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Sang Min Yoon,So Yeon Kim,Young-Suk Lim,Kang Mo Kim,Ju Hyun Shim,Danbi Lee,Jihyun An,Jinhong Jung,Jong Hoon Kim,Han Chu Lee 대한간학회 2020 Clinical and Molecular Hepatology(대한간학회지) Vol.26 No.4
Background/Aims: Stereotactic body radiation therapy (SBRT) is used as an alternative ablative treatment in patients with hepatocellular carcinoma (HCC) not suitable for curative treatments. The purpose of this prospective study was to evaluate the long-term efficacy of SBRT for small (≤5 cm) HCCs. Methods: A phase II, single-arm clinical trial on SBRT for small HCCs was conducted at an academic tertiary care center. The planned SBRT dose was 45 Gy with a fraction size of 15-Gy over 3 consecutive days. The primary endpoint was 2-year local control rate. Radiologic responses were assessed according to the Response Evaluation Criteria in Solid Tumors (RECIST, version 1.1) and the modified RECIST criteria. Results: Between 2013 and 2016, 50 patients (53 lesions) were enrolled, with a median follow-up period of 47.8 months (range, 2.9–70.6). Patients’ age ranged from 41 to 74 years, and 80% were male. Median tumor size was 1.3 cm (range, 0.7–3.1). The 2- and 5-year local control rates were 100% and 97.1%, respectively. The 5-year overall survival rate was 77.6%. Six months after SBRT, radiologic responses were evident in 44 lesions (83%) according to the RECIST criteria and 49 (92.4%) according to the modified RECIST criteria. None of the patients showed grade ≥3 adverse events. Conclusions: SBRT showed excellent results as an ablative treatment for patients with small HCCs while showing minimal toxicities. SBRT can be a good alternative for both curative and salvage intents in patients with HCCs that are unsuitable for curative treatments.
Ultraviolet B (UVB) Induces Down-regulation of Parkin Gene Expression
Sung Hoon Kim,Yeo Wool Kang,Juyeon Lee,Hyun-Kyung Kim,Byung Chul Jung,Bohee Kim,Dai Joong Kim,Yoon Suk Kim 대한의생명과학회 2016 Biomedical Science Letters Vol.22 No.1
Ultraviolet (UV) irradiation induces cellular damage. A variety of cellular responses for repairing cellular damage including DNA damage occur after UV irradiation. During the repair processes, expression and activation of various molecules are regulated depending on the types of cellular damage. Parkin is an E3 ligase and act as a tumor suppressor. Recently, it has been reported that Parkin is involved in the DNA repair process. In the current study, we investigated whether UVB irradiation influences expression of Parkin. Parkin expression transiently decreased after UVB irradiation both at the mRNA and protein levels, but returned to normal levels thereafter. Taken together with cell viability data, Parkin expression is down-regulated during UVB-induced suppression of cell growth and is increased again in accordance with recovery of UVB-induced cell growth inhibition. However, Parkin overexpression or knockdown did not influence UVB-induced cell growth inhibition and recovery. We propose that Parkin could be a useful molecular marker for evaluating conditions of cells after UVB irradiation.
Oral manifestation and root canal therapy of the patient with mucopolysaccharidosis
Yoon, Ji-Hye,Lee, Hyo-Il,Jang, Ji-Hyun,Choi, Sung-Hyeon,Chang, Hoon-Sang,Hwang, Yun-Chan,Hwang, In-Nam,Lee, Bin-Na,Oh, Won-Mann The Korean Academy of Conservative Dentistry 2019 Restorative Dentistry & Endodontics Vol.44 No.2
Mucopolysaccharidosis (MPS) is an inherited metabolic disorder caused by a deficiency in enzymes that participate in the degradation of glycosaminoglycans (GAGs) such as heparin sulfate and dermatan sulfate. Left untreated, patients show progressive mental and physical deterioration due to deposition of GAGs in organs. Death often occurs due to cardiac or respiratory failure before patients reach their early twenties. MPS has several oral and dental manifestations. An enlarged head, short neck, and open mouth associated with a large tongue are major characteristics of MPS patients. Dental complications can be severe, including unerupted dentition, dentigerous cyst-like follicles, malocclusions, condylar defects, and gingival hyperplasia. A 21-year-old female patient with MPS was described in this article, with special emphasis on oral manifestations and dental treatment.
