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      • KCI등재

        시베리아내전의 발발과 연해주 한인사회의 동향

        윤상원(Yun Sang-won) 고려사학회 2010 한국사학보 Vol.- No.41

        The aim of this article is to clarify the origin of the Korean armed struggle in Chien tao and Russian Far East in the early 1920s. In conclusion, I believe that the origin of Korean armed struggle is the Russian Revolution in 1917 and ensuing civil war in Siberia. In particular, Japanese forces in Siberia after the Russian Revolution made Koreans in that region to struggle with Soviet Red Army and Russian partisan troops. Japan has sent troops to Siberia in 1918 and supported White army in Russian civil war. For this reason Koreans naturally jumped into the fight against the Japanese and the Whites. And the armed struggle taken place in Siberia soon had an impact on the Korean community in Chientao. Korean patriots in Chien tao also began a battle with the Japanese. From this wide range of armed struggle has unfolded in Chientao and Russian Far East in the early 1920s. But the Koreans partisan movement in Russia also had to be affected to the presence and movements of Koreans in that Region in the previous time. Korean community in Russia also had a class problem. Some of Koreans who early imigrated to the Russian territory and acquired Russian nationality, received land distribution from the Russian government and were incorporated into the ruling class. They were called 'Won-he-in'. In contrast, there were Koreans who were not acquired Russian nationality. As there was no land for them, They had cultivated the land of Russian landlord or Won-ho-in. otherwise, became the daily agricultural workers. They were "Yo-ho-in". And of course, Won-he-in were the side of White army and Red army had the support of Yo-ho-in.

      • KCI등재후보

        Growth Inhibition of Colon Cancer through Inactivation of STAT3 Pathway by IL-10 and IL-1ra Released from Murine Macrophage

        Jin Tae Hong, Dohee Won1, Mi Hee Park, Sun Mi Kown, Miran Jo, Sang-Yoon Nam, Beom Jun Lee, Young Won Yun, Ki-Wan Oh, Sang Bae Han 충북대학교 동물의학연구소 2011 Journal of Biomedical and Translational Research Vol.12 No.4

        The objective of this study was to determine the effect of macrophages on growth of human colon cancer cells. The results showed that co-culture of colon cancer cells with macrophages inhibited the growth of colon cancer cells (HCT116 and SW620) depending on the number of macrophages, RAW 264.7 cells, and activated THP-1 cells accompanied by down regulation of pSTAT3 in cancer cells. We also found that expression and release of cancer cell growth inhibitory cytokines, IL-1 receptor antagonist (IL-1ra) and IL-10, was increased in macrophages. Blocking of the STAT3 pathway with specific inhibitor and siRNA of STAT3 abolished the growth of colon cancer cells and expression of IL-1ra and IL-10. In addition, neutralization of IL-1ra and IL-10 with antibodies resulted in reversal of macrophage-induced inhibition of cancer cell growth. These data showed that IL-1ra and IL-10 released from macrophages inhibit growth of colon cancer cells through inhibition of the STAT3 pathway

      • 자동착유시스템 설치농가의 설치 후 만족도에 관한 실태조사

        기광석,김종형,정영훈,김윤호,박성재,김상범,이왕식,이현준,조원모,백광수,김현섭,권응기,김완영,여준모,Ki, Kwang-Seok,Kim, Jong-Hyeong,Jeong, Young-Hun,Kim, Yun-Ho,Park, Sung-Jai,Kim, Sang-Bum,Lee, Wang-Shik,Lee, Hyun-June,Cho, Won-Mo,Baek, Kwang- 한국축산환경학회 2011 축산시설환경학회지 Vol.17 No.1

