young Lee ),( Yoon Hee Park ),( Hyun Cheol Bae ),( Sang Wook Son ) 대한피부과학회 2011 초록집 Vol.49 No.20
Sung Ku Kwon,김병환,박종문,김보우,Seong Wook Yoo,Kun Sik Park,Yoon Kyu Bae,Kwang Ho Kwon 한국전자통신연구원 2002 ETRI Journal Vol.24 No.3
This study characterizes an oxide etching process in a magnetically enhanced reactive ion etching (MERIE) reactor with a CHF3/CF4 gas chemistry. We use a statistical 24-1 experimental design plus one center point to characterize the relationships between the process factors and etch responses. The factors that we varied in the design include RF power, pressure, and gas composition, and the modeled etch responses were the etch rate, etch selectivity to TiN, and uniformity. The developed models produced 3D response plots. Etching of SiO2 mainly depends on F density and ion bombardment. SiO2 etch selectivity to TiN sensitively depends on the F density in the plasma and the effects of ion bombardment. The process conditions for a high etch selectivity are a 0.3 to 0.5 CF4 flow ratio and a –600 V to –650 V DC bias voltage according to the process pressure in our experiment. Etching uniformity was improved with an increas e in the CF4 flow ratio in the gas mixture, an increase in the source power, and a higher pressure. Our characterization of via etching in a CHF3/CF4 MERIE using neural networks was successful, economical, and effective. The results provide highly valuable information about etching mechanisms and optimum etching conditions.
Sang Hee Park,Sung Han Shim,Yong Wook Jung,So Hyun Shim,Mi Uk Chin,Ji Eun Park,Sung Mi Bae,Sang Woo Lyu,Dong Hyun Cha 대한의학유전학회 2017 대한의학유전학회지 Vol.14 No.1
Cat eye syndrome (CES) is a very rare chromosomal syndrome characterized by various malformations such as anal atresia, preauricular malformation, coloboma of the iris, and congenial heart and renal defects. This genetic disorder is caused by partial duplication of chromosome 22, mostly as a result of a supernumerary isodicentric marker chromosome idic(22)(q11.2). Various congenital abnormalities and extreme phenotypic variability in CES patients have been reported, which have made prenatal diagnosis of CES difficult. We report the first case diagnosed with CES prenatally by multiplex ligation-dependent probe amplification in a woman who was referred to our hospital, for a fetus presenting with heart anomaly.
Dietary compound ellagic acid alleviates skin wrinkle and inflammation induced by UV-B irradiation
Bae, Ji-Young,Choi, Jung-Suk,Kang, Sang-Wook,Lee, Yong-Jin,Park, Jinseu,Kang, Young-Hee Blackwell Publishing Ltd 2010 Experimental dermatology Vol.19 No.8
<P><I>Please cite this paper as:</I> Dietary compound ellagic acid alleviates skin wrinkle and inflammation induced by UV-B irradiation. Experimental Dermatology 2010; <B>19</B>: e182–e190.</P><P>Abstract: </P><P>Ellagic acid, a polyphenol compound present in berries and pomegranate, has received attention as an agent that may have potential bioactivities preventing chronic diseases. This study examined photoprotective effects of ellagic acid on collagen breakdown and inflammatory responses in UV (ultraviolet)-B irradiated human skin cells and hairless mice. Ellagic acid attenuated the UV-B-induced toxicity of HaCaT keratinocytes and human dermal fibroblasts. Non-toxic ellagic acid markedly prevented collagen degradation by blocking matrix metalloproteinase production in UV-B-exposed fibroblasts. Anti-wrinkle activity of ellagic acid was further investigated in hairless mice exposed to UV-B, in which it attenuated UV-B-triggered skin wrinkle formation and epidermal thickening. Topical application of 10 &mgr;mol/l ellagic acid diminished production of pro-inflammatory cytokines IL-1&bgr; and IL-6, and blocked infiltration of inflammatory macrophages in the integuments of SKH-1 hairless mice exposed to UV-B for 8 weeks. In addition, this compound mitigated inflammatory intracellular cell adhesion molecule-1 expression in UV-B-irradiated keratinocytes and photoaged mouse epidermis. These results demonstrate that ellagic acid prevented collagen destruction and inflammatory responses caused by UV-B. Therefore, dietary and pharmacological interventions with berries rich in ellagic acid may be promising treatment strategies interrupting skin wrinkle and inflammation associated with chronic UV exposure leading to photoageing.</P>