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층간분리 형상계수(f_(S))가 FRMLs의 층간분리 성장률(dA_(D)/da)에 미치는 영향
송삼홍,이원평,김광래,김철웅 한국공작기계학회 2003 한국공작기계학회 춘계학술대회논문집 Vol.2003 No.-
Most previous researches for the hybrid composite materials such as FRMLs (Al/AFRP, Al/GFRP) have evaluated the fatigue delamination behavior using the traditional fracture mechanism. However, most previous researches have not generally been fumed yet. Because delamination growth behavior in hybrid composite should be consider delamination growth rate, dA_(D)/da using the delamination shape factors, f_(S) instead of traditional fracture mechanic parameters. The major purpose of this study was to evaluate the relationship between delamination shape factor, f_(S) s and delamination growth rate, dA_(D)/da. And a propose parameter on the delamination aspect ratio, b/a. The details of the study are as follow : 1) Relationship between crack length, a and delamination width, b. 2) Relationship between delamination aspect ratio, b/a and delamination area rate, (A_(D))_(N)/(A_(D))_(All). 3) Variation of delamination growth rate, dA_(D)/da was attendant on delamination shape factors, f_(S1), f_(S2), f_(S3). The test results indicated the delamination growth rate depends on delamination shape factors.
嚴世雄,盧三赫 弘益大學校 科學技術硏究所 1996 科學技術硏究論文集 Vol.7 No.2
I/O subsystems are becoming a serious bottleneck of system performance. Recently, we have seen a concentration of research dedicated to alleviating this problem. Research in such areas as caching , prefetching, parallel file systems, and RAID are some examples. However, these studies have mostly concentrated on single stand-alone systems. The expansion of these ideas to distributed systems have been limited. This paper describes the simulation framework needed to extend the studies on these areas. Details of the design and implementation of a simulator for file systems in a distributed environment are described.
최순호,류대웅,이미경,이삼윤 원광대학교 의과학연구소 2009 圓光醫科學 Vol.24 No.1
배경: 젊은 성인에서 자발성기흉의 치료는 논란이 많다. 흉관삽관술로 구성된 고식적인 치료는 흉관 삽관시기의 이환율, 장기간의 입원 그리고 일정기간 안에 수술을 요한다. 젊은 성인에서 기흉은 보통 폐 첨부의 기포를 동반한 것처럼, 저자는 첫 기흉의 발생 시기에 기포의 흉강경하 절제는 낮은 이환율과 짧은 입원 일을 동반하는 효과적인 치료이며 개흉술에 대한 훌륭한 대체수단이라고 가정하였다. 대상 및 방법:2005년 1월부터 2006년 12월까지 166명의 기흉환자에서 비디오흉강경수술을 시행하였다. 155명은 남자이었고 11명은 여자이었다. 평균 나이는 29.3±6.7세(15-75세)이었다. 환자는 특히 날씬하고 키가 컸으며 증상의 발현시기에 경도의 호흡곤란과 흉통을 보였다. 폐 첨부의 기포는 조직 검사로 확인을 하였다.130명의 환자는 5일이상의 지속적인 공기누출과 흉부 컴퓨터사진상 다발성 기포 때문에,15명은 반대편 기흉으로, 7명은 양측성 기흉, 그리고 5명은 흉관삽관술의 치료 후 재발한 경우로 수술을 받았다. 모든 환자에서 Endo-GIA stapler 에 의한 폐 쐐기절제수술과 탈크도포, 그리고 늑막찰과상이 수행되었다. 추적 동안에 환자의 재발 과 잔존 만성 흉통을 관찰하였다. 결과: 수술사망은 없었다. 수술 후 합병증은 1명에서 과도한 늑막찰과상에 기인한 출혈로 재수술,9명의 환자에서는 7일 이상의 지속적인 공기누출, 그리고 3명에서 재발을 보였다. 재발은 수술 후 1-3개월 동안에 발생하였다. 그리고 또한 16명에서 경도의 잔존 흉통을 호소하였지만 진통제는 필요하지 않았다. 입원 일은 원발성 기흉 환자에서는 5.2±2.4일 그리고 이차성 기흉환자는 7.5±3.2일 이었다. 결론: 늑막유착술을 동반한 폐 첨부의 쐐기절제수술은 낮은 이환율과 짧은 입원 일을 동반하고, 초기 흉관삽관술이나 개흉수술 같은 고식적인 수술에 대한 매력적인 대체수단이다. 흉강경수술은 자발성 기흉 환자를 위한 효과적으로 처음 시도하는 수술일 수 있다. 이 질환의 병태생리상 기흉 환자는 기흉의 재발 때문에 엄밀한 추적을 요한다. Background:The treatment of spontaneous pneumothorax in young adult has been controversial. Conventional treatment consisting of chest tube thoracostomy may be associated with morbidity at the time of tube insertion, prolonged hospitalization, and interval operation in many patients. As spontaneous pneumothorax in young adults is usually associated with apical blebs, we hypothesized that video-assisted thoracic surgery(VATS) resection of the blebs at the time the first pneumothorax may be effective treatment associated with low morbidity and short hospital stay, and also viable alternative to thoracotomy. Method & materials. From Jan.2005 to Dec.2006,a series of 165 patients with spontaneous pneumothorax were treated by video-assisted thoracic surgery, there were 135 men and 11 women. The mean age was 29.3±6.7 years old(range:15to 78 years).Patients were predominantly tall and thin and also mildly symptomatic at the time of presentation. Apical bullae was confirmed in the pathologic specimen.139 patients was treated for persistent air leak(>5days) and multiple blebs & bullae on Chest CT, 15 patients for contralateral pneumothorax. 