        본 시험은 국내에 도입되기 시작한 AMS에 대하여 설치 동기, 설치 후 우유생산량과우유품질, AMS 설치계기 및 설치 후 만족도, AMS 운영상 애로점 및 건의사항 등을 조사 분석하였다. 설치 계기가 무엇인가에 대한 응답비율은 노동력 부족 44%, 체험목장으로 전환 25%, 소들의 고능력화에 대응 19% 순이었으며 기타 6%였다. AMS 설치농가의 사육경력은 평균 24.9년, 평균 연령은 53.2세로 나타났으며 가족노동력만으로 경영하는 목장이 조사농가의 38%, 고용+자가노동력 형태의 목장이 63%로 나타났다. 목장의 산유능력은 두당 평균 유량은 1일 $30.9{\ell}$, 평균 유지율 3.9%, 세균수는 9.1천개/$m{\ell}$ 수준이었다. 후계자 육성에 대한 질문에 매우 그렇다라고 응답한 비율은 68%였으며, 보통 18%, 아니다와 매우 아니다라고 응답한 비율은 18%로 나타났다. 시스템 운영현황 및 애로사항을 파악하기 위하여 AMS의 프로그램 주운영자에 대한 질문에 본인 44%, 부인 6%, 자녀 또는 후계자사람이 44%, 기타 6%나 되었다. AMS 운영상 가장 어려운 점에 대한 조사결과, 기기 작동 및 복잡한 프로그램 운영이 각각 31%로 가장 많았다. 그 외 기계 에러 및 고장에 대한 애로사항이 25%이였다. 도태원인에 대하여 유방염 28%, 번식장애 20%, 발굽질환 19%, AMS에 부적합한 유두 배열 12%, 분만 후 대사성질병 7%, 노산 등 기타 14%였다. 시스템 설치 후 유지보수 계약 체결유무 및 비용에 대하여 유지보수 계약 56%, 유지 보수 계약 미체결 44%이었다. 유지보수 계약 평균 계약비용은 연간 658만원 정도였다. 시스템 설치 후 항목별 만족도에 대하여 5점 만점에 3.9점이었으며, 노동력 절감 3.7점, 업체의 A/S 3.6점, 산유량 증가 3.2점, 원유의 체세포 수 저감 2.8점이었다. 시스템 설치 시 고려사항 및 건의사항에 대하여 고가의 장비를 효율적으로 사용하기 위하여 젖소의 유방과 유두 배열이 적합하도록 젖소를 선발하는 것, 시스템을 운용할 수 있는 능력, 적합한 환경, 재정적 능력과 부지 확보, 지속적인 관찰 등이 권장되어야 할 것으로 나타났으며, 설치 업체에 대해서는 컨설팅이 체계화될 필요가 가장 높게 나타났으며 이어서 보다 저렴한 설치와 서비스의 체계화를 요구하는 결과를 보였다. The present survey was conducted to provide basic information on automatic milking system (AMS) in relation to purchase motive, milk yield and quality, customer satisfaction, difficulties of operation and customer suggestions, etc. Purchase motives of AMS were insufficient labor (44%), planning of dairy experience farm (25%), better performance of high yield cows (19%) and others (6%), respectively. Average cow performance after using AMS was 30.9l/d for milk yield, 3.9% for milk fat, 9,100/ml for bacterial counts. Sixty-eight percentage of respondents were very positive in response to AMS use for their successors but 18% were negative. The AMS operators were owner (44%), successor (44%), wife (6%) and company worker (6%), respectively. The most difficulty (31%) in using AMS was operating the system and complicated program manual. The rate of response to system error and breakdown was 25%. The reasons for culling cow after using AMS were mastitis (28%), reproduction failure (19%), incorrect teat placement (12%), metabolic disease (7%) and others (14%), respectively. Fifty-six percentages of the respondents made AMS maintenance contract and 44% did not. Average annual cost of the maintenance contract was 6,580,000 won. Average score for AMS satisfaction measurement (1 to 5 range) was 3.2 with decrease of labor cost 3.7, company A/S 3.6, increase of milk yield 3.2 and decrease of somatic cell count 2.8, respectively. Suggestions for the higher efficiency in using AMS were selecting cows with correct udder shape and teat placement, proper environment, capital and land, and attitude for continuous observation. Systematic consulting was highly required for AMS companies followed by low cost for AMS setup and systematization of A/S.

      • KCI등재

        오공약침의 안전성에 대한 임상적 연구

        소기숙,최회강,박소영,고강훈,김성남,이옥자,윤민영,문형철,김성철,이정훈,나원경,So, Ki-suk,Choi, Hoi-kang,Park, So-young,Koh, Kang-hun,Kim, Sung-nam,Lee, Ok-ja,Yun, Min-young,Mun, Hyung-chul,Kim, Sung-chul,Lee, Jung-hun,Na, Won-kyung 대한침구의학회 2004 대한침구의학회지 Vol.21 No.1