초산부, 경산부 초유 중 PCDDs, PCDFs, dioxin-like PCBs의 축적수준 및 상관성 평가
Sung-Ug We(위성욱),Ki-Ho Kim(김기호),Yu-Jin Cho(조유진),Bong-Hui Cho(조봉희),Sang-Ah Park(박상아),In-Cheon Baek(백인천),Seong-Hoon Kang(강성훈),Cho-Hee Yoon(윤조희),Byung-Yoon Min(민병윤) 한국생명과학회 2010 생명과학회지 Vol.20 No.7
PCDDs, PCDFs, dl-PCBs는 많은 역학 연구에서 독성오염물질이라고 간주되고 있는 생물축적 화학물질이다. 본 연구는 산모 초유 중에 이들 오염물질을 조사 분석하여 산모특성에 따른 축적성 및 상관성을 평가한 것으로, 실험대상 산모는 2007년에 평균연령 31.5세(표준편차=3.6세)의 건강한 초산부와 경산부이다. PCDDs 7개 이성질체, PCDFs 10개 이성질체, non-ortho PCBs 4개와 mono-ortho PCBs 8개 이성질체가 HRGC/HRMS로 분석되었다. 총 WHO-TEQs 평균값은 9.41 pg TEQ/g lipid로 다른 나라 농도에 비하여 낮은 수준이었다. 백분율의 증가와 함께 총 WHO-TEQs의 주요 기여자는 2,3,4,7,8-PeCDF, 1,2,3,7,8-PeCDD 및 3,3´,4,4´,5-PCB (#126)이며, 총 WHO-TEQs의 60% 이상으로 나타났다. PCDFs 농도와 총 WHO-TEQs는 출산경험에 대해서는 음의 상관관계를 나타내었으며(p<0.05) 산모의 연령은 총 WHO-TEQs에 대해서 양의 상관관계를 나타내었다(p<0.01). 그러나, 임신 전 체질량지수와 어류섭취의 상관관계는 유의성이 없었다. 이들 결과로부터 출산경력과 산모 연령은 모유 내의 PCDD/DFs 및 dl-PCBs의 농도에 영향을 미치는 중요한 인자로 판단된다. Polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and dioxin-like polychlorinated biphenyls (dl-PCBs) are bioaccumulative chemicals that are considered to be toxic contaminants based on several epidemiological studies. These chemicals in colostrum were investigated and estimated for their residual consistencies by maternal characteristics like parity and maternal ages. Test subjects were healthy primipara and multipara mothers with a mean age of 31.5 (S.D=3.6) in 2007. Seven isomers of PCDDs, 10 of PCDFs, 4 of non-orthopolychlorinated biphenyls(non-ortho PCBs) and 8 of mono-orthochlorinated polychlorinated biphenyls (mono-ortho PCBs) were analyzed by HRGC/HRMS. From the analyzed data, the mean level of total WHO-TEQs was 9.41 pg TEQ/g lipid, which is significantly lower than the level found in individuals from other countries. The main contributors to the total WHO-TEQs with increasing percentages were 2,3,4,7,8-PeCDF, 1,2,3,7,8-PeCDD and 3,3',4,4',5-PCB (#126), and they accounted for more than 60% of the total WHO-TEQs. PCDFs concentrations and total WHO-TEQs were negatively associated with parity (p<0.05), and maternal age was positively associated with total WHO-TEQs (p<0.01). However, the associations with body mass index (BMI) and fish intake during pregnancy were not significant. These results were suggested that parity and maternal age are an important factor affecting the concentrations of PCDD/DFs and dl-PCBs in these specimens.
Hoon Seok Yoon,Won Beom Koh,You-Sung Oh,In-Jung Kim 한국응용생명화학회 2009 Applied Biological Chemistry (Appl Biol Chem) Vol.52 No.5
Petalonia binghamiae extracts (PBE) suppressed melanin synthesis in a dose-dependent manner in α-melanocyte stimulating hormone (α-MSH)-treated B16/F10 murine melanoma cells. Specifically, the cell tyrosinase activity and melanin content were inhibited by 72% and 48%, respectively, in response to treatment with 100 µg/mL of PBE. The results of western blot analysis suggest that PBE induced the inhibition of tyrosinase and TRP-1 protein expression through suppression of α- MSH induced p38 and ERK activation.
Yoon, Na Young,Lee, Sang-Hoon,Shim, Kil Bo,Lim, Chi-Won,Lee, Moon-Hee,Cho, Hyun-Ah,Xie, Chengliang The Korean Society of Fisheries and Aquatic Scienc 2013 Fisheries and Aquatic Sciences Vol.16 No.1
To assess the feasibility of phlorotannins from Eisenia bicyclis as cancer chemopreventative agents, we tested whether they induced quinone reductase (QR) in Hepa1c1c7 cells. The ethyl acetate (EtOAc) soluble fraction obtained from E. bicyclis exhibited a QR induction activity in Hepa1c1c7 cells. Successive column chromatography of the active EtOAc fraction resulted in the isolation of four phlorotannins. Their structures were elucidated using one- and two-dimensional nuclear magnetic resonance spectroscopic techniques and characterized as phloroglucinol (1), dioxinodehydroeckol (2), dieckol (3), and fucofuroeckol-A (4). Among these compounds, fucofuroeckol-A (4) showed moderate QR induction activity, and dioxinodehydroeckol (2) exhibited potent QR induction potency with $2.05{\pm}0.04$ fold induction at a concentration of $50{\mu}M$ compared to the dimethyl sulfoxide solvent-treated control cells. However, phloroglucinol (1) and dieckol (3) exerted no detectable QR induction activity in Hepa1c1c7 cells. These results suggest that dioxinodehydroeckol could serve as a useful cancer chemopreventive chemical.