7 patients for bilateral pneumothorax, and another 5 patients for recurrent pneumothotax after conservative treatment. Stalpling of blebs and bullae with Edo-GIA stapler and pleurodesis by Talc poudrage and pleural abrasion was performed in all cases. During follow-up patients were observed for recurrence and residual chronic chest pain. Results: There was no postoperative death. Postoperative complications were reoperation due to excessive pleural abrasion in one patient and continued air leaks more than 7 days in 9 patients, and recurrence in 3 patients.Recurrence were occurred during postoperative 1 to 2 months also mild chronic residual chest pain also noted in 16 patients, but no required analgesics. The hospital stay was mean 5.2±2.4 days in primary spontaneous pneumothorax and mean 7.5±3.2 days in secondary pneumothorax. Conclusions: VATS wedge resection of apical bullaes with pleurodesis is associated with low morbidity and short hospitalization, and provides an attractive alternative to the conventional treatment of initial tube thoracostomy and possible interval repeat thoracostomy or operations. VATS may be an effective first line treatment for spontaneous pneumothorax.Due to the pathophysiology of this disease, patients should be closely followed for the occurrence of the pneumothorax.
방선균 J-144K가 생산하는 Adenosine Deaminase Inhibitor에 관한 연구
전홍기,김상웅,조영배,이인 부산대학교 유전공학연구소 1996 분자생물학 연구보 Vol.12 No.-
Adenosine deaminase의 새로운 저해제를 검색하기 위해 토양으로부터 adenosine deaminase 저해제를 생산하는 8균주의 방선균을 분리하였으며, 그중에서 저해활성이 가장 우수한 J-144K균주를 공시균주로 선정하였다. Adenosine deaminase 저해제 생산을 위한 최적배지 조성은 1.0% dextrose, 0.5% yeast extract, 0.5% peptone, 0.1% KH_2PO_4이었으며, 초적온도와 pH는 각각 30˚C와 7.0이었다. 이러한 조건에서 500ml용 진탕플라스크에 최적배지 100ml를 넣어 배양했을 경우 정지기인 배양 60시간째에 adenosine deaminade 저해활성이 가장 높게 나타났다. 분리균주 J-144K의 배양상등액으로부터 활성탄 흡착 및 유기용매 추출, Dowex 50 H^+ X-8 column chromatography, Dowex 1 Cl^- X-8 column chromatography, Sephadex G-15 gel filtration 등의 과정을 거쳐 adenosine deaminase 저해제를 정제한 결과, 3가지 종류의 저해제가 존재함을 알 수 있었다. In the screening of actinomycetes' culture filtrate for inhibitor of adenosine deaminase, a novel inhibitor was found in a cultured broth of strain J-144K. The optimum conditions for the adenosine deaminase inhibitor production from the isolated strain J-144K were evaluated. This strain showed the maximum yield of adenosine deaminase inhibitor when grown at pH 7.0 and 30˚C for 60 hours in the medium of 1.0% dextrose, 0.5% yeast extract, 0.5% peptone and 0.1 % KH_2PO_4 under the aerobic condition. Through the activated charcoal extraction, methanol fractionation, Dowex 50 H^+X-8 ion exchange column chromatography, Dowex Cl^- X-8 ion exchange column chromatography, and Sephadex G-15 gel filtration procedures, this inhibitor was purified with three materials.
이미경,류대웅,이삼윤,최순호 원광대학교 의과학연구소 2009 圓光醫科學 Vol.24 No.1
Intrathoracic goiter consist of two types, namely, the primary intrathoracic goiter and secondary intrathoracic goiter. Primary intrathoracic goiters are very rare. Fifteen to fifty percent of these patients are asymptomatic. Symptoms, when present, are usually the result of tracheal or esophageal compression. Standard chest roentgenograms are often diagnostic but computed tomographic or radioactive iodine scans may be helpful. In symptomatic patients or those in whom explorations are undertaken for diagnostic purpose or exclude carcinoma, surgical removal is indicated. We report here on a case that was completely removed with using the thoracoscopic assist technique. The postoperative courses were uneventful.
최근 10년간 원광의대병원에서 시행한 소아 심장혈관 수술의 임상적 고찰
윤향석,정수미,최두영,오광수,오연균,김종덕,양현웅,이삼윤,김형곤,최종범,최순호,노병석 圓光大學校 醫科學硏究所 1995 圓光醫科學 Vol.11 No.2
We reviewed 10 years experiences of the clinical aspects and early postoperative results in 544 pediatric patients(age less than 16 years old). Among them. 529 cases had the congenital heart diseases, and 15 had the acquired diseases. Open heart surgery was performed in 413 patients. 115 cases were treated with non-open heart surgery. 16 with interventional catheterization. Annual increase of the cardiac patients was not significant in recent 10 years, except slight increase in 1994. The mean age of the study patients had been evidently changed to younger year by year. Total mortality rate of the open heart surgery was 6.4%. The cyanotic congenital heart diseases were high in early postoperative mortality by 25.7%, whereas 4% in acyanotic group. The age group less than one month was most highest in surgical mortality(66.7%). There were no deaths in patients with patent ductus arteriosus(103 cases), atrial septal defect(83 cases) or pulmonary stenosis(17 cases). Among 220 patients with ventricular septal defects(VSD). 10(4.5%) were died early postoperatively. In cyanotic group, the patients with pulmonary atresia with ventricular septal defects(PAVSD), transposition of the great arteries(TGA), interrupted aortic arch(IAA), complex cardiac anomalies with isomerism seemed to be most susceptible to an early death.
Antioxidant Properties of Peptides Extracted from Tenebrio molitor Larvae
Sam Woong Kim(김삼웅),Sang Wan Gal(갈상완),Won-Jae Chi(지원재),Woo Young Bang(방우영),So Jeong Park(박소정),Tae Wan Kim(김태완),Kyu Ho Bang(방규호) 한국생명과학회 2023 생명과학회지 Vol.33 No.5
본 연구는 기능성 식품의 개발을 위해 갈색거저리 유충 유래 추출물에서 새로운 생리활성 펩타이드를 확인하는 것이다. 동결건조된 T. molitor 유충에서 다양한 용매로 시간에 따라 추출하였다. T. molitor 유충추출 결과 물 추출물에서 5시간과 10시간에서 총 단백질과 고형분 함량당 각각 가장 높은 2,2,1-diphenyl-1-picrylhydrazyl (DPPH) 활성을 보였다. 물 추출물을 메탄올 농도에 따라 분획하였을 때, 높은 메탄올 농도는 상등액 중에 고분자량 단백질의 수준을 감소시키는 반면, 상등액의 DPPH 활성 수준을 증가시켜 저분자량 펩타이드가 항산화 활성을 매개하는 것으로 나타났다. 유기용매 분배에서 부탄올을 제외한 유기용매 분배에서 물층에서 유사한 활성을 보였다. 유기용매분획물을 열처리 후 활성이 28~44% 감소하여 열에 대한 불안정한 성분이 존재하는 것으로 추정되었다. 물 추출물에 프로테아제 K를 첨가하면 DPPH활성이 10~20% 증가하여 전체 단백질에서 방출되는 펩타이드가 항산화 활성을 부분적으로 증가시켰음을 알 수 있다. 그러므로, T. molitor 유충 추출물은 항산화제로써 기능을 수행할 수 있는 물질이 존재하는 것으로 제의할 수 있다. The goal of this study was to identify new bioactive peptides in extracts derived from Tenebrio molitor (T. molitor) larvae for the development of functional foods. After extraction from freeze-dried T. molitor larvae with various solvents on time course, the extracts showed the highest 2,2,1-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity at 5 and 10 hr per total protein and solid contents, respectively. When the water extract was fractionated, a high methanol concentration led to a reduced level of high-molecular-weight proteins in the centrifugal supernatant, whereas increased DPPH activity in the supernatants suggests low-molecular-weight peptides may mediate antioxidant activity in the supernatant. Most of the organic solvent partitions, excluding butanol, showed similar activities in the water phases, and the organic solvent partition fraction exhibited a 28~44% decrease in activity following heat treatment, implying that some components in the fraction become unstable in the presence of heat. The addition of proteinase K to the water extract increased DPPH activity by 10~20%, suggesting that peptides, when released from total proteins, partially increase antioxidant activity. Therefore, we suggest that the antioxidants in T. molitor larval extracts make them a potential source of functional animal food.