        Objective: Recently scolopendrid aquacupuncture has been a good effect on pain control but it has not been known about clinical safety. So, In order to prove the clinical safety of scolopendrid aquacupuncture, We have observed the physical reac-tion and clinical pathology test after scolopendrid aquacupuncture treatment. Methods: We analyzed physical reaction and clinical pathology test before and after Scolopendrid aquacupuncture treatment of 30 patients suffering from pain, who admitted department of Acupunture and Moxibustion, College of Oriental Medicine, Won-Kwang University Kwangju hospital. Results & Conclusions: The results were summarized as follows. 1) The distribution of sex was 14 males and 16 females, and the average of patients age was 46.2 years. 2) The distribution of symptom was lumbago, lumbago with radiating pain, nuchal pain and knee joint pain. 3) In the 30 patients treated with Scolopendrid aquacupuncture, hematologic test did not show remarkable change. 4) In the 30 patients treated with Scolopendrid aquacupuncture, Liver function test(AST, ALT, ALP) showed a slight decrease on the contrary, and abnormal rate showed a decrease of 1.0%(from 3.3% to 2.3%) compared with previous study. 5) In the 30 patients treated with Scolopendrid aquacupuncture, Renal function test(BUN, Cr) and abnormal rate(from 2.5% to 2.0%) showed a slight decrease on the contrary. 6) In the 30 patients treated with Scolopendrid aquacupuncture. Electrolyte were normal range before & after treatment. 7) In the results of the Urine analysis of 30 patients, Leukocyte, Protein. Glucose, Keton, Bilirubin, U-bilinogen were not detected before and after Scolopendrid aquacupuncture treatment, and the rest almost made no difference. 8) In the Physical reactions, all of the patients complained of pain of body partially, only one patient showed reddish and itch, but symptoms like those were entirely disappeared within 24 hours and whole body pain, swelling, headache, dizziness, fatigue and nausea was not observed.

      • Pneumomediastinum, Subcutaneous Emphysema and Pneumoretroperitoneum Secondary to Colonoscopic Perforation in the Absence of Pneumoperitoneum

        ( Yun Won Jo ),( Seung Suk Yoo ),( Sung Soo Kim ),( Jeong Mi Lee ),( Hyun Ju Min ),( Chang Yoon Ha ),( Hong Jun Kim ),( Woon Tae Jung ),( Ok Jae Lee ),( Hyun Jin Kim ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1

        Colonoscopic polypectomy is a commonly performed procedure in Korea, subsequently prevents colon cancer. The increase of therapeutic colonoscopy, polypectomy, results in inevitably various complications including bowel perforation that is rare and requires emergent decision of treatment modalities and timely treatment. The bowel perforation is usually diagnosed on the basis of pneumoperitoneum on simple X-ray images. Surgery is the treatment of choice for most cases of colonic perforation. A 58-year-old woman was referred to the gastroenterologist for endoscopic mucosal resection (EMR) of laterally spreading flat adenoma in the sigmoid colon. The EMR was performed with flexible and insulated tip knives. The patient was hospitalized for close observation of post-EMR complications. On the day of the polypectomy, simple X-ray images were taken to rule out colonic perforation, which revealed a large amount of intracolonic gas, but no free air in the subphrenic area. The next day of the procedure, subcutaneous emphysema was observed by the clinicians. Then abdomen computed tomography (CT) scan was performed, which showed diffuse bilateral retroperitoneal air extending to the mediastinum without intraperitoneal gas. The patient was discharged from the hospital after medical treatment and supportive care. We herein report a case of colonoscopic perforation in which pneumomediastinum, subcutaneous emphysema and peumoretroperitoneum occurred in the absence of pneumoperitoneum. The perforation was successfully treated with medical treatment and endoscopic clipping. Colonoscopists should not exclude colonic perforation even though free air on simple X-ray images is not visible.

      • A case of colovesical fistula complicated by sigmoid diverticulitis

        ( Yun Hyuk Yim ),( Hyo Keun Lee ),( June Sung Lee ),( Kyung Ah Kim ),( Nam Hoon Kim ),( Tae Jun Song ),( Won Ki Bae ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1

        Colovesical fistula is a rare complication of inflammatory or neoplastic disease, and traumatic or iatrogenic injuries. Among them, sigmoid diverticulitis is the most frequent cause of colovesical fistula. There are few reported cases of the colovesical fistula in Korean literature, that is probably because the left colonic diverticulum is not common in Korea. We present here a case of patient with colovesical fistula complicated by sigmoid diverticulitis. A 66-year-old male patient was transferred to our hospital due to complaining of abdominal pain and mucoid stool. An abdominal and pelvic CT scan revealed diverticulitis and peridiverticular abscess in sigmoid colon. The patient was admitted and treated with intravenous antibiotic agents for four weeks, followed by oral antibiotic therapy. Six weeks after being discharged from the hospital, he was admitted again with complaints of pneumaturia, fecaluria, and dysuria. Follow up CT scan demonstrated fistula between sigmoid colon and bladder dome portion. Under the diagnosis of colovesical fistula due to diverticulitis of sigmoid colon, low anterior resection and partial cystectomy with cystostomy were performed.

      • SCIESCOPUSKCI등재

        Urinary MicroRNAs of Prostate Cancer: Virus-Encoded hsv1-miRH18 and hsv2-miR-H9-5p Could Be Valuable Diagnostic Markers

        Yun, Seok Joong,Jeong, Pildu,Kang, Ho Won,Kim, Ye-Hwan,Kim, Eun-Ah,Yan, Chunri,Choi, Young-Ki,Kim, Dongho,Kim, Jung Min,Kim, Seon-Kyu,Kim, Seon-Young,Kim, Sang Tae,Kim, Won Tae,Lee, Ok-Jun,Koh, Gou-Yo Korean Continence Society 2015 International Neurourology Journal Vol.19 No.2

        <P><B>Purpose:</B></P><P>MicroRNAs (miRNAs) in biological fluids are potential biomarkers for the diagnosis and assessment of urological diseases such as benign prostatic hyperplasia (BPH) and prostate cancer (PCa). The aim of the study was to identify and validate urinary cell-free miRNAs that can segregate patients with PCa from those with BPH. </P><P><B>Methods:</B></P><P>In total, 1,052 urine, 150 serum, and 150 prostate tissue samples from patients with PCa or BPH were used in the study. A urine-based miRNA microarray analysis suggested the presence of differentially expressed urinary miRNAs in patients with PCa, and these were further validated in three independent PCa cohorts, using a quantitative reverse transcriptionpolymerase chain reaction analysis. </P><P><B>Results:</B></P><P>The expression levels of hsa-miR-615-3p, hsv1-miR-H18, hsv2-miR-H9-5p, and hsa-miR-4316 were significantly higher in urine samples of patients with PCa than in those of BPH controls. In particular, herpes simplex virus (hsv)-derived hsv1-miR-H18 and hsv2-miR-H9-5p showed better diagnostic performance than did the serum prostate-specific antigen (PSA) test for patients in the PSA gray zone. Furthermore, a combination of urinary hsv2-miR-H9-5p with serum PSA showed high sensitivity and specificity, providing a potential clinical benefit by reducing unnecessary biopsies. </P><P><B>Conclusions:</B></P><P>Our findings showed that hsv-encoded hsv1-miR-H18 and hsv2-miR-H9-5p are significantly associated with PCa and can facilitate early diagnosis of PCa for patients within the serum PSA gray zone.</P>

      • Expression, purification, and characterization of a dentin phosphoprotein produced by Escherichia coli, and its odontoblastic differentiation effects on human dental pulp cells.

        Yun, Ye-Rang,Jeon, Eunyi,Lee, Sujin,Kang, Wonmo,Kim, Sang-Gi,Kim, Hae-Won,Suh, Chang Kook,Jang, Jun-Hyeog Kluwer Academic/Plenum 2012 The Protein Journal Vol.31 No.6

        <P>To investigate the functions of recombinant human dentin phosphoprotein (rhDPP), we examined cell adhesion, viability and the odontoblastic differentiation activity of human dental pulp cells (hDPCs). Firstly, rhDPP was constructed using pBAD-HisA plasmid in Escherichia coli. Cell adhesion and viability of hDPCs by rhDPP was examined using a crystal violet assay and a MTT assay, ALP, mineralization activity and odontoblastic differentiation-related mRNA levels of hDPCs were measured to elucidate the odontoblastic differentiation effect of rhDPP on hDPCs. Initially, rhDPP significantly and dose-dependently increased hDPCs adhesion versus the untreated control (p < 0.05). Cell viability was also significantly increased by rhDPP at 5 days (p < 0.001). Furthermore, the odontoblastic differentiation effect of rhDPP was verified by measuring ALP activity, mineralization activity and the mRNA levels of odontoblastic differentiation markers. Taken together, rhDPP is expected to play an important role on hDPCs, thereby suggesting its potential use for tooth repair and regeneration.</P